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Associate Professor Marie-Odile Parat
Associate Professor

Marie-Odile Parat

Email: 
Phone: 
+61 7 334 61851

Overview

Background

Marie-Odile Parat (MO) joined the School of Pharmacy as Senior Lecturer in December 2007.

MO obtained her Pharm.D. from University Joseph Fourier in Grenoble, France, a Masters in Cutaneous Biology from University Claude Bernard in Lyon, France and her Ph.D. in Cell Biology from University Joseph Fourier in Grenoble, France. She further has post graduate diplomas in the fields of Biomedical and Industrial Pharmacy, Photobiology, Pharmaceutical Management, and Public Health.

MO did her Pharmaceutical Residency at the University Hospitals of Grenoble, France in the Sterile Pharmaceutical Supplies Headquarters, the Department of Nuclear Medicine, and the Laboratory Medicine Department of Biochemistry. Attracted by international working experience, she carried out research within the R&D laboratories of Estee Lauder in Melville, NY. She further worked for the United Nations International Trade center in Geneva, Switzerland, where she was the Product Specialist on market information for pharmaceutical raw materials/essential drugs for three years in collaboration with the World Health Organization.

She later performed post-doctoral research in the Universidade de São Paulo, SP, Brasil and The Cleveland Clinic Foundation in the United States. She was appointed as a Staff Scientist in the Center for Anesthesiology Research of the Cleveland Clinic in 2003, an Assistant Professor of Molecular Medicine in the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and a Member of the Case Cancer Center.

During her research career MO has attracted awards from various funding agencies including the Research Funding Agency of the State of São Paulo (FAPESP), the American Heart Association, the Ohio Cancer Research Associates, the American Cancer Society, the National Heart Foundation of Australia, Cancer Council Queensland, Australian and New Zealand College of Anaesthetists and the Australia Research Council (ARC).

The long term goal of the Parat laboratory is to provide insight for novel cancer therapies. A basic science team focusses on endothelial and cancer cell migration, invasion, angiogenesis, and specialized plasma membrane subdomains termed caveolae. A translational axis of research evaluates novel mechanisms by which opioids administered to cancer patients modulate the risk of long term tumour recurrence and metastasis.

Availability

Associate Professor Marie-Odile Parat is:
Available for supervision
Media expert

Qualifications

  • Doctor of Philosophy, Institution to be confirmed
  • Doctor of Philosophy, Université Joseph Fourier

Research interests

  • Morphine and metastasis

  • Caveola-forming proteins and cancer

  • Caveolin and caveolae in cell migration, angiogenesis and lymphangiogenesis

  • Caveolae and cellular entry of drug delivery systems

  • Plant bioactive discovery

Research impacts

Research on the effect of opioids on tumour growth and metastasis informs the choices that are made to manage the perioperative pain of cancer surgery patients, with the goal of minimizing the risk of post surgical cancer recurrence or metastasis. Furthermore, optimizing opioid administration to surgery patients in order to promote analgesia while reducing the likelihood of undesirable effects, including the risk of eliciting persistent opioid use, is of high significance.

Works

Search Professor Marie-Odile Parat’s works on UQ eSpace

117 works between 1995 and 2025

101 - 117 of 117 works

2004

Journal Article

Oxidative stress, caveolae and caveolin-1

Parat, Marie-Odile and Fox, Paul L (2004). Oxidative stress, caveolae and caveolin-1. Sub-cellular biochemistry, 37, 425-441.

Oxidative stress, caveolae and caveolin-1

2003

Journal Article

Differential Caveolin-1 Polarization in Endothelial Cells during Migration in Two and Three Dimensions

Parat, M. O., Anande-Apte, B. and Fox, P. L. (2003). Differential Caveolin-1 Polarization in Endothelial Cells during Migration in Two and Three Dimensions. Molecular biology of the cell, 14 (8), 3156-3168. doi: 10.1091/mbc.E02-11-0761

Differential Caveolin-1 Polarization in Endothelial Cells during Migration in Two and Three Dimensions

2003

Conference Publication

Differential caveolin-1 polarization in endothelial cells during migration in 2-and 3-dimensions

Parat, M. O., Anand-Apte, B. and Fox, P. L. (2003). Differential caveolin-1 polarization in endothelial cells during migration in 2-and 3-dimensions. Experimental Biology 2003 Meeting, San Diego CA, United States, 11-15 April 2003. Bethesda, MD, United States: Federation of American Societies for Experimental Biology.

Differential caveolin-1 polarization in endothelial cells during migration in 2-and 3-dimensions

2002

Journal Article

Oxidative stress inhibits caveolin-1 palmitoylation and trafficking in endothelial cells

Parat, M. O., Stachowicz, R. Z. and Fox, P. L. (2002). Oxidative stress inhibits caveolin-1 palmitoylation and trafficking in endothelial cells. Biochemical Journal, 361 (3), 681-688. doi: 10.1042/0264-6021:3610681

Oxidative stress inhibits caveolin-1 palmitoylation and trafficking in endothelial cells

2002

Conference Publication

Cooperative effects of zinc/selenium and thiols in the protection against UV-induced genomic DNA damage

Richard, Marie-Jeanne, Emonet-Piccardi, Nathalie, Didier, Christine, Jourdan, Eric, Leccia, Marie-Thérèse, Parat, Marie-Odile, Cadet, Jean, Beani, Jean Claude and Favier, Alain (2002). Cooperative effects of zinc/selenium and thiols in the protection against UV-induced genomic DNA damage. 10th International Symposium on Trace Elements in Man and Animals (TEMA 10), Evian les Bains, France, 2 - 7 May 1999. 9780306463785: Springer.

