Associate Professor Marie-Odile Parat
Associate Professor

Marie-Odile Parat

Email: 
Phone: 
+61 7 334 61851

Background

Marie-Odile Parat (MO) joined the School of Pharmacy as Senior Lecturer in December 2007.

MO obtained her Pharm.D. from University Joseph Fourier in Grenoble, France, a Masters in Cutaneous Biology from University Claude Bernard in Lyon, France and her Ph.D. in Cell Biology from University Joseph Fourier in Grenoble, France. She further has post graduate diplomas in the fields of Biomedical and Industrial Pharmacy, Photobiology, Pharmaceutical Management, and Public Health.

MO did her Pharmaceutical Residency at the University Hospitals of Grenoble, France in the Sterile Pharmaceutical Supplies Headquarters, the Department of Nuclear Medicine, and the Laboratory Medicine Department of Biochemistry. Attracted by international working experience, she carried out research within the R&D laboratories of Estee Lauder in Melville, NY. She further worked for the United Nations International Trade center in Geneva, Switzerland, where she was the Product Specialist on market information for pharmaceutical raw materials/essential drugs for three years in collaboration with the World Health Organization.

She later performed post-doctoral research in the Universidade de São Paulo, SP, Brasil and The Cleveland Clinic Foundation in the United States. She was appointed as a Staff Scientist in the Center for Anesthesiology Research of the Cleveland Clinic in 2003, an Assistant Professor of Molecular Medicine in the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and a Member of the Case Cancer Center.

During her research career MO has attracted awards from various funding agencies including the Research Funding Agency of the State of São Paulo (FAPESP), the American Heart Association, the Ohio Cancer Research Associates, the American Cancer Society, the National Heart Foundation of Australia, Cancer Council Queensland, Australian and New Zealand College of Anaesthetists and the Australia Research Council (ARC).

The long term goal of the Parat laboratory is to provide insight for novel cancer therapies. A basic science team focusses on endothelial and cancer cell migration, invasion, angiogenesis, and specialized plasma membrane subdomains termed caveolae. A translational axis of research evaluates novel mechanisms by which opioids administered to cancer patients modulate the risk of long term tumour recurrence and metastasis.

Availability

Associate Professor Marie-Odile Parat is:
Available for supervision
Media expert

Fields of research

Biological Sciences Clinical sciences Oncology and carcinogenesis

Qualifications

  • Doctor of Philosophy, Institution to be confirmed
  • Doctor of Philosophy, Université Joseph Fourier

Research interests

  • Morphine and metastasis

  • Caveola-forming proteins and cancer

  • Caveolin and caveolae in cell migration, angiogenesis and lymphangiogenesis

  • Caveolae and cellular entry of drug delivery systems

  • Plant bioactive discovery

Research impacts

Research on the effect of opioids on tumour growth and metastasis informs the choices that are made to manage the perioperative pain of cancer surgery patients, with the goal of minimizing the risk of post surgical cancer recurrence or metastasis. Furthermore, optimizing opioid administration to surgery patients in order to promote analgesia while reducing the likelihood of undesirable effects, including the risk of eliciting persistent opioid use, is of high significance.

Search Professor Marie-Odile Parat’s works on UQ eSpace

117 works between 1995 and 2025
All (117) Journal Article (89) Book Chapter (7) Conference Publication (20) Book (1)

41 - 60 of 117 works

2016

Journal Article

Morphine decreases the pro-angiogenic interaction between breast cancer cells and macrophages in vitro

Khabbazi, Samira, Nassar, Zeyad D., Goumon, Yannick and Parat, Marie-Odile (2016). Morphine decreases the pro-angiogenic interaction between breast cancer cells and macrophages in vitro. Scientific Reports, 6 (1) 31572, 31572. doi: 10.1038/srep31572

Morphine decreases the pro-angiogenic interaction between breast cancer cells and macrophages in vitro

2016

Journal Article

Express in vitro plasmid transfection achieved with 16+ asymmetric peptide dendrimers

Rewatkar, Prartana V., Sester, David P., Parekh, Harendra S. and Parat, Marie-Odile (2016). Express in vitro plasmid transfection achieved with 16+ asymmetric peptide dendrimers. ACS Biomaterials Science and Engineering, 2 (3), 438-445. doi: 10.1021/acsbiomaterials.6b00033

Express in vitro plasmid transfection achieved with 16+ asymmetric peptide dendrimers

2016

Journal Article

Traditional aboriginal preparation alters the chemical profile of carica papaya leaves and impacts on cytotoxicity towards human squamous cell carcinoma

