Overview
Background
Dr Melanie Robitaille is a Senior Post-Doctoral Researcher working with the Calcium Signalling in Therapeutics Team (CaSTT) in the School of Pharmacy. This team specializes in the development and application of novel methodologies and cellular assays in drug discovery, including the use of genetically encoded indicator for high-content imaging in live cells.
Her interests are to elucidate how calcium signals are remodelled in disease states, to identify calcium transporters as new therapeutic targets and to develop molecular and cellular screening tools to be used in drug development programs. She has an established profile in cellular and molecular biology, with high expertise in plasmid cloning, lentiviral transduction and the use of CRISPR/Cas9 to modulate gene expression.
Availability
- Dr Melanie Robitaille is:
- Not available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Université de Montréal
Works
Search Professor Melanie Robitaille’s works on UQ eSpace
2024
Journal Article
TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells
Bong, Alice H. L., Robitaille, Mélanie, Lin, Sichun, McCart-Reed, Amy, Milevskiy, Michael, Angers, Stéphane, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2024). TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells. Cell Death Discovery, 10 (1) 421. doi: 10.1038/s41420-024-02183-0
2024
Conference Publication
Understanding changes in host cell calcium signalling during coronavirus infection
Chan, Shao Ming, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2024). Understanding changes in host cell calcium signalling during coronavirus infection. OPTIONS XII for the Control of Influenza, Brisbane, QLD Australia, 29 September - 2 October 2024.
2024
Conference Publication
ORAI1 isoforms have differential sensitivity to extracellular pH
Robitaille, Melanie, McCullough, Michael H., So, Choon Leng, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2024). ORAI1 isoforms have differential sensitivity to extracellular pH. BioMolecular Horizons 2024, Melbourne, VIC, Australia, 22-26 September 2024.
2024
Conference Publication
Calcium signaling in the breast cancer microenvironment
Forouz, Farzaneh, Bong, Alice H., Robitaille, Melanie, Roberts-Thomson, Sarah and Monteith, Gregory (2024). Calcium signaling in the breast cancer microenvironment. BioMolecular Horizons 2024, Melbourne, VIC Australia, 22-26 September 2024.
2024
Conference Publication
A high-throughput method to monitor live-cell calcium signalling changes during coronavirus infection.
Chan, Shao Ming, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2024). A high-throughput method to monitor live-cell calcium signalling changes during coronavirus infection.. 17th International Meeting of the European Calcium Society, Cambridge, United Kingdom, 31 August - 4 September 2024.
2024
Conference Publication
A calcium influx pathway regulates adaptive melanoma drug tolerance
Guan, Yimeng, Robitaille, Melanie, Torrano, Joachim, Haass, Nikolas, Roberts-Thomson, Sarah, Monteith, Gregory and Schaider, Helmut (2024). A calcium influx pathway regulates adaptive melanoma drug tolerance. ASDR 2024 Annual Scientific Meeting, Sydney, NSW Australia, 18-20 July 2024.
2024
Conference Publication
Exploring calcium signalling remodelling during adaptive cancer drug tolerance
Robitaille, Melanie, Schaider, Helmut, Monteith, Gregory and Roberts-Thomson, Sarah (2024). Exploring calcium signalling remodelling during adaptive cancer drug tolerance. Calcium Signaling- Gordon Research Conference, Barga, Lucca, Italy, 30 June - 5 July 2024.
2024
Journal Article
Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells
So, Choon Leng, Robitaille, Mélanie, Sadras, Francisco, McCullough, Michael H., Milevskiy, Michael J. G., Goodhill, Geoffrey J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2024). Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells. Communications Biology, 7 (1) 467, 467. doi: 10.1038/s42003-024-06163-z
2023
Conference Publication
Developing a human cell model to study calcium signalling during coronavirus infection.
Chan, Shao Ming, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2023). Developing a human cell model to study calcium signalling during coronavirus infection.. ASCEPT Annual Scientific Meeting, Sydney, NSW, Australia, 20-23 November 2023.
2023
Conference Publication
Calcium signaling and the breast cancer microenvironment
Forouz, Farzaneh, Bong, Alice H. L., Gieniec, Krystyna A., Sadras, Francisco, Robitaille, Mélanie, Roberts- Thomson, Sarah J., Davis, Felicity M. and Monteith, Gregory R. (2023). Calcium signaling and the breast cancer microenvironment. ASCEPT Annual Scientific Meeting, Sydney, NSW Australia, 20-23 November 2023.
2023
Conference Publication
Gene expression of calcium signalling modulators in SARS-CoV-2 infection
Akison, Mia C., Eschke, Kathrin, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2023). Gene expression of calcium signalling modulators in SARS-CoV-2 infection. ASCEPT Annual Scientific, Sydney, NSW, Australia, 20-23 November 2023.
