Professor Gregory Monteith
Professor

Gregory Monteith

Email: 
Phone: 
+61 7 334 61855

Background

Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.

His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.

Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.

In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).

Availability

Professor Gregory Monteith is:
Available for supervision

Fields of research

Biological Sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor (Honours), University of Sydney
  • Doctor of Philosophy, University of Sydney

Research interests

  • calcium regulation in disease and cell signalling

    Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.

  • High throughput calcium assays for biomolecular screening and cancer research

    Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.

Search Professor Gregory Monteith’s works on UQ eSpace

419 works between 1992 and 2024
All (419) Journal Article (138) Book Chapter (7) Conference Publication (273) Book (1)

1 - 20 of 419 works

2022

Journal Article

ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway

Bassett, John J., Robitaille, Mélanie, Peters, Amelia A., Bong, Alice H. L., Taing, Meng‐Wong, Wood, Ian A., Sadras, Francisco, Roberts‐Thomson, Sarah J. and Monteith, Gregory R. (2022). ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway. The FASEB Journal, 36 (1) e22108, e22108. doi: 10.1096/fj.202002031rr

ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway

Featured

2020

Journal Article

A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions

Azimi, Iman, Stevenson, Ralph J., Zhang, Xuexin, Meizoso-Huesca, Aldo, Xin, Ping, Johnson, Martin, Flanagan, Jack U., Chalmers, Silke B., Yoast, Ryan E., Kapure, Jeevak S., Ross, Benjamin P., Vetter, Irina, Ashton, Mark R., Launikonis, Bradley S., Denny, William A., Trebak, Mohamed and Monteith, Gregory R. (2020). A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions. ACS Pharmacology and Translational Science, 3 (1) acsptsci.9b00081, 135-147. doi: 10.1021/acsptsci.9b00081

A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions

Featured

2017

Journal Article

Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells

Peters, A. A., Jamaludin, S. Y. N., Yapa, K. T. D. S., Chalmers, S., Wiegmans, A. P., Lim, H. F., Milevskiy, M. J. G., Azimi, I., Davis, F. M., Northwood, K. S., Pera, E., Marcial, D. L., Dray, E., Waterhouse, N. J., Cabot, P. J., Gonda, T. J., Kenny, P. A., Brown, M. A., Khanna, K. K., Roberts-Thomson, S. J. and Monteith, G. R. (2017). Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells. Oncogene, 36 (46), 6490-6500. doi: 10.1038/onc.2017.234

Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells

Featured

2017

Journal Article

The calcium-cancer signalling nexus

Monteith, Gregory R., Prevarskaya, Natalia and Roberts-Thomson, Sarah J. (2017). The calcium-cancer signalling nexus. Nature Reviews Cancer, 17 (6), 367-380. doi: 10.1038/nrc.2017.18

The calcium-cancer signalling nexus

Featured

2014

Journal Article

Targeting EMT in cancer: opportunities for pharmacological intervention

Davis, Felicity M., Stewart, Teneale A., Thompson, Erik W. and Monteith, Gregory R. (2014). Targeting EMT in cancer: opportunities for pharmacological intervention. Trends in Pharmacological Sciences, 35 (9), 479-488. doi: 10.1016/j.tips.2014.06.006

Targeting EMT in cancer: opportunities for pharmacological intervention

Featured

2014

Journal Article

Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent

Davis, F. M., Azimi, I., Faville, R. A., Peters, A. A., Jalink, K., Putney Jr, J. W., Goodhill, G. J., Thompson, E. W., Roberts-Thomson, S. J. and Monteith, G. R. (2014). Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent. Oncogene, 33 (18), 2307-2316. doi: 10.1038/onc.2013.187

Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent

Featured

2010

Journal Article

Store-independent activation of Orai1 by SPCA2 in mammary tumors

Feng, Mingye, Grice, Desma, Faddy, Helen, Nguyen, Nguyen, Leitch, Sharon, Wang, Yingyu, Muend, Sabina, Kenny, Paraic A, Sukumar, Saraswati, Roberts-Thomson, Sarah J., Monteith, Gregory R. and Rao, Rajini (2010). Store-independent activation of Orai1 by SPCA2 in mammary tumors. Cell, 143 (1), 84-98. doi: 10.1016/j.cell.2010.08.040

