Associate Professor Marie-Odile Parat
Associate Professor

Marie-Odile Parat

Email: 
Phone: 
+61 7 334 61851

Background

Marie-Odile Parat (MO) joined the School of Pharmacy as Senior Lecturer in December 2007.

MO obtained her Pharm.D. from University Joseph Fourier in Grenoble, France, a Masters in Cutaneous Biology from University Claude Bernard in Lyon, France and her Ph.D. in Cell Biology from University Joseph Fourier in Grenoble, France. She further has post graduate diplomas in the fields of Biomedical and Industrial Pharmacy, Photobiology, Pharmaceutical Management, and Public Health.

MO did her Pharmaceutical Residency at the University Hospitals of Grenoble, France in the Sterile Pharmaceutical Supplies Headquarters, the Department of Nuclear Medicine, and the Laboratory Medicine Department of Biochemistry. Attracted by international working experience, she carried out research within the R&D laboratories of Estee Lauder in Melville, NY. She further worked for the United Nations International Trade center in Geneva, Switzerland, where she was the Product Specialist on market information for pharmaceutical raw materials/essential drugs for three years in collaboration with the World Health Organization.

She later performed post-doctoral research in the Universidade de São Paulo, SP, Brasil and The Cleveland Clinic Foundation in the United States. She was appointed as a Staff Scientist in the Center for Anesthesiology Research of the Cleveland Clinic in 2003, an Assistant Professor of Molecular Medicine in the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and a Member of the Case Cancer Center.

During her research career MO has attracted awards from various funding agencies including the Research Funding Agency of the State of São Paulo (FAPESP), the American Heart Association, the Ohio Cancer Research Associates, the American Cancer Society, the National Heart Foundation of Australia, Cancer Council Queensland, Australian and New Zealand College of Anaesthetists and the Australia Research Council (ARC).

The long term goal of the Parat laboratory is to provide insight for novel cancer therapies. A basic science team focusses on endothelial and cancer cell migration, invasion, angiogenesis, and specialized plasma membrane subdomains termed caveolae. A translational axis of research evaluates novel mechanisms by which opioids administered to cancer patients modulate the risk of long term tumour recurrence and metastasis.

Availability

Associate Professor Marie-Odile Parat is:
Available for supervision
Media expert

Fields of research

Biological Sciences Clinical sciences Oncology and carcinogenesis

Qualifications

  • Doctor of Philosophy, Institution to be confirmed
  • Doctor of Philosophy, Université Joseph Fourier

Research interests

  • Morphine and metastasis

  • Caveola-forming proteins and cancer

  • Caveolin and caveolae in cell migration, angiogenesis and lymphangiogenesis

  • Caveolae and cellular entry of drug delivery systems

  • Plant bioactive discovery

Research impacts

Research on the effect of opioids on tumour growth and metastasis informs the choices that are made to manage the perioperative pain of cancer surgery patients, with the goal of minimizing the risk of post surgical cancer recurrence or metastasis. Furthermore, optimizing opioid administration to surgery patients in order to promote analgesia while reducing the likelihood of undesirable effects, including the risk of eliciting persistent opioid use, is of high significance.

Search Professor Marie-Odile Parat’s works on UQ eSpace

123 works between 1995 and 2025
All (123) Book (1) Journal Article (95) Conference Publication (20) Book Chapter (7)

21 - 40 of 123 works

2021

Journal Article

New insights on tramadol and immunomodulation

Saeed, Iqira, La Caze, Adam, Hollmann, Markus W., Shaw, Paul N. and Parat, Marie-Odile (2021). New insights on tramadol and immunomodulation. Current Oncology Reports, 23 (11) 123, 123. doi: 10.1007/s11912-021-01121-y

New insights on tramadol and immunomodulation

2021

Journal Article

Anticancer activities of dietary benzyl isothiocyanate: A comprehensive review

Dinh, Thao Nhu, Parat, Marie-Odile, Ong, Yong Sze and Khaw, Kooi Yeong (2021). Anticancer activities of dietary benzyl isothiocyanate: A comprehensive review. Pharmacological Research, 169 105666, 105666. doi: 10.1016/j.phrs.2021.105666

