Associate Professor

Graham Leggatt

Email: 
Phone: 
+61 7 344 34315

Availability

Associate Professor Graham Leggatt is:
Not available for supervision

Fields of research

Clinical sciences Immunology Oncology and carcinogenesis

Search Professor Graham Leggatt’s works on UQ eSpace

131 works between 1991 and 2024
All (131) Journal Article (105) Book Chapter (1) Conference Publication (24) Book (1)

101 - 120 of 131 works

2003

Conference Publication

Immunotherapy for HPV associated pre-cancer

Frazer, Ian H., Leggatt, G. J., Matsumoto, K., De Kluyver, R., Quinn, M., Nicklin, J., Tan, J., Perrin, L., Ng, P., O'Connor, V., White, O., Wendt, N., Martin, J., Mitchelll, S.V., McKenzie, A., Crowley, J., Edwards, S. and Maher, D. (2003). Immunotherapy for HPV associated pre-cancer. Cancer Vaccine Collaborative 2002, Multiple locations, September 30 - October 1 2002. The Academy of Cancer Immunology.

Immunotherapy for HPV associated pre-cancer

2003

Journal Article

Paucity of functional CTL epitopes in the E7 oncoprotein of cervical cancer associated human papillomavirus type 16

Khammanivong, Vithagna, Liu, Xiao Song, Liu, Wen Jun, Rodda, Stuart J., Leggatt, Graham R., Tindle, Robert W., Frazer, Ian H. and Fernando, Germain J. P. (2003). Paucity of functional CTL epitopes in the E7 oncoprotein of cervical cancer associated human papillomavirus type 16. Immunology and Cell Biology, 81 (1), 1-7. doi: 10.1046/j.1440-1711.2003.01130.x

Paucity of functional CTL epitopes in the E7 oncoprotein of cervical cancer associated human papillomavirus type 16

2002

Journal Article

Antigen-specific CD4+ T-Cell Help Is Required to Activate a Memory CD8+ T Cell to a Fully Functional Tumor Killer Cell

Gao, Feng Guang, Khammanivong, Vithagna, Liu, Wen Jun, Leggatt, Graham R., Frazer, Ian H. and Fernando, Germain J. P. (2002). Antigen-specific CD4+ T-Cell Help Is Required to Activate a Memory CD8+ T Cell to a Fully Functional Tumor Killer Cell. Cancer Research, 62 (22), 6438-6441.

Antigen-specific CD4+ T-Cell Help Is Required to Activate a Memory CD8+ T Cell to a Fully Functional Tumor Killer Cell

2002

Journal Article

Interferon-gamma enhances cytotoxic T lymphocyte recognition of endogenous peptide in keratinocytes without lowering the requirement for surface peptide

Leggatt, Graham R., Dunn, Linda A., De Kluyver, Rachel L., Stewart, Trina and Frazer, Ian H. (2002). Interferon-gamma enhances cytotoxic T lymphocyte recognition of endogenous peptide in keratinocytes without lowering the requirement for surface peptide. Immunology and Cell Biology, 80 (5), 415-424. doi: 10.1046/j.1440-1711.2002.01105.x

Interferon-gamma enhances cytotoxic T lymphocyte recognition of endogenous peptide in keratinocytes without lowering the requirement for surface peptide

2002

Journal Article

Chimeric human papilloma virus-simian/human immunodeficiency virus virus-like-particle vaccines: Immunogenicity and protective efficacy in macaques

Dale, C. Jane, Liu, Xiao Song Song, De Rose, Robert, Purcell, Damian F. J., Anderson, Jenny, Xu, Yan, Leggatt, Graham R., Frazer, Ian H. and Kent, Stephen J. (2002). Chimeric human papilloma virus-simian/human immunodeficiency virus virus-like-particle vaccines: Immunogenicity and protective efficacy in macaques. Virology, 301 (1), 176-187. doi: 10.1006/viro.2002.1589

Chimeric human papilloma virus-simian/human immunodeficiency virus virus-like-particle vaccines: Immunogenicity and protective efficacy in macaques

2002

Journal Article

The number of long-lasting functional memory CD8(+) T cells generated depends on the nature of the initial nonspecific stimulation

