Overview
Background
Our work on human pigmentation genetics has allowed understanding of normal variation in this physical trait and the associated genotypic risk for skin cancer. The genes that determine an individual's skin phototype and the cellular mechanisms that result in the tanning response of melanocytes after UV-exposure of the skin are actively being investigated.
Assoc. Prof Rick Sturm is group leader in the Dermatology Research Centre within the Frazer Institue.
Availability
- Associate Professor Rick Sturm is:
- Available for supervision
- Media expert
Fields of research
Research interests
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Skin, hair, eye colour and cancer � MC1R/OCA2, the genetic links
Pigmentary traits such as red hair and fair skin, moles, eye colour, lack of tanning ability and propensity to freckle have been identified as genetic risk factors for skin cancer when combined with the environmental risk factor of high ultraviolet exposure. The major areas of investigation are the role of the OCA2 gene in directing eye colour, and the role of human melanocortin-1 receptor (MC1R) gene variants in directing skin phototype and response to UV-induced ligand binding and receptor activation. The MC1R coding sequence is highly polymorphic in human populations and we have examined MC1R variant allele frequencies in the general community as well as a collection of adolescent dizygotic and monozygotic twins with defined pigmentation characteristics. Subscription required to access this paper Variant allele frequencies have also been determined in several case-control studies of sporadic melanoma, basal cell carcinoma and squamous cell carcinoma, and in familial melanoma kindreds collected within Australia. These studies have shown that three MC1R alleles � Arg151Cys, Arg160Trp and Asp294His � were associated with increased risk in all forms of skin cancer and with penetrance and age of onset in familial melanoma in CDKN2A mutation carriers. There is a significant MC1R variant allele heterozygote carrier effect on skin phototype and skin cancer risk, which indicates that these alleles do not behave in a strictly recessive manner.
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Characterisation of melanoblast stem cell differentiation
The process of development and differentiation of the melanocytic cell lineage is being investigated using primary melanoblast and melanocyte cells cultured in vitro from human skin. This will provide information to allow the genes and processes involved in melanoma tumour formation and metastasis to be examined. These studies focus on the identification and molecular characterisation of the genes involved in melanocyte function.
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Mechanisms of melanoma metastasis
Expression of the �3 integrin gene in melanoma in situ has been found to be the single most important marker of metastasis yet discovered. Experiments to investigate the effects of this expression has involved the use of Adenoviral gene transduction of the �3 integrin subunit into radial growth phase (RGP) melanoma cell lines and differential gene screening. A skin reconstruction model was used to assay the invasivness of RGP melanoma cells after ectopic �3 integrin expression and these studies have discovered induction of the anti-adhesive protein osteonectin is required for melanoma metastasis.
Works
Search Professor Rick Sturm’s works on UQ eSpace
2016
Journal Article
Heritability of naevus patterns in an adult twin cohort from the Brisbane Twin Registry: A cross-sectional study
Lee, S., Duffy, D.L., Mcclenahan, P., Lee, K. J., McEniery, E., Burke, B., Jagirdar, K., Martin, N.G., Sturm, R.A., Soyer, H.P. and Schaider, H. (2016). Heritability of naevus patterns in an adult twin cohort from the Brisbane Twin Registry: A cross-sectional study. British Journal of Dermatology, 174 (2), 356-363. doi: 10.1111/bjd.14291
2016
Journal Article
A distinct expression profile separates Turkish and Australian melanocytic naevi
Fox, Carly, Schaider, Helmut, Akalin, Taner, Turkmen, Meltem, Sturm, Rick, Lambie, Duncan, Karaarslan, Isil K., Soyer, H. Peter, Ozdemir, Fezal and Gabrielli, Brian (2016). A distinct expression profile separates Turkish and Australian melanocytic naevi. Histopathology, 69 (1), 151-154. doi: 10.1111/his.12906
2016
Conference Publication
On Nevus Research in Southeast Queensland
Soyer, H. Peter and Sturm, Rick A. (2016). On Nevus Research in Southeast Queensland. Joint meeting of the Australasian Wound and Tissue Repair Society (AWTRS) and the Molecular & Experimental Pathology Society of Australasia (MEPSA): Melbourne Convention and Exhibition Centre,, Melbourne, Australia, 7–9 November 2016. HOBOKEN: Wiley. doi: 10.1111/wrr.12489
2016
Conference Publication
Epigenetic remodelling of H3K9Me3 leads to early stress induced drug tolerance in cancer
Emran, A. A., Menon, D. R., Marzese, D., Hammerlindl, H., Brafford, P., Stark, M., Huang, S., Hammerlindl, S., Gupta, D., Soyer, P., Sturm, R., Hoon, D., Gabrielli, B., Herlyn, M. and Schaider, H. (2016). Epigenetic remodelling of H3K9Me3 leads to early stress induced drug tolerance in cancer. Asia‐Pacific Combined Dermatology Research Conference 2016, Noosa, QLD Australia, 25–28 August 2016. Richmond, VIC Australia: Wiley-Blackwell.
