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Ecological and evolutionary genomics

My research group uses genetic markers as tools for understanding dispersal and gene flow, often with conservation implications and most frequently focusing on highly dispersive marine animals such as fishes, mussels, and corals. We also study how gene flow and natural selection affect genomic variation and limit gene exchange across genomes, populations, and species.

Dr Melanie Robitaille is a Senior Post-Doctoral Researcher working with the Calcium Signalling in Therapeutics Team (CaSTT) in the School of Pharmacy. This team specializes in the development and application of novel methodologies and cellular assays in drug discovery, including the use of genetically encoded indicator for high-content imaging in live cells.

Her interests are to elucidate how calcium signals are remodelled in disease states, to identify calcium transporters as new therapeutic targets and to develop molecular and cellular screening tools to be used in drug development programs. She has an established profile in cellular and molecular biology, with high expertise in plasmid cloning, lentiviral transduction and the use of CRISPR/Cas9 to modulate gene expression.

Research interest: Monitoring ecosystem health of coral reefs and seagrass habitats, integrating field and remote sensing image datasets, and the developing applied cost-effective mapping and monitoring approaches. Developed approaches have been adopted as standard practice globally, making a difference in conservation of these valuable habitats. The long term monitoring studies at Heron and Moreton Bay formed the basis for the development of mapping and monitoring over time and space at local to global scale. See here major research impact

Major projects:

• Long term monitoring of benthic composition at Heron Reef (2002-ongoing).
• Long term monitoring of seagrass composition and abundance in Moreton bay Marine Park (2000-ongoing).
• Smart Sat CRC Hyperspectral Remote Sensing of Seagrass and Coral Reefs 2023-2027.
• Developement of Underwater Field Spectrometry and Benthic Photo Collection and Analysis
• 3D GBR Habitat Mapping Project 2015 - ongoing:
• Global habitat mapping project 2019-2023 Allen Coral Atlas .

Current position: Associate Professior in Marine Remote Sensing leading the Marine Ecosystem Monitoring Lab. . Academic Director Heron Island Research Station and affiliated researchers with Centre for Marine Science and Centre for Biodiversity and Conservation Science

Capacity Building and Citizen Science: Capacity: under/post graduate courses; Msc/PhD supervision, workshops/courses; Remote Sensing Educational Toolkit, and online courses (e.g. TNC).Strong supporter of citizen science based projects, as trainer, organiser and advisor for Reef Check Australia, CoralWatch, Great Reef Census and UniDive.

Professor Eugeni Roura is a nutritionist by background with specific research interests in digestive physiology and chemosensory science. He joined the University of Queensland (UQ) in 2010 as a member of the Centre for Nutrition and Food Sciences, where he leads a research team active in the interface between basic and translational research aiming at industrial and societal applications. The main research interests include gut nutrient sensing mechanisms and appetite modulation (including taste and smell) relevant to humans, pigs and poultry. Recently, the research focus has evolved to include transgenerational nutrition studies including foetal development in pigs and “in ovo” applications in chickens. In 2011 he joined the UQ School of Biomedical Sciences as an Affiliated Lecturer.

Professor Roura graduated with a Veterinary Science degree from the Universitat Autonoma de Barcelona (UAB) before pursuing post-graduate studies in Nutrition at the University of California (UC Davis). After finishing a Post-Doctoral position at UC Davis, he started a sixteen-year industry career working for the feed and food industries in R&D and market-focused technical services, culminating as Group Deputy R&D Director of Lucta S.A.

