
Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
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High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2023
Journal Article
Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer
Janke, Ellen K., Chalmers, Silke B., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2023). Intersection between calcium signalling and epithelial-mesenchymal plasticity in the context of cancer. Cell Calcium, 112 102741, 1-9. doi: 10.1016/j.ceca.2023.102741
2023
Conference Publication
Abstract 3629: Calcium signalling and the breast cancer microenvironment
Bong, Alice H., Gieniec, Krystyna A., Sadras, Francisco, Robitaille, Mélanie, Roberts-Thomson, Sarah J., Davis, Felicity M. and Monteith, Gregory R. (2023). Abstract 3629: Calcium signalling and the breast cancer microenvironment. 114th Annual Meeting of the American Association for Cancer Research (AACR), Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-3629
2023
Journal Article
TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluids
So, Choon Leng, Robitaille, Mélanie and Monteith, Gregory R. (2023). TRPV4 and the paradox of faster cellular migration rates in more viscous extracellular fluids. Cell Calcium, 109 102685, 1-3. doi: 10.1016/j.ceca.2022.102685
2022
Conference Publication
Measuring intracellular calcium signalling dynamics between cell-in-cell structures using genetically-encoded calcium indicators
Janke, Ellen, Sadras, Francisco, Robitaille, Mélanie, Roberts-Thomson, Sarah and Monteith, Gregory (2022). Measuring intracellular calcium signalling dynamics between cell-in-cell structures using genetically-encoded calcium indicators. APSA-ASCEPT 2022 Joint Conference, Perth, WA Australia, 29 November- 2 December 2022.
2022
Conference Publication
The role of RunX2 in calcium-related signaling pathways in breast cancer cells
Zhang, Junkai, Monteith, Gregory R., Roberts-Thomson, Sarah and Robitaille, Mélanie (2022). The role of RunX2 in calcium-related signaling pathways in breast cancer cells. APSA-ASCEPT 2022 Joint Conference, Perth, WA Australia, 29 November- 2 December 2022.
2022
Journal Article
AKT regulation of ORAI1-mediated calcium influx in breast cancer cells
Bong, Alice Hui Li, Hua, Trinh, So, Choon Leng, Peters, Amelia A., Robitaille, Mélanie, Tan, Yin Yi, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2022). AKT regulation of ORAI1-mediated calcium influx in breast cancer cells. Cancers, 14 (19) 4794, 1-14. doi: 10.3390/cancers14194794
2022
Conference Publication
Use of genetically-encoded calcium indicators to measure intracellular calcium signalling dynamics between cell-in-cell structures
Janke, Ellen, Sadras, Francisco, Robitaille, Melanie, Roberts-Thomson, Sarah and Monteith, Gregory R. (2022). Use of genetically-encoded calcium indicators to measure intracellular calcium signalling dynamics between cell-in-cell structures. 16th International Meeting of the European Calcium Society, Cork, Ireland, 21-25 August 2022.
2022
Journal Article
Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells
So, Choon Leng, Meinert, Christoph, Xia, Qing, Robitaille, Mélanie, Roberts-Thomson, Sarah J and Monteith, Gregory R (2022). Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells. Cell Calcium, 104 102569, 1-10. doi: 10.1016/j.ceca.2022.102569
2022
Journal Article
ORAI1-regulated gene expression in breast cancer cells: Roles for STIM1 binding, calcium influx and transcription factor translocation
Robitaille, Mélanie, Chan, Shao Ming, Peters, Amelia A., Dai, Limin, So, Choon Leng, Bong, Alice H. L., Sadras, Francisco, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2022). ORAI1-regulated gene expression in breast cancer cells: Roles for STIM1 binding, calcium influx and transcription factor translocation. International Journal of Molecular Sciences, 23 (11) 5867, 1-14. doi: 10.3390/ijms23115867
2022
Journal Article
Uncoiling the link between STIM1 and metastatic pathways in estrogen receptor negative breast cancer cells
Monteith, Prof. Gregory R, Robitaille, Mélanie and Roberts-Thomson, Sarah J. (2022). Uncoiling the link between STIM1 and metastatic pathways in estrogen receptor negative breast cancer cells. Cell Calcium, 103 102563, 102563. doi: 10.1016/j.ceca.2022.102563
2021
Conference Publication
Incomplete apoptosis in non-stimulated MDA-MB-468 breast cancer cells
Hua, Trinh N., Sadras, Francisco, Robitaille, Mélanie, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2021). Incomplete apoptosis in non-stimulated MDA-MB-468 breast cancer cells. ASCEPT 2021 Virtual Scientific Meeting, Virtual, 29 November- 2 December 2021.