2023
Conference Publication
Exploring calcium signalling remodelling during adaptive cancer drug tolerance
Robitaille, Mélanie, Schaider, Helmut, Roberts-Thomson, Sarah and Monteith, Gregory (2023). Exploring calcium signalling remodelling during adaptive cancer drug tolerance. ASCEPT Annual Scientific Meeting, Sydney, NSW Australia, 20-23 November 2023.
2023
Journal Article
The intersection between cysteine proteases, Ca2+ signalling and cancer cell apoptosis
Hua, Trinh, Robitaille, Mélanie, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2023). The intersection between cysteine proteases, Ca2+ signalling and cancer cell apoptosis. Biochimica et Biophysica Acta - Molecular Cell Research, 1870 (7) 119532, 1-13. doi: 10.1016/j.bbamcr.2023.119532
2023
Conference Publication
Abstract 3629: Calcium signalling and the breast cancer microenvironment
Bong, Alice H., Gieniec, Krystyna A., Sadras, Francisco, Robitaille, Mélanie, Roberts-Thomson, Sarah J., Davis, Felicity M. and Monteith, Gregory R. (2023). Abstract 3629: Calcium signalling and the breast cancer microenvironment. 114th Annual Meeting of the American Association for Cancer Research (AACR), Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-3629
2023
Journal Article
TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluids
So, Choon Leng, Robitaille, Mélanie and Monteith, Gregory R. (2023). TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluids. Cell Calcium, 109 102685, 1-3. doi: 10.1016/j.ceca.2022.102685
2022
Conference Publication
Measuring intracellular calcium signalling dynamics between cell-in-cell structures using genetically-encoded calcium indicators
Janke, Ellen, Sadras, Francisco, Robitaille, Mélanie, Roberts-Thomson, Sarah and Monteith, Gregory (2022). Measuring intracellular calcium signalling dynamics between cell-in-cell structures using genetically-encoded calcium indicators. APSA-ASCEPT 2022 Joint Conference, Perth, WA Australia, 29 November- 2 December 2022.
2022
Conference Publication
The role of RunX2 in calcium-related signaling pathways in breast cancer cells
Zhang, Junkai, Monteith, Gregory R., Roberts-Thomson, Sarah and Robitaille, Mélanie (2022). The role of RunX2 in calcium-related signaling pathways in breast cancer cells. APSA-ASCEPT 2022 Joint Conference, Perth, WA Australia, 29 November- 2 December 2022.
2022
Journal Article
AKT regulation of ORAI1-mediated calcium influx in breast cancer cells
Bong, Alice Hui Li, Hua, Trinh, So, Choon Leng, Peters, Amelia A., Robitaille, Mélanie, Tan, Yin Yi, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2022). AKT regulation of ORAI1-mediated calcium influx in breast cancer cells. Cancers, 14 (19) 4794, 1-14. doi: 10.3390/cancers14194794
2022
Conference Publication
Use of genetically-encoded calcium indicators to measure intracellular calcium signalling dynamics between cell-in-cell structures
Janke, Ellen, Sadras, Francisco, Robitaille, Melanie, Roberts-Thomson, Sarah and Monteith, Gregory R. (2022). Use of genetically-encoded calcium indicators to measure intracellular calcium signalling dynamics between cell-in-cell structures. 16th International Meeting of the European Calcium Society, Cork, Ireland, 21-25 August 2022.
2022
Journal Article
Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells
So, Choon Leng, Meinert, Christoph, Xia, Qing, Robitaille, Mélanie, Roberts-Thomson, Sarah J and Monteith, Gregory R (2022). Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells. Cell Calcium, 104 102569, 1-10. doi: 10.1016/j.ceca.2022.102569
Funding
Current funding
Supervision
Availability
- Dr Melanie Robitaille is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Principal Advisor
Other advisors: Professor Gregory Monteith, Dr Larisa Labzin
-
Doctor Philosophy
Designing novel bivalent ligands that target the mu and nociceptin opioid receptors for reduced side effects
Associate Advisor
Other advisors: Professor Peter Cabot
-
Doctor Philosophy
Calcium signalling and cell death pathways in breast cancer cells
Associate Advisor
Other advisors: Professor Gregory Monteith
-
Doctor Philosophy
Targeting peripheral kappa and mu bivalent opioid receptors with bivalent opioid peptides for inflammatory pain
Associate Advisor
Other advisors: Dr Ben Ross, Professor Peter Cabot
Completed supervision
-
2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Associate Advisor
Other advisors: Professor Gregory Monteith
Media
Enquiries
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