Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
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High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
Featured
2024
Journal Article
Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells
So, Choon Leng, Robitaille, Mélanie, Sadras, Francisco, McCullough, Michael H., Milevskiy, Michael J. G., Goodhill, Geoffrey J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2024). Cellular geometry and epithelial-mesenchymal plasticity intersect with PIEZO1 in breast cancer cells. Communications Biology, 7 (1) 467, 467. doi: 10.1038/s42003-024-06163-z
Featured
2022
Journal Article
ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway
Bassett, John J., Robitaille, Mélanie, Peters, Amelia A., Bong, Alice H. L., Taing, Meng‐Wong, Wood, Ian A., Sadras, Francisco, Roberts‐Thomson, Sarah J. and Monteith, Gregory R. (2022). ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway. The FASEB Journal, 36 (1) e22108, e22108. doi: 10.1096/fj.202002031rr
Featured
2020
Journal Article
A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions
Azimi, Iman, Stevenson, Ralph J., Zhang, Xuexin, Meizoso-Huesca, Aldo, Xin, Ping, Johnson, Martin, Flanagan, Jack U., Chalmers, Silke B., Yoast, Ryan E., Kapure, Jeevak S., Ross, Benjamin P., Vetter, Irina, Ashton, Mark R., Launikonis, Bradley S., Denny, William A., Trebak, Mohamed and Monteith, Gregory R. (2020). A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions. ACS Pharmacology and Translational Science, 3 (1) acsptsci.9b00081, 135-147. doi: 10.1021/acsptsci.9b00081
Featured
2017
Journal Article
Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells
Peters, A. A., Jamaludin, S. Y. N., Yapa, K. T. D. S., Chalmers, S., Wiegmans, A. P., Lim, H. F., Milevskiy, M. J. G., Azimi, I., Davis, F. M., Northwood, K. S., Pera, E., Marcial, D. L., Dray, E., Waterhouse, N. J., Cabot, P. J., Gonda, T. J., Kenny, P. A., Brown, M. A., Khanna, K. K., Roberts-Thomson, S. J. and Monteith, G. R. (2017). Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells. Oncogene, 36 (46), 6490-6500. doi: 10.1038/onc.2017.234
Featured
2017
Journal Article
The calcium-cancer signalling nexus
Monteith, Gregory R., Prevarskaya, Natalia and Roberts-Thomson, Sarah J. (2017). The calcium-cancer signalling nexus. Nature Reviews Cancer, 17 (6), 367-380. doi: 10.1038/nrc.2017.18
Featured
2014
Journal Article
Targeting EMT in cancer: opportunities for pharmacological intervention
Davis, Felicity M., Stewart, Teneale A., Thompson, Erik W. and Monteith, Gregory R. (2014). Targeting EMT in cancer: opportunities for pharmacological intervention. Trends in Pharmacological Sciences, 35 (9), 479-488. doi: 10.1016/j.tips.2014.06.006
Featured
2014
Journal Article
Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent
Davis, F. M., Azimi, I., Faville, R. A., Peters, A. A., Jalink, K., Putney Jr, J. W., Goodhill, G. J., Thompson, E. W., Roberts-Thomson, S. J. and Monteith, G. R. (2014). Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent. Oncogene, 33 (18), 2307-2316. doi: 10.1038/onc.2013.187
Featured
2010
Journal Article
Store-independent activation of Orai1 by SPCA2 in mammary tumors
Feng, Mingye, Grice, Desma, Faddy, Helen, Nguyen, Nguyen, Leitch, Sharon, Wang, Yingyu, Muend, Sabina, Kenny, Paraic A, Sukumar, Saraswati, Roberts-Thomson, Sarah J., Monteith, Gregory R. and Rao, Rajini (2010). Store-independent activation of Orai1 by SPCA2 in mammary tumors. Cell, 143 (1), 84-98. doi: 10.1016/j.cell.2010.08.040
Featured
2007
Journal Article
Calcium and cancer: targeting Ca2+ transport
Monteith, Gregory R., McAndrew, Damara, Faddy, Helen M. and Roberts-Thomson, Sarah J. (2007). Calcium and cancer: targeting Ca2+ transport. Nature Reviews Cancer, 7 (7), 519-530. doi: 10.1038/nrc2171
2024
Journal Article
TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells
Bong, Alice H. L., Robitaille, Mélanie, Lin, Sichun, McCart-Reed, Amy, Milevskiy, Michael, Angers, Stéphane, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2024). TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells. Cell Death Discovery, 10 (1) 421, 421. doi: 10.1038/s41420-024-02183-0
2024
Conference Publication
Understanding changes in host cell calcium signalling during coronavirus infection
Chan, Shao Ming, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2024). Understanding changes in host cell calcium signalling during coronavirus infection. OPTIONS XII for the Control of Influenza, Brisbane, QLD Australia, 29 September - 2 October 2024.