Fernando, G. J. P., Khammanivong, V., Leggatt, G. R., Liu, W. J. and Frazer, I. H. (2002). The number of long-lasting functional memory CD8(+) T cells generated depends on the nature of the initial nonspecific stimulation. European Journal of Immunology, 32 (6), 1541-1549. doi: 10.1002/1521-4141(200206)32:63.0.CO;2-S

The number of long-lasting functional memory CD8(+) T cells generated depends on the nature of the initial nonspecific stimulation

2002

Journal Article

Route of administration of chimeric BPV1VLP determines the character of the induced immune responses

Liu, Xiao Song, Liu, Wen Jun, Zhao, Kong Nan, Liu, Yue Hua, Leggatt, Graham and Frazer, Ian H. (2002). Route of administration of chimeric BPV1VLP determines the character of the induced immune responses. Immunology and Cell Biology, 80 (1), 21-29. doi: 10.1046/j.1440-1711.2002.01051.x

Route of administration of chimeric BPV1VLP determines the character of the induced immune responses

2001

Journal Article

Polynucleotide viral vaccines: codon optimisation and ubiquitin conjugation enhances prophylactic and therapeutic efficacy

Liu, Wen jun, Zhao, Kong-Nan, Gao, Feng Guang, Leggatt, Graham R., Fernando, Germain J. and Frazer, Ian H. (2001). Polynucleotide viral vaccines: codon optimisation and ubiquitin conjugation enhances prophylactic and therapeutic efficacy. Vaccine, 20 (5-6), 862-869. doi: 10.1016/S0264-410X(01)00406-6

Polynucleotide viral vaccines: codon optimisation and ubiquitin conjugation enhances prophylactic and therapeutic efficacy

2001

Journal Article

Tolerance or immunity to a tumor antigen expressed in somatic cells can be determined by systemic proinflammatory signals at the time of first antigen exposure

Frazer, Ian H., De Kluyver, Rachel L., Leggatt, Graham R., Guo, Hua, Dunn, Linda A., White, Olivia J., Harris, Craig, Liem, Amy and Lambert, Paul F. (2001). Tolerance or immunity to a tumor antigen expressed in somatic cells can be determined by systemic proinflammatory signals at the time of first antigen exposure. The Journal of Immunology, 167 (11), 6180-6187. doi: 10.4049/jimmunol.167.11.6180

Tolerance or immunity to a tumor antigen expressed in somatic cells can be determined by systemic proinflammatory signals at the time of first antigen exposure

2001

Journal Article

Nonspecific down-regulation of CD8+ T-Cell responses in mice expressing human Papillomavirus Type 16 E7 oncoprotein from the keratin-14 promoter

Tindle, Robert W., Herd, Karen A., Doan, Tracy, Bryson, Greg, Leggatt, Graham R., Lambert, Paul, Ian H. Frazer, and Street, Michael D. (2001). Nonspecific down-regulation of CD8+ T-Cell responses in mice expressing human Papillomavirus Type 16 E7 oncoprotein from the keratin-14 promoter. Journal of Virology, 75 (13), 5985-5997. doi: 10.1128/JVI.75.13.5985-5997.2001

Nonspecific down-regulation of CD8+ T-Cell responses in mice expressing human Papillomavirus Type 16 E7 oncoprotein from the keratin-14 promoter

2001

Conference Publication

Mucosal and systemic immunization with BPVL1E7VLP vaccine induce effective cellular immunity

Saito, J., Kanzaki, H., Leggatt, G. and Frazer, I. (2001). Mucosal and systemic immunization with BPVL1E7VLP vaccine induce effective cellular immunity. 53rd Annual Congress of the Japan Society of Obstetrics and Gynecology, Sapporo, Japan, 12-15 May 2001. 40128 BOLOGNA: Medimond S R L.

