
Overview
Background
Marie-Odile Parat (MO) joined the School of Pharmacy as Senior Lecturer in December 2007.
MO obtained her Pharm.D. from University Joseph Fourier in Grenoble, France, a Masters in Cutaneous Biology from University Claude Bernard in Lyon, France and her Ph.D. in Cell Biology from University Joseph Fourier in Grenoble, France. She further has post graduate diplomas in the fields of Biomedical and Industrial Pharmacy, Photobiology, Pharmaceutical Management, and Public Health.
MO did her Pharmaceutical Residency at the University Hospitals of Grenoble, France in the Sterile Pharmaceutical Supplies Headquarters, the Department of Nuclear Medicine, and the Laboratory Medicine Department of Biochemistry. Attracted by international working experience, she carried out research within the R&D laboratories of Estee Lauder in Melville, NY. She further worked for the United Nations International Trade center in Geneva, Switzerland, where she was the Product Specialist on market information for pharmaceutical raw materials/essential drugs for three years in collaboration with the World Health Organization.
She later performed post-doctoral research in the Universidade de São Paulo, SP, Brasil and The Cleveland Clinic Foundation in the United States. She was appointed as a Staff Scientist in the Center for Anesthesiology Research of the Cleveland Clinic in 2003, an Assistant Professor of Molecular Medicine in the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and a Member of the Case Cancer Center.
During her research career MO has attracted awards from various funding agencies including the Research Funding Agency of the State of São Paulo (FAPESP), the American Heart Association, the Ohio Cancer Research Associates, the American Cancer Society, the National Heart Foundation of Australia, Cancer Council Queensland, Australian and New Zealand College of Anaesthetists and the Australia Research Council (ARC).
The long term goal of the Parat laboratory is to provide insight for novel cancer therapies. A basic science team focusses on endothelial and cancer cell migration, invasion, angiogenesis, and specialized plasma membrane subdomains termed caveolae. A translational axis of research evaluates novel mechanisms by which opioids administered to cancer patients modulate the risk of long term tumour recurrence and metastasis.
Availability
- Associate Professor Marie-Odile Parat is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Doctor of Philosophy, Institution to be confirmed
- Doctor of Philosophy, Université Joseph Fourier
Research interests
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Morphine and metastasis
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Caveola-forming proteins and cancer
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Caveolin and caveolae in cell migration, angiogenesis and lymphangiogenesis
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Caveolae and cellular entry of drug delivery systems
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Plant bioactive discovery
Research impacts
Research on the effect of opioids on tumour growth and metastasis informs the choices that are made to manage the perioperative pain of cancer surgery patients, with the goal of minimizing the risk of post surgical cancer recurrence or metastasis. Furthermore, optimizing opioid administration to surgery patients in order to promote analgesia while reducing the likelihood of undesirable effects, including the risk of eliciting persistent opioid use, is of high significance.
Works
Search Professor Marie-Odile Parat’s works on UQ eSpace
2004
Journal Article
Oxidative stress, caveolae and caveolin-1
Parat, Marie-Odile and Fox, Paul L (2004). Oxidative stress, caveolae and caveolin-1. Sub-cellular biochemistry, 37, 425-441.
2003
Journal Article
Differential Caveolin-1 Polarization in Endothelial Cells during Migration in Two and Three Dimensions
Parat, M. O., Anande-Apte, B. and Fox, P. L. (2003). Differential Caveolin-1 Polarization in Endothelial Cells during Migration in Two and Three Dimensions. Molecular biology of the cell, 14 (8), 3156-3168. doi: 10.1091/mbc.E02-11-0761
2003
Conference Publication
Differential caveolin-1 polarization in endothelial cells during migration in 2-and 3-dimensions
Parat, M. O., Anand-Apte, B. and Fox, P. L. (2003). Differential caveolin-1 polarization in endothelial cells during migration in 2-and 3-dimensions. Experimental Biology 2003 Meeting, San Diego CA, United States, 11-15 April 2003. Bethesda, MD, United States: Federation of American Societies for Experimental Biology.
2002
Journal Article
Oxidative stress inhibits caveolin-1 palmitoylation and trafficking in endothelial cells
Parat, M. O., Stachowicz, R. Z. and Fox, P. L. (2002). Oxidative stress inhibits caveolin-1 palmitoylation and trafficking in endothelial cells. Biochemical Journal, 361 (3), 681-688. doi: 10.1042/0264-6021:3610681
2002
Conference Publication
Cooperative effects of zinc/selenium and thiols in the protection against UV-induced genomic DNA damage
Richard, Marie-Jeanne, Emonet-Piccardi, Nathalie, Didier, Christine, Jourdan, Eric, Leccia, Marie-Thérèse, Parat, Marie-Odile, Cadet, Jean, Beani, Jean Claude and Favier, Alain (2002). Cooperative effects of zinc/selenium and thiols in the protection against UV-induced genomic DNA damage. 10th International Symposium on Trace Elements in Man and Animals (TEMA 10), Evian les Bains, France, 2 - 7 May 1999. 9780306463785: Springer.
