
Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
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High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2019
Conference Publication
Orai channel alterations as a consequence of differentiation in a human neural progenitor cell line
Chalmers, Silke B., Sadras, Francisco, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2019). Orai channel alterations as a consequence of differentiation in a human neural progenitor cell line. ASCEPT-PAGANZ Joint Scientific Meeting, Queenstown, New Zealand, 25-29 November 2019. Hamilton Central, QLD, Australia: ASCEPT.
2018
Journal Article
Pharmacological inhibition of store-operated calcium entry in MDA-MB-468 basal A breast cancer cells: consequences on calcium signalling, cell migration and proliferation
Azimi, Iman, Bong, Alice H., Poo, Greta X. H., Armitage, Kaela, Lok, Dawn, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2018). Pharmacological inhibition of store-operated calcium entry in MDA-MB-468 basal A breast cancer cells: consequences on calcium signalling, cell migration and proliferation. Cellular and Molecular Life Sciences, 75 (24), 4525-4537. doi: 10.1007/s00018-018-2904-y
2018
Journal Article
ORAI channels and cancer
Chalmers, Silke B. and Monteith, Gregory R. (2018). ORAI channels and cancer. Cell Calcium, 74, 160-167. doi: 10.1016/j.ceca.2018.07.011
2018
Journal Article
An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay
Stevenson, Ralph J, Azimi, Iman, Flanagan, Jack U, Inserra, Marco, Vetter, Irina, Monteith, Gregory R and Denny, William A (2018). An SAR study of hydroxy-trifluoromethylpyrazolines as inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a convenient Fluorescence Imaging Plate Reader assay. Bioorganic & Medicinal Chemistry, 26 (12), 3406-3413. doi: 10.1016/j.bmc.2018.05.012
2018
Journal Article
An automated epifluorescence microscopy imaging assay for the identification of phospho-AKT level modulators in breast cancer cells
Kaemmerer, Elke, Turner, Dane, Peters, Amelia A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2018). An automated epifluorescence microscopy imaging assay for the identification of phospho-AKT level modulators in breast cancer cells. Journal of pharmacological and toxicological methods, 92, 13-19. doi: 10.1016/j.vascn.2018.02.005
2018
Journal Article
Calcium signaling and the therapeutic targeting of cancer cells
Bong, Alice H. L. and Monteith, Gregory R. (2018). Calcium signaling and the therapeutic targeting of cancer cells. Biochimica et Biophysica Acta, 1865 (11), 1786-1794. doi: 10.1016/j.bbamcr.2018.05.015
2018
Conference Publication
Sarco/endoplasmic reticulum ATPase inhibition activates calcium signalling pathways for microvesicle biogenesis
Taylor, Jack D., Johnson, Michael, Monteith, Gregory and Bebawy, Mary (2018). Sarco/endoplasmic reticulum ATPase inhibition activates calcium signalling pathways for microvesicle biogenesis. ISEV2018, Barcelona, Spain, 2-6 May 2018. Barcelona, Spain: Wiley. doi: 10.1080/20013078.2018.1461450
2018
Journal Article
Assessment of CXC ligand 12-mediated calcium signalling and its regulators in basal-like breast cancer cells
Jamaludin, S. Y. N., Azimi, I., Davis, F. M., Peters, A. A., Gonda, T. J., Thompson, E. W., Roberts-Thomson, S. J. and Monteith, G. R. (2018). Assessment of CXC ligand 12-mediated calcium signalling and its regulators in basal-like breast cancer cells. Oncology Letters, 15 (4), 4289-4295. doi: 10.3892/ol.2018.7827
2018
Journal Article
Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels
Yapa, Kunsala T. D. S., Deuis, Jennifer, Peters, Amelia A., Kenny, Paraic A., Roberts-Thomson, Sarah J., Vetter, Irina and Monteith, Gregory R. (2018). Assessment of the TRPM8 inhibitor AMTB in breast cancer cells and its identification as an inhibitor of voltage gated sodium channels. Life Sciences, 198, 128-135. doi: 10.1016/j.lfs.2018.02.030
2018
Journal Article
Assessment of cytosolic free calcium changes during ceramide-induced cell death in MDA-MB-231 breast cancer cells expressing the calcium sensor GCaMP6m
Bassett, John J., Bong, Alice H.L., Janke, Ellen K., Robitaille, Mélanie, Roberts-Thomson, Sarah J., Peters, Amelia A. and Monteith, Gregory R. (2018). Assessment of cytosolic free calcium changes during ceramide-induced cell death in MDA-MB-231 breast cancer cells expressing the calcium sensor GCaMP6m. Cell Calcium, 72, 39-50. doi: 10.1016/j.ceca.2018.02.003
2018
Conference Publication
The AKT activator SC79 promotes Ca2+ influx in MDA-MB-231 breast cancer cells
Tan, Yin Y., Bong, Alice H., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2018). The AKT activator SC79 promotes Ca2+ influx in MDA-MB-231 breast cancer cells. Australasian Society for Clinical and Experimental Pharmacologists and Toxicologists, Adelaide, SA, Australia, 27 - 30 November 2018.