Mucosal and systemic immunization with BPVL1E7VLP vaccine induce effective cellular immunity

2000

Journal Article

Papillomavirus virus-like particles for the delivery of multiple cytotoxic T cell epitopes

Liu, WJ, Liu, XS, Zhao, KN, Leggatt, GR and Frazer, IH (2000). Papillomavirus virus-like particles for the delivery of multiple cytotoxic T cell epitopes. Virology, 273 (2), 374-382. doi: 10.1006/viro.2000.0435

Papillomavirus virus-like particles for the delivery of multiple cytotoxic T cell epitopes

2000

Journal Article

Cytotoxic T-cell adherence assay (CAA)

Leggatt, G. R. and Berzofsky, J. A. (2000). Cytotoxic T-cell adherence assay (CAA). Methods in molecular biology (Clifton, N.J.), 134, 277-281.

Cytotoxic T-cell adherence assay (CAA)

1999

Journal Article

Potential strategies utilised by papillomavirus to evade host immunity

Frazer, Ian H., Thomas, Ranjeny, Zhou, Jian A., Leggatt, Graham R., Dunn, Linda, Mcmillan, Nigel A. J., Tindle, Robert W., Filgueira, Luis, Manders, Peter, Barnard, Paula and Sharkey, Michael (1999). Potential strategies utilised by papillomavirus to evade host immunity. Immunological Reviews, 168 (1), 131-142. doi: 10.1111/j.1600-065X.1999.tb01288.x

Potential strategies utilised by papillomavirus to evade host immunity

1999

Book Chapter

Immunology of HPV infection

Leggatt, G. R. and Frazer, I. H. (1999). Immunology of HPV infection. Vaccines for Human Papillomavirus Infection and Anogenital Disease. (pp. 13-31) edited by Robert W. Tindle. Austin, USA: R. G. Landes Company.

Immunology of HPV infection

1998

Journal Article

The importance of pairwise interactions between peptide residues in the delineation of TCR specificity

Leggatt, G. R., Hosmalin, A., Pendleton, C. D., Kumar, A., Hoffman, S. and Berzofsky, J. A. (1998). The importance of pairwise interactions between peptide residues in the delineation of TCR specificity. Journal of Immunology, 161 (9), 4728-4735.

The importance of pairwise interactions between peptide residues in the delineation of TCR specificity

1998

Journal Article

Split tolerance to a viral antigen expressed in thymic epithelium and keratinocytes

Frazer, Ian H., Fernando, Germain J. P., Fowler, Nina, Leggatt, Graham R., Lambert, Paul F., Liem, Amy, Malcolm, Karen and Tindle, Robert W. (1998). Split tolerance to a viral antigen expressed in thymic epithelium and keratinocytes. European Journal of Immunology, 28 (9), 2791-2800. doi: 10.1002/(SICI)1521-4141(199809)28:093.0.CO;2-B

Split tolerance to a viral antigen expressed in thymic epithelium and keratinocytes

1997

Journal Article

Cloning and expression of a cDNA encoding a nonintegrin laminin-binding protein from Echinococcus granulosus with localization of the laminin-binding domain

Zhang, L. H., Leggatt, G. R., Kalinna, B. H., Piva, T. J. and McManus, D. P. (1997). Cloning and expression of a cDNA encoding a nonintegrin laminin-binding protein from Echinococcus granulosus with localization of the laminin-binding domain. Molecular and Biochemical Parasitology, 87 (2), 183-192. doi: 10.1016/S0166-6851(97)00066-2

Cloning and expression of a cDNA encoding a nonintegrin laminin-binding protein from Echinococcus granulosus with localization of the laminin-binding domain

1997

Journal Article

Cytotoxic T lymphocyte (CTL) adherence assay (CAA): A non-radioactive assay for murine CTL recognition of peptide-MHC class I complexes

Leggatt, G. R., Alexander-Miller, M. A., Kumar, A., Hoffman, S. L. and Berzofsky, J. A. (1997). Cytotoxic T lymphocyte (CTL) adherence assay (CAA): A non-radioactive assay for murine CTL recognition of peptide-MHC class I complexes. Journal of Immunological Methods, 201 (1), 1-10. doi: 10.1016/S0022-1759(96)00203-7

Cytotoxic T lymphocyte (CTL) adherence assay (CAA): A non-radioactive assay for murine CTL recognition of peptide-MHC class I complexes