Nguyen, Thao T., Parat, Marie-Odile, Shaw, Paul N., Hewavitharana, Amitha K. and Hodson, Mark P. (2016). Traditional aboriginal preparation alters the chemical profile of carica papaya leaves and impacts on cytotoxicity towards human squamous cell carcinoma. PLoS ONE, 11 (2) e0147956, e0147956. doi: 10.1371/journal.pone.0147956

Traditional aboriginal preparation alters the chemical profile of carica papaya leaves and impacts on cytotoxicity towards human squamous cell carcinoma

2016

Journal Article

Molecular determinants of the cellular entry of asymmetric peptide dendrimers and role of caveolae

Rewatkar, Prartana V., Parekh, Harendra S. and Parat, Marie-Odile (2016). Molecular determinants of the cellular entry of asymmetric peptide dendrimers and role of caveolae. PLoS One, 11 (1) e0147491, e0147491.1-e0147491.15. doi: 10.1371/journal.pone.0147491

Molecular determinants of the cellular entry of asymmetric peptide dendrimers and role of caveolae

2016

Journal Article

Chemical characterization and in vitro cytotoxicity on squamous cell carcinoma cells of Carica papaya leaf extracts

Nguyen, Thao T., Parat, Marie-Odile, Hodson, Mark P., Pan, Jenny, Shaw, Paul N. and Hewavitharana, Amitha K. (2016). Chemical characterization and in vitro cytotoxicity on squamous cell carcinoma cells of Carica papaya leaf extracts. Toxins, 8 (1), 7.1-7.11. doi: 10.3390/toxins8010007

Chemical characterization and in vitro cytotoxicity on squamous cell carcinoma cells of Carica papaya leaf extracts

2016

Conference Publication

Establishment of new methods to quantify the Mu-opioid and Tlr-4 receptor activation potential in biological samples to assess the influence of opioids on tumor metastasis

Xie, Nan, Cabot, Peter, Shaw, Paul N., Sturgess, David and Parat, Marie-Odile (2016). Establishment of new methods to quantify the Mu-opioid and Tlr-4 receptor activation potential in biological samples to assess the influence of opioids on tumor metastasis. COSA's 43rd and ANZBCTG's 38th Annual Scientific Meetings. Partners for Progress in Breast Cancer Research and Care, Gold Coast, QLD, Australia, 15–17 November 2016. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.

Establishment of new methods to quantify the Mu-opioid and Tlr-4 receptor activation potential in biological samples to assess the influence of opioids on tumor metastasis

2015

Journal Article

The role of perioperative adjuncts in cancer outcomes: beta-adrenergic receptor antagonists, NSAIDs and anti-fibrinolytics

Hiller, Jonathan G., Parat, Marie-Odile and Ben-Eliyahu, Shamgar (2015). The role of perioperative adjuncts in cancer outcomes: beta-adrenergic receptor antagonists, NSAIDs and anti-fibrinolytics. Current Anesthesiology Reports, 5 (3), 291-304. doi: 10.1007/s40140-015-0113-x

The role of perioperative adjuncts in cancer outcomes: beta-adrenergic receptor antagonists, NSAIDs and anti-fibrinolytics

2015

Journal Article

Opioid analgesic agents and cancer cell biology

Xie, Nan and Parat, Marie-Odile (2015). Opioid analgesic agents and cancer cell biology. Current Anesthesiology Reports, 5 (3), 278-284. doi: 10.1007/s40140-015-0118-5

Opioid analgesic agents and cancer cell biology

2015

Journal Article

Non-caveolar caveolin-1 expression in prostate cancer cells promotes lymphangiogenesis

Zeyad Nassar, Hill, Michelle, Parton, Robert G., Francois, Mathias and Parat, Marie-Odile (2015). Non-caveolar caveolin-1 expression in prostate cancer cells promotes lymphangiogenesis. Oncoscience, 2 (7), 635-645. doi: 10.18632/oncoscience.180

Non-caveolar caveolin-1 expression in prostate cancer cells promotes lymphangiogenesis

2015

Journal Article

Morphine modulates interleukin-4- or breast cancer cell-induced pro-metastatic activation of macrophages

Khabbazi, Samira, Goumon, Yannick and Parat, Marie-Odile (2015). Morphine modulates interleukin-4- or breast cancer cell-induced pro-metastatic activation of macrophages. Scientific Reports, 5 (1) 11389, 11389.1-11389.12. doi: 10.1038/srep11389

Morphine modulates interleukin-4- or breast cancer cell-induced pro-metastatic activation of macrophages