2016
Conference Publication
A case-control study of the associations of PGC1 beta genotype with melanoma, skin reflectance, and naevus count
Ling, X., Yong, H., Pflugfelder, A., Duffy, D., Jagirdar, K., Lee, K., Garbe, C., Soyer, H. P. and Sturm, R. (2016). A case-control study of the associations of PGC1 beta genotype with melanoma, skin reflectance, and naevus count. Asia‐Pacific Combined Dermatology Research Conference 2016, Noosa, QLD, Australia, 25-28 August 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12584
2016
Other Outputs
Acquired Melanocytic Nevi Images documented with dermoscopy, pigmentation characteristics and MC1R genotypes in a Han Chinese population
Dong, Huiting, Soyer, H. Peter, Sturm, Richard A., Lee, Katie, Jagirdar, Kasturee and Duffy, David (2016). Acquired Melanocytic Nevi Images documented with dermoscopy, pigmentation characteristics and MC1R genotypes in a Han Chinese population. The University of Queensland. (Dataset) doi: 10.14264/uql.2017.109
2016
Journal Article
The microphthalmia-associated transcription factor p.E318K mutation does not play a major role in sporadic renal cell tumors from Caucasian patients
Stoehr, Christine G., Walter, Bernhard, Denzinger, Stefan, Ghiorzo, Paola, Sturm, Richard A., Hinze, Raoul, Moch, Holger, Junker, Kerstin, Hartmann, Arndt and Stoehr, Robert (2016). The microphthalmia-associated transcription factor p.E318K mutation does not play a major role in sporadic renal cell tumors from Caucasian patients. Pathobiology, 83 (4), 165-169. doi: 10.1159/000443311
2016
Conference Publication
Testing of viable clonal human skin cell cultures as an approach to validating microsampling of naevi
Ainger, S., Ling, X., Yong, H., Tan, J. -M., Jagirdar, K., Smit, D., Soyer, H. P. and Sturm, R. (2016). Testing of viable clonal human skin cell cultures as an approach to validating microsampling of naevi. Asia‐Pacific Combined Dermatology Research Conference 2016, Noosa, QLD, Australia, 25-28 August 2016. Richmond, VIC, Australia: Wiley-Blackwell Publishing. doi: 10.1111/ajd.12584
2016
Conference Publication
Global histone modifications define early stress induced drug tolerance in cancer
Al Emran, Abdullah, Menon, Dinoop Ravindran, Soyer, Peter, Gabrielli, Brian, Sturm, Rick, Herlyn, Meenhard and Schaider, Helmut (2016). Global histone modifications define early stress induced drug tolerance in cancer. American-Association-for-Cancer-Research (AACR) Special Conference on Chromatin and Epigenetics in Cancer, Atlanta, GA, United States, 24-27 September 2015. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.CHROMEPI15-B34
2016
Conference Publication
Naevus endophenotypes and melanoma risk
McWhirter, S., Lee, K., Wimberley, G., Ong, N., Leikvold, A., Ashley, A., Jagirdar, K., Duffy, D., Soyer, H. P. and Sturm, R. (2016). Naevus endophenotypes and melanoma risk. -, -, -. HOBOKEN: WILEY-BLACKWELL.