Store-independent activation of Orai1 by SPCA2 in mammary tumors

Featured

2007

Journal Article

Calcium and cancer: targeting Ca2+ transport

Monteith, Gregory R., McAndrew, Damara, Faddy, Helen M. and Roberts-Thomson, Sarah J. (2007). Calcium and cancer: targeting Ca2+ transport. Nature Reviews Cancer, 7 (7), 519-530. doi: 10.1038/nrc2171

Calcium and cancer: targeting Ca2+ transport

2024

Journal Article

TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells

Bong, Alice H. L., Robitaille, Mélanie, Lin, Sichun, McCart-Reed, Amy, Milevskiy, Michael, Angers, Stéphane, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2024). TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells. Cell Death Discovery, 10 (1) 421. doi: 10.1038/s41420-024-02183-0

TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells

2024

Conference Publication

Understanding changes in host cell calcium signalling during coronavirus infection

Chan, Shao Ming, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2024). Understanding changes in host cell calcium signalling during coronavirus infection. OPTIONS XII for the Control of Influenza, Brisbane, QLD Australia, 29 September - 2 October 2024.

Understanding changes in host cell calcium signalling during coronavirus infection

2024

Conference Publication

Calcium signaling in the breast cancer microenvironment

Forouz, Farzaneh, Bong, Alice H., Robitaille, Melanie, Roberts-Thomson, Sarah and Monteith, Gregory (2024). Calcium signaling in the breast cancer microenvironment. BioMolecular Horizons 2024, Melbourne, VIC Australia, 22-26 September 2024.

Calcium signaling in the breast cancer microenvironment

2024

Conference Publication

A high-throughput method to monitor live-cell calcium signalling changes during coronavirus infection.

Chan, Shao Ming, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2024). A high-throughput method to monitor live-cell calcium signalling changes during coronavirus infection.. 17th International Meeting of the European Calcium Society, Cambridge, United Kingdom, 31 August - 4 September 2024.

A high-throughput method to monitor live-cell calcium signalling changes during coronavirus infection.

2024

Conference Publication

A calcium influx pathway regulates adaptive melanoma drug tolerance

Guan, Yimeng, Robitaille, Melanie, Torrano, Joachim, Haass, Nikolas, Roberts-Thomson, Sarah, Monteith, Gregory and Schaider, Helmut (2024). A calcium influx pathway regulates adaptive melanoma drug tolerance. ASDR 2024 Annual Scientific Meeting, Sydney, NSW Australia, 18-20 July 2024.

A calcium influx pathway regulates adaptive melanoma drug tolerance

2024

Conference Publication

Exploring calcium signalling remodelling during adaptive cancer drug tolerance

Robitaille, Melanie, Schaider, Helmut, Monteith, Gregory and Roberts-Thomson, Sarah (2024). Exploring calcium signalling remodelling during adaptive cancer drug tolerance. Calcium Signaling- Gordon Research Conference, Barga, Lucca, Italy, 30 June - 5 July 2024.

Exploring calcium signalling remodelling during adaptive cancer drug tolerance

2024

Journal Article

Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells

So, Choon Leng, Robitaille, Mélanie, Sadras, Francisco, McCullough, Michael H., Milevskiy, Michael J. G., Goodhill, Geoffrey J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2024). Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells. Communications Biology, 7 (1) 467, 467. doi: 10.1038/s42003-024-06163-z

Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells

2023

Conference Publication

Gene expression of calcium signalling modulators in SARS-CoV-2 infection

Akison, Mia C., Eschke, Kathrin, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2023). Gene expression of calcium signalling modulators in SARS-CoV-2 infection. ASCEPT Annual Scientific, Sydney, NSW, Australia, 20-23 November 2023.