2015

Book Chapter

Cavin family: new players in the biology of caveolae

Nassar, Zeyad D. and Parat, Marie-Odile (2015). Cavin family: new players in the biology of caveolae. International review of cell and molecular biology. (pp. 235-306) edited by Kwang W. Jeon. Maryland Heights, MO, United States: Academic Press. doi: 10.1016/bs.ircmb.2015.07.009

Cavin family: new players in the biology of caveolae

2015

Journal Article

Diet-induced hypercholesterolemia promotes androgenindependent prostate cancer metastasis via IQGAP1 and caveolin-1

Moon, Hyeongsun, Ruelcke, Jayde E., Choi, Eunju, Sharpe, Laura J., Nassar, Zeyad D., Bielefeldt-ohmann, Helle, Parat, Marie-Odile, Shah, Anup, Francois, Mathias, Inder, Kerry L., Brown, Andrew J., Russell, Pamela J., Parton, Robert G. and Hill, Michelle M. (2015). Diet-induced hypercholesterolemia promotes androgenindependent prostate cancer metastasis via IQGAP1 and caveolin-1. Oncotarget, 6 (10), 7438-7453. doi: 10.18632/oncotarget.3476

Diet-induced hypercholesterolemia promotes androgenindependent prostate cancer metastasis via IQGAP1 and caveolin-1

2015

Conference Publication

Quantification the mu-opioid and TLR4 receptor activation potential in the circulation of mice and humans to assess the influence of morphine on tumour metastasis

Parat, M. O., Xie, N., Cabot, P., Shaw, N., Gregory, K. and Sturgess, D. (2015). Quantification the mu-opioid and TLR4 receptor activation potential in the circulation of mice and humans to assess the influence of morphine on tumour metastasis. Australian and New Zealand College of Anaesthetists Annual Scientific Meeting, Adelaide AU, 2-5 May 2015.

Quantification the mu-opioid and TLR4 receptor activation potential in the circulation of mice and humans to assess the influence of morphine on tumour metastasis

2015

Journal Article

Are caveolae a cellular entry route for non-viral therapeutic delivery systems?

Rewatkar, Prarthana V., Parton, Robert G., Parekh, Harendra S. and Parat, Marie-Odile (2015). Are caveolae a cellular entry route for non-viral therapeutic delivery systems?. Advanced Drug Delivery Reviews, 91, 92-108. doi: 10.1016/j.addr.2015.01.003

Are caveolae a cellular entry route for non-viral therapeutic delivery systems?

2015

Journal Article

Comparison and analysis of the animal models used to study the effect of morphine on tumour growth and metastasis

Afsharimani, B., Doornebal, C. W., Cabot, P. J., Hollmann, M. W. and Parat, M.-O. (2015). Comparison and analysis of the animal models used to study the effect of morphine on tumour growth and metastasis. British Journal of Pharmacology, 172 (2), 251-259. doi: 10.1111/bph.12589

Comparison and analysis of the animal models used to study the effect of morphine on tumour growth and metastasis

2015

Journal Article

Consensus statement from the BJA workshop on cancer and anaesthesia

Buggy, D. J., Borgeat, A., Cata, J., Doherty, D. G., Doornebal, C. W., Forget, P., Gottumukkala, V., Gottschalk, A., Gupta, A., Gupta, K., Hales, T. G., Hemmings, H. C., Hollmann, M. W., Kurz, A., Ma, D., Parat, M. O., Sessler, D. I., Shorten, G. and Singleton, P. (2015). Consensus statement from the BJA workshop on cancer and anaesthesia. British Journal of Anaesthesia, 114 (1), 2-3. doi: 10.1093/bja/aeu262

Consensus statement from the BJA workshop on cancer and anaesthesia

2014

Journal Article

Effect of lysine antifibrinolytics and cyclooxygenase inhibitors on the proteolytic profile of breast cancer cells interacting with macrophages or endothelial cells

Afsharimani, B., Cabot, P. J. and Parat, M.-O. (2014). Effect of lysine antifibrinolytics and cyclooxygenase inhibitors on the proteolytic profile of breast cancer cells interacting with macrophages or endothelial cells. British Journal of Anaesthesia, Advance Access (SUPPL. 1), 1-10. doi: 10.1093/bja/aet468

Effect of lysine antifibrinolytics and cyclooxygenase inhibitors on the proteolytic profile of breast cancer cells interacting with macrophages or endothelial cells

2014

Conference Publication

Hypercholesterolemia promotes prostate cancer PC-3 metastases in orthotopic xenograft mice

Moon, Hyeongsun, Sharpe, Laura, Choi, Eunju, Bielefeldt-Ohmann, Helle, Nassar, Zeyad, Parat, Marie-Odile, Francois, Mathias, Lee, C. Soon, Brown, Andrew, Russell, Pamela, Inder, Kerry and Hill, Michelle (2014). Hypercholesterolemia promotes prostate cancer PC-3 metastases in orthotopic xenograft mice. 105th Annual Meeting of the American Association for Cancer Research (AACR), San Diego, CA United States, 05-09 April 2014. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2014-4950

