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2024 Journal Article Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicityWright, Quentin G., Sinha, Debottam, Wells, James W., Frazer, Ian H., Gonzalez Cruz, Jazmina L. and Leggatt, Graham Robert (2024). Peritumoral administration of immunomodulatory antibodies as a triple combination suppresses skin tumor growth without systemic toxicity. Journal for ImmunoTherapy of Cancer, 12 (1) e007960, e007960. doi: 10.1136/jitc-2023-007960 |
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2021 Journal Article PD-1 and beyond to activate T cells in cutaneous squamous cell cancers: the case for 4-1BB and VISTA antibodies in combination therapyWright, Quentin, Gonzalez Cruz, Jazmina L., Wells, James W. and Leggatt, Graham R. (2021). PD-1 and beyond to activate T cells in cutaneous squamous cell cancers: the case for 4-1BB and VISTA antibodies in combination therapy. Cancers, 13 (13) 3310, 3310. doi: 10.3390/cancers13133310 |
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2018 Journal Article HPV16E7 Induced Hyperplasia Promotes CXCL9/10 Expression and Induces CXCR3+ T cell Migration to SkinKuo, Paula, Tuong, Zewen K, Teoh, Siok Min, Frazer, Ian H, Mattarollo, Stephen and Leggatt, Graham R (2018). HPV16E7 Induced Hyperplasia Promotes CXCL9/10 Expression and Induces CXCR3+ T cell Migration to Skin. The Journal of investigative dermatology, 138 (6), 1348-1359. doi: 10.1016/j.jid.2017.12.021 |
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2011 Journal Article Prevention and treatment of papillomavirus-related cancers through immunizationFrazer, Ian H., Leggatt, Graham R. and Mattarollo, Stephen R. (2011). Prevention and treatment of papillomavirus-related cancers through immunization. Annual Review of Immunology, 29, 111-138. doi: 10.1146/annurev-immunol-031210-101308 |
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2007 Journal Article Secondary immunisation with high-dose heterologous peptide leads to CD8 T cell populations with reduced functional avidityNarayan, S., Choyce, A., Fernando, G. J. P. and Leggatt, G. R. (2007). Secondary immunisation with high-dose heterologous peptide leads to CD8 T cell populations with reduced functional avidity. European Journal of Immunology, 37 (2), 406-415. doi: 10.1002/eji.200535688 |
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2004 Journal Article Impaired Antigen Presentation and Effectiveness of Combined Active/Passive Immunotherapy for Epithelial TumorsMatsumoto, K., Leggatt, G. R., Zhong, J., Liu, X. S., De Kluyver, R. L., Peters, T., Fernando, G. J. P., Liem, A., Lambert, P. F. and Frazer, I. H. (2004). Impaired Antigen Presentation and Effectiveness of Combined Active/Passive Immunotherapy for Epithelial Tumors. Journal of the National Cancer Institute, 96 (21), 1611-1619. doi: 10.1093/jnci/dhj301 |
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2003 Journal Article Inhibition of early tumor growth requires Jα18-positive (natural killer T) cellsStewart, Trina J., Smyth, Mark J., Fernando, Germain J. P., Frazer, Ian H. and Leggatt, Graham R. (2003). Inhibition of early tumor growth requires Jα18-positive (natural killer T) cells. Cancer Research, 63 (12), 3058-3060. |
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1996 Journal Article Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTLAlexander-Miller, M. A., Leggatt, G. R., Sarin, A. and Berzofsky, J. A. (1996). Role of antigen, CD8, and cytotoxic T lymphocyte (CTL) avidity in high dose antigen induction of apoptosis of effector CTL. Journal of Experimental Medicine, 184 (2), 485-492. doi: 10.1084/jem.184.2.485 |
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1996 Journal Article Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapyAlexander-Miller, M. A., Leggatt, G. R. and Berzofsky, J. A. (1996). Selective expansion of high- or low-avidity cytotoxic T lymphocytes and efficacy for adoptive immunotherapy. Proceedings of the National Academy of Sciences of the United States of America, 93 (9), 4102-4107. doi: 10.1073/pnas.93.9.4102 |
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2024 Journal Article Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survivalDang, Thi Viet Trinh, Gillinder, Kevin R., Nguyen, Quan, Mulay, Onkar, Vo, Tuan, Mehdi, Ahmed M., Zhou, Chenhao, Brooks, Andrew J., Leggatt, Graham R., Hume, David A., Frazer, Ian H. and Chandra, Janin (2024). Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen‐processing‐presentation machinery and poor patient survival. Clinical and Translational Immunology, 13 (12) e70018, 1-18. doi: 10.1002/cti2.70018 |
