Professor Peter Cabot
Professor

Peter Cabot

Email: 
Phone: 
+61 7 334 61854

Background

Peter Cabot is the Professor and Head of School in the School of Pharmacy. He joined the School staff in this position in 1999 after completing postdoctoral positions at Johns Hopkins University, Baltimore USA, The NIH, Baltimore USA and within the School of Pharmacy at UQ.

The primary focus of my research is on the elucidation of the peripheral mechanisms involved in analgesia associated with inflammation. Key discoveries were made in this field that highlighted the importance of the immune system in inflammatory pain. The results of which were published in the notable journals; JBC, PAIN, Nature Medicine and The Journal of Clinical Investigation.

Availability

Professor Peter Cabot is:
Available for supervision
Media expert

Fields of research

Clinical sciences Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor of Applied Science, Charles Sturt University
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Opioids in inflammation

    In the area I work as a translational scientist, exploring drug discovery of novel opioids and inflammatory mechanisms as well as developing new alternatives, paring this with translational work into preclinical and clinical studies looking for better outcomes for patients.

  • Biotransformation of Opioids in Disease

  • Pain in Inflammatory Diseases

  • Natural Products Drug Discovery

Research impacts

Our current research is focussed on novel opioid ligands that target opioid receptors aligned with less addictive properties, bioactivity of endogenous and natural products that may provide insights into better pain therapy or reduction in inflammatory disorders such as sinusitis.

Search Professor Peter Cabot’s works on UQ eSpace

159 works between 1992 and 2024
All (159) Journal Article (93) Book Chapter (1) Conference Publication (61) Other Outputs (4)

1 - 20 of 159 works

2024

Journal Article

C-reactive protein (CRP) is associated with chronic pain independently of biopsychosocial factors

Farrell, Scott F., Armfield, Nigel R., Cabot, Peter J., Elphinston, Rachel A., Gray, Paul, Minhas, Gunjeet, Collyer, Martin R. and Sterling, Michele (2024). C-reactive protein (CRP) is associated with chronic pain independently of biopsychosocial factors. The Journal of Pain, 25 (2), 476-496. doi: 10.1016/j.jpain.2023.09.008

C-reactive protein (CRP) is associated with chronic pain independently of biopsychosocial factors

2023

Conference Publication

Leveraging eportfolios to support a learner-centred approach in the Master of Pharmaceutical Industry Practice Program

Cabot, Peter John, Bowker, Shari and Slade, Christine (2023). Leveraging eportfolios to support a learner-centred approach in the Master of Pharmaceutical Industry Practice Program. 2023 Eportfolio Forum: Emerging, Connecting, Sustaining, Darwin, NT, Australia, 11-12 October 2023. Adelaide, SA, Australia: ePortfolios Australia.

Leveraging eportfolios to support a learner-centred approach in the Master of Pharmaceutical Industry Practice Program

2023

Conference Publication

Ivermectin effects on interleukin-6 induced nuclear translocation of STAT3 in a macrophage based cell line

Cabot, Peter, Daniel, Sona and Alawie, Rayan (2023). Ivermectin effects on interleukin-6 induced nuclear translocation of STAT3 in a macrophage based cell line. 81st FIP World Congress Of Pharmacy And Pharmaceutical Sciences, Brisbane, QLD Australia, 24-28 September 2023. PKP Publishing. doi: 10.46542/pe.2023.236.314328

Ivermectin effects on interleukin-6 induced nuclear translocation of STAT3 in a macrophage based cell line

2023

Conference Publication

Bivalent kappa-selective opioid peptides with enhanced metabolic stability and potency

Saifuddin, D., Lohman, R.-J., Tupally, K., Parekh, H. and Cabot, P. (2023). Bivalent kappa-selective opioid peptides with enhanced metabolic stability and potency. 81st FIP World Congress Of Pharmacy And Pharmaceutical Sciences, Brisbane, QLD Australia, 24-28 September 2023. PKP Publishing.