He has authored more than 100 peer-reviewed scientific publications, and he has been invited as keynote speaker to ca 50 scientific meetings. He is currently serving as a member of the National Committee for Nutrition of the Australian Academy of Sciences, International Steering Committee of the Digestive Physiology of pigs, R&D and Education Committee of the Australasian Pork Research Institute Ltd., expert evaluator of 1 international and 2 national research grant programs, and as Editorial Board of two scientific journals ("Journal of Animal Science and Biotechnology" and "Animals"). Main past positions include President of the Austral-Asian Chemosensory Society, Vice-Chairperson of the Board Specialty Committee of Mongolian Medicine, Standards Australia FT-022 Committee “Sensory Analysis of Food”, Master of Dietetics Studies Engagement Committee (UQ), AgriFutures Chicken Meat Advisory Panel, and the European Feed Additive Federation (FEFANA) amongst others. In addition, Professor Eugeni Roura has been involved in several national and international conference organizing committees including acting as leading co-Chair of the Digestive Physiology of Pigs 2018.

I currently have a number of research interests, both in Biomedical and well as in Teaching-Focussed Research.

Biomedical projects have traditionally been done with collaborators, and some of the projects have included:

• mechanisms of action of animal venoms and toxins, and we have used the organ bath laboratory and pharmacologoical techniques as bioassays
• study of bitter tasting compounds on pig digestive processes, to better understand activation of bitter taste receptors in vivo

Teaching-focussed interested are around university student behaviour with regard to learning activities and engagement. Universities around the world are grappling with shifts in effective and engaging educational strategies, as well as student expectations, in their delivery of content. In an age where students can do on-line courses at universities far from Australia, academics are carefully considering student engagement and success here at UQ.

• Lecture slots currently have the bulk of contact hours in most courses, with ~39 lectures per course across a semester. These are largely recorded and used as a teaching resource. Student attendance to the traditional lecture spaces has decreased significantly across all campuses, with a UQ average of ~60% across all courses. This type of analysis has recently led to UQ offering smaller venues for larger courses in which there have been patterns of partial attendance.
• My work seeks to better understand what motivates students to attend these spaces in their traditional sense and in the transition to an increasing number of flipped classroom models and blended learning, where the academics are less on the stage, and are instead facilitating activities for learning, while students will be engaged in learning content largely outside the lecture slots.
• "Embracing the Unknown" Experience in third year science courses is also an interest, in which research work and its associated uncertainties cause varying levels of anxiety in some students. Best understanding this process and supporting students through it is also an interest of mine.

Professor Pankaj Sah is Director of the Queensland Brain Institute (QBI) at The University of Queensland (UQ). He is renowned for his work in understanding the neural circuitry of the amygdala, an area of the brain that plays a central role in learning and memory formation. Dysfunction of the amygdala leads to a host of anxiety-related disorders. His laboratory uses a combination of molecular tools, electrophysiology, anatomical reconstruction, calcium imaging and behavioural studies to examine the electrophysiological signatures of different brain regions and their impact on disease. Recently, his laboratory has been working with patients undergoing electrode implantation for deep brain stimulation, which is used to treat a variety of disorders such as Parkinson's disease, Tourette's syndrome and essential tremor. Professor Sah trained in medicine at The University of New South Wales and, after completing his internship, gained a PhD from the Australian National University. Following postdoctoral work at the University of California, San Francisco, and UQ, he established his own laboratory at the University of Newcastle in 1994. He then joined the John Curtin School of Medical Research at the Australian National University as a group leader in 1997. He was recruited to QBI as a founding member in 2003, and has been Director since July 2015. Professor Sah has published over 110 papers in international peer-reviewed journals. He is also the Editor-in-Chief of the Nature Partner Journal npj Science of Learning, the first journal to bring together the findings of neuroscientists, psychologists, and education researchers to understand how the brain learns.

The human nervous system is no longer thought of has hard-wired, and is in fact capable of rapid change throughout life. This plasticity is important for learning, memory and recovery from brain injury. I am interested in using emerging brain stimulation and imaging techniques to "artificially" induce plasticity in the human brain, to ultimately improve the treatment outcomes for various neurological conditions, particularly stroke. These stimulation techniques include transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS).