Cooperative effects of zinc/selenium and thiols in the protection against UV-induced genomic DNA damage

2001

Journal Article

Palmitoylation of caveolin-1 in endothelial cells is post-translational but irreversible

Parat, Marie-Odile and Fox, Paul L. (2001). Palmitoylation of caveolin-1 in endothelial cells is post-translational but irreversible. Journal of Biological Chemistry, 276 (19), 15776-15782. doi: 10.1074/jbc.M006722200

Palmitoylation of caveolin-1 in endothelial cells is post-translational but irreversible

2000

Conference Publication

Palmitoylation of caveolin-1 in endothelial cells: recycling does not occur due to absence of depalmitoylation

Parat, M. O. and Fox, P. L. (2000). Palmitoylation of caveolin-1 in endothelial cells: recycling does not occur due to absence of depalmitoylation. -, -, -. Bethesda, MD, United States: American Society for Cell Biology.

Palmitoylation of caveolin-1 in endothelial cells: recycling does not occur due to absence of depalmitoylation

1999

Journal Article

Impairment of cultured cell proliferation and metallothionein expression by metal chelator NNN'N'-tetrakis-(2-pyridylmethyl)ethylene diamine

Parat, Marie-Odile, Richard, Marie-Jeanne, Meplan, Catherine, Favier, Alain and Beani, Jean-Claude (1999). Impairment of cultured cell proliferation and metallothionein expression by metal chelator NNN'N'-tetrakis-(2-pyridylmethyl)ethylene diamine. Biological Trace Element Research, 70 (1), 51-68. doi: 10.1007/BF02783849

Impairment of cultured cell proliferation and metallothionein expression by metal chelator NNN'N'-tetrakis-(2-pyridylmethyl)ethylene diamine

1998

Journal Article

Metal chelator NNN'N'-tetrakis-(2-pyridylmethyl)ethylene diamine inhibits the induction of heat shock protein 70 synthesis by heat in cultured keratinocytes

Parat, Marie-Odile, Richard, Marie-Jeanne, Favier, Alain and Beani, Jean-Claude (1998). Metal chelator NNN'N'-tetrakis-(2-pyridylmethyl)ethylene diamine inhibits the induction of heat shock protein 70 synthesis by heat in cultured keratinocytes. Biological Trace Element Research, 65 (3), 261-270. doi: 10.1007/BF02789101

Metal chelator NNN'N'-tetrakis-(2-pyridylmethyl)ethylene diamine inhibits the induction of heat shock protein 70 synthesis by heat in cultured keratinocytes

1998

Journal Article

Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc

Verhaegh, Gerald W., Parat, Marie-Odile, Richard, Marie-Jeanne and Hainaut, Pierre (1998). Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc. Molecular Carcinogenesis, 21 (3), 205-214. doi: 10.1002/(SICI)1098-2744(199803)21:33.0.CO;2-K

Modulation of p53 protein conformation and DNA-binding activity by intracellular chelation of zinc

1997

Journal Article

Involvement of zinc in intracellular oxidant/antioxidant balance

Parat, Marie-Odile, Richard, Marie-Jeanne, Beani, Jean-Claude and Favier, Alain (1997). Involvement of zinc in intracellular oxidant/antioxidant balance. Biological Trace Element Research, 60 (3), 187-204. doi: 10.1007/BF02784439

Involvement of zinc in intracellular oxidant/antioxidant balance

1997

Journal Article

Zinc and DNA fragmentation in keratinocyte apoptosis: its inhibitory effect in UVB irradiated cells

Parat, Marie-Odile, Richard, Marie-Jeanne, Pollet, Ségolène, Hadjur, Christophe, Favier, Alain and Beani, Jean-Claude (1997). Zinc and DNA fragmentation in keratinocyte apoptosis: its inhibitory effect in UVB irradiated cells. Journal of Photochemistry and Photobiology B: Biology, 37 (1-2), 101-106. doi: 10.1016/S1011-1344(96)07334-4

Zinc and DNA fragmentation in keratinocyte apoptosis: its inhibitory effect in UVB irradiated cells

1996

Journal Article

Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells

Hadjur, Christophe, Richard, Marie-Jeanne, Parat, Marie-Odile, Jardon, Pierre and Favier, Alain (1996). Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells. Photochemistry and Photobiology, 64 (2), 375-381. doi: 10.1111/j.1751-1097.1996.tb02474.x

Photodynamic effects of hypericin on lipid peroxidation and antioxidant status in melanoma cells