Gene expression of calcium signalling modulators in SARS-CoV-2 infection

2023

Conference Publication

Exploring calcium signalling remodelling during adaptive cancer drug tolerance

Robitaille, Mélanie, Schaider, Helmut, Roberts-Thomson, Sarah and Monteith, Gregory (2023). Exploring calcium signalling remodelling during adaptive cancer drug tolerance. ASCEPT Annual Scientific Meeting, Sydney, NSW Australia, 20-23 November 2023.

Exploring calcium signalling remodelling during adaptive cancer drug tolerance

2023

Conference Publication

Developing a human cell model to study calcium signalling during coronavirus infection.

Chan, Shao Ming, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2023). Developing a human cell model to study calcium signalling during coronavirus infection.. ASCEPT Annual Scientific Meeting, Sydney, NSW, Australia, 20-23 November 2023.

Developing a human cell model to study calcium signalling during coronavirus infection.

2023

Conference Publication

Calcium signaling and the breast cancer microenvironment

Forouz, Farzaneh, Bong, Alice H. L., Gieniec, Krystyna A., Sadras, Francisco, Robitaille, Mélanie, Roberts- Thomson, Sarah J., Davis, Felicity M. and Monteith, Gregory R. (2023). Calcium signaling and the breast cancer microenvironment. ASCEPT Annual Scientific Meeting, Sydney, NSW Australia, 20-23 November 2023.

Calcium signaling and the breast cancer microenvironment

2023

Journal Article

The intersection between cysteine proteases, Ca2+ signalling and cancer cell apoptosis

Hua, Trinh, Robitaille, Mélanie, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2023). The intersection between cysteine proteases, Ca2+ signalling and cancer cell apoptosis. Biochimica et Biophysica Acta - Molecular Cell Research, 1870 (7) 119532, 1-13. doi: 10.1016/j.bbamcr.2023.119532

The intersection between cysteine proteases, Ca2+ signalling and cancer cell apoptosis

Current funding

  • 2023 - 2024
    A calcium influx pathway regulates adaptive cancer drug tolerance
    TdC Pioneering Grant
    Open grant
  • 2023 - 2026
    A calcium influx pathway regulates adaptive cancer drug tolerance
    NHMRC IDEAS Grants
    Open grant
  • 2022 - 2025
    An active ion transport pathway exploited by coronaviruses
    ARC Discovery Projects
    Open grant

