Associate Professor Marie-Odile Parat
Associate Professor

Marie-Odile Parat

Email: 
Phone: 
+61 7 334 61851

Background

Marie-Odile Parat (MO) joined the School of Pharmacy as Senior Lecturer in December 2007.

MO obtained her Pharm.D. from University Joseph Fourier in Grenoble, France, a Masters in Cutaneous Biology from University Claude Bernard in Lyon, France and her Ph.D. in Cell Biology from University Joseph Fourier in Grenoble, France. She further has post graduate diplomas in the fields of Biomedical and Industrial Pharmacy, Photobiology, Pharmaceutical Management, and Public Health.

MO did her Pharmaceutical Residency at the University Hospitals of Grenoble, France in the Sterile Pharmaceutical Supplies Headquarters, the Department of Nuclear Medicine, and the Laboratory Medicine Department of Biochemistry. Attracted by international working experience, she carried out research within the R&D laboratories of Estee Lauder in Melville, NY. She further worked for the United Nations International Trade center in Geneva, Switzerland, where she was the Product Specialist on market information for pharmaceutical raw materials/essential drugs for three years in collaboration with the World Health Organization.

She later performed post-doctoral research in the Universidade de São Paulo, SP, Brasil and The Cleveland Clinic Foundation in the United States. She was appointed as a Staff Scientist in the Center for Anesthesiology Research of the Cleveland Clinic in 2003, an Assistant Professor of Molecular Medicine in the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and a Member of the Case Cancer Center.

During her research career MO has attracted awards from various funding agencies including the Research Funding Agency of the State of São Paulo (FAPESP), the American Heart Association, the Ohio Cancer Research Associates, the American Cancer Society, the National Heart Foundation of Australia, Cancer Council Queensland, Australian and New Zealand College of Anaesthetists and the Australia Research Council (ARC).

The long term goal of the Parat laboratory is to provide insight for novel cancer therapies. A basic science team focusses on endothelial and cancer cell migration, invasion, angiogenesis, and specialized plasma membrane subdomains termed caveolae. A translational axis of research evaluates novel mechanisms by which opioids administered to cancer patients modulate the risk of long term tumour recurrence and metastasis.

Availability

Associate Professor Marie-Odile Parat is:
Available for supervision
Media expert

Fields of research

Biological Sciences Clinical sciences Oncology and carcinogenesis

Qualifications

  • Doctor of Philosophy, Institution to be confirmed
  • Doctor of Philosophy, Université Joseph Fourier

Research interests

  • Morphine and metastasis

  • Caveola-forming proteins and cancer

  • Caveolin and caveolae in cell migration, angiogenesis and lymphangiogenesis

  • Caveolae and cellular entry of drug delivery systems

  • Plant bioactive discovery

Research impacts

Research on the effect of opioids on tumour growth and metastasis informs the choices that are made to manage the perioperative pain of cancer surgery patients, with the goal of minimizing the risk of post surgical cancer recurrence or metastasis. Furthermore, optimizing opioid administration to surgery patients in order to promote analgesia while reducing the likelihood of undesirable effects, including the risk of eliciting persistent opioid use, is of high significance.

Search Professor Marie-Odile Parat’s works on UQ eSpace

113 works between 1995 and 2024
All (113) Journal Article (85) Book Chapter (7) Conference Publication (20) Book (1)

1 - 20 of 113 works

2024

Journal Article

Phase transforming in situ gels for sustained and controlled transmucosal drug delivery via the intravaginal route

Thapa, Ritu, Pandey, Preeti, Parat, Marie-Odile, Gurung, Shila and Parekh, Harendra S. (2024). Phase transforming in situ gels for sustained and controlled transmucosal drug delivery via the intravaginal route. International Journal of Pharmaceutics, 655 124054, 124054. doi: 10.1016/j.ijpharm.2024.124054

Phase transforming in situ gels for sustained and controlled transmucosal drug delivery via the intravaginal route

2024

Journal Article

Probing the anti-Aβ42 aggregation and protective effects of prenylated xanthone against Aβ42-induced toxicity in transgenic Caenorhabditis elegans model

Thew, Hin Yee, Boon Keat, Khor, Tan, Yong Chiang, Ong, Yong Sze, Parat, Marie-Odile, Murugaiyah, Vikneswaran, Goh, Bey Hing and Khaw, Kooi Yeong (2024). Probing the anti-Aβ42 aggregation and protective effects of prenylated xanthone against Aβ42-induced toxicity in transgenic Caenorhabditis elegans model. Chemico-Biological Interactions, 394 110978, 110978. doi: 10.1016/j.cbi.2024.110978

