Associate Professor Marie-Odile Parat
Associate Professor

Marie-Odile Parat

Email: 
Phone: 
+61 7 334 61851

Background

Marie-Odile Parat (MO) joined the School of Pharmacy as Senior Lecturer in December 2007.

MO obtained her Pharm.D. from University Joseph Fourier in Grenoble, France, a Masters in Cutaneous Biology from University Claude Bernard in Lyon, France and her Ph.D. in Cell Biology from University Joseph Fourier in Grenoble, France. She further has post graduate diplomas in the fields of Biomedical and Industrial Pharmacy, Photobiology, Pharmaceutical Management, and Public Health.

MO did her Pharmaceutical Residency at the University Hospitals of Grenoble, France in the Sterile Pharmaceutical Supplies Headquarters, the Department of Nuclear Medicine, and the Laboratory Medicine Department of Biochemistry. Attracted by international working experience, she carried out research within the R&D laboratories of Estee Lauder in Melville, NY. She further worked for the United Nations International Trade center in Geneva, Switzerland, where she was the Product Specialist on market information for pharmaceutical raw materials/essential drugs for three years in collaboration with the World Health Organization.

She later performed post-doctoral research in the Universidade de São Paulo, SP, Brasil and The Cleveland Clinic Foundation in the United States. She was appointed as a Staff Scientist in the Center for Anesthesiology Research of the Cleveland Clinic in 2003, an Assistant Professor of Molecular Medicine in the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and a Member of the Case Cancer Center.

During her research career MO has attracted awards from various funding agencies including the Research Funding Agency of the State of São Paulo (FAPESP), the American Heart Association, the Ohio Cancer Research Associates, the American Cancer Society, the National Heart Foundation of Australia, Cancer Council Queensland, Australian and New Zealand College of Anaesthetists and the Australia Research Council (ARC).

The long term goal of the Parat laboratory is to provide insight for novel cancer therapies. A basic science team focusses on endothelial and cancer cell migration, invasion, angiogenesis, and specialized plasma membrane subdomains termed caveolae. A translational axis of research evaluates novel mechanisms by which opioids administered to cancer patients modulate the risk of long term tumour recurrence and metastasis.

Availability

Associate Professor Marie-Odile Parat is:
Available for supervision
Media expert

Fields of research

Biological Sciences Clinical sciences Oncology and carcinogenesis

Qualifications

  • Doctor of Philosophy, Institution to be confirmed
  • Doctor of Philosophy, Université Joseph Fourier

Research interests

  • Morphine and metastasis

  • Caveola-forming proteins and cancer

  • Caveolin and caveolae in cell migration, angiogenesis and lymphangiogenesis

  • Caveolae and cellular entry of drug delivery systems

  • Plant bioactive discovery

Research impacts

Research on the effect of opioids on tumour growth and metastasis informs the choices that are made to manage the perioperative pain of cancer surgery patients, with the goal of minimizing the risk of post surgical cancer recurrence or metastasis. Furthermore, optimizing opioid administration to surgery patients in order to promote analgesia while reducing the likelihood of undesirable effects, including the risk of eliciting persistent opioid use, is of high significance.

Search Professor Marie-Odile Parat’s works on UQ eSpace

117 works between 1995 and 2025
All (117) Journal Article (89) Book Chapter (7) Conference Publication (20) Book (1)

81 - 100 of 117 works

2011

Journal Article

Clearing the confusion of Cav1 and caveolae in cancer compartments

Hill, Michelle M., Parat, Marie-Odile, Parton, Robert G. and Lee, C. Soon (2011). Clearing the confusion of Cav1 and caveolae in cancer compartments. Cell Online, 146 (1).