1996

Journal Article

The ultrastructural localization of Echinococcus granulosus antigen 5

Jones, M. K., Zhang, L. H., Leggatt, G. R., Stenzel, D. J. and McManus, D. P. (1996). The ultrastructural localization of Echinococcus granulosus antigen 5. Parasitology, 113 (3), 213-222. doi: 10.1017/S0031182000081993

The ultrastructural localization of Echinococcus granulosus antigen 5

Past funding

  • 2020 - 2022
    Intradermal delivery of therapeutic antibodies in skin cancer
    TdC Pioneering Grant
    Open grant
  • 2017 - 2019
    Targeting immunomodulatory molecules on T cells in non-melanoma skin cancer
    Cancer Council Queensland
    Open grant
  • 2015 - 2016
    Novel therapeutic targets for HPV-driven cancers (Cancer Council Queensland grant administered by Griffith University
    Griffith University
    Open grant
  • 2014
    Local immune response to perineural squamous cell carcinoma
    PA Research Foundation
    Open grant
  • 2014 - 2017
    Memory CD8 T cell subsets in non-melanoma skin cancer
    Cancer Council Queensland
    Open grant
  • 2013 - 2014
    The Gavin Chase Research Project Grant
    Cancer Council Queensland
    Open grant
  • 2012 - 2013
    RNA interference and the Immune System (NHMRC Project Grant administered by Griffith University)
    Griffith University
    Open grant
  • 2010 - 2012
    Suppressor NKT cell trafficking to epithelial precancer
    Cancer Council Queensland
    Open grant
  • 2008 - 2009
    Histone deacetylase inhibitors can inhibit tumour growth via induction of an anti-tumour immune response
    Cancer Council Queensland
    Open grant
  • 2008 - 2009
    The Role of RNA interference in the induction of immune responses
    ARC Linkage Projects
    Open grant
  • 2006 - 2008
    Mechanisms of dendritic cell-induced T-cell tolerance
    NHMRC Project Grant
    Open grant
  • 2005 - 2006
    Optimising Immunotherapy in Tumour Antigen Experienced Host
    Queensland Cancer Fund
    Open grant
  • 2005 - 2006
    The role of NKT and CD8 cells in tumour immunotherapy using epithelial tumour models
    Queensland Cancer Fund
    Open grant
  • 2004 - 2008
    Improving Vaccines Against Viruses And Tumours: Optimising the Cytotoxic T Lymphocyte Response
    Lions Medical Research Foundation
    Open grant
  • 2004 - 2005
    NHMRC_Equipment Grant _HLTH_CICR_Med SCD
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2006
    Treatment Of Virally-Induced Cancers By RNA Interference
    NHMRC Project Grant
    Open grant
  • 2003 - 2004
    Immunoregulatory Immune Responses To A Peripherally Presented Tumour Antigen
    NHMRC Project Grant
    Open grant
  • 2003
    Zeiss Cell Observer Video Microscopy System
    NHMRC Equipment Grant
    Open grant
  • 2002
    CTL avidity as a determinant of the mature, antigen-specific immune repertoire.
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2001
    CTL Avidity As A Determinant Of The Mature, Antigen-Specific Immune Repertoire
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 2001 - 2003
    CTL Avidity as a Determinant of the Mature, Antigen-specific Immune Repertoire
    NHMRC Project Grant
    Open grant
  • 2000
    CTL avidity as a determinant of the mature, antigen-specific immune repertoire
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999
    Analysis of functional activation thresholds in peripheral CD8+ T cells
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999
    Clonal selection of CTL avidity in the periphery
    Princess Alexandra Hospital R&D Foundation
    Open grant
  • 1999
    CTL avidity and cell number as determinants of E7 tumour regression in vivo
    Cancer Bequest Fund
    Open grant
  • 1999 - 2001
    Development of hybrid HPV/HIV VLPs, a novel vaccine to prevent both HIV and HPV infection
    NHMRC Project Grant
    Open grant
  • 1998
    The Role of CTL Avidity and Cytokine Environment in the Control of Papillomavirus Infection and Epithelial Tumours
    Mayne Bequest Fund
    Open grant

Availability

Associate Professor Graham Leggatt is:
Not available for supervision

Supervision history

Current supervision

Completed supervision

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