Associate Professor Marie-Odile Parat
Associate Professor

Marie-Odile Parat

Email: 
Phone: 
+61 7 334 61851

Background

Marie-Odile Parat (MO) joined the School of Pharmacy as Senior Lecturer in December 2007.

MO obtained her Pharm.D. from University Joseph Fourier in Grenoble, France, a Masters in Cutaneous Biology from University Claude Bernard in Lyon, France and her Ph.D. in Cell Biology from University Joseph Fourier in Grenoble, France. She further has post graduate diplomas in the fields of Biomedical and Industrial Pharmacy, Photobiology, Pharmaceutical Management, and Public Health.

MO did her Pharmaceutical Residency at the University Hospitals of Grenoble, France in the Sterile Pharmaceutical Supplies Headquarters, the Department of Nuclear Medicine, and the Laboratory Medicine Department of Biochemistry. Attracted by international working experience, she carried out research within the R&D laboratories of Estee Lauder in Melville, NY. She further worked for the United Nations International Trade center in Geneva, Switzerland, where she was the Product Specialist on market information for pharmaceutical raw materials/essential drugs for three years in collaboration with the World Health Organization.

She later performed post-doctoral research in the Universidade de São Paulo, SP, Brasil and The Cleveland Clinic Foundation in the United States. She was appointed as a Staff Scientist in the Center for Anesthesiology Research of the Cleveland Clinic in 2003, an Assistant Professor of Molecular Medicine in the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and a Member of the Case Cancer Center.

During her research career MO has attracted awards from various funding agencies including the Research Funding Agency of the State of São Paulo (FAPESP), the American Heart Association, the Ohio Cancer Research Associates, the American Cancer Society, the National Heart Foundation of Australia, Cancer Council Queensland, Australian and New Zealand College of Anaesthetists and the Australia Research Council (ARC).

The long term goal of the Parat laboratory is to provide insight for novel cancer therapies. A basic science team focusses on endothelial and cancer cell migration, invasion, angiogenesis, and specialized plasma membrane subdomains termed caveolae. A translational axis of research evaluates novel mechanisms by which opioids administered to cancer patients modulate the risk of long term tumour recurrence and metastasis.

Availability

Associate Professor Marie-Odile Parat is:
Available for supervision
Media expert

Fields of research

Biological Sciences Clinical sciences Oncology and carcinogenesis

Qualifications

  • Doctor of Philosophy, Institution to be confirmed
  • Doctor of Philosophy, Université Joseph Fourier

Research interests

  • Morphine and metastasis

  • Caveola-forming proteins and cancer

  • Caveolin and caveolae in cell migration, angiogenesis and lymphangiogenesis

  • Caveolae and cellular entry of drug delivery systems

  • Plant bioactive discovery

Research impacts

Research on the effect of opioids on tumour growth and metastasis informs the choices that are made to manage the perioperative pain of cancer surgery patients, with the goal of minimizing the risk of post surgical cancer recurrence or metastasis. Furthermore, optimizing opioid administration to surgery patients in order to promote analgesia while reducing the likelihood of undesirable effects, including the risk of eliciting persistent opioid use, is of high significance.

Search Professor Marie-Odile Parat’s works on UQ eSpace

117 works between 1995 and 2025
All (117) Journal Article (89) Book Chapter (7) Conference Publication (20) Book (1)

61 - 80 of 117 works

2014

Conference Publication

1588P - Caveolin-1 Modulates Vegf-A and Vegf-C Expression and Enhances Prostate Cancer Lymphangiogenesis Potential

Nassar, Z.D., Francois, M., Parton, R.G. and Parat, M.O. (2014). 1588P - Caveolin-1 Modulates Vegf-A and Vegf-C Expression and Enhances Prostate Cancer Lymphangiogenesis Potential. 39th ESMO Congress (ESMO 2014), Madrid, Spain, 26 – 30 September 2014. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/annonc/mdu358.19

1588P - Caveolin-1 Modulates Vegf-A and Vegf-C Expression and Enhances Prostate Cancer Lymphangiogenesis Potential