I completed a BSc in 1994 and received a First Class Honours in Physiology in 1995 from the University of Adelaide. I then completed a Bachelor of Physiotherapy Degree at the University of South Australia. Returning to research in 2005, I undertook a PhD at the University of Adelaide, which I completed in 2009. My doctoral studies focussed on a new and exciting area of neuroscience – neuroplasticity. At the time of commencing my PhD, it was becoming clear that various non-invasive brain stimulation techniques (such as TMS) were able to temporarily reorganise the circuitry in the human brain in a similar way to what happens when we learn something new or store a memory. I was interested in trying to understand why some people responded to these stimulation paradigms, and others didn’t. What I discovered was that it an important driver of plasticity in humans was when the stimulation was delivered. In effect, the brain seemed to learn better at night time compared to the morning. This has important clinical implications, as it suggests that rehabilitation might be more effective at a certain time of day.

I was awarded a University of Queensland Postdoctoral Fellowship in 2010, and then a NH&MRC Postdoctoral Research Fellowship in 2011 to investigate more intensely how the brains of stroke patients rewire. I am using state-of-the-art stimulation and imaging techniques such as TMS, magnetic resonance imaging (MRI) and electroencephalography (EEG) to understand how the brain reorganises when it stores information, and how we can boost this process.

I am currently an Associate Professor and Head of Physiotherapy within the School of Health and Rehabilitation Sciences at UQ. I head my own brain stimulation and imaging laboratory, and am conducting experiments in the following areas:

a) investigating the link between brain oscillations, sleep, plasticity and ageing;

b) improving hazard perception with brain sitmulation;

c) identifying factors that improve neuroplasticity induction in health and disease.

Dr Steve Salisbury is an Associate Professor in the School of Biological Sciences at The University of Queensland, where he is head of the UQ Dinosaur Lab and Chair of First Nations Engagement. He is also Research Associate at the Carnegie Museum of Natural History, Pittsburgh, Pennsylvania, USA, Associate Editor for the Journal of Vertebrate Paleontology, and a Scientific Board member of the Jurassic Foundation.

Steve studied biology and geology at the University of Sydney, receiving the Edgeworth David Award for Palaeontology in 1993. He then moved to the University of New South Wales (UNSW), where he completed his Honours thesis on fossil crocodilians from Murgon, south-eastern Queensland. Continuing at the UNSW, Steve travelled to Germany and the UK to complete a PhD on crocodilian locomotor evolution. He returned to Australia in 2000 to pursue a life-long dream of searching for Australian dinosaurs, and joined The University of Queensland in 2003 as a Postdoctoral Fellow.

Steve's research focuses on the evolution of Gondwanan continental vertebrates, in particular dinosaurs and crocodilians. He is also interested in vertebrate biomechanics and using extant animals to better understand the anatomy, behaviour and evolution of extinct ones. His field-based research takes him to various parts of Queensland, the Kimberley, New Zealand and Antarctica.

I am Professor, NHMRC Investigator Fellow (EL2) and group leader (Exosome Biology Laboratory) at UQ Centre for Clinical Research. I am nationally and internationally (>20 invitations to international meetings in the last 5 years) acknowledged key opinion leader on Extracellular Vesicle (rated 3th worldwide (Top 0.015%) and 1st in Australia in expertise for “Extracellular Vesicles and Exosomes” on Expertscape) and biomarker discovery (140 publications, and >8000 citations in the last 7 year). I have made a major conceptual contribution to EV biology with diagnostic and therapeutic implications. In the last 8 years, my primary research and commercialisation activities have focused on the identification and validation of biomarkers, and development of In Vitro Multivariate Index Assays for clinically relevant complications (including ovarian cancers, and obstetrical syndromes) and their translation into clinical applications. In Academia, I have pursued these objectives through the development and leadership of clinical translation research teams and facilities, both in Australia and overseas. For example, I had a leadership role in established the Centre for Clinical Diagnostics (CCD). Within the UQCCR, I established an exosome research team to evaluate the clinical utility of extracellular vesicles as liquid biopsies, IVDs and therapeutics. Much of our effort in this field of endeavour has involved optimising isolation methods for extracellular vesicles and their analytical analysis - including the use of protein solution array (e.g. Luminex), mass spectrometry profiling (using MS/MS SWATH) and more recently miRNA analysis.