1996

Conference Publication

Zinc and DNA fragmentation in keratinocyte apoptosis

Parat, M. O., Richard, M. J., Favier, A., Amblard, P. and Beani, J. C. (1996). Zinc and DNA fragmentation in keratinocyte apoptosis. Congrès Annuel de Recherche Dermatologique 96, -, 1996. London, United Kingdom: Nature Publishing Group. doi: 10.1111/1523-1747.ep12329774

Zinc and DNA fragmentation in keratinocyte apoptosis

1995

Journal Article

Photodynamically induced cytotoxicity of hypericin dye on human fibroblast cell line MRC5

Hadjur, C., Richard, M. J., Parat, M. O., Favier, A. and Jardon, P. (1995). Photodynamically induced cytotoxicity of hypericin dye on human fibroblast cell line MRC5. Journal of Photochemistry and Photobiology B: Biology, 27 (2), 139-146. doi: 10.1016/1011-1344(94)07064-U

Photodynamically induced cytotoxicity of hypericin dye on human fibroblast cell line MRC5

1995

Conference Publication

Zinc and UVB cytotoxicity on cultured transformed keratinocytes

Parat, M.O., Mammone, T., Richard, M.J., Amblard, P., Beani, J.C. and Favier, A. (1995). Zinc and UVB cytotoxicity on cultured transformed keratinocytes. Meeting, unknown, 1995. London, United Kingdom: Nature Publishing Group.

Zinc and UVB cytotoxicity on cultured transformed keratinocytes

1995

Journal Article

Does manganese protect cultured human skin fibroblasts against oxidative injury by UVA, dithranol and hydrogen peroxide?

Parat, Marie-Odile, Richard, Marie-Jeanne, Leccia, Marie Thérèse, Amblard, Pierre, Favier, Alain and Béani, Jean Claude (1995). Does manganese protect cultured human skin fibroblasts against oxidative injury by UVA, dithranol and hydrogen peroxide?. European Journal of Endocrinology, 23 (4), 339-351. doi: 10.3109/10715769509065255

Does manganese protect cultured human skin fibroblasts against oxidative injury by UVA, dithranol and hydrogen peroxide?

Funding

Current funding

  • 2024 - 2029
    The Opioid Cohort Consortium (OPICO) to investigate the effects of using opioids on cancer risk (NIH led by International Agency for Research on Cancer)
    International Agency for Research on Cancer
    Open grant

Past funding

  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    The assessment of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells to identify and characterize new therapeutic targets for diseases
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014
    A medium-throughput cell isolation and analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Deciphering the cellular functions of caveolae that govern lymphatic vascular development.
    ARC Discovery Projects
    Open grant
  • 2014 - 2015
    Perioperative opioids and tumour growth and metastasis
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2010 - 2012
    Does PTRF-cavin control endothelial cell migration and angiogenesis?
    Cancer Council Queensland
    Open grant
  • 2010
    High content imaging analysis for bioactive and novel therapeutic target evaluation
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009
    A core pharmacy facility for molecular biology, expression and protein post translational modification studies in cancer, cardiovascular, pain and epilepsy research
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2012
    Calcium Influx Pathways and Breast Cancer
    NHMRC Project Grant
    Open grant
  • 2009 - 2010
    Caveolin-1 and the formation of new blood vessels
    National Heart Foundation of Australia
    Open grant
  • 2008 - 2010
    Morphine in Breast Cancer Growth and Metastisis
    Cancer Bequest Fund
    Open grant
  • 2008 - 2009
    Spatial modulation of nitric oxide production in angiogenic endothelial cells
    UQ New Staff Research Start-Up Fund
    Open grant

Supervision

Availability

Associate Professor Marie-Odile Parat is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Detection, identification and characterisation of opioid receptor-active metabolites produced by the human gut microbiome

    Principal Advisor

  • Doctor Philosophy

    Application of Sol-gel Technology for the Treatment of Gynaecological Conditions

    Associate Advisor

    Other advisors: Dr Harendra Parekh

  • Doctor Philosophy

    Development of a recombinant, multicomponent targeted gene delivery platform

    Associate Advisor

    Other advisors: Associate Professor Peter Moyle

  • Doctor Philosophy

    Development of a recombinant, multicomponent targeted gene delivery platform

    Associate Advisor

    Other advisors: Associate Professor Peter Moyle

  • Doctor Philosophy

    Extraction of bioactives from natural resources using supercritical fluid technology and their activity testing for the pharmaceutical and food industry

    Associate Advisor

    Other advisors: Dr James Robert Falconer

  • Doctor Philosophy

    Application of Sol-gel Technology for the Treatment of Gynaecological Conditions

    Associate Advisor

    Other advisors: Dr Harendra Parekh

  • Doctor Philosophy

    Navigating the use of artificial intelligence in pharmacy curriculum: Curriculum design and academic integrity

    Associate Advisor

    Other advisors: Associate Professor Adam La Caze

Completed supervision

Media

Enquiries

Contact Associate Professor Marie-Odile Parat directly for media enquiries about:

  • Angiogenesis
  • Cancer drug discovery
  • Cell migration
  • Endothelial cells
  • Metastasis

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au