Clearing the confusion of Cav1 and caveolae in cancer compartments

2011

Journal Article

Morphine and tumor growth and metastasis

Afsharimani, Banafsheh, Cabot, Peter and Parat, Marie-Odile (2011). Morphine and tumor growth and metastasis. Cancer and Metastasis Reviews, 30 (2), 225-238. doi: 10.1007/s10555-011-9285-0

Morphine and tumor growth and metastasis

2011

Journal Article

PTRF-cavin -1 expression decreases the migration of PC3 prostate cancer cells: Role of matrix metalloprotease 9

Cho, Sanda Aung, Hill, Michelle M., Bastiani, Michele, Parton, Robert G. and Parat, Marie-Odile (2011). PTRF-cavin -1 expression decreases the migration of PC3 prostate cancer cells: Role of matrix metalloprotease 9. European Journal of Cell Biology, 90 (2-3), 136-142. doi: 10.1016/j.ejcb.2010.06.004

PTRF-cavin -1 expression decreases the migration of PC3 prostate cancer cells: Role of matrix metalloprotease 9

2011

Conference Publication

Alterations in purinergic receptor-mediated signalling as a consequence of epidermal growth factor-induced epithelial mesenchymal transition (EMT) in breast cancer cells

Davis, Felicity, Kenny, P. A., Soo, E. T. L., van Denderen, B. J., Thompson, E. W., Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Alterations in purinergic receptor-mediated signalling as a consequence of epidermal growth factor-induced epithelial mesenchymal transition (EMT) in breast cancer cells. 3rd EMBO Meeting, Vienna, Austria, 10-13 September 2011.

Alterations in purinergic receptor-mediated signalling as a consequence of epidermal growth factor-induced epithelial mesenchymal transition (EMT) in breast cancer cells

2011

Conference Publication

Remodeling of purinergic receptor-mediated calcium signalling during epidermal growth factor-induced EMT in a breast cancer cell line

Davis, Felicity, Kenny, Paraic A., Soo, Eliza T.-L., van Denderen, Bryce J. W., Thompson, Erik W., Cabot, Peter J., Marie-Odile Parat, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Remodeling of purinergic receptor-mediated calcium signalling during epidermal growth factor-induced EMT in a breast cancer cell line. 5th International Epithelial-Mesenchymal Transition Meeting, Singapore, 10-13 October 2011.

Remodeling of purinergic receptor-mediated calcium signalling during epidermal growth factor-induced EMT in a breast cancer cell line

2010

Journal Article

Role of juxtamembrane and transmembrane domains in the mechanism of natriuretic peptide receptor a activation

Parat, Marie, Blanchet, Jonathan and De Léan, André (2010). Role of juxtamembrane and transmembrane domains in the mechanism of natriuretic peptide receptor a activation. Biochemistry, 49 (22), 4601-4610. doi: 10.1021/bi901711w

Role of juxtamembrane and transmembrane domains in the mechanism of natriuretic peptide receptor a activation

2010

Journal Article

Mango extracts and the mango component mangiferin promote endothelial cell migration

Daud, Noor Huda, Aung, Cho Sanda, Hewavitharana, Amitha K., Wilkinson, Ashley S., Pierson, Jean-Thomas, Roberts-Thomson, Sarah J., Shaw, P. Nicholas, Monteith, Gregory R., Gidley, Michael J. and Parat, Marie-Odile (2010). Mango extracts and the mango component mangiferin promote endothelial cell migration. Journal of Agricultural and Food Chemistry, 58 (8), 5181-5186. doi: 10.1021/jf100249s

Mango extracts and the mango component mangiferin promote endothelial cell migration

2010

Conference Publication

Growth factor-mediated changes in purinergic receptor signaling in breast cancer cells

Davis, Felicity, Paraic, Kenny A, Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2010). Growth factor-mediated changes in purinergic receptor signaling in breast cancer cells. ASCEPT Annual Scientific Meeting 2010, Melbourne, 28 November - 1 December 2010.

Growth factor-mediated changes in purinergic receptor signaling in breast cancer cells

2010

Conference Publication

Growth factor-mediated changes in receptor-stimulated calcium signaling in breast cancer cells

Davis, Felicity, Paraic, Kenny A, Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2010). Growth factor-mediated changes in receptor-stimulated calcium signaling in breast cancer cells. New Horizons in Calcium Signaling, Beijiing, China, October 10-13 2010.