Dr Jodi Saunus is a senior fellow who specialises in translational research on metastatic breast cancer. Based at Brisbane’s Translational Research Institute, she was recruited by Mater Research in 2022 to help facilitate patient-focused research at the interface of biomedical R&D and clinical practice.

Dr Saunus has an honours degree in biochemistry and biomedical science, a PhD in breast cancer molecular genetics, and broad post-doctoral experience in immunology, molecular cell biology, pathology informatics, and early-phase investigator-initiated clinical trials. Her current portfolio focuses finding new ways to improve the clinical management of aggressive breast cancer, with a focus on triple-negative breast cancer, and the prevention and treatment of brain metastases. This work spans across multiple disciplines and capabilities, and broadly involves:

• Molecular profiling of patient-donated blood and tumour tissue samples to identify features that can predict treatment response, or represent previously uncharacterised therapeutic targets.
• Using experimental models of breast cancer metastasis to learn about the molecular mechanisms exploited by cancer cells to survive and grow in brain tissue.
• Developing innovative treatment strategies that work differently to conventional cancer drugs, including alpha-particle endoradiotherapy and in-situ vaccination.

With an outstanding network of collaborators from academia and clinical practice, she has secured more than $6M to fund this work and has a track record of publishing in prominent biomedical research journals (e.g., Cancer Research, Nature, Science Translational Medicine, Nature Communications and The Journal of Pathology).

Peripherally, Jodi is a strong proponent of biospecimen banking, and clinician and consumer engagement in translational research.

Professor Mark Schembri is a prominent microbiologist with experience in combating the global health crisis presented by multi-drug resistant pathogens. Professor Schembri’s expertise on the virulence of bacterial pathogens and his innovative analysis of biofilm formation aims to improve the outcomes of the >400 million individuals that suffer from urinary tract infections each year across the globe.

Through the application of genetic, genomic and functional studies on uropathogenic E. coli, Professor Schembri has identified targets to reduce the virulence of this pathogen, and will pursue the development of life-saving therapeutic and preventative advances with the assistance of NHMRC, MRFF and ARC grants. Professor Schembri has tracked the rapid emergence and global spread of a virulent, drug-resistant E. coli clone and used genome sequencing to understand its evolution and virulence.

Links: Professor Schembri collaborates with national and international research leaders, including in Denmark, where he was a lecturer. Professor Schembri has strong links with other international experts in his field, including at the Pasteur Institute and the Wellcome Trust Sanger Institute in Cambridge. His research collaborations also span lead groups at UQ and other top Australian institutes, including Griffith and La Trobe Universities.

Membership, Funding and patents: Since 2014, Professor Schembri has been awarded over $15 million in funding from competitive national research funding bodies. He holds provisional patents for the development of novel therapeutic agents and vaccine antigens. He is a Fellow of the American Academy of Microbiology, and is regularly invited to speak at international conferences in his field.

Awards and Communication: Professor Schembri was the recipient of the Frank Fenner Award (2010) and the ASM BacPath Oration Award (2019) for his outstanding original research contribution to the study of Infectious Disease. He was an Australian Research Council Future Fellow (2011-2015) a National Health and Medical Research Council Senior Research Fellow (2016-2020). Professor Schembri is the author of >240 peer-reviewed research manuscripts. He is President of the Australian Society for Microbiology (2022-2026).

