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Dr Melanie Robitaille
Dr

Melanie Robitaille

Email: 
Phone: 
+61 7 334 61856

Overview

Background

Dr Melanie Robitaille is a Senior Post-Doctoral Researcher working with the Calcium Signalling in Therapeutics Team (CaSTT) in the School of Pharmacy. This team specializes in the development and application of novel methodologies and cellular assays in drug discovery, including the use of genetically encoded indicator for high-content imaging in live cells.

Her interests are to elucidate how calcium signals are remodelled in disease states, to identify calcium transporters as new therapeutic targets and to develop molecular and cellular screening tools to be used in drug development programs. She has an established profile in cellular and molecular biology, with high expertise in plasmid cloning, lentiviral transduction and the use of CRISPR/Cas9 to modulate gene expression.

Availability

Dr Melanie Robitaille is:
Not available for supervision

Qualifications

  • Doctor of Philosophy, Université de Montréal

Works

Search Professor Melanie Robitaille’s works on UQ eSpace

73 works between 2006 and 2024

1 - 20 of 73 works

2024

Journal Article

TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells

Bong, Alice H. L., Robitaille, Mélanie, Lin, Sichun, McCart-Reed, Amy, Milevskiy, Michael, Angers, Stéphane, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2024). TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells. Cell Death Discovery, 10 (1) 421. doi: 10.1038/s41420-024-02183-0

TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells

2024

Conference Publication

Understanding changes in host cell calcium signalling during coronavirus infection

Chan, Shao Ming, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2024). Understanding changes in host cell calcium signalling during coronavirus infection. OPTIONS XII for the Control of Influenza, Brisbane, QLD Australia, 29 September - 2 October 2024.

Understanding changes in host cell calcium signalling during coronavirus infection

2024

Conference Publication

Calcium signaling in the breast cancer microenvironment

Forouz, Farzaneh, Bong, Alice H., Robitaille, Melanie, Roberts-Thomson, Sarah and Monteith, Gregory (2024). Calcium signaling in the breast cancer microenvironment. BioMolecular Horizons 2024, Melbourne, VIC Australia, 22-26 September 2024.

Calcium signaling in the breast cancer microenvironment

2024

Conference Publication

ORAI1 isoforms have differential sensitivity to extracellular pH

Robitaille, Melanie, McCullough, Michael H., So, Choon Leng, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2024). ORAI1 isoforms have differential sensitivity to extracellular pH. BioMolecular Horizons 2024, Melbourne, VIC, Australia, 22-26 September 2024.

ORAI1 isoforms have differential sensitivity to extracellular pH

2024

Conference Publication

A high-throughput method to monitor live-cell calcium signalling changes during coronavirus infection.

Chan, Shao Ming, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2024). A high-throughput method to monitor live-cell calcium signalling changes during coronavirus infection.. 17th International Meeting of the European Calcium Society, Cambridge, United Kingdom, 31 August - 4 September 2024.

A high-throughput method to monitor live-cell calcium signalling changes during coronavirus infection.

2024

Conference Publication

A calcium influx pathway regulates adaptive melanoma drug tolerance

Guan, Yimeng, Robitaille, Melanie, Torrano, Joachim, Haass, Nikolas, Roberts-Thomson, Sarah, Monteith, Gregory and Schaider, Helmut (2024). A calcium influx pathway regulates adaptive melanoma drug tolerance. ASDR 2024 Annual Scientific Meeting, Sydney, NSW Australia, 18-20 July 2024.

A calcium influx pathway regulates adaptive melanoma drug tolerance

2024

Conference Publication

Exploring calcium signalling remodelling during adaptive cancer drug tolerance

Robitaille, Melanie, Schaider, Helmut, Monteith, Gregory and Roberts-Thomson, Sarah (2024). Exploring calcium signalling remodelling during adaptive cancer drug tolerance. Calcium Signaling- Gordon Research Conference, Barga, Lucca, Italy, 30 June - 5 July 2024.

Exploring calcium signalling remodelling during adaptive cancer drug tolerance

2024

Journal Article

Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells

So, Choon Leng, Robitaille, Mélanie, Sadras, Francisco, McCullough, Michael H., Milevskiy, Michael J. G., Goodhill, Geoffrey J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2024). Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells. Communications Biology, 7 (1) 467, 467. doi: 10.1038/s42003-024-06163-z

Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells

2023

Conference Publication

Gene expression of calcium signalling modulators in SARS-CoV-2 infection

Akison, Mia C., Eschke, Kathrin, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2023). Gene expression of calcium signalling modulators in SARS-CoV-2 infection. ASCEPT Annual Scientific, Sydney, NSW, Australia, 20-23 November 2023.

Gene expression of calcium signalling modulators in SARS-CoV-2 infection

2023

Conference Publication

Exploring calcium signalling remodelling during adaptive cancer drug tolerance

Robitaille, Mélanie, Schaider, Helmut, Roberts-Thomson, Sarah and Monteith, Gregory (2023). Exploring calcium signalling remodelling during adaptive cancer drug tolerance. ASCEPT Annual Scientific Meeting, Sydney, NSW Australia, 20-23 November 2023.

Exploring calcium signalling remodelling during adaptive cancer drug tolerance

2023

Conference Publication

Developing a human cell model to study calcium signalling during coronavirus infection.

Chan, Shao Ming, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2023). Developing a human cell model to study calcium signalling during coronavirus infection.. ASCEPT Annual Scientific Meeting, Sydney, NSW, Australia, 20-23 November 2023.

Developing a human cell model to study calcium signalling during coronavirus infection.