Anticancer activities of dietary benzyl isothiocyanate: A comprehensive review

2021

Journal Article

Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

McMahon, Kerrie-Ann, Stroud, David A., Gambin, Yann, Tillu, Vikas, Bastiani, Michele, Sierecki, Emma, Polinkovsky, Mark E., Hall, Thomas E., Gomez, Guillermo A., Wu, Yeping, Parat, Marie-Odile, Martel, Nick, Lo, Harriet P., Khanna, Kum Kum, Alexandrov, Kirill, Daly, Roger, Yap, Alpha, Ryan, Michael T. and Parton, Robert G. (2021). Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response. eLife, 10 e61407, 1-35. doi: 10.7554/elife.61407

Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

2020

Journal Article

Compound identification and in vitro cytotoxicity of the supercritical carbon dioxide extract of papaya freeze-dried leaf juice

Khaw, Kooi-Yeong, Shaw, Paul Nicholas, Parat, Marie-Odile, Pandey, Saurabh and Falconer, James Robert (2020). Compound identification and in vitro cytotoxicity of the supercritical carbon dioxide extract of papaya freeze-dried leaf juice. Processes, 8 (5) 610, 610. doi: 10.3390/pr8050610

Compound identification and in vitro cytotoxicity of the supercritical carbon dioxide extract of papaya freeze-dried leaf juice

2020

Journal Article

Caveola-forming proteins and prostate cancer

Nassar, Zeyad D. and Parat, Marie-Odile (2020). Caveola-forming proteins and prostate cancer. Cancer and Metastasis Reviews, 39 (2), 415-433. doi: 10.1007/s10555-020-09874-x

Caveola-forming proteins and prostate cancer

2020

Journal Article

A role for caveola‐forming proteins caveolin‐1 and CAVIN1 in the pro‐invasive response of glioblastoma to osmotic and hydrostatic pressure

Pu, Wenjun, Qiu, Jiawen, Nassar, Zeyad D., Shaw, Paul N., McMahon, Kerrie‐Ann, Ferguson, Charles, Parton, Robert G., Riggins, Gregory J., Harris, Jonathan M. and Parat, Marie‐Odile (2020). A role for caveola‐forming proteins caveolin‐1 and CAVIN1 in the pro‐invasive response of glioblastoma to osmotic and hydrostatic pressure. Journal of Cellular and Molecular Medicine, 24 (6) jcmm.15076, 3724-3738. doi: 10.1111/jcmm.15076

A role for caveola‐forming proteins caveolin‐1 and CAVIN1 in the pro‐invasive response of glioblastoma to osmotic and hydrostatic pressure

2020

Journal Article

Matrix protease production, epithelial-to-mesenchymal transition marker expression and invasion of glioblastoma cells in response to osmotic or hydrostatic pressure

Pu, Wenjun, Qiu, Jiawen, Riggins, Gregory J. and Parat, Marie-Odile (2020). Matrix protease production, epithelial-to-mesenchymal transition marker expression and invasion of glioblastoma cells in response to osmotic or hydrostatic pressure. Scientific Reports, 10 (1) 2634, 2634. doi: 10.1038/s41598-020-59462-w

Matrix protease production, epithelial-to-mesenchymal transition marker expression and invasion of glioblastoma cells in response to osmotic or hydrostatic pressure

2019

Journal Article

Corrigendum: Morphine binds creatine kinase B and inhibits its activity (vol 12, 464, 2018)

Weinsanto, Ivan, Mouheiche, Jinane, Laux-Biehlmann, Alexis, Delalande, Francois, Marquette, Arnaud, Chavant, Virginie, Gabel, Florian, Cianferani, Sarah, Charlet, Alexandre, Parat, Marie-Odile and Goumon, Yannick (2019). Corrigendum: Morphine binds creatine kinase B and inhibits its activity (vol 12, 464, 2018). Frontiers in Cellular Neuroscience, 13 292, 292. doi: 10.3389/fncel.2019.00292