Bivalent kappa-selective opioid peptides with enhanced metabolic stability and potency

2023

Journal Article

Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom

Galante, Priscilla, Campos, Gabriel A. A., Moser, Jacqueline C. G., Martins, Danubia B., Dos Santos Cabrera, Marcia P., Rangel, Marisa, Coelho, Luiza C., Simon, Karina S., Amado, Veronica M., de A. I. Muller, Jessica, Koehbach, Johannes, Lohman, Rink-Jan, Cabot, Peter J., Vetter, Irina, Craik, David J., Toffoli-Kadri, Monica C., Monge-Fuentes, Victoria, Goulart, Jair T., Schwartz, Elisabeth F., Silva, Luciano P., Bocca, Anamelia L. and Mortari, Márcia R (2023). Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom. Scientific Reports, 13 (1) 12491, 1-15. doi: 10.1038/s41598-023-38828-w

Exploring the therapeutic potential of an antinociceptive and anti-inflammatory peptide from wasp venom

2023

Journal Article

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

Lohman, Rink-Jan, Reddy Tupally, Karnaker, Kandale, Ajit, Cabot, Peter J. and Parekh, Harendra S. (2023). Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy. Frontiers in Pharmacology, 14 1150313, 1-16. doi: 10.3389/fphar.2023.1150313

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

2023

Journal Article

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

Lohman, Rink-Jan, Tupally, Karnaker Reddy, Kandale, Ajit, Cabot, Peter J and Parekh, Harendra S (2023). Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy. Frontiers in Pharmacology, 14 1150313, 1150313. doi: 10.3389/fphar.2023.1150313

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

2023

Journal Article

National wastewater reconnaissance of analgesic consumption in Australia

Ahmed, Fahad, Tscharke, Benjamin, O’Brien, Jake W., Hall, Wayne D., Cabot, Peter J., Sowa, P. Marcin, Samanipour, Saer and Thomas, Kevin V. (2023). National wastewater reconnaissance of analgesic consumption in Australia. Environmental Science and Technology, 57 (4), 1712-1720. doi: 10.1021/acs.est.2c06691

National wastewater reconnaissance of analgesic consumption in Australia

2022

Journal Article

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

Lohman, Rink-Jan, Tupally, Karnaker Reddy, Kandale, Ajit, Cabot, Peter J. and Parekh, Harendra S. (2022). Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy. British Journal of Pharmacology, 180 (1), 129-129. doi: 10.1111/bph.15862

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

2022

Journal Article

Application of mesoporous silica nanoparticles in cancer therapy and delivery of repurposed anthelmintics for cancer therapy

Koohi Moftakhari Esfahani, Maedeh, Alavi, Seyed Ebrahim, Cabot, Peter J., Islam, Nazrul and Izake, Emad L. (2022). Application of mesoporous silica nanoparticles in cancer therapy and delivery of repurposed anthelmintics for cancer therapy. Pharmaceutics, 14 (8) 1579, 1-27. doi: 10.3390/pharmaceutics14081579

Application of mesoporous silica nanoparticles in cancer therapy and delivery of repurposed anthelmintics for cancer therapy

2022

Journal Article

β-lactoglobulin-modified mesoporous silica nanoparticles: a promising carrier for the targeted delivery of fenbendazole into prostate cancer cells

Esfahani, Maedeh Koohi Moftakhari, Alavi, Seyed Ebrahim, Cabot, Peter J., Islam, Nazrul and Izake, Emad L. (2022). β-lactoglobulin-modified mesoporous silica nanoparticles: a promising carrier for the targeted delivery of fenbendazole into prostate cancer cells. Pharmaceutics, 14 (4) 884, 884. doi: 10.3390/pharmaceutics14040884

β-lactoglobulin-modified mesoporous silica nanoparticles: a promising carrier for the targeted delivery of fenbendazole into prostate cancer cells

2021

Journal Article

Pegylated mesoporous silica nanoparticles (MCM-41): a promising carrier for the targeted delivery of fenbendazole into prostrate cancer cells

Esfahani, Maedeh Koohi Moftakhari, Alavi, Seyed Ebrahim, Cabot, Peter J., Islam, Nazrul and Izake, Emad L. (2021). Pegylated mesoporous silica nanoparticles (MCM-41): a promising carrier for the targeted delivery of fenbendazole into prostrate cancer cells. Pharmaceutics, 13 (10) 1605, 1605. doi: 10.3390/pharmaceutics13101605

Pegylated mesoporous silica nanoparticles (MCM-41): a promising carrier for the targeted delivery of fenbendazole into prostrate cancer cells

2021

Other Outputs

Peptides and uses thereof

Parekh, Harendra, Tupally, Karnaker, Cabot, Peter and Kandale, Ajit (2021). Peptides and uses thereof. 2021300202.