Growth factor-mediated changes in receptor-stimulated calcium signaling in breast cancer cells

2009

Book Chapter

The biology of caveolae: Achievements and perspectives

Parat, Marie-Odile (2009). The biology of caveolae: Achievements and perspectives. International review of cell and molecular biology. (pp. 117-162) edited by Kwang W. Jeon. Maryland Heights, MO, United States: Academic Press. doi: 10.1016/S1937-6448(08)01804-2

The biology of caveolae: Achievements and perspectives

2008

Journal Article

Can regional analgesia reduce the risk of recurrence after breast cancer?: Methodology of a multicenter randomized trial

Sessler, Daniel I., Ben-Eliyahu, Shamgar, Mascha, Edward J., Parat, Marie-Odile and Buggy, Donal J. (2008). Can regional analgesia reduce the risk of recurrence after breast cancer?: Methodology of a multicenter randomized trial. Contemporary Clinical Trials, 29 (4), 517-526. doi: 10.1016/j.cct.2008.01.002

Can regional analgesia reduce the risk of recurrence after breast cancer?: Methodology of a multicenter randomized trial

2008

Journal Article

Altered localization of H-Ras in caveolin-1-null cells is palmitoylation-independent

Baran, J., Mundy, D. I., Vasanji, A. and Parat, M-O. (2008). Altered localization of H-Ras in caveolin-1-null cells is palmitoylation-independent. Journal of Cell Communication and Signaling, 1 (3-4), 195-204. doi: 10.1007/s12079-008-0017-3

Altered localization of H-Ras in caveolin-1-null cells is palmitoylation-independent

2007

Journal Article

Reassessing the Role of Phosphocaveolin-1 in Cell Adhesion and Migration

Hill, Michelle M., Scherbakov, Nadja, Schiefermeier, Natalia, Baran, JoAnne, Hancock, John F., Huber, Lukas A., Parton, Robert G. and Parat, Marie-Odile (2007). Reassessing the Role of Phosphocaveolin-1 in Cell Adhesion and Migration. Traffic, 8 (12), 1695-1705. doi: 10.1111/j.1600-0854.2007.00653.x

Reassessing the Role of Phosphocaveolin-1 in Cell Adhesion and Migration

2007

Journal Article

Caveolin-1 polarization in transmigrating endothelial cells requires binding to intermediate filaments

Santilman, V., Baran, J., Anand-Apte, B., Evans, R. M. and Parat, M. (2007). Caveolin-1 polarization in transmigrating endothelial cells requires binding to intermediate filaments. Angiogenesis, 10 (4), 297-305. doi: 10.1007/s10456-007-9083-z

Caveolin-1 polarization in transmigrating endothelial cells requires binding to intermediate filaments

2006

Journal Article

Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient

Santilman, Virginie, Baran, JoAnne, Anand-Apte, Bela, Fox, Paul L. and Parat, Marie-Odile (2006). Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient. Cell Motility and the Cytoskeleton, 63 (11), 673-680. doi: 10.1002/cm.20153

Caveolin-1 polarization in migrating endothelial cells is directed by substrate topology not chemoattractant gradient

2006

Journal Article

Could Endothelial Caveolae be the Target of General Anaesthetics

Parat, M. O. (2006). Could Endothelial Caveolae be the Target of General Anaesthetics. British Journal of Anaesthesia, 96 (5), 547-550. doi: 10.1093/bja/ael079

Could Endothelial Caveolae be the Target of General Anaesthetics

2004

Journal Article

A role for caveolae in cell migration

Navarro, Angels, Anand-Apte, Bela and Parat, Marie-Odile (2004). A role for caveolae in cell migration. The FASEB Journal, 18 (15), 1801-1811. doi: 10.1096/fj.04-2516rev

A role for caveolae in cell migration

2004

Journal Article

Oxidative stress, caveolae and caveolin-1

Parat, Marie-Odile and Fox, Paul L (2004). Oxidative stress, caveolae and caveolin-1. Sub-cellular biochemistry, 37, 425-41.