2018
Conference Publication
Cancer associated fibroblasts undergo a calcium channel switch
Sadras, Francisco, Stewart, Teneale A., Robitaille, Melanie, Kalita-de Croft, Priyakshi, Patsy, Soon, Saunus, Jodi M., Makhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2018). Cancer associated fibroblasts undergo a calcium channel switch. Australasian Society for Clinical and Experimental Pharmacologists and Toxicologists, Adelaide, SA, Australia, 27 - 30 November 2018.
2018
Conference Publication
Application of automated epifluorescence microscopy methods for the assessment of calcium signalling events in processes relevant to breast cancer progression
Monteith, Gregory, Bassett, John and Sadras, Francisco (2018). Application of automated epifluorescence microscopy methods for the assessment of calcium signalling events in processes relevant to breast cancer progression. XV International Meeting of the European Calcium Society, Hamburg, Germany, 9-13 September 2018.
2018
Conference Publication
Expression of calcium pumps, channels and channel regulators in a model of therapy resistance in melanoma
Chua, Chia C., Hammerlinde, Heinz, Robitaille, Melanie, Roberts-Thomson, Sarah J., Schauder, Helmut and Monteith, Gregory R. (2018). Expression of calcium pumps, channels and channel regulators in a model of therapy resistance in melanoma. Australasian Society for Clinical and Experimental Pharmacologists and Toxicologists, Adelaide, SA Australia, 27 - 30 November 2018.
2018
Conference Publication
Development of novel automated epifluorescence microscopy based assays for calcium signalling in breast cancer cells
Janke, Ellen K, Bassett, John J, Sadras, Francisco, Roberts-Thomson, Sarah J and Monteith, Gregory R (2018). Development of novel automated epifluorescence microscopy based assays for calcium signalling in breast cancer cells. Australasian Society for Clinical and Experimental Pharmacologists and Toxicologists, Adelaide, SA, Australia, 27 - 30 November 2018.
2018
Conference Publication
Automated epifluorescence microscopy based imaging of breast cancer cells with fixed cellular geometry
So, Choon Leng, Bassett, John J., Nguyen, Nam-Trung, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2018). Automated epifluorescence microscopy based imaging of breast cancer cells with fixed cellular geometry. Australasian Society for Clinical and Experimental Pharmacologists and Toxicologists, Adelaide, SA, Australia, 27 - 30 November 2018.
2018
Conference Publication
Calcium permeable ion channels and cell death pathways in breast cancer cells
Monteith, Gregory R. (2018). Calcium permeable ion channels and cell death pathways in breast cancer cells. World Congress of Basic and Clinical Pharmacology, Kyoto, Japan, 1-6 July 2018.
2017
Journal Article
Hypoxia-induced reactive oxygen species mediate N-cadherin and SERPINE1 expression, EGFR signalling and motility in MDA-MB-468 breast cancer cells
Azimi, Iman, Petersen, Rosalie M., Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2017). Hypoxia-induced reactive oxygen species mediate N-cadherin and SERPINE1 expression, EGFR signalling and motility in MDA-MB-468 breast cancer cells. Scientific Reports, 7 (1) 15140, 1-11. doi: 10.1038/s41598-017-15474-7
2017
Journal Article
TRPC1 is a differential regulator of hypoxia-mediated events and Akt signalling in PTEN-deficient breast cancer cells
Azimi, Iman, Milevskiy, Michael J. G., Kaemmerer, Elke, Turner, Dane, Yapa, Kunsala T. D. S., Brown, Melissa A., Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2017). TRPC1 is a differential regulator of hypoxia-mediated events and Akt signalling in PTEN-deficient breast cancer cells. Journal of Cell Science, 130 (14), 2292-2305. doi: 10.1242/jcs.196659
2017
Journal Article
Breast cancer cells: focus on the consequences of epithelial-to-mesenchymal transition
Bong, Alice H. L. and Monteith, Gregory R. (2017). Breast cancer cells: focus on the consequences of epithelial-to-mesenchymal transition. International Journal of Biochemistry & Cell Biology, 87 (33), 23-26. doi: 10.1016/j.biocel.2017.03.014
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Calcium signalling pathways in cancer progression
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Calcium signalling changes associated with viral infection
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Calcium channels and pumps as drug targets
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Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
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Doctor Philosophy
Calcium signalling in the context of cell in cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
Calcium signalling and cell death pathways in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Master Philosophy
Investigating the role of exosomes in cancer progression and immunology
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
Completed supervision
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2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
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2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
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2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
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2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
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2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
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2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
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2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
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2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
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2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
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2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
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2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
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2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
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2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
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2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
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2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
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2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
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2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
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2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
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2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
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Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
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