Peptides and uses thereof

2021

Conference Publication

Novel opioid peptides as allosteric modulators of nociception

Saifuddin, Danial, Lohman, Rink-Jan, Tupally, Karnaker Reddy, Parekh, Harendra S. and Cabot, Peter J. (2021). Novel opioid peptides as allosteric modulators of nociception. ASMR medical research week: Queensland virtual symposium, Online, 9-10 June 2021.

Novel opioid peptides as allosteric modulators of nociception

2021

Journal Article

Development of Thiabendazole-Loaded Mesoporous Silica Nanoparticles for Cancer Therapy

Esfahani, Maedeh Koohi Moftakhari, Islam, Nazrul, Cabot, Peter J. and Izake, Emad L. (2021). Development of Thiabendazole-Loaded Mesoporous Silica Nanoparticles for Cancer Therapy. ACS Biomaterials Science and Engineering, 8 (10) acsbiomaterials.1c00066, 4153-4162. doi: 10.1021/acsbiomaterials.1c00066

Development of Thiabendazole-Loaded Mesoporous Silica Nanoparticles for Cancer Therapy

2021

Journal Article

Developing GLP-1 conjugated self-assembling nanofibers using copper-catalyzed alkyne–azide cycloaddition and evaluation of their biological activity

Alavi, Seyed Ebrahim, Cabot, Peter J., Raza, Aun and Moyle, Peter M. (2021). Developing GLP-1 conjugated self-assembling nanofibers using copper-catalyzed alkyne–azide cycloaddition and evaluation of their biological activity. Bioconjugate Chemistry, 32 (4), 810-820. doi: 10.1021/acs.bioconjchem.1c00091

Developing GLP-1 conjugated self-assembling nanofibers using copper-catalyzed alkyne–azide cycloaddition and evaluation of their biological activity

2021

Journal Article

Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem

Raza, Aun, Sime, Fekade Bruck, Cabot, Peter J., Roberts, Jason A., Falconer, James R., Kumeria, Tushar and Popat, Amirali (2021). Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem. ACS Biomaterials Science and Engineering, 7 (5) acsbiomaterials.0c01284, 1836-1853. doi: 10.1021/acsbiomaterials.0c01284

Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem

2020

Journal Article

Oral meropenem for superbugs: challenges and opportunities

Raza, Aun, Ngieng, Shih Chen, Sime, Fekade Bruck, Cabot, Peter J., Roberts, Jason A., Popat, Amirali, Kumeria, Tushar and Falconer, James R. (2020). Oral meropenem for superbugs: challenges and opportunities. Drug Discovery Today, 26 (2), 551-560. doi: 10.1016/j.drudis.2020.11.004

Oral meropenem for superbugs: challenges and opportunities

2020

Journal Article

Can wastewater analysis be used as a tool to assess the burden of pain treatment within a population?

Ahmed, Fahad, Tscharke, Benjamin, O'Brien, Jake W., Cabot, Peter J., Hall, Wayne D., Mueller, Jochen F. and Thomas, Kevin V. (2020). Can wastewater analysis be used as a tool to assess the burden of pain treatment within a population?. Environmental Research, 188 109769, 109769. doi: 10.1016/j.envres.2020.109769

Can wastewater analysis be used as a tool to assess the burden of pain treatment within a population?

2020

Journal Article

Systemic inflammatory markers in neck pain: a systematic review with meta-analysis

Farrell, Scott F., de Zoete, Rutger M. J., Cabot, Peter J. and Sterling, Michele (2020). Systemic inflammatory markers in neck pain: a systematic review with meta-analysis. European Journal of Pain, 24 (9) ejp.1630, 1666-1686. doi: 10.1002/ejp.1630

Systemic inflammatory markers in neck pain: a systematic review with meta-analysis

