Overview
Background
Dr Melanie Robitaille is a Senior Research Fellow working with the Calcium Signalling in Therapeutics Team (CaSTT) in the School of Pharmacy and Pharmaceutical Sciences. This team specializes in the development and application of novel methodologies and cellular assays in drug discovery, including the use of genetically encoded indicator for high-content imaging in live cells.
Her interests are to elucidate how calcium signals are remodelled in disease states, to identify calcium transporters as new therapeutic targets and to develop molecular and cellular screening tools to be used in drug development programs. She has an established profile in cellular and molecular biology, with high expertise in plasmid cloning, lentiviral transduction and the use of CRISPR/Cas9 to modulate gene expression.
Availability
- Dr Melanie Robitaille is:
- Not available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Université de Montréal
Works
Search Professor Melanie Robitaille’s works on UQ eSpace
2009
Journal Article
The role of molecular chaperones in the assembly of heterotrimeric G proteins
Robitaille, Melanie, Dupre, Denis J. and Hebert, Terence E. (2009). The role of molecular chaperones in the assembly of heterotrimeric G proteins. M S-Medecine Sciences, 25 (10), 821-825. doi: 10.1051/medsci/20092510821
2009
Journal Article
Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor
Zhang, Xiaoping, Wang, Guansong, Dupre, Denis J., Feng, Yumei, Robitaille, Melanie, Lazartigues, Eric, Feng, Ying-Hong, Hebert, Terence E. and Wu, Guangyu (2009). Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor. Journal of Pharmacology and Experimental Therapeutics, 330 (1), 109-117. doi: 10.1124/jpet.109.153460
2009
Journal Article
A single conserved leucine residue on the first intracellular loop regulates ER export of G protein-coupled receptors
Duvernay, Matthew T., Dong, Chunmin, Zhang, Xiaoping, Robitaille, Melanie, Hebert, Terence E. and Wu, Guangyu (2009). A single conserved leucine residue on the first intracellular loop regulates ER export of G protein-coupled receptors. Traffic, 10 (5), 552-566. doi: 10.1111/j.1600-0854.2009.00890.x
2009
Journal Article
Intracellular trafficking and assembly of specific Kir3 channel/G protein complexes
Robitaille, Melanie, Ramakrishnan, Nitya, Baragli, Alessandra and Hebert, Terence E. (2009). Intracellular trafficking and assembly of specific Kir3 channel/G protein complexes. Cellular Signalling, 21 (4), 488-501. doi: 10.1016/j.cellsig.2008.11.011
2009
Book Chapter
Novel tools for use in Bioluminescence Resonance Energy Transfer (BRET) assays
Robitaille, Melanie, Heroux, Isabelle, Baragli, Alessandra and Hebert, Terence E. (2009). Novel tools for use in Bioluminescence Resonance Energy Transfer (BRET) assays. Bioluminescence: Methods and Protocols. (pp. 215-234) edited by Preston B. Rich and Christelle Douillet. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-321-3_18
2008
Journal Article
Combining protein complementation assays with resonance energy transfer to detect multipartner protein complexes in living cells
Rebois, R. Victor, Robitaille, Melanie, Petrin, Darlaine, Zylbergold, Peter, Trieu, Phan and Hebert, Terence E. (2008). Combining protein complementation assays with resonance energy transfer to detect multipartner protein complexes in living cells. Methods, 45 (3), 214-218. doi: 10.1016/j.ymeth.2008.06.006
2007
Journal Article
Dopamine receptor-interacting protein 78 acts as a molecular chaperone for G gamma subunits before assembly with G beta
Dupre, Denis J., Robitaille, Melanie, Richer, Maxime, Ethier, Nathalie, Mamarbachi, Aida M. and Hebert, Terence E. (2007). Dopamine receptor-interacting protein 78 acts as a molecular chaperone for G gamma subunits before assembly with G beta. Journal of Biological Chemistry, 282 (18), 13703-13715. doi: 10.1074/jbc.M608846200
2006
Journal Article
Seven transmembrane receptor core signaling complexes are assembled prior to plasma membrane trafficking
Dupre, Denis J., Robitaille, Melanie, Ethier, Nathalie, Villeneuve, Louis R., Mamarbachi, Aida M. and Hebert, Terence E. (2006). Seven transmembrane receptor core signaling complexes are assembled prior to plasma membrane trafficking. Journal of Biological Chemistry, 281 (45), 34561-34573. doi: 10.1074/jbc.M605012200
2006
Journal Article
Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells
Rebois, R. Victor, Robitaille, Melanie, Gales, Celine, Dupre, Denis J., Baragli, Alessandra, Trieu, Phan, Ethier, Nathalie, Bouvier, Michel and Hebert, Terence E. (2006). Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells. Journal of Cell Science, 119 (13), 2807-2818. doi: 10.1242/jcs.03021
Supervision
Availability
- Dr Melanie Robitaille is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
The intersection between calcium signaling and coronavirus infection
Principal Advisor
Other advisors: Professor Gregory Monteith, Dr Larisa Labzin
-
Doctor Philosophy
Development of novel methods to identify calcium channels and pumps as drug targets in diseases.
Associate Advisor
Other advisors: Professor Gregory Monteith
-
Doctor Philosophy
Designing novel bivalent ligands that target the Kappa and nociceptin opioid receptors for reduced side effects
Associate Advisor
Other advisors: Dr Danial Saifuddin, Dr Rink-Jan Lohman, Professor Peter Cabot
-
Doctor Philosophy
Synthesis and characterisation of dynorphin and hemopressin analogues within novel bivalent constructs to target both CB1 and KOP receptors
Associate Advisor
Other advisors: Dr Rink-Jan Lohman, Dr Danial Saifuddin, Professor Peter Cabot
-
Doctor Philosophy
Mutation Targeting Therapy for Cancer with dCas9
Associate Advisor
Other advisors: Associate Professor Joy Wolfram
-
Doctor Philosophy
Targeting peripheral mu and delta opioid receptors with bivalent opioid peptides for pain treatment
Associate Advisor
Other advisors: Dr Ben Ross, Dr Danial Saifuddin, Professor Peter Cabot
-
Doctor Philosophy
Calcium-mediated Signaling Pathways in Breast Cancer
Associate Advisor
Other advisors: Professor Gregory Monteith
Completed supervision
-
2025
Doctor Philosophy
Calcium signalling in the context of cell-in-cell structures in a model of entosis in breast cancer cells
Associate Advisor
Other advisors: Professor Gregory Monteith
-
2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Associate Advisor
Other advisors: Professor Gregory Monteith
Media
Enquiries
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