Probing the anti-Aβ42 aggregation and protective effects of prenylated xanthone against Aβ42-induced toxicity in transgenic Caenorhabditis elegans model

2023

Conference Publication

Regular Use of Pharmaceutical Opioids and Subsequent Risk of Lung Cancer

Sheikh, M., Alcala, K., Mariosa, D., Feng, X., Sarich, P., Weber, M., Fournier, A., Brennan, P., Parat, M.-O., Pearson, S.-A. and Robbins, H.A. (2023). Regular Use of Pharmaceutical Opioids and Subsequent Risk of Lung Cancer. 2023 World Conference on Lung Cancer, Singapore, 9-12 September 2023. New York, NY United States: Elsevier. doi: 10.1016/j.jtho.2023.09.132

Regular Use of Pharmaceutical Opioids and Subsequent Risk of Lung Cancer

2022

Journal Article

Flow cytometric reporter assays provide robust functional analysis of signaling complexes

Muusse, Timothy W., Lee, Morris Y.L., Kim, Hyoyoung, Parat, Marie-Odile, Nanson, Jeffrey D., Kobe, Bostjan, Vajjhala, Parimala R. and Stacey, Katryn J. (2022). Flow cytometric reporter assays provide robust functional analysis of signaling complexes. Journal of Biological Chemistry, 298 (12) 102666, 102666. doi: 10.1016/j.jbc.2022.102666

Flow cytometric reporter assays provide robust functional analysis of signaling complexes

2022

Book Chapter

Opioids and cancer

Saeed, Iqira, La Caze, Adam, Shaw, Paul N. and Parat, Marie-Odile (2022). Opioids and cancer. Perioperative Care of The Cancer Patient. (pp. 140-154) edited by Carin Hagberg, Joseph Nates , Berhard Riedel, Vijaya Gottumukkala and Donal Buggy. Philadelphia, PA United States: Elsevier. doi: 10.1016/B978-0-323-69584-8.00012-8

Opioids and cancer

2022

Journal Article

A simple liquid extraction for simultaneous determination of 12 opioid ligands in plasma by LC-MS/MS

Yang, Dan, Zheng, Qiuda, Ahmed, Fahad, Parat, Marie-Odile and Tscharke, Benjamin J. (2022). A simple liquid extraction for simultaneous determination of 12 opioid ligands in plasma by LC-MS/MS. Analytical Methods, 14 (15), 1523-1528. doi: 10.1039/d1ay01631h

A simple liquid extraction for simultaneous determination of 12 opioid ligands in plasma by LC-MS/MS

2022

Journal Article

Application of sol–gels for treatment of gynaecological conditions—physiological perspectives and emerging concepts in intravaginal drug delivery

Thapa, Ritu, Gurung, Shila, Parat, Marie-Odile, Parekh, Harendra S. and Pandey, Preeti (2022). Application of sol–gels for treatment of gynaecological conditions—physiological perspectives and emerging concepts in intravaginal drug delivery. Gels, 8 (2) 99, 99. doi: 10.3390/gels8020099

Application of sol–gels for treatment of gynaecological conditions—physiological perspectives and emerging concepts in intravaginal drug delivery

2021

Journal Article

Opioid receptor-mediated and non-opioid receptor-mediated roles of opioids in tumour growth and metastasis

Scroope, Claudia A., Singleton, Zane, Hollmann, Markus W. and Parat, Marie-Odile (2021). Opioid receptor-mediated and non-opioid receptor-mediated roles of opioids in tumour growth and metastasis. Frontiers in Oncology, 11 792290, 792290. doi: 10.3389/fonc.2021.792290

Opioid receptor-mediated and non-opioid receptor-mediated roles of opioids in tumour growth and metastasis

2021

Journal Article

High intraluminal pressure promotes vascular inflammation via caveolin-1

Michell, Danielle L., Shihata, Waled A., Andrews, Karen L., Abidin, Nurul Aisha Zainal, Jefferis, Ann-Maree, Sampson, Amanda K., Lumsden, Natalie G., Huet, Olivier, Parat, Marie-Odile, Jennings, Garry L., Parton, Robert G., Woollard, Kevin J., Kaye, David M., Chin-Dusting, Jaye P. F. and Murphy, Andrew J. (2021). High intraluminal pressure promotes vascular inflammation via caveolin-1. Scientific Reports, 11 (1) 5894, 5894. doi: 10.1038/s41598-021-85476-z