2001
Journal Article
Palmitoylation of caveolin-1 in endothelial cells is post-translational but irreversible
Parat, Marie-Odile and Fox, Paul L. (2001). Palmitoylation of caveolin-1 in endothelial cells is post-translational but irreversible. Journal of Biological Chemistry, 276 (19), 15776-15782. doi: 10.1074/jbc.M006722200
2000
Conference Publication
Palmitoylation of caveolin-1 in endothelial cells: recycling does not occur due to absence of depalmitoylation
Parat, M. O. and Fox, P. L. (2000). Palmitoylation of caveolin-1 in endothelial cells: recycling does not occur due to absence of depalmitoylation. -, -, -. Bethesda, MD, United States: American Society for Cell Biology.
1999
Journal Article
Impairment of cultured cell proliferation and metallothionein expression by metal chelator NNN'N'-tetrakis-(2-pyridylmethyl)ethylene diamine
Parat, Marie-Odile, Richard, Marie-Jeanne, Meplan, Catherine, Favier, Alain and Beani, Jean-Claude (1999). Impairment of cultured cell proliferation and metallothionein expression by metal chelator NNN'N'-tetrakis-(2-pyridylmethyl)ethylene diamine. Biological Trace Element Research, 70 (1), 51-68. doi: 10.1007/BF02783849
1998
Journal Article
Metal chelator NNN'N'-tetrakis-(2-pyridylmethyl)ethylene diamine inhibits the induction of heat shock protein 70 synthesis by heat in cultured keratinocytes
Parat, Marie-Odile, Richard, Marie-Jeanne, Favier, Alain and Beani, Jean-Claude (1998). Metal chelator NNN'N'-tetrakis-(2-pyridylmethyl)ethylene diamine inhibits the induction of heat shock protein 70 synthesis by heat in cultured keratinocytes. Biological Trace Element Research, 65 (3), 261-270. doi: 10.1007/BF02789101
1998
Journal Article
Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc
Verhaegh, Gerald W., Parat, Marie-Odile, Richard, Marie-Jeanne and Hainaut, Pierre (1998). Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc. Molecular Carcinogenesis, 21 (3), 205-214. doi: 10.1002/(SICI)1098-2744(199803)21:33.0.CO;2-K
1997
Journal Article
Involvement of zinc in intracellular oxidant/antioxidant balance
Parat, Marie-Odile, Richard, Marie-Jeanne, Beani, Jean-Claude and Favier, Alain (1997). Involvement of zinc in intracellular oxidant/antioxidant balance. Biological Trace Element Research, 60 (3), 187-204. doi: 10.1007/BF02784439
1997
Journal Article
Zinc and DNA fragmentation in keratinocyte apoptosis: its inhibitory effect in UVB irradiated cells
Parat, Marie-Odile, Richard, Marie-Jeanne, Pollet, Ségolène, Hadjur, Christophe, Favier, Alain and Beani, Jean-Claude (1997). Zinc and DNA fragmentation in keratinocyte apoptosis: its inhibitory effect in UVB irradiated cells. Journal of Photochemistry and Photobiology B: Biology, 37 (1-2), 101-106. doi: 10.1016/S1011-1344(96)07334-4
1996
Journal Article
Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells
Hadjur, Christophe, Richard, Marie-Jeanne, Parat, Marie-Odile, Jardon, Pierre and Favier, Alain (1996). Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells. Photochemistry and Photobiology, 64 (2), 375-381. doi: 10.1111/j.1751-1097.1996.tb02474.x
1996
Conference Publication
Zinc and DNA fragmentation in keratinocyte apoptosis
Parat, M. O., Richard, M. J., Favier, A., Amblard, P. and Beani, J. C. (1996). Zinc and DNA fragmentation in keratinocyte apoptosis. Congrès Annuel de Recherche Dermatologique 96, -, 1996. London, United Kingdom: Nature Publishing Group. doi: 10.1111/1523-1747.ep12329774
1995
Journal Article
Photodynamically induced cytotoxicity of hypericin dye on human fibroblast cell line MRC5
Hadjur, C., Richard, M. J., Parat, M. O., Favier, A. and Jardon, P. (1995). Photodynamically induced cytotoxicity of hypericin dye on human fibroblast cell line MRC5. Journal of Photochemistry and Photobiology B: Biology, 27 (2), 139-146. doi: 10.1016/1011-1344(94)07064-U
1995
Conference Publication
Zinc and UVB cytotoxicity on cultured transformed keratinocytes
Parat, M.O., Mammone, T., Richard, M.J., Amblard, P., Beani, J.C. and Favier, A. (1995). Zinc and UVB cytotoxicity on cultured transformed keratinocytes. Meeting, unknown, 1995. London, United Kingdom: Nature Publishing Group.