Corrigendum: Morphine binds creatine kinase B and inhibits its activity (vol 12, 464, 2018)

2019

Journal Article

Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1

Pu, Wenjun, Nassar, Zeyad D., Khabbazi, Samira, Xie, Nan, McMahon, Kerrie-Ann, Parton, Robert G., Riggins, Gregory J., Harris, Jonathan M. and Parat, Marie-Odile (2019). Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1. Journal of Neuro-Oncology, 143 (2), 207-220. doi: 10.1007/s11060-019-03161-8

Correlation of the invasive potential of glioblastoma and expression of caveola-forming proteins caveolin-1 and CAVIN1

2019

Journal Article

Rivastigmine and metabolite analogues with putative Alzheimer’s disease-modifying properties in a Caenorhabditis elegans model

Dighe, Satish N., De la Mora, Eugenio, Chan, Stephen, Kantham, Srinivas, McColl, Gawain, Miles, Jared A., Veliyath, Suresh Kumar, Sreenivas, B. Yogi, Nassar, Zeyad D., Silman, Israel, Sussman, Joel L., Weik, Martin, McGeary, Ross P., Parat, Marie-Odile, Brazzolotto, Xavier and Ross, Benjamin P. (2019). Rivastigmine and metabolite analogues with putative Alzheimer’s disease-modifying properties in a Caenorhabditis elegans model. Communications Chemistry, 2 (1) 35. doi: 10.1038/s42004-019-0133-4

Rivastigmine and metabolite analogues with putative Alzheimer’s disease-modifying properties in a Caenorhabditis elegans model

2019

Journal Article

Factorial design-assisted supercritical carbon-dioxide extraction of cytotoxic active principles from Carica papaya leaf juice

Khaw, Kooi-Yeong, Parat, Marie-Odile, Shaw, Paul Nicholas, Nguyen, Thao T. T., Pandey, Saurabh, Thurecht, Kristofer J. and Falconer, James Robert (2019). Factorial design-assisted supercritical carbon-dioxide extraction of cytotoxic active principles from Carica papaya leaf juice. Scientific Reports, 9 (1) 1716, 1716. doi: 10.1038/s41598-018-37171-9

Factorial design-assisted supercritical carbon-dioxide extraction of cytotoxic active principles from Carica papaya leaf juice

2018

Journal Article

Morphine binds creatine kinase B and inhibits its activity

Weinsanto, Ivan, Mouheiche, Jinane, Laux-Biehlmann, Alexis, Delalande, Francois, Marquette, Arnaud, Chavant, Virginie, Gabel, Florian, Cianferani, Sarah, Charlet, Alexandre, Parat, Marie-Odile and Goumon, Yannick (2018). Morphine binds creatine kinase B and inhibits its activity. Frontiers in Cellular Neuroscience, 12 464, 464. doi: 10.3389/fncel.2018.00464

Morphine binds creatine kinase B and inhibits its activity

2018

Journal Article

Stable isotope-labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice

Weinsanto, Ivan, Laux-Biehlmann, Alexis, Mouheiche, Jinane, Maduna, Tando, Delalande, François, Chavant, Virginie, Gabel, Florian, Darbon, Pascal, Charlet, Alexandre, Poisbeau, Pierrick, Lamshöft, Marc, Van Dorsselaer, Alain, Cianferani, Sarah, Parat, Marie-Odile and Goumon, Yannick (2018). Stable isotope-labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice. British Journal of Pharmacology, 175 (19), 3844-3856. doi: 10.1111/bph.14454

Stable isotope-labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice

2018

Journal Article

Effect of perioperative opioids on cancer-relevant circulating parameters: mu opioid receptor and TLR4 activation potential, and proteolytic profile