High intraluminal pressure promotes vascular inflammation via caveolin-1

2021

Journal Article

Interaction of opioids with TLR4—mechanisms and ramifications

Gabr, Mai Mahmoud, Saeed, Iqira, Miles, Jared A., Ross, Benjamin P., Shaw, Paul Nicholas, Hollmann, Markus W. and Parat, Marie-Odile (2021). Interaction of opioids with TLR4—mechanisms and ramifications. Cancers, 13 (21) 5274, 5274. doi: 10.3390/cancers13215274

Interaction of opioids with TLR4—mechanisms and ramifications

2021

Journal Article

New insights on tramadol and immunomodulation

Saeed, Iqira, La Caze, Adam, Hollmann, Markus W., Shaw, Paul N. and Parat, Marie-Odile (2021). New insights on tramadol and immunomodulation. Current Oncology Reports, 23 (11) 123, 123. doi: 10.1007/s11912-021-01121-y

New insights on tramadol and immunomodulation

2021

Journal Article

Anticancer activities of dietary benzyl isothiocyanate: A comprehensive review

Dinh, Thao Nhu, Parat, Marie-Odile, Ong, Yong Sze and Khaw, Kooi Yeong (2021). Anticancer activities of dietary benzyl isothiocyanate: A comprehensive review. Pharmacological Research, 169 105666, 105666. doi: 10.1016/j.phrs.2021.105666

Anticancer activities of dietary benzyl isothiocyanate: A comprehensive review

2021

Journal Article

Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

McMahon, Kerrie-Ann, Stroud, David A., Gambin, Yann, Tillu, Vikas, Bastiani, Michele, Sierecki, Emma, Polinkovsky, Mark E., Hall, Thomas E., Gomez, Guillermo A., Wu, Yeping, Parat, Marie-Odile, Martel, Nick, Lo, Harriet P., Khanna, Kum Kum, Alexandrov, Kirill, Daly, Roger, Yap, Alpha, Ryan, Michael T. and Parton, Robert G. (2021). Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response. eLife, 10 e61407, 1-35. doi: 10.7554/elife.61407

Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

2020

Journal Article

Compound identification and in vitro cytotoxicity of the supercritical carbon dioxide extract of papaya freeze-dried leaf juice

Khaw, Kooi-Yeong, Shaw, Paul Nicholas, Parat, Marie-Odile, Pandey, Saurabh and Falconer, James Robert (2020). Compound identification and in vitro cytotoxicity of the supercritical carbon dioxide extract of papaya freeze-dried leaf juice. Processes, 8 (5) 610, 610. doi: 10.3390/pr8050610

Compound identification and in vitro cytotoxicity of the supercritical carbon dioxide extract of papaya freeze-dried leaf juice

2020

Journal Article

Caveola-forming proteins and prostate cancer

Nassar, Zeyad D. and Parat, Marie-Odile (2020). Caveola-forming proteins and prostate cancer. Cancer and Metastasis Reviews, 39 (2), 415-433. doi: 10.1007/s10555-020-09874-x

Caveola-forming proteins and prostate cancer

2020

Journal Article

A role for caveola‐forming proteins caveolin‐1 and CAVIN1 in the pro‐invasive response of glioblastoma to osmotic and hydrostatic pressure

Pu, Wenjun, Qiu, Jiawen, Nassar, Zeyad D., Shaw, Paul N., McMahon, Kerrie‐Ann, Ferguson, Charles, Parton, Robert G., Riggins, Gregory J., Harris, Jonathan M. and Parat, Marie‐Odile (2020). A role for caveola‐forming proteins caveolin‐1 and CAVIN1 in the pro‐invasive response of glioblastoma to osmotic and hydrostatic pressure. Journal of Cellular and Molecular Medicine, 24 (6) jcmm.15076, 3724-3738. doi: 10.1111/jcmm.15076

A role for caveola‐forming proteins caveolin‐1 and CAVIN1 in the pro‐invasive response of glioblastoma to osmotic and hydrostatic pressure

2020

Journal Article

Matrix protease production, epithelial-to-mesenchymal transition marker expression and invasion of glioblastoma cells in response to osmotic or hydrostatic pressure

Pu, Wenjun, Qiu, Jiawen, Riggins, Gregory J. and Parat, Marie-Odile (2020). Matrix protease production, epithelial-to-mesenchymal transition marker expression and invasion of glioblastoma cells in response to osmotic or hydrostatic pressure. Scientific Reports, 10 (1) 2634, 2634. doi: 10.1038/s41598-020-59462-w

Matrix protease production, epithelial-to-mesenchymal transition marker expression and invasion of glioblastoma cells in response to osmotic or hydrostatic pressure

2019

Journal Article

Corrigendum: Morphine binds creatine kinase B and inhibits its activity (vol 12, 464, 2018)