2013

Journal Article

PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis

Nassar, Zeyad D., Moon, Hyeongsun, Duong, Tam, Neo, LiQi, Hill, Michelle M., Francois, Mathias, Parton, Robert G. and Parat, Marie-Odile (2013). PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis. Oncotarget, 4 (10), 1844-1855. doi: 10.18632/oncotarget.1300

PTRF/Cavin-1 decreases prostate cancer angiogenesis and lymphangiogenesis

2013

Journal Article

Morphine and breast tumor metastasis: the role of matrix-degrading enzymes

Afsharimani, Banafsheh, Baran, JoAnne, Watanabe, Satoshi, Lindner, Daniel, Cabot, Peter J. and Parat, Marie-Odile (2013). Morphine and breast tumor metastasis: the role of matrix-degrading enzymes. Clinical and Experimental Metastasis, Online First (2), 1-10. doi: 10.1007/s10585-013-9616-3

Morphine and breast tumor metastasis: the role of matrix-degrading enzymes

2013

Journal Article

Caveola-forming proteins caveolin‑1 and PTRF in prostate cancer

Nassar, Zeyad D., Hill, Michelle M., Parton, Robert G. and Parat, Marie-Odile (2013). Caveola-forming proteins caveolin‑1 and PTRF in prostate cancer. Nature Reviews Urology, 10 (9), 529-536. doi: 10.1038/nrurol.2013.168

Caveola-forming proteins caveolin‑1 and PTRF in prostate cancer

2013

Journal Article

Assessment of gene expression of intracellular calcium channels, pumps and exchangers with epidermal growth factor-induced epithelial-mesenchymal transition in a breast cancer cell line

Davis, Felicity M., Parsonage, Michelle T., Cabot, Peter J., Parat, Marie-Odile, Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Assessment of gene expression of intracellular calcium channels, pumps and exchangers with epidermal growth factor-induced epithelial-mesenchymal transition in a breast cancer cell line. Cancer Cell International, 13 (76) 76, 1-7. doi: 10.1186/1475-2867-13-76

Assessment of gene expression of intracellular calcium channels, pumps and exchangers with epidermal growth factor-induced epithelial-mesenchymal transition in a breast cancer cell line

2013

Book Chapter

Morphine and metastasis: from bench to bedside

Parat, Marie-Odile (2013). Morphine and metastasis: from bench to bedside. Morphine and metastasis. (pp. 1-13) edited by Marie-Odile Para. Dordrecht, Netherlands: Springer. doi: 10.1007/978-94-007-5678-6_1

Morphine and metastasis: from bench to bedside

2013

Conference Publication

Morphine modulates the paracrine interaction between breast tumor cells and macrophages

Imani, Banafsheh Afshar, Baran, JoAnne, Cabot, Peter J. and Parat, Marie-Odile (2013). Morphine modulates the paracrine interaction between breast tumor cells and macrophages. 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington Dc, 6 - 10 April 2013. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2013-2808

Morphine modulates the paracrine interaction between breast tumor cells and macrophages

2013

Book Chapter

Could opioids affect cancer recurrence or metastases? Current experimental and translational evidence

Buggy, Donal, Shannon, Hilary and Parat, Marie-Odile (2013). Could opioids affect cancer recurrence or metastases? Current experimental and translational evidence. Morphine and metastasis. (pp. 79-94) edited by Marie-Odile Parat. Dordrecht , Netherlands: Springer. doi: 10.1007/978-94-007-5678-6_6

Could opioids affect cancer recurrence or metastases? Current experimental and translational evidence

2013

Book

Morphine and metastasis

Marie-Odile Parat ed. (2013). Morphine and metastasis. Dordrecht, Netherlands: Springer. doi: 10.1007/978-94-007-5678-6

Morphine and metastasis

2013

Journal Article

Anticancer activity of Carica papaya: a review

Nguyen, Thao T. T., Shaw, Paul N., Parat, Marie-Odile and Hewavitharana, Amitha K. (2013). Anticancer activity of Carica papaya: a review. Molecular Nutrition and Food Research, 57 (1), 153-164. doi: 10.1002/mnfr.201200388

Anticancer activity of Carica papaya: a review

2012

Journal Article

Caveolin-1 plays a critical role in the differentiation of monocytes into macrophages