Xie, Nan, Matigian, Nicholas, Vithanage, Tharindu D., Gregory, Kye, Nassar, Zeyad D., Cabot, Peter J., Shaw, Paul Nicholas, Kirkpatrick, Carl Mj, Lê Cao, Kim-Anh, Sturgess, David and Parat, Marie-Odile (2018). Effect of perioperative opioids on cancer-relevant circulating parameters: mu opioid receptor and TLR4 activation potential, and proteolytic profile. Clinical Cancer Research, 24 (10), 2319-2327. doi: 10.1158/1078-0432.CCR-18-0172

Effect of perioperative opioids on cancer-relevant circulating parameters: mu opioid receptor and TLR4 activation potential, and proteolytic profile

2018

Journal Article

Lithium reverses mechanical allodynia through a mu opioid-dependent mechanism

Weinsanto, Ivan, Mouheiche, Jinane, Laux-Biehlmann, Alexis, Aouad, Maya, Maduna, Tando, Petit-Demoulière, Nathalie, Chavant, Virginie, Poisbeau, Pierrick, Darbon, Pascal, Charlet, Alexandre, Giersch, Anne, Parat, Marie-Odile and Goumon, Yannick (2018). Lithium reverses mechanical allodynia through a mu opioid-dependent mechanism. Molecular Pain, 14, 1744806917754142. doi: 10.1177/1744806917754142

Lithium reverses mechanical allodynia through a mu opioid-dependent mechanism

2017

Journal Article

Effect of the Biphenyl Neolignan Honokiol on Aβ42-Induced Toxicity in Caenorhabditis elegans, Aβ42 Fibrillation, Cholinesterase Activity, DPPH Radicals, and Iron(II) Chelation

Kantham, Srinivas, Chan, Stephen, McColl, Gawain, Miles, Jared A., Veliyath, Suresh Kumar, Deora, Girdhar Singh, Dighe, Satish N., Khabbazi, Samira, Parat, Marie-Odile and Ross, Benjamin P. (2017). Effect of the Biphenyl Neolignan Honokiol on Aβ42-Induced Toxicity in Caenorhabditis elegans, Aβ42 Fibrillation, Cholinesterase Activity, DPPH Radicals, and Iron(II) Chelation. ACS Chemical Neuroscience, 8 (9), 1901-1912. doi: 10.1021/acschemneuro.7b00071

Effect of the Biphenyl Neolignan Honokiol on Aβ42-Induced Toxicity in Caenorhabditis elegans, Aβ42 Fibrillation, Cholinesterase Activity, DPPH Radicals, and Iron(II) Chelation

2017

Journal Article

Multifunctional Analogs of Kynurenic Acid for the Treatment of Alzheimer's Disease: Synthesis, Pharmacology, and Molecular Modeling Studies

Deora, Girdhar Singh, Kantham, Srinivas, Chan, Stephen, Dighe, Satish N, Veliyath, Suresh K, McColl, Gawain, Parat, Marie-Odile, McGeary, Ross P and Ross, Benjamin P (2017). Multifunctional Analogs of Kynurenic Acid for the Treatment of Alzheimer's Disease: Synthesis, Pharmacology, and Molecular Modeling Studies. ACS chemical neuroscience, 8 (12), 2667-2675. doi: 10.1021/acschemneuro.7b00229

Multifunctional Analogs of Kynurenic Acid for the Treatment of Alzheimer's Disease: Synthesis, Pharmacology, and Molecular Modeling Studies

2017

Journal Article

Morphine alters the circulating proteolytic profile in mice: functional consequences on cellular migration and invasion

Xie, Nan, Khabbazi, Samira, Nassar, Zeyad D, Gregory, Kye, Vithanage, Tharindu, Anand-Apte, Bela, Cabot, Peter J, Sturgess, David, Shaw, Paul N and Parat, Marie-Odile (2017). Morphine alters the circulating proteolytic profile in mice: functional consequences on cellular migration and invasion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31 (12), 5208-5216. doi: 10.1096/fj.201700546R