Weinsanto, Ivan, Mouheiche, Jinane, Laux-Biehlmann, Alexis, Delalande, Francois, Marquette, Arnaud, Chavant, Virginie, Gabel, Florian, Cianferani, Sarah, Charlet, Alexandre, Parat, Marie-Odile and Goumon, Yannick (2019). Corrigendum: Morphine binds creatine kinase B and inhibits its activity (vol 12, 464, 2018). Frontiers in Cellular Neuroscience, 13 292, 292. doi: 10.3389/fncel.2019.00292

Corrigendum: Morphine binds creatine kinase B and inhibits its activity (vol 12, 464, 2018)

2019

Journal Article

Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1

Pu, Wenjun, Nassar, Zeyad D., Khabbazi, Samira, Xie, Nan, McMahon, Kerrie-Ann, Parton, Robert G., Riggins, Gregory J., Harris, Jonathan M. and Parat, Marie-Odile (2019). Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1. Journal of Neuro-Oncology, 143 (2), 207-220. doi: 10.1007/s11060-019-03161-8

Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1

2019

Journal Article

Rivastigmine and metabolite analogues with putative Alzheimer’s disease-modifying properties in a Caenorhabditis elegans model

Dighe, Satish N., De la Mora, Eugenio, Chan, Stephen, Kantham, Srinivas, McColl, Gawain, Miles, Jared A., Veliyath, Suresh Kumar, Sreenivas, B. Yogi, Nassar, Zeyad D., Silman, Israel, Sussman, Joel L., Weik, Martin, McGeary, Ross P., Parat, Marie-Odile, Brazzolotto, Xavier and Ross, Benjamin P. (2019). Rivastigmine and metabolite analogues with putative Alzheimer’s disease-modifying properties in a Caenorhabditis elegans model. Communications Chemistry, 2 (1) 35. doi: 10.1038/s42004-019-0133-4

Rivastigmine and metabolite analogues with putative Alzheimer’s disease-modifying properties in a Caenorhabditis elegans model

Current funding

  • 2024 - 2029
    The Opioid Cohort Consortium (OPICO) to investigate the effects of using opioids on cancer risk (NIH led by International Agency for Research on Cancer)
    International Agency for Research on Cancer
    Open grant

Past funding

  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    The assessment of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells to identify and characterize new therapeutic targets for diseases
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014
    A medium-throughput cell isolation and analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Deciphering the cellular functions of caveolae that govern lymphatic vascular development.
    ARC Discovery Projects
    Open grant
  • 2014 - 2015
    Perioperative opioids and tumour growth and metastasis
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2010 - 2012
    Does PTRF-cavin control endothelial cell migration and angiogenesis?
    Cancer Council Queensland
    Open grant
  • 2010
    High content imaging analysis for bioactive and novel therapeutic target evaluation
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009
    A core pharmacy facility for molecular biology, expression and protein post translational modification studies in cancer, cardiovascular, pain and epilepsy research
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2012
    Calcium Influx Pathways and Breast Cancer
    NHMRC Project Grant
    Open grant
  • 2009 - 2010
    Caveolin-1 and the formation of new blood vessels
    National Heart Foundation of Australia
    Open grant
  • 2008 - 2010
    Morphine in Breast Cancer Growth and Metastisis
    Cancer Bequest Fund
    Open grant
  • 2008 - 2009
    Spatial modulation of nitric oxide production in angiogenic endothelial cells
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Associate Professor Marie-Odile Parat is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Extraction of bioactives from natural resources using supercritical fluid technology and their activity testing for the pharmaceutical and food industry

    Associate Advisor

    Other advisors: Dr James Robert Falconer

  • Doctor Philosophy

    Application of Sol-gel Technology for the Treatment of Gynaecological Conditions

    Associate Advisor

    Other advisors: Dr Harendra Parekh

  • Doctor Philosophy

    Development of a recombinant, multicomponent targeted gene delivery platform

    Associate Advisor

    Other advisors: Associate Professor Peter Moyle

  • Doctor Philosophy

    Application of Sol-gel Technology for the Treatment of Gynaecological Conditions

    Associate Advisor

    Other advisors: Dr Harendra Parekh

  • Doctor Philosophy

    Development of a recombinant, multicomponent targeted gene delivery platform

    Associate Advisor

    Other advisors: Associate Professor Peter Moyle

Completed supervision

Enquiries

Contact Associate Professor Marie-Odile Parat directly for media enquiries about:

  • Angiogenesis
  • Cancer drug discovery
  • Cell migration
  • Endothelial cells
  • Metastasis

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