Hypercholesterolemia promotes prostate cancer PC-3 metastases in orthotopic xenograft mice

2014

Conference Publication

Carbetocin use during caesarean section is independently associated with a reduction in post-partum haemorrhage

Sturgess, D., Morrison, S., Turner, M., Gregory, K. and Parat, M.-O. (2014). Carbetocin use during caesarean section is independently associated with a reduction in post-partum haemorrhage. Australian and New Zealand College of Anaesthetists Annual Scientific Meeting, Singapore, 5-9 May 2014.

Carbetocin use during caesarean section is independently associated with a reduction in post-partum haemorrhage

2014

Conference Publication

1588P - Caveolin-1 Modulates Vegf-A and Vegf-C Expression and Enhances Prostate Cancer Lymphangiogenesis Potential

Nassar, Z.D., Francois, M., Parton, R.G. and Parat, M.O. (2014). 1588P - Caveolin-1 Modulates Vegf-A and Vegf-C Expression and Enhances Prostate Cancer Lymphangiogenesis Potential. 39th ESMO Congress (ESMO 2014), Madrid, Spain, 26 – 30 September 2014. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/annonc/mdu358.19

1588P - Caveolin-1 Modulates Vegf-A and Vegf-C Expression and Enhances Prostate Cancer Lymphangiogenesis Potential

Current funding

  • 2024 - 2029
    The Opioid Cohort Consortium (OPICO) to investigate the effects of using opioids on cancer risk (NIH led by International Agency for Research on Cancer)
    International Agency for Research on Cancer
    Open grant

Past funding

  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    The assessment of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells to identify and characterize new therapeutic targets for diseases
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014
    A medium-throughput cell isolation and analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2016
    Deciphering the cellular functions of caveolae that govern lymphatic vascular development.
    ARC Discovery Projects
    Open grant
  • 2014 - 2015
    Perioperative opioids and tumour growth and metastasis
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2010 - 2012
    Does PTRF-cavin control endothelial cell migration and angiogenesis?
    Cancer Council Queensland
    Open grant
  • 2010
    High content imaging analysis for bioactive and novel therapeutic target evaluation
    UQ Major Equipment and Infrastructure
    Open grant
  • 2009
    A core pharmacy facility for molecular biology, expression and protein post translational modification studies in cancer, cardiovascular, pain and epilepsy research
    UQ School/Centre Co-Funding
    Open grant
  • 2009 - 2012
    Calcium Influx Pathways and Breast Cancer
    NHMRC Project Grant
    Open grant
  • 2009 - 2010
    Caveolin-1 and the formation of new blood vessels
    National Heart Foundation of Australia
    Open grant
  • 2008 - 2010
    Morphine in Breast Cancer Growth and Metastisis
    Cancer Bequest Fund
    Open grant
  • 2008 - 2009
    Spatial modulation of nitric oxide production in angiogenic endothelial cells
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Associate Professor Marie-Odile Parat is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Detection, identification and characterisation of opioid receptor-active metabolites produced by the human gut microbiome

    Principal Advisor

  • Doctor Philosophy

    Application of Sol-gel Technology for the Treatment of Gynaecological Conditions

    Associate Advisor

    Other advisors: Dr Harendra Parekh

  • Doctor Philosophy

    Navigating the use of artificial intelligence in pharmacy curriculum: Curriculum design and academic integrity

    Associate Advisor

    Other advisors: Associate Professor Adam La Caze

  • Doctor Philosophy

    Application of Sol-gel Technology for the Treatment of Gynaecological Conditions

    Associate Advisor

    Other advisors: Dr Harendra Parekh

  • Doctor Philosophy

    Development of a recombinant, multicomponent targeted gene delivery platform

    Associate Advisor

    Other advisors: Associate Professor Peter Moyle

  • Doctor Philosophy

    Development of a recombinant, multicomponent targeted gene delivery platform

    Associate Advisor

    Other advisors: Associate Professor Peter Moyle

  • Doctor Philosophy

    Extraction of bioactives from natural resources using supercritical fluid technology and their activity testing for the pharmaceutical and food industry

    Associate Advisor

    Other advisors: Dr James Robert Falconer

Completed supervision

Enquiries

Contact Associate Professor Marie-Odile Parat directly for media enquiries about:

  • Angiogenesis
  • Cancer drug discovery
  • Cell migration
  • Endothelial cells
  • Metastasis

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au