1995
Journal Article
Does manganese protect cultured human skin fibroblasts against oxidative injury by UVA, dithranol and hydrogen peroxide?
Parat, Marie-Odile, Richard, Marie-Jeanne, Leccia, Marie Thérèse, Amblard, Pierre, Favier, Alain and Béani, Jean Claude (1995). Does manganese protect cultured human skin fibroblasts against oxidative injury by UVA, dithranol and hydrogen peroxide?. European Journal of Endocrinology, 23 (4), 339-351. doi: 10.3109/10715769509065255
Funding
Current funding
Supervision
Availability
- Associate Professor Marie-Odile Parat is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Detection, identification and characterisation of opioid receptor-active metabolites produced by the human gut microbiome
Principal Advisor
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Doctor Philosophy
Application of Sol-gel Technology for the Treatment of Gynaecological Conditions
Associate Advisor
Other advisors: Dr Harendra Parekh
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Doctor Philosophy
Development of a recombinant, multicomponent targeted gene delivery platform
Associate Advisor
Other advisors: Associate Professor Peter Moyle
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Doctor Philosophy
Development of a recombinant, multicomponent targeted gene delivery platform
Associate Advisor
Other advisors: Associate Professor Peter Moyle
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Doctor Philosophy
Extraction of bioactives from natural resources using supercritical fluid technology and their activity testing for the pharmaceutical and food industry
Associate Advisor
Other advisors: Dr James Robert Falconer
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Doctor Philosophy
Application of Sol-gel Technology for the Treatment of Gynaecological Conditions
Associate Advisor
Other advisors: Dr Harendra Parekh
-
Doctor Philosophy
Navigating the use of artificial intelligence in pharmacy curriculum: Curriculum design and academic integrity
Associate Advisor
Other advisors: Associate Professor Adam La Caze
Completed supervision
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2018
Doctor Philosophy
MORPHINE AND CANCER METASTASIS
Principal Advisor
Other advisors: Professor Peter Cabot, Professor David Sturgess, Professor Nick Shaw
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2017
Doctor Philosophy
THE MODULATORY EFFECT OF MORPHINE ON TUMOUR CELL-MACROPHAGE INTERACTIONS IN THE CONTEXT OF CANCER
Principal Advisor
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2016
Doctor Philosophy
The role of caveolae in chemical carrier-mediated cellular delivery
Principal Advisor
Other advisors: Dr Harendra Parekh
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2015
Doctor Philosophy
The Role of Caveola-Forming Proteins in Prostate Cancer Angiogenesis and Lymphangiogenesis
Principal Advisor
Other advisors: Dr Harendra Parekh
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2014
Doctor Philosophy
Effect of perioperative medications on the interaction between breast tumour and its microenvironment
Principal Advisor
Other advisors: Professor Peter Cabot
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2021
Doctor Philosophy
Metabolite and lipid profiling of plasma and urine in an obese population using an untargeted approach: Biomarker discovery in obesity
Associate Advisor
Other advisors: Professor Nick Shaw
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2019
Doctor Philosophy
Novel extraction and evaluation of papaya leaf for chemotherapeutic molecules
Associate Advisor
Other advisors: Professor Nick Shaw, Dr James Robert Falconer
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2018
Doctor Philosophy
Evaluation of Pittosporum angustifolium Lodd. leaf extracts for their biological activities and chemical profiles
Associate Advisor
Other advisors: Professor Nick Shaw
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2016
Doctor Philosophy
Investigation of bioactive compounds with anti-cancer potential in Carica papaya leaves
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Amitha Hewavitharana
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2016
Doctor Philosophy
Development of Ultrasound-Responsive Nanobubbles for the Enhancement of Posterior Eye Drug Delivery
Associate Advisor
Other advisors: Dr Harendra Parekh
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2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Gregory Monteith, Professor Peter Cabot
Media
Enquiries
Contact Associate Professor Marie-Odile Parat directly for media enquiries about:
- Angiogenesis
- Cancer drug discovery
- Cell migration
- Endothelial cells
- Metastasis
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