2015
Journal Article
Lack of protection from development of multiple melanomas by an injected melanocortin analogue in a combined high-risk MC1R/CDKN2A genotype patient
Bohm, M., Jagirdar, K., Sturm, R.A., Konig, S., Bauer, J., Metze, D., Luger, T.A. and Weishaupt, C. (2015). Lack of protection from development of multiple melanomas by an injected melanocortin analogue in a combined high-risk MC1R/CDKN2A genotype patient. Journal of the European Academy of Dermatology and Venereology, 30 (10), e65-e67. doi: 10.1111/jdv.13310
2015
Journal Article
TLR3 drives IRF6-dependent IL-23p19 expression and p19/EBI3 heterodimer formation in keratinocytes
Ramnath, Divya, Tunny, Kathryn, Hohenhaus, Daniel M., Pitts, Claire M., Bergot, Anne-Sophie, Hogarth, P. Mark, Hamilton, John A., Kapetanovic, Ronan, Sturm, Richard A., Scholz, Glen M. and Sweet, Matthew J. (2015). TLR3 drives IRF6-dependent IL-23p19 expression and p19/EBI3 heterodimer formation in keratinocytes. Immunology and Cell Biology, 93 (9), 771-779. doi: 10.1038/icb.2015.77
2015
Journal Article
Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up
Liu, Fan, Visser, Mijke, Duffy, David L., Hysi, Pirro G., Jacobs, Leonie C., Lao, Oscar, Zhong, Kaiyin, Walsh, Susan, Chaitanya, Lakshmi, Wollstein, Andreas, Zhu, Gu, Montgomery, Grant W., Henders, Anjali K., Mangino, Massimo, Glass, Daniel, Bataille, Veronique, Sturm, Richard A., Rivadeneira, Fernando, Hofman, Albert, van IJcken, Wilfred F. J., Uitterlinden, André G., Palstra, Robert-Jan T. S., Spector, Timothy D., Martin, Nicholas G., Nijsten, Tamar E. C. and Kayser, Manfred (2015). Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up. Human Genetics, 134 (8), 823-835. doi: 10.1007/s00439-015-1559-0
2015
Journal Article
Src and SCC: getting to the FAKs
Ainger, Stephen A. and Sturm, Richard A. (2015). Src and SCC: getting to the FAKs. Experimental Dermatology, 24 (7), 487-488. doi: 10.1111/exd.12725
2015
Conference Publication
The correlation of skin color with dermoscopic nevus patterns in a Queensland high risk melanoma cohort
Ong, Natalie, Duffy, David, Lee, Katie, McClenahan, Phil, Jagirdar, Kasturee, Sturm, Richard and Soyer, H. Peter (2015). The correlation of skin color with dermoscopic nevus patterns in a Queensland high risk melanoma cohort. American Academy of Dermatology 73rd Annual Meeting, San Francisco, CA, United States, 20-24 March 2015. New York, NY, United States: Elsevier . doi: 10.1016/j.jaad.2015.02.722
2015
Journal Article
BRAF wild-type melanoma in situ arising in a BRAF V600E mutant dysplastic nevus
Tan, Jean-Marie, Lin, Lynlee L., Lambie, Duncan, Flewell-Smith, Ross, Jagirdar, Kasturee, Schaider, Helmut, Sturm, Richard A., Prow, Tari W. and Soyer, H. Peter (2015). BRAF wild-type melanoma in situ arising in a BRAF V600E mutant dysplastic nevus. JAMA Dermatology, 151 (4), 417-421. doi: 10.1001/jamadermatol.2014.3775
2015
Conference Publication
Glutathione S-transferase P1 Ile105Val polymorphism: phenotypic characteristics and melanoma risk
Daley, G. M., Lee, K. J., Jagirdar, K., Smithers, B. M., Duffy, D. L., Sturm, R. A. and Soyer, H. P. (2015). Glutathione S-transferase P1 Ile105Val polymorphism: phenotypic characteristics and melanoma risk. 48th Annual Scientific Meeting of the Australasian College of Dermatologists, Adelaide SA, Australia, 16 May 2015. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12337
2015
Journal Article
High incidence of primary melanomas in an MC1R RHC homozygote/CDKN2A mutant genotype patient
Sinnya, Sudipta, Jagirdar, Kasturee, De'Ambrosis, Brian, McMeniman, Erin, Sturm, Richard A. and Soyer, H. Peter (2015). High incidence of primary melanomas in an MC1R RHC homozygote/CDKN2A mutant genotype patient. Archives of Dermatological Research, 307 (8), 741-745. doi: 10.1007/s00403-015-1582-y
2015
Conference Publication
Molecular profiles of reticular and globular naevus patterns: a pilot study
Ong, N., Duffy, D., Leikvold, A., Lee, K., Jagirdar, K., Lin, Lynlee L., Yamada, M., Sturm, R. A., Prow, T. W., Schaider, H. and Soyer, H. P. (2015). Molecular profiles of reticular and globular naevus patterns: a pilot study. 48th Annual Scientific Meeting of the Australasian College of Dermatologists, Adelaide SA, Australia, 16 May 2015. Richmond, VIC Australia: Wiley-Blackwell Publishing Asia. doi: 10.1111/ajd.12337
2015
Conference Publication
Feasibility of genotyping melanocytic lesions by microsampling
Tan, Jean-Marie, Lin, Lynlee L., Lambie, Duncan, Ong, Natalie, Flewell-Smith, Ross, Jagirdar, Kasturee, Schaider, Helmut, Sturm, Richard A., Prow, Tarl W. and Soyer, H. Peter (2015). Feasibility of genotyping melanocytic lesions by microsampling. 73rd Annual Meeting of the American Academy of Dermatology, San Francisco, California, 20–24 March 2015. Philadelphia, PA United States: Mosby.