I obtained a Diploma in Chemistry from the University of Bern in Switzerland in 1992. Upon receiving the award of an International Postgraduate Research Scholarship (IPRS) I joined The University of Queensland (UQ) in 1993 to carry out research towards a PhD in Biochemistry(supervisors: Assoc. Profs. Peter Nixon and Ron Duggleby). I graduated in 1997 and continued postdoctoral research at UQ under the guidance of Profs John de Jersey, Susan Hamilton and Graeme Hanson. During this period, I was awarded Fellowships from both the Wellcome Trust and UQ. In 2000 I spent several months in the Department of Chemistry at the University of Newcastle-upon-Tyne, England, collaborating with Prof. Geoff Sykes, and later that year I commenced a Senior Postdoctoral Fellowship in the Chemistry Department at Stanford University (advisor: Prof. Edward Solomon). In 2003 I was appointed to a Lectureship in (Bio)Physical Chemistry at UQ. In 2006 I was promoted to Senior Lecturer. Following the award of a UQ Foundation Research Excellence Award (in 2007) I was promoted to Associate Professor (in 2008), and between 2011 and 2013 I was also on a fractional professorial appointment (50%) at Maynooth University, Ireland. From 2013 to 2017 I held a Future Fellowship from the Australian Research Council, and during this period I was promoted to Full Professor at UQ (2015). I also hold affiliate professorships in the Sustainable Minerals Institute and the Australian Institute for Bioengineering and Nanotechnology, both located at UQ.

I have successfully focused my research on the investigation of enzyme-catalysed reactions, their optimisation for applications in biotechnology and the synthesis of small molecules that mimic their structure and catalytic function (i.e. biomimetics). I advanced understanding of the contribution of metals to enzyme-catalysed reactions and employed state-of-the-art technologies (e.g. cryo-EM, ancestral gene reconstruction) to develop enzyme inhibitors as leads for novel biocides (herbicides, fungicides, antibacterial compounds) and engineer enzymes with enhanced catalytic properties for industrial applications in the advanced manufacturing sector (i.e. cell-free enzyme cascades, next-gen fertilisers). My work into enzyme mechanisms, regulation and engineering received international acclaim evidenced by invitations to provide plenary and keynote lectures and review articles in prestigious journals. I have published over 250 peer-reviewed articles, including over 40 papers in the ACS staple (J. Am. Chem. Soc, ACS Catalysis, ACS Sus. Chem. Eng., Inorg. Chem, Chem. Rev., Acc. Chem. Rev.) as well as landmark studies in Nature, Nature Catalysis, Nature Communications and Proc. Natl. Acad. Sci. (USA). For my leadership in enzymology I was awarded a Future Fellowship by the Australian Research Council, a Foundation Research Excellence Award by UQ and, most recently, the prestigious role as Ambassador for the Technical University of Munich (TUM), an honour bestowed upon me also for my leading role in building an extensive network of collaborations between UQ and TUM in the areas of bioengineering and bioeconomy. The network has since evolved into the Global Bioeconomy Alliance.

Susanne leads a vibrant team researching natural ecosystems and agroecosystems focussed on plants, microbes and soil. This aims to advance the circular nutrient economy, the restoration of degraded soils and landscapes, and the sustainable use of Australia's flora in research that is led by Indigenous experts and communities.

Funded PhD and MPhil positions are available in the (i) Bushfood project and the (ii) Next-generation fertilisers project and soil ameliorants project. Honours and Masters projects are available in all active projects. Please register your interest emailing Susanne.Schmidt@uq.edu.au

Active projects:

• Climate smart agriculture: quantifying the benefits of cultural burning in QLD grazing lands (led by Firesticks Alliance, funded by the AustDAF)
• A Deadly Solution: Traditional Knowledge and Western Science for an Indigenous-led Bushfood Industry (ARC Discovery-Indigenous)
• Realising Smart Compost Formulations (End Food Waste CRC)
• Next-generation fertilisers and soil ameliorants (ARC Industry Transformation Training Centre 'Transforming Biosolids')