Fu, Yi, Moore, Xiao-Lei, Lee, Man K. S., Fernández-Rojo, Manuel A., Parat, Marie-Odile, Parton, Robert G., Meikle, Peter J., Sviridov, Dmitri and Chin-Dusting, Jaye P. F. (2012). Caveolin-1 plays a critical role in the differentiation of monocytes into macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology, 32 (9), e117-e125. doi: 10.1161/ATVBAHA.112.254151

Caveolin-1 plays a critical role in the differentiation of monocytes into macrophages

2012

Journal Article

Co-regulation of cell polarization and migration by caveolar proteins PTRF/cavin-1 and caveolin-1

Hill, Michelle M., Daud, Noor Huda, Aung, Cho Sanda, Loo, Dorothy, Martin, Sally, Murphy, Samantha, Black, Debra M., Barry, Rachael, Simpson, Fiona, Liu, Libin, Pilch, Paul F, Hancock, John F., Marie-Odile Parat and Parton, Robert G. (2012). Co-regulation of cell polarization and migration by caveolar proteins PTRF/cavin-1 and caveolin-1. PLoS One, 7 (8) e43041, e43041.1-e43041.9. doi: 10.1371/journal.pone.0043041

Co-regulation of cell polarization and migration by caveolar proteins PTRF/cavin-1 and caveolin-1

2012

Journal Article

Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor negative breast cancer

Peters, Amelia A., Simpson, Peter T., Bassett, Johnathon J., Lee, Jane M., Da Silva, Leonard, Reid, Lynne E., Song, Sarah, Parat, Marie-Odile, Lakhani, Sunil R., Kenny, Paraic A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor negative breast cancer. Molecular Cancer Therapeutics, 11 (10), 2158-2168. doi: 10.1158/1535-7163.MCT-11-0965

Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor negative breast cancer

2012

Journal Article

Caveolin-1, caveolae, and glioblastoma

Parat, Marie-Odile and Riggins, Gregory J. (2012). Caveolin-1, caveolae, and glioblastoma. Neuro-Oncology, 14 (6), 679-688. doi: 10.1093/neuonc/nos079

Caveolin-1, caveolae, and glioblastoma

2012

Journal Article

Non-stimulated, agonist-stimulated and store-operated ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF-induced EMT on calcium entry

Davis, Felicity M., Peters, Amelia A., Grice, Desma M., Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Non-stimulated, agonist-stimulated and store-operated ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF-induced EMT on calcium entry. PLoS One, 7 (5) e36923, e36923.1-e36923.11. doi: 10.1371/journal.pone.0036923

Non-stimulated, agonist-stimulated and store-operated ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF-induced EMT on calcium entry

2012

Journal Article

Altered angiogenesis in caveolin-1 gene-deficient mice is restored by ablation of endothelial nitric oxide synthase

Morais, Christudas, Ebrahem, Quteba, Anand-Apte, Bela and Parat, Marie-Odile (2012). Altered angiogenesis in caveolin-1 gene-deficient mice is restored by ablation of endothelial nitric oxide synthase. American Journal of Pathology, 180 (4), 1702-1714. doi: 10.1016/j.ajpath.2011.12.018

Altered angiogenesis in caveolin-1 gene-deficient mice is restored by ablation of endothelial nitric oxide synthase

2012

Conference Publication

Calcium channel transient receptor potential V6 (TRPV6) as a potential therapeutic target for some breast cancers

Peters, A. A., Simpson, P. T., Bassett, J. J., Lee, J. M., Song, S., Parat, M. O., Lakhani, S. R., Kenny, P. A., Roberts-Thomson, S. J. and Monteith, G. R. (2012). Calcium channel transient receptor potential V6 (TRPV6) as a potential therapeutic target for some breast cancers. 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin, Ireland, 6-9 November 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/S0959-8049(12)72328-6

Calcium channel transient receptor potential V6 (TRPV6) as a potential therapeutic target for some breast cancers

2011

Journal Article

Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells

Weber, Genevieve L., Parat, Marie-Odile, Binder, Zev A., Gallia, Gary L. and Riggins, Gregory J. (2011). Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells. Oncotarget, 2 (11), 833-849. doi: 10.18632/oncotarget.346

Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells

2011

Journal Article

Morphine use in cancer surgery

Afsharimani, Banafsheh, Cabot, Peter J. and Parat, Marie-Odile (2011). Morphine use in cancer surgery. Frontiers in Pharmacology, 2 (46) Article 46, 1-8. doi: 10.3389/fphar.2011.00046

Morphine use in cancer surgery

2011

Journal Article

Remodeling of purinergic receptor-mediated Ca(2+) signaling as a consequence of EGF-induced epithelial-mesenchymal transition in breast cancer cells

Davis, Felicity M., Kenny, Paraic A., Soo, Eliza T.-L., van Denderen, Bryce J. W., Thompson, Erik W., Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Remodeling of purinergic receptor-mediated Ca(2+) signaling as a consequence of EGF-induced epithelial-mesenchymal transition in breast cancer cells. PLoS One, 6 (8) e23464, e23464.1-e23464.9. doi: 10.1371/journal.pone.0023464

Remodeling of purinergic receptor-mediated Ca(2+) signaling as a consequence of EGF-induced epithelial-mesenchymal transition in breast cancer cells

Current funding

  • 2024 - 2029
    The Opioid Cohort Consortium (OPICO) to investigate the effects of using opioids on cancer risk (NIH led by International Agency for Research on Cancer)
    International Agency for Research on Cancer
    Open grant

Past funding

  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    The assessment of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells to identify and characterize new therapeutic targets for diseases
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014
    A medium-throughput cell isolation and analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Deciphering the cellular functions of caveolae that govern lymphatic vascular development.
    ARC Discovery Projects
    Open grant
  • 2014 - 2015
    Perioperative opioids and tumour growth and metastasis
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2010 - 2012
    Does PTRF-cavin control endothelial cell migration and angiogenesis?
    Cancer Council Queensland
    Open grant
  • 2010
    High content imaging analysis for bioactive and novel therapeutic target evaluation
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009
    A core pharmacy facility for molecular biology, expression and protein post translational modification studies in cancer, cardiovascular, pain and epilepsy research
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2012
    Calcium Influx Pathways and Breast Cancer
    NHMRC Project Grant
    Open grant
  • 2009 - 2010
    Caveolin-1 and the formation of new blood vessels
    National Heart Foundation of Australia
    Open grant
  • 2008 - 2010
    Morphine in Breast Cancer Growth and Metastisis
    Cancer Bequest Fund
    Open grant
  • 2008 - 2009
    Spatial modulation of nitric oxide production in angiogenic endothelial cells
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Associate Professor Marie-Odile Parat is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Detection, identification and characterisation of opioid receptor-active metabolites produced by the human gut microbiome

    Principal Advisor

  • Doctor Philosophy

    Application of Sol-gel Technology for the Treatment of Gynaecological Conditions

    Associate Advisor

    Other advisors: Dr Harendra Parekh

  • Doctor Philosophy

    Navigating the use of artificial intelligence in pharmacy curriculum: Curriculum design and academic integrity

    Associate Advisor

    Other advisors: Associate Professor Adam La Caze

  • Doctor Philosophy

    Application of Sol-gel Technology for the Treatment of Gynaecological Conditions

    Associate Advisor

    Other advisors: Dr Harendra Parekh

  • Doctor Philosophy

    Development of a recombinant, multicomponent targeted gene delivery platform

    Associate Advisor

    Other advisors: Associate Professor Peter Moyle

  • Doctor Philosophy

    Development of a recombinant, multicomponent targeted gene delivery platform

    Associate Advisor

    Other advisors: Associate Professor Peter Moyle

  • Doctor Philosophy

    Extraction of bioactives from natural resources using supercritical fluid technology and their activity testing for the pharmaceutical and food industry

    Associate Advisor

    Other advisors: Dr James Robert Falconer

Completed supervision

Enquiries

Contact Associate Professor Marie-Odile Parat directly for media enquiries about:

  • Angiogenesis
  • Cancer drug discovery
  • Cell migration
  • Endothelial cells
  • Metastasis

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