Past funding

  • 2020 - 2024
    Deciphering and intercepting messages between cancer cells and cells in the breast cancer microenvironment: Roles for intracellular calcium signaling
    United States Congressionally Directed Medical Research Programs - Breast Cancer Research Program
    Open grant
  • 2020 - 2023
    A recently identified calcium channel provides diverse opportunities for pharmacotherapy in breast cancer
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2021
    Exploiting remodelling of calcium signalling to specifically target triple negative breast cancer via promotion of apoptosis
    Cancer Council Queensland
    Open grant
  • 2018 - 2024
    Australian Red Cross Blood Service Chair in Donor Behaviour
    Australian Red Cross Blood Service
    Open grant
  • 2018 - 2021
    Calcium cycling and heat generation in skeletal muscle fibres
    ARC Discovery Projects
    Open grant
  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2020
    Pharmacological targeting of an adaptive breast cancer cell survival pathway as a novel treatment for breast cancer: Constitutive Ca2+ influx mechanisms in triple negative breast cancer cells
    Cancer Council Queensland
    Open grant
  • 2017 - 2021
    Exploiting the Remodeling of Ca2+ Signaling in Breast Cancer Cell Microenvironments to Control Metastasis and to Specifically Target Brain Metastases
    United States Congressionally Directed Medical Research Programs - Breast Cancer Research Program
    Open grant
  • 2015 - 2021
    Collaborative Grants between WMHHS and University of Queensland
    West Moreton Hospital and Health Service
    Open grant
  • 2015 - 2017
    Exploiting the overexpression of a specific calcium permeable ion channel in breast cancer cells: a new pharmacological approach to targeting breast cancer.
    NHMRC Project Grant
    Open grant
  • 2015 - 2018
    Resistance to Herceptin (trastuzumab) in HER2 positive breast cancers: the role of calcium signalling
    NHMRC Project Grant
    Open grant
  • 2015
    The assessment of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells to identify and characterize new therapeutic targets for diseases
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014
    A medium-throughput cell isolation and analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2013 - 2014
    QUE ORAI1 PROJECT
    Cancer Bequest Fund
    Open grant
  • 2013 - 2014
    Identification and characterisation of calcium signalling modifying proteins as drug targets for basal breast cancer
    Cancer Council Queensland
    Open grant
  • 2012 - 2015
    Calcium signaling and epithelial-mesenchymal transition: a new approach to identifying pharmacological targets for metastasis
    NHMRC Project Grant
    Open grant
  • 2011 - 2013
    The development of store operated calcium channel monoclonal antibody inhibitors as a therapeutic option for breast cancer treatment
    NHMRC Development Grant
    Open grant
  • 2011
    Establishment of a robotic liquid handling platofrm for the use of 384 and 1536 well plates
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Cost effective acquisition of an LC-MS/MS system to support CIPDD organics analysis and preclinical and clinical operations
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    High content imaging analysis for bioactive and novel therapeutic target evaluation
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2013
    Two recently identified calcium transporters in lactation and during mammary epithelial cell apoptosis.
    NHMRC Project Grant
    Open grant
  • 2009 - 2011
    QUMmap and website
    Department of Health and Ageing (Commonwealth of Australia)
    Open grant
  • 2009 - 2010
    Multiphoton microscopy of living animals as a tool for immunology and cell biology studies
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2009
    A core pharmacy facility for molecular biology, expression and protein post translational modification studies in cancer, cardiovascular, pain and epilepsy research
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2012
    Calcium Influx Pathways and Breast Cancer
    NHMRC Project Grant
    Open grant
  • 2009
    Robotics Instrumentation for High Throughput Sample preparation for Increased Productivity of the CIPDD/TetraQ's HPLC-MS/MS Systems for Quantitative Analysis of Organics in a Quality Systems NATA-Acc
    UQ Faculty Co-Funding
    Open grant
  • 2009 - 2011
    Secretory pathway calcium regulation and breast cancer
    Cancer Council Queensland
    Open grant
  • 2008 - 2011
    Nutritional properties of mango fruits: linking plant genomics to cellular bioactivities
    ARC Linkage Projects
    Open grant
  • 2008 - 2010
    Partnerships in Health Research Collaborative Challenge - Pick your Partners!
    Cancer Bequest Fund
    Open grant
  • 2008 - 2009
    QUMmap and Website June 2008
    Department of Health and Ageing (Commonwealth of Australia)
    Open grant
  • 2006 - 2007
    Calcium transporters and breast cancer: exploiting the link for new pharmaceutically relevant drug targets.
    UQ Foundation Research Excellence Awards - DVC(R) Funding
    Open grant
  • 2006 - 2008
    Maintenance and Promotion of the QUMMAP