Funding
Past funding
Supervision
Availability
- Associate Professor Rick Sturm is:
- Available for supervision
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Supervision history
Completed supervision
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2009
Doctor Philosophy
The molecular mechanism of MC1R association with skin cancer risk phenotypes
Principal Advisor
Other advisors: Professor Jennifer Stow
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2008
Doctor Philosophy
A Melanocyte-Keratinocyte Coculture Model to Study MC1R Dependent Pigmentation Responses
Principal Advisor
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2006
Doctor Philosophy
MOLECULAR CHANGES DEFINING THE TRANSITION FROM RADIAL TO VERTICAL GROWTH PHASE IN MELANOMA
Principal Advisor
Other advisors: Professor Jennifer Stow
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2004
Doctor Philosophy
MODELS OF HUMAN NEURAL CREST CELL DIFFERENTIATION IN VITRO
Principal Advisor
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2020
Master Philosophy
Gene Polymorphisms Associated with Amelanotic/Hypopigmented and Nodular Melanoma
Associate Advisor
Other advisors: Professor Peter Soyer
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2020
Master Philosophy
The role of SETDB1/2-mediated H3K9me3 in drug-tolerant cancer
Associate Advisor
Other advisors: Associate Professor Helmut Schaider
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2020
Doctor Philosophy
Genotypic and phenotypic correlations in a cohort of patients with multiple primary melanoma
Associate Advisor
Other advisors: Professor Peter Soyer
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2018
Master Philosophy
Dermoscopic and molecular correlation of melanocytic naevi
Associate Advisor
Other advisors: Dr Mitchell Stark, Professor Peter Soyer
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2018
Master Philosophy
The correlation of skin colour, skin reflectance, freckling, MC1R, TYR, IRF-4 and TPCN2 genotypes with naevus pattern within a case-control study of melanoma
Associate Advisor
Other advisors: Associate Professor Helmut Schaider
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2018
Doctor Philosophy
Phenotypes and Genotypes of Melanoma Patients
Associate Advisor
Other advisors: Professor Peter Soyer
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2017
Doctor Philosophy
Investigating the role of the MITF-BRN2 expression axis in metastatic melanoma
Associate Advisor
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2016
Doctor Philosophy
Investigating the role of NR4A genes in response to cellular stress
Associate Advisor
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2014
Doctor Philosophy
Role of IRF6 in epithelial cell-mediated host defence and inflammation
Associate Advisor
Other advisors: Professor Matt Sweet
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2004
Doctor Philosophy
STRUCTURE-FUNCTION ANALYSIS OF NUCLEAR HORMONE RECEPTORS NUR77 AND NOR I: EVIDENCE FOR A ROLE IN MUSCLE
Associate Advisor
Media
Enquiries
Contact Associate Professor Rick Sturm directly for media enquiries about:
- Basal cell carcinoma
- Carcinoma
- Eye colour
- Genetics
- Hair colour
- Human pigmentation
- Melanoma
- Pigmentation - human skin
- Skin cancer
- Skin colour
- Skin tanning
- Squamous cell carcinoma
- Sun cancer
- Sun damage
- Sun exposure
- Tanning - of skin
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