Morphine alters the circulating proteolytic profile in mice: functional consequences on cellular migration and invasion

2017

Journal Article

Solvent supercritical fluid technologies to extract bioactive compounds from natural sources: a review

Khaw, Kooi-Yeong, Parat, Marie-Odile, Shaw, Paul Nicholas and Falconer, James Robert (2017). Solvent supercritical fluid technologies to extract bioactive compounds from natural sources: a review. Molecules, 22 (7) 1186, 1186. doi: 10.3390/molecules22071186

Solvent supercritical fluid technologies to extract bioactive compounds from natural sources: a review

2017

Journal Article

Stably engineered nanobubbles and ultrasound - An effective platform for enhanced macromolecular delivery to representative cells of the retina

Thakur, Sachin S., Ward, Micheal S., Popat, Amirali, Flemming, Nicole B., Parat, Marie-Odile, Barnett, Nigel L. and Parekh, Harendra S. (2017). Stably engineered nanobubbles and ultrasound - An effective platform for enhanced macromolecular delivery to representative cells of the retina. Plos One, 12 (5) e0178305, e0178305. doi: 10.1371/journal.pone.0178305

Stably engineered nanobubbles and ultrasound - An effective platform for enhanced macromolecular delivery to representative cells of the retina

Current funding

  • 2024 - 2029
    The Opioid Cohort Consortium (OPICO) to investigate the effects of using opioids on cancer risk (NIH led by International Agency for Research on Cancer)
    International Agency for Research on Cancer
    Open grant

Past funding

  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    The assessment of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells to identify and characterize new therapeutic targets for diseases
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014
    A medium-throughput cell isolation and analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Deciphering the cellular functions of caveolae that govern lymphatic vascular development.
    ARC Discovery Projects
    Open grant
  • 2014 - 2015
    Perioperative opioids and tumour growth and metastasis
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2010 - 2012
    Does PTRF-cavin control endothelial cell migration and angiogenesis?
    Cancer Council Queensland
    Open grant
  • 2010
    High content imaging analysis for bioactive and novel therapeutic target evaluation
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009
    A core pharmacy facility for molecular biology, expression and protein post translational modification studies in cancer, cardiovascular, pain and epilepsy research
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2012
    Calcium Influx Pathways and Breast Cancer
    NHMRC Project Grant
    Open grant
  • 2009 - 2010
    Caveolin-1 and the formation of new blood vessels
    National Heart Foundation of Australia
    Open grant
  • 2008 - 2010
    Morphine in Breast Cancer Growth and Metastisis
    Cancer Bequest Fund
    Open grant
  • 2008 - 2009
    Spatial modulation of nitric oxide production in angiogenic endothelial cells
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Associate Professor Marie-Odile Parat is:
Available for supervision

Looking for a supervisor? Read our advice on how to choose a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Investigating the association between pain and subsequent risk of cancer incidence

    Principal Advisor

    Other advisors: Associate Professor Adam La Caze

  • Doctor Philosophy

    Detection, identification and characterisation of opioid receptor-active metabolites produced by the human gut microbiome

    Principal Advisor

    Other advisors: Associate Professor Peter Moyle

  • Doctor Philosophy

    Navigating the use of artificial intelligence in pharmacy curriculum: Curriculum design and academic integrity

    Associate Advisor

    Other advisors: Associate Professor Adam La Caze

  • Doctor Philosophy

    Extraction of bioactives from natural resources using supercritical fluid technology and their activity testing for the pharmaceutical and food industry

    Associate Advisor

    Other advisors: Dr James Robert Falconer

  • Doctor Philosophy

    Development of recombinant and synthetic, multicomponent tumour-targeted gene delivery platforms

    Associate Advisor

    Other advisors: Associate Professor Peter Moyle

Completed supervision

Enquiries

Contact Associate Professor Marie-Odile Parat directly for media enquiries about:

  • Angiogenesis
  • Cancer drug discovery
  • Cell migration
  • Endothelial cells
  • Metastasis

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