2021
Conference Publication
ORAI1-dependant IL6 Gene Regulation via Store-operated Calcium Entry in Triple-negative Breast Cancer
Chan, Shao Ming, Robitaille, Mélanie, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2021). ORAI1-dependant IL6 Gene Regulation via Store-operated Calcium Entry in Triple-negative Breast Cancer. AuPS Meeting, Gold Coast, QLD Australia, 21-24 November 2021.
2021
Conference Publication
CRISPR/Cas9 and lentiviral rescue methods to study ORAI1 function in transcription activation
Robitaille, Mélanie, Chan, Shao Ming, Peters, Amelia A., Dai, Limin, Bong, Alice H.L., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2021). CRISPR/Cas9 and lentiviral rescue methods to study ORAI1 function in transcription activation. AuPS Meeting, Gold Coast, QLD Australia, 21-24 November 2021.
2021
Journal Article
An emerging role for calcium signaling in cancer-associated fibroblasts
Sadras, Francisco, Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2021). An emerging role for calcium signaling in cancer-associated fibroblasts. International Journal of Molecular Sciences, 22 (21) 11366, 1-11. doi: 10.3390/ijms222111366
2021
Conference Publication
MetaXpress analysis – Ca2+, transcription factors and using IF after live imaging
Sadras, Francisco, So, Choon Leng, Robitaille, Melanie, Roberts-Thomson, Sarah and Monteith, Gregory (2021). MetaXpress analysis – Ca2+, transcription factors and using IF after live imaging. High Content 2021 SBI2’s 8th Annual Conference, Online, 4-6 October 2021.
2021
Journal Article
Altered calcium influx pathways in cancer-associated fibroblasts
Sadras, Francisco, Stewart, Teneale A., Robitaille, Mélanie, Peters, Amelia A., Croft, Priyakshi Kalita-de, Soon, Patsy S., Saunus, Jodi M., Lakhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2021). Altered calcium influx pathways in cancer-associated fibroblasts. Biomedicines, 9 (6) 680, 1-13. doi: 10.3390/biomedicines9060680
2021
Conference Publication
High-throughput assessment of calcium signaling in MCF-7 breast cancer cells adopting various cellular geometry
So, Choon Leng, Sadras, Francisco, Robitaille, Melanie, Roberts-Thomson, Sarah and Monteith, Gregory (2021). High-throughput assessment of calcium signaling in MCF-7 breast cancer cells adopting various cellular geometry. SLAS 2021 Virtual Conference, Virtual, 25-27 January 2021.
2020
Journal Article
Activation of the ion channel TRPV4 induces epithelial to mesenchymal transition in breast cancer cells
Azimi, Iman, Robitaille, Mélanie, Armitage, Kaela, So, Choon Leng, Milevskiy, Michael J. G., Northwood, Korinne, Lim, Huai Fang, Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2020). Activation of the ion channel TRPV4 induces epithelial to mesenchymal transition in breast cancer cells. International Journal of Molecular Sciences, 21 (24) 9417, 1-14. doi: 10.3390/ijms21249417
2020
Journal Article
Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels
Zhang, Xuexin, Xin, Ping, Yoast, Ryan E., Emrich, Scott M., Johnson, Martin T., Pathak, Trayambak, Benson, J. Cory, Azimi, Iman, Gill, Donald L., Monteith, Gregory R. and Trebak, Mohamed (2020). Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels. Cell Calcium, 91 102281, 102281. doi: 10.1016/j.ceca.2020.102281
2020
Conference Publication
Matrix Stiffness effects on calcium signaling in GCaMP6m-MDA-MB-231 breast cancer cells
So, Choon Leng, Meinert, Christoph, Robitaille, Melanie, Roberts-Thomson, Sarah and Monteith, Gregory (2020). Matrix Stiffness effects on calcium signaling in GCaMP6m-MDA-MB-231 breast cancer cells. 7th Society of Biomolecular Imaging and Informatics (SBI2) High Content Meeting, Virtual, 16-17 September 2020.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Calcium signalling pathways in cancer progression
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Calcium signalling changes associated with viral infection
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Calcium channels and pumps as drug targets
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Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
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Doctor Philosophy
Calcium signalling in the context of cell in cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
Calcium signalling and cell death pathways in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Master Philosophy
Investigating the role of exosomes in cancer progression and immunology
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
Completed supervision
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2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
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2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
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2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
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2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
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2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
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2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
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2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
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2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
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2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
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2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
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2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
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2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
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2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
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2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
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2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
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2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
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2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
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2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
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2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
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Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
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