2024
Conference Publication
Calcium signaling in the breast cancer microenvironment
Forouz, Farzaneh, Bong, Alice H., Robitaille, Melanie, Roberts-Thomson, Sarah and Monteith, Gregory (2024). Calcium signaling in the breast cancer microenvironment. BioMolecular Horizons 2024, Melbourne, VIC Australia, 22-26 September 2024.
2024
Conference Publication
A high-throughput method to monitor live-cell calcium signalling changes during coronavirus infection.
Chan, Shao Ming, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2024). A high-throughput method to monitor live-cell calcium signalling changes during coronavirus infection.. 17th International Meeting of the European Calcium Society, Cambridge, United Kingdom, 31 August - 4 September 2024.
2024
Conference Publication
A calcium influx pathway regulates adaptive melanoma drug tolerance
Guan, Yimeng, Robitaille, Melanie, Torrano, Joachim, Haass, Nikolas, Roberts-Thomson, Sarah, Monteith, Gregory and Schaider, Helmut (2024). A calcium influx pathway regulates adaptive melanoma drug tolerance. ASDR 2024 Annual Scientific Meeting, Sydney, NSW Australia, 18-20 July 2024.
2024
Conference Publication
Exploring calcium signalling remodelling during adaptive cancer drug tolerance
Robitaille, Melanie, Schaider, Helmut, Monteith, Gregory and Roberts-Thomson, Sarah (2024). Exploring calcium signalling remodelling during adaptive cancer drug tolerance. Calcium Signaling- Gordon Research Conference, Barga, Lucca, Italy, 30 June - 5 July 2024.
2023
Conference Publication
Gene expression of calcium signalling modulators in SARS-CoV-2 infection
Akison, Mia C., Eschke, Kathrin, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2023). Gene expression of calcium signalling modulators in SARS-CoV-2 infection. ASCEPT Annual Scientific, Sydney, NSW, Australia, 20-23 November 2023.
2023
Conference Publication
Exploring calcium signalling remodelling during adaptive cancer drug tolerance
Robitaille, Mélanie, Schaider, Helmut, Roberts-Thomson, Sarah and Monteith, Gregory (2023). Exploring calcium signalling remodelling during adaptive cancer drug tolerance. ASCEPT Annual Scientific Meeting, Sydney, NSW Australia, 20-23 November 2023.
2023
Conference Publication
Developing a human cell model to study calcium signalling during coronavirus infection.
Chan, Shao Ming, Monteith, Gregory, Roberts-Thomson, Sarah, Labzin, Larisa and Robitaille, Mélanie (2023). Developing a human cell model to study calcium signalling during coronavirus infection.. ASCEPT Annual Scientific Meeting, Sydney, NSW, Australia, 20-23 November 2023.
2023
Conference Publication
Calcium signaling and the breast cancer microenvironment
Forouz, Farzaneh, Bong, Alice H. L., Gieniec, Krystyna A., Sadras, Francisco, Robitaille, Mélanie, Roberts- Thomson, Sarah J., Davis, Felicity M. and Monteith, Gregory R. (2023). Calcium signaling and the breast cancer microenvironment. ASCEPT Annual Scientific Meeting, Sydney, NSW Australia, 20-23 November 2023.
2023
Journal Article
The intersection between cysteine proteases, Ca2+ signalling and cancer cell apoptosis
Hua, Trinh, Robitaille, Mélanie, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2023). The intersection between cysteine proteases, Ca2+ signalling and cancer cell apoptosis. Biochimica et Biophysica Acta - Molecular Cell Research, 1870 (7) 119532, 1-13. doi: 10.1016/j.bbamcr.2023.119532
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Calcium signalling pathways in cancer progression
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Calcium signalling changes associated with viral infection
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Calcium channels and pumps as drug targets
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Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
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Doctor Philosophy
Calcium signalling and cell death pathways in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Miss Alice Bong, Dr Ben Ross
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Miss Alice Bong, Dr Ben Ross
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Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Master Philosophy
Investigating the role of exosomes in cancer progression and immunology
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
Completed supervision
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2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
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2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
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2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
Other advisors: Dr Amelia Peters
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2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
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2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
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2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
Other advisors: Dr Amelia Peters
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2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
Other advisors: Dr Amelia Peters
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2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
Other advisors: Dr Amelia Peters
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2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
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2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
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2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
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2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
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2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
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2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
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2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
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2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
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2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
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2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
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2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
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2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
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Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
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