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2023 Journal Article Metabolomics at the tumor microenvironment interface: decoding cellular conversationsBerrell, Naomi, Sadeghirad, Habib, Blick, Tony, Bidgood, Charles, Leggatt, Graham R., O'Byrne, Ken and Kulasinghe, Arutha (2023). Metabolomics at the tumor microenvironment interface: decoding cellular conversations. Medicinal Research Reviews, 44 (3), 1121-1146. doi: 10.1002/med.22010 |
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2021 Journal Article Evolution of cancer vaccines—challenges, achievements and future directionsTay, Ban Qi, Wright, Quentin, Ladwa, Rahul, Perry, Christopher, Leggatt, Graham, Simpson, Fiona, Wells, James W., Panizza, Benedict J., Frazer, Ian H. and Cruz, Jazmina L. G. (2021). Evolution of cancer vaccines—challenges, achievements and future directions. Vaccines, 9 (5) 535, 535. doi: 10.3390/vaccines9050535 |
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2021 Journal Article Investigating T cell immunity in cancer: achievements and prospectsZeng, Zhen, Chew, Hui Yi, Cruz, Jazmina G., Leggatt, Graham R. and Wells, James W. (2021). Investigating T cell immunity in cancer: achievements and prospects. International Journal of Molecular Sciences, 22 (6) 2907, 1-17. doi: 10.3390/ijms22062907 |
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2020 Journal Article Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environmentKobayashi, Takumi, Lam, Pui Yeng, Jiang, Hui, Bednarska, Karolina, Gloury, Renee Elyse, Murigneux, Valentine, Tay, Joshua, Jacquelot, Nicolas, Li, Rui, Tuong, Zewen Kelvin, Leggatt, Graham, Gandhi, Maher K., Hill, Michelle M, Belz, Gabrielle T., Ngo, Shyuan, Kallies, Axel and Mattarollo, Stephen R. (2020). Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment. Blood, 136 (26), 3004-3017. doi: 10.1182/blood.2020005602 |
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2020 Journal Article Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epitheliumBashaw, Abate Assefa, Zhou, Chenhao, Yu, Meihua, Tolley, Lynn, Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2020). Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium. The Journal of Investigative Dermatology, 141 (5), 1264-1273.e3. doi: 10.1016/j.jid.2020.10.011 |
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2020 Journal Article Serum antibodies against Toxoplasma gondii and Neospora caninum in southeast Queensland dugongsWong, Arthur, Lanyon, Janet M., O'Handley, Ryan, Linedale, Richard, Woolford, Lucy, Long, Trevor and Leggatt, Graham R. (2020). Serum antibodies against Toxoplasma gondii and Neospora caninum in southeast Queensland dugongs. Marine Mammal Science, 36 (1) mms.12629, 180-194. doi: 10.1111/mms.12629 |
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2019 Journal Article Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stageTuong, Zewen, Lewandowski, Andrew, Bridge, Jennifer, Gonzalez-Cruz, Jazmina, Yamada, Miko, Lambie, Duncan, Lewandowski, Richard, Steptoe, Raymond, Leggatt, Graham, Simpson, Fiona, Frazer, Ian, Soyer, Peter and Wells, James W. (2019). Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage. Scientific Reports, 9 (1) 17754, 17754. doi: 10.1038/s41598-019-54435-0 |
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2019 Journal Article HPV16 E7-driven epithelial hyperplasia promotes impaired antigen presentation and regulatory T cell developmentBashaw, Abate Assefa, Teoh, Siok M., Tuong, Zewen K., Leggatt, Graham R., Frazer, Ian H. and Chandra, Janin (2019). HPV16 E7-driven epithelial hyperplasia promotes impaired antigen presentation and regulatory T cell development. Journal of Investigative Dermatology, 139 (12), 2467-2476.e3. doi: 10.1016/j.jid.2019.03.1162 |
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2019 Journal Article NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsionLam, Pui Yeng, Kobayashi, Takumi, Soon, Megan, Zeng, Bijun, Dolcetti, Riccardo, Leggatt, Graham, Thomas, Ranjeny and Mattarollo, Stephen R. (2019). NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion. Cancer Immunology Research, 7 (6), 952-962. doi: 10.1158/2326-6066.cir-18-0650 |
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2018 Journal Article Recruitment of antigen presenting cells to skin draining lymph node from HPV16E7-expressing skin requires E7-Rb interactionKuo, Paula, Teoh, Siok Min, Tuong, Zewen K., Leggatt, Graham R., Mattarollo, Stephen R. and Frazer, Ian H. (2018). Recruitment of antigen presenting cells to skin draining lymph node from HPV16E7-expressing skin requires E7-Rb interaction. Frontiers in Immunology, 9 2896, 2896. doi: 10.3389/fimmu.2018.02896 |