Oxidative stress, caveolae and caveolin-1

2004

Book Chapter

Oxidative Stress, Caveolae and Caveolin-1

Parat, Marie-Odile and Fox, Paul L. (2004). Oxidative Stress, Caveolae and Caveolin-1. Membrane dynamics and domains. (pp. 425-441) edited by Peter. J. Quinn. New York: Springer.

Oxidative Stress, Caveolae and Caveolin-1

2004

Book Chapter

Oxidative stress, caveolae and caveolin-1

Parat, Marie-Odile and Fox, Paul L (2004). Oxidative stress, caveolae and caveolin-1. Membrane Dynamics and Domains. (pp. 425-441) edited by Quinn, Peter J.. Boston. MA, United States: Springer. doi: 10.1007/978-1-4757-5806-1_13

Oxidative stress, caveolae and caveolin-1

Current funding

  • 2024 - 2029
    The Opioid Cohort Consortium (OPICO) to investigate the effects of using opioids on cancer risk (NIH led by International Agency for Research on Cancer)
    International Agency for Research on Cancer
    Open grant

Past funding

  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    The assessment of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells to identify and characterize new therapeutic targets for diseases
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014
    A medium-throughput cell isolation and analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Deciphering the cellular functions of caveolae that govern lymphatic vascular development.
    ARC Discovery Projects
    Open grant
  • 2014 - 2015
    Perioperative opioids and tumour growth and metastasis
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2010 - 2012
    Does PTRF-cavin control endothelial cell migration and angiogenesis?
    Cancer Council Queensland
    Open grant
  • 2010
    High content imaging analysis for bioactive and novel therapeutic target evaluation
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009
    A core pharmacy facility for molecular biology, expression and protein post translational modification studies in cancer, cardiovascular, pain and epilepsy research
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2012
    Calcium Influx Pathways and Breast Cancer
    NHMRC Project Grant
    Open grant
  • 2009 - 2010
    Caveolin-1 and the formation of new blood vessels
    National Heart Foundation of Australia
    Open grant
  • 2008 - 2010
    Morphine in Breast Cancer Growth and Metastisis
    Cancer Bequest Fund
    Open grant
  • 2008 - 2009
    Spatial modulation of nitric oxide production in angiogenic endothelial cells
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Associate Professor Marie-Odile Parat is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Detection, identification and characterisation of opioid receptor-active metabolites produced by the human gut microbiome

    Principal Advisor

  • Doctor Philosophy

    Extraction of bioactives from natural resources using supercritical fluid technology and their activity testing for the pharmaceutical and food industry

    Associate Advisor

    Other advisors: Dr James Robert Falconer

  • Doctor Philosophy

    Application of Sol-gel Technology for the Treatment of Gynaecological Conditions

    Associate Advisor

    Other advisors: Dr Harendra Parekh

  • Doctor Philosophy

    Navigating the use of artificial intelligence in pharmacy curriculum: Curriculum design and academic integrity

    Associate Advisor

    Other advisors: Associate Professor Adam La Caze

  • Doctor Philosophy

    Application of Sol-gel Technology for the Treatment of Gynaecological Conditions

    Associate Advisor

    Other advisors: Dr Harendra Parekh

  • Doctor Philosophy

    Development of a recombinant, multicomponent targeted gene delivery platform

    Associate Advisor

    Other advisors: Associate Professor Peter Moyle

  • Doctor Philosophy

    Development of a recombinant, multicomponent targeted gene delivery platform

    Associate Advisor

    Other advisors: Associate Professor Peter Moyle

Completed supervision

Enquiries

Contact Associate Professor Marie-Odile Parat directly for media enquiries about:

  • Angiogenesis
  • Cancer drug discovery
  • Cell migration
  • Endothelial cells
  • Metastasis

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