    Department of Health and Ageing
    Open grant
  • 2005 - 2008
    Identification of nutritional bioactives in tropical fruit
    ARC Linkage Projects
    Open grant
  • 2005
    Establishment of an improved model of relapsing MS and the characterisation of the role of Peroxisome Proliferator - activated receoptors alpha and beta
    Multiple Sclerosis Research Australia
    Open grant
  • 2005
    Ethanol, PPARb and Breast Cancer
    Australian Brewers' Foundation
    Open grant
  • 2005
    NHMRC_Equipment Grant = DSI Telemetry System
    NHMRC Equipment Grant
    Open grant
  • 2005
    Uncharacterized Calcium Transporters as Targets for Disease: Training of a Pharmacy Student in Drug Target Identification and Characterization
    Pharmaceutical Society of Australia
    Open grant
  • 2004 - 2005
    NHMRC_Equipment Grant_HLTH_Pharmacy
    NHMRC Equipment Grant
    Open grant
  • 2004
    PPARb In Breast Cancer: Gene Transcription And Molecular Mechanisms
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2004
    Role Of Plasma Membrane Ca Pump In High Glucose Induced Changes In Ca Signalling
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2003 - 2004
    Assessment of Ca2+ levels in subcellular organelles and the activity of Ca2+ efflux pathways using fluorescence didgital imaging techniques: Application to high throughput screening
    Society for Biomolecular Screening
    Open grant
  • 2003
    Development of high-throughput assays for the identification of novel anticancer agents.
    Pharmaceutical Society of Australia
    Open grant
  • 2003
    Malvern Zetasizer 3000HS
    NHMRC Equipment Grant
    Open grant
  • 2003
    Unprecedented Alkaloid Hybrids that Selectively Modulate Various Cancers and the Central Nervous System
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2003
    The Maintenance and promotion of the quality use of medicines mapping project website.
    Department of Health and Ageing
    Open grant
  • 2002
    Funding for molecular biology computer software
    Brain Research Fund
    Open grant
  • 2002 - 2003
    Pharmacological investigation of the toxicological effects of high doses of systemic morphine
    Queensland Cancer Fund
    Open grant
  • 2002 - 2003
    The plasma membrane calcium ATPase (PMCA) in breast tumorigenic cells
    Queensland Cancer Fund
    Open grant
  • 2001 - 2002
    NHMRC Equipment Grant 2000
    NHMRC Equipment Grant
    Open grant
  • 2001
    A biohazard laminar flow hood for neuronal cell cultures:partial cost recovery from emergency purchase
    Brain Research Fund
    Open grant
  • 2001
    Partial funding to purchase a Biohazard II laminar flow hood.
    Pharmaceutical Society of Australia
    Open grant
  • 2001
    The plasma membrane Ca2+-ATPase (PMCA) in human mammary gland tumorigenesis
    Cancer Bequest Fund
    Open grant
  • 2000
    The regulation of mitochondrial calcium in tumorigenic and non-tumorigenic breast epithelial cells
    Pharmaceutical Society of Australia
    Open grant
  • 2000
    What are the consequences of plasma membrane calcium pump inhibition? implications for calcium homeostasis, proliferation and apoptosis.
    ARC Australian Research Council (Small grants)
    Open grant
  • 1999
    Expression of the plasma membrane calcium pump during hypoxia and ischemia
    Pharmaceutical Society of Australia
    Open grant
  • 1999
    PPAR and neurotoxicity
    Brain Research Fund
    Open grant
  • 1999 - 2001
    The plasma membrane calcium pump as a target for inhibition by tyrosine kinase phosphorylation: implications for cardiovascular disease
    National Heart Foundation of Australia
    Open grant
  • 1999
    The use of fluorescence microscopy to investigate the role of the calcium pump in disease and the mechanism of excitatory side effects by high dose morphine
    Ramaciotti Foundation
    Open grant
  • 1999
    Travel costs to neurosciences meeting 1999
    Potter Foundation
    Open grant
  • 1998
    Regulation of calcium pumps in smooth muscle
    Pharmaceutical Society of Australia
    Open grant

Availability

Professor Gregory Monteith is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Calcium signalling pathways in cancer progression

  • Calcium signalling changes associated with viral infection

  • Calcium channels and pumps as drug targets

  • Design of innovative high throughput methods for drug screening and testing

Supervision history

Current supervision

  • Doctor Philosophy

    Calcium signalling and cell death pathways in breast cancer cells

    Principal Advisor

    Other advisors: Dr Melanie Robitaille

  • Doctor Philosophy

    he intersection between calcium signaling pathways and viral infection

    Associate Advisor

    Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille

  • Master Philosophy

    Investigating the role of exosomes in cancer progression and immunology

    Associate Advisor

    Other advisors: Dr Sherry Wu

  • Doctor Philosophy

    A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer

    Associate Advisor

    Other advisors: Miss Alice Bong, Dr Ben Ross

Completed supervision

Enquiries

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