Past funding

  • 2022 - 2024
    Development of small nerve fibre pathology in chronic whiplash-associated disorder (RBWH Foundation Grant administered by MNHHS)
    Royal Brisbane and Women's Hospital Foundation
    Open grant
  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Establishing a High-Throughput, Microwave-Assisted Automated Peptide Synthesis Facility at PACE
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    Murine behavioural phenotyping facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    The assessment of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells to identify and characterize new therapeutic targets for diseases
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014
    A medium-throughput cell isolation and analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2015
    Perioperative opioids and tumour growth and metastasis
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2010
    Analytical instrumentation enabling rapid compound separation and chemical structure analysis via mass fingerprinting
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Cost effective acquisition of an LC-MS/MS system to support CIPDD organics analysis and preclinical and clinical operations
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    High content imaging analysis for bioactive and novel therapeutic target evaluation
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Why do people keep hurting their back: A longitudinal study of biological, psychological and social predictors
    NHMRC Project Grant
    Open grant
  • 2009
    A core pharmacy facility for molecular biology, expression and protein post translational modification studies in cancer, cardiovascular, pain and epilepsy research
    UQ School/Centre Co-Funding
    Open grant
  • 2009
    Robotics Instrumentation for High Throughput Sample preparation for Increased Productivity of the CIPDD/TetraQ's HPLC-MS/MS Systems for Quantitative Analysis of Organics in a Quality Systems NATA-Acc
    UQ Faculty Co-Funding
    Open grant
  • 2005
    Establishment of an improved model of relapsing MS and the characterisation of the role of Peroxisome Proliferator - activated receoptors alpha and beta
    Multiple Sclerosis Research Australia
    Open grant
  • 2005
    NHMRC_Equipment Grant = DSI Telemetry System
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2005
    NHMRC_Equipment Grant_HLTH_Pharmacy
    NHMRC Equipment Grant
    Open grant
  • 2001
    Immunosupression and inflammatory Pain: the role of the immune system
    Cancer Bequest Fund
    Open grant
  • 2001
    Mechanical and Thermal Nociceptive thresholds in rats with Immunosuppression and Inflammatory Pain.
    UQ Early Career Researcher
    Open grant
  • 2001 - 2003
    Peripheral Mechanisms of Analgesia in Inflammation
    NHMRC Project Grant
    Open grant
  • 2000
    A pilot study investigating the role of Low Level Laser Therapy (LLLT) in an inflammatory model
    Royal Brisbane & Women's Hospital Research Foundation
    Open grant
  • 2000
    Investigating the role of Low Level Laser Therapy (LLTP) in an inflammatory model
    Centre of Nat. Res. on Disability & Rehab Medicine
    Open grant
  • 1999
    Site-directed trafficking of opioid producing lymphocytes in localised inflammation and the involvement in pain control
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Professor Peter Cabot is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Peripheral Mechanisms of Analgesia and the Involvement of the Immune System

  • Opioid biotransformation and inflammation

  • Novel opioid peptides for the treatment of addiction and tolerance

Supervision history

Current supervision

  • Doctor Philosophy

    The pharmacological evaluation of beta-endorphin analogues: opioid-based bivalent peptide DB1-7 targeting multiple opioid receptors.

    Principal Advisor

    Other advisors: Dr Harendra Parekh, Dr Karnaker Reddy Tupally

  • Doctor Philosophy

    Designing novel bivalent ligands that target the mu and nociceptin opioid receptors for reduced side effects

    Principal Advisor

    Other advisors: Dr Melanie Robitaille

  • Doctor Philosophy

    the role of TLR4 in the effect of opioids on tumour growth and metastasis

    Principal Advisor

    Other advisors: Dr Harendra Parekh, Dr Karnaker Reddy Tupally

  • Doctor Philosophy

    Bivalent opioid constructs as allosteric modulators of nociception

    Principal Advisor

    Other advisors: Dr Harendra Parekh, Dr Karnaker Reddy Tupally

  • Doctor Philosophy

    Targeting peripheral kappa and mu bivalent opioid receptors with bivalent opioid peptides for inflammatory pain

    Principal Advisor

    Other advisors: Dr Ben Ross, Dr Melanie Robitaille

Completed supervision

Enquiries

Contact Professor Peter Cabot directly for media enquiries about:

  • Inflammation - pharmacology
  • Pain pharmacology
  • Pharmacology - pain

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