2023

Conference Publication

Calcium signaling and the breast cancer microenvironment

Forouz, Farzaneh, Bong, Alice H. L., Gieniec, Krystyna A., Sadras, Francisco, Robitaille, Mélanie, Roberts- Thomson, Sarah J., Davis, Felicity M. and Monteith, Gregory R. (2023). Calcium signaling and the breast cancer microenvironment. ASCEPT Annual Scientific Meeting, Sydney, NSW Australia, 20-23 November 2023.

Calcium signaling and the breast cancer microenvironment

2023

Journal Article

The intersection between cysteine proteases, Ca2+ signalling and cancer cell apoptosis

Hua, Trinh, Robitaille, Mélanie, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2023). The intersection between cysteine proteases, Ca2+ signalling and cancer cell apoptosis. Biochimica et Biophysica Acta - Molecular Cell Research, 1870 (7) 119532, 1-13. doi: 10.1016/j.bbamcr.2023.119532

The intersection between cysteine proteases, Ca2+ signalling and cancer cell apoptosis

2023

Conference Publication

Abstract 3629: Calcium signalling and the breast cancer microenvironment

Bong, Alice H., Gieniec, Krystyna A., Sadras, Francisco, Robitaille, Mélanie, Roberts-Thomson, Sarah J., Davis, Felicity M. and Monteith, Gregory R. (2023). Abstract 3629: Calcium signalling and the breast cancer microenvironment. 114th Annual Meeting of the American Association for Cancer Research (AACR), Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-3629

Abstract 3629: Calcium signalling and the breast cancer microenvironment

2023

Journal Article

TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluids

So, Choon Leng, Robitaille, Mélanie and Monteith, Gregory R. (2023). TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluids. Cell Calcium, 109 102685, 1-3. doi: 10.1016/j.ceca.2022.102685

TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluids

2022

Conference Publication

Measuring intracellular calcium signalling dynamics between cell-in-cell structures using genetically-encoded calcium indicators

Janke, Ellen, Sadras, Francisco, Robitaille, Mélanie, Roberts-Thomson, Sarah and Monteith, Gregory (2022). Measuring intracellular calcium signalling dynamics between cell-in-cell structures using genetically-encoded calcium indicators. APSA-ASCEPT 2022 Joint Conference, Perth, WA Australia, 29 November- 2 December 2022.

Measuring intracellular calcium signalling dynamics between cell-in-cell structures using genetically-encoded calcium indicators

2022

Conference Publication

The role of RunX2 in calcium-related signaling pathways in breast cancer cells

Zhang, Junkai, Monteith, Gregory R., Roberts-Thomson, Sarah and Robitaille, Mélanie (2022). The role of RunX2 in calcium-related signaling pathways in breast cancer cells. APSA-ASCEPT 2022 Joint Conference, Perth, WA Australia, 29 November- 2 December 2022.

The role of RunX2 in calcium-related signaling pathways in breast cancer cells

2022

Journal Article

AKT regulation of ORAI1-mediated calcium influx in breast cancer cells

Bong, Alice Hui Li, Hua, Trinh, So, Choon Leng, Peters, Amelia A., Robitaille, Mélanie, Tan, Yin Yi, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2022). AKT regulation of ORAI1-mediated calcium influx in breast cancer cells. Cancers, 14 (19) 4794, 1-14. doi: 10.3390/cancers14194794

AKT regulation of ORAI1-mediated calcium influx in breast cancer cells

2022

Conference Publication

Use of genetically-encoded calcium indicators to measure intracellular calcium signalling dynamics between cell-in-cell structures

Janke, Ellen, Sadras, Francisco, Robitaille, Melanie, Roberts-Thomson, Sarah and Monteith, Gregory R. (2022). Use of genetically-encoded calcium indicators to measure intracellular calcium signalling dynamics between cell-in-cell structures. 16th International Meeting of the European Calcium Society, Cork, Ireland, 21-25 August 2022.

Use of genetically-encoded calcium indicators to measure intracellular calcium signalling dynamics between cell-in-cell structures

2022

Journal Article

Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells

So, Choon Leng, Meinert, Christoph, Xia, Qing, Robitaille, Mélanie, Roberts-Thomson, Sarah J and Monteith, Gregory R (2022). Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells. Cell Calcium, 104 102569, 1-10. doi: 10.1016/j.ceca.2022.102569

Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells

Funding

Current funding

  • 2023 - 2026
    A calcium influx pathway regulates adaptive cancer drug tolerance
    NHMRC IDEAS Grants
    Open grant
  • 2022 - 2025
    An active ion transport pathway exploited by coronaviruses
    ARC Discovery Projects
    Open grant

Past funding

  • 2023 - 2024
    A calcium influx pathway regulates adaptive cancer drug tolerance
    TdC Pioneering Grant
    Open grant

Supervision

Availability

Dr Melanie Robitaille is:
Not available for supervision

Supervision history

Current supervision

  • Doctor Philosophy

    he intersection between calcium signaling pathways and viral infection

    Principal Advisor

    Other advisors: Professor Gregory Monteith, Dr Larisa Labzin

  • Doctor Philosophy

    Designing novel bivalent ligands that target the mu and nociceptin opioid receptors for reduced side effects

    Associate Advisor

    Other advisors: Professor Peter Cabot

  • Doctor Philosophy

    Calcium signalling and cell death pathways in breast cancer cells

    Associate Advisor

    Other advisors: Professor Gregory Monteith

  • Doctor Philosophy

    Targeting peripheral kappa and mu bivalent opioid receptors with bivalent opioid peptides for inflammatory pain

    Associate Advisor

    Other advisors: Dr Ben Ross, Professor Peter Cabot

Completed supervision

Media

Enquiries

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