Completed recent projects

• Environmentally responsive bio-composite fertilisers
• Ecofriendly fertilisers for sustainable farming
• Effective microbial biostimulants in horticulture
• New technologies and management: transforming nitrogen use efficiency in cane production
• Recycled phosphorus from waste streams as efficient sources for agriculture
• License to farm - nitrogen use efficiency in sugarcane production
• Developing sugarcane-legume companion cropping to reduce greenhouse gas emissions
• Spinifex desert grass - ecophysiology and nano-cellulose production for novel biomaterials
• The role of soil microbes to restore soil carbon in tropical reforestation
• Soil carbon sequestration in the Cooloola biosphere chronosequence
• Advancing Livestock Waste as Low Emission-High Efficiency Fertilizers
• Ecogenomic profiling of Queensland sugarcane soils

Professor Kate Schroder heads the Inflammasome Laboratory and is Director of the Centre for Inflammation and Disease Research at the Institute for Molecular Bioscience (IMB), University of Queensland, as an NHMRC Leadership Fellow. Kate’s graduate studies defined novel macrophage activation mechanisms and her subsequent postdoctoral research identified surprising inter-species divergence in the inflammatory programs of human versus mouse macrophages. As an NHMRC CJ Martin Fellow in Switzerland, Kate trained with the pioneer of inflammasome biology, Jürg Tschopp. The IMB Inflammasome Laboratory, which Kate heads, investigates the molecular mechanisms governing inflammasome activity and caspase activation, the cellular mediators of inflammasome-dependent inflammation, and mechanisms of inflammasome inhibition by cellular pathways and small molecule inhibitors.

Kate is a co-inventor on patents for small molecule inhibitors of the NLRP3 inflammasome, currently under commercialisation by Inflazome Ltd. Inflazome Ltd was recently acquired by Roche in a landmark deal – one of the largest in Australian and Irish biotech history. The acquisition gives Roche full rights to Inflazome’s portfolio of inflammasome inhibitors. Two of the company’s drug candidates are in clinical trials for the treatment of debilitating conditions such as cardiovascular disease, arthritis and neurodegenerative diseases such as Parkinson’s, Alzheimer’s and motor neuron disease.

Kate has authored more than 140 publications, featuring in journals such as Science, Cell, Nature Genetics, Nature Medicine, Nature Chemical Biology, Journal of Experimental Medicine and PNAS USA, and her work has been cited more than 35,000 times. Kate is an Editorial Board Member for international journals including Science Signaling, Clinical and Translational Immunology and Cell Death Disease. She is the recipient of the 2022 Women in Technology Excellence in Science Award, 2020 Nancy Mills Award for Women in Science, 2019 ANZSCDB Emerging Leader Award, 2019 Merck Research Medal, 2014 Milstein Young Investigator Award, 2013 Tall Poppy Award, 2012 Gordon Ada Career Award, 2010 QLD Premier’s Postdoctoral Award, and the 2008 Society for Leukocyte Biology’s Dolph Adams Award.

INFLAMMASOME LABORATORY RESEARCH

During injury or infection, our body’s immune system protects us by launching inflammation. But uncontrolled inflammation drives diseases such as gout, diabetes, neurodegenerative disease and cancer. The Inflammasome Lab is defining the molecular and cellular processes of inflammation. We seek to unravel the secrets of inflammasomes – protein complexes at the heart of inflammation and disease – to allow for new therapies to fight human diseases.

The Inflammasome Laboratory integrates molecular and cell biology approaches with in vivo studies to gain a holistic understanding of inflammasome function during infection, and inflammasome dysfunction in human inflammatory disease. Current research interests include the molecular mechanisms governing inflammasome activity and caspase activation, the cellular mediators of inflammasome-dependent inflammation, and inflammasome suppression by autophagy and small molecule inhibitors.

I graduated with a degree in Chemical Engineering and Science in 2000 from The University of Queensland, after which I joined Proteome Systems, an Australian biotechnology company. In 2004 I moved to the ETH Zurich in Switzerland for my doctoral studies. I joined the School of Chemistry & Molecular Biosciences as a University of Queensland Postdoctoral Research Fellow in 2008 and NHMRC Career Development Fellow in 2012. I am now Associate Professor in Biochemistry.