Dr Fekade Sime
Dr

Fekade Sime

Email: 
Phone: 
+61 7 334 65023

Availability

Dr Fekade Sime is:
Available for supervision

Qualifications

  • Doctor of Philosophy, University of South Australia

Search Professor Fekade Sime’s works on UQ eSpace

87 works between 2012 and 2024
All (87) Journal Article (78) Book Chapter (3) Conference Publication (6)

1 - 20 of 87 works

2024

Journal Article

Is there evidence on the optimal duration of aminoglycoside therapy in beta-lactam/aminoglycoside combination regimens used for the treatment of Gram-negative bacterial infections? -A Systematic Review

Wale, Yalew M., Roberts, Jason A., Wolie, Zenaw T. and Sime, Fekade B. (2024). Is there evidence on the optimal duration of aminoglycoside therapy in beta-lactam/aminoglycoside combination regimens used for the treatment of Gram-negative bacterial infections? -A Systematic Review. International Journal of Antimicrobial Agents, 64 (4) 107297, 107297. doi: 10.1016/j.ijantimicag.2024.107297

Is there evidence on the optimal duration of aminoglycoside therapy in beta-lactam/aminoglycoside combination regimens used for the treatment of Gram-negative bacterial infections? -A Systematic Review

2024

Journal Article

Safety and efficacy of outpatient parenteral antimicrobial therapy: a systematic review and meta-analysis of randomized clinical trials

Mohammed, Solomon Ahmed, Roberts, Jason A, Cotta, Menino Osbert, Rogers, Benjamin, Pollard, James, Assefa, Getnet Mengistu, Erku, Daniel and Sime, Fekade B (2024). Safety and efficacy of outpatient parenteral antimicrobial therapy: a systematic review and meta-analysis of randomized clinical trials. International Journal of Antimicrobial Agents, 64 (2) 107263, 107263. doi: 10.1016/j.ijantimicag.2024.107263

Safety and efficacy of outpatient parenteral antimicrobial therapy: a systematic review and meta-analysis of randomized clinical trials

2024

Journal Article

Editorial: Commercialization and industrialization of pharmacology of infectious diseases: 2022

Huang, Yanqin, Nang, Sue C., Lin, Yu-Wei and Sime, Fekade (2024). Editorial: Commercialization and industrialization of pharmacology of infectious diseases: 2022. Frontiers in Pharmacology, 15 1438072. doi: 10.3389/fphar.2024.1438072

Editorial: Commercialization and industrialization of pharmacology of infectious diseases: 2022

2024

Journal Article

Current practices and challenges of outpatient parenteral antimicrobial therapy: a narrative review

Wolie, Zenaw T, Roberts, Jason A, Gilchrist, Mark, McCarthy, Kate and Sime, Fekade B (2024). Current practices and challenges of outpatient parenteral antimicrobial therapy: a narrative review. Journal of Antimicrobial Chemotherapy. doi: 10.1093/jac/dkae177

Current practices and challenges of outpatient parenteral antimicrobial therapy: a narrative review

2024

Journal Article

Barriers and facilitators for the implementation and expansion of outpatient parenteral antimicrobial therapy: systematic review

Mohammed, Solomon Ahmed, Cotta, Menino Osbert, Assefa, Getnet Mengistu, Erku, Daniel and Sime, Fekade (2024). Barriers and facilitators for the implementation and expansion of outpatient parenteral antimicrobial therapy: systematic review. Journal of Hospital Infection, 147, 1-16. doi: 10.1016/j.jhin.2024.02.006

Barriers and facilitators for the implementation and expansion of outpatient parenteral antimicrobial therapy: systematic review

2024

Journal Article

What are the optimal pharmacokinetic/pharmacodynamic targets for β-lactamase inhibitors? A systematic review

Assefa, Getnet M, Roberts, Jason A, Mohammed, Solomon A and Sime, Fekade B (2024). What are the optimal pharmacokinetic/pharmacodynamic targets for β-lactamase inhibitors? A systematic review. Journal of Antimicrobial Chemotherapy, 79 (5) dkae058, 946-958. doi: 10.1093/jac/dkae058

What are the optimal pharmacokinetic/pharmacodynamic targets for β-lactamase inhibitors? A systematic review

2024

Journal Article

Evaluation of the stability of ceftazidime/avibactam in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy utilizing a national stability protocol framework

Naicker, Saiyuri, Roberts, Jason A, Won, Hayoung, Wallis, Steven C, Unwin, Sean, Jamieson, Conor, Hills, Tim, Gilchrist, Mark, Santillo, Mark, Seaton, R Andrew, Drummond, Felicity and Sime, Fekade B (2024). Evaluation of the stability of ceftazidime/avibactam in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy utilizing a national stability protocol framework. JAC-Antimicrobial Resistance, 6 (2) dlae056, dlae056. doi: 10.1093/jacamr/dlae056

Evaluation of the stability of ceftazidime/avibactam in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy utilizing a national stability protocol framework

2024

Journal Article

The global epidemiology of ventilator-associated pneumonia caused by multi-drug resistant Pseudomonas aeruginosa: a systematic review and meta-analysis

Li, Yixuan, Roberts, Jason A., Walker, Mikaela M., Aslan, Abdullah Tarik, Harris, Patrick N. A. and Sime, Fekade (2024). The global epidemiology of ventilator-associated pneumonia caused by multi-drug resistant Pseudomonas aeruginosa: a systematic review and meta-analysis. International Journal of Infectious Diseases, 139, 78-85. doi: 10.1016/j.ijid.2023.11.023

The global epidemiology of ventilator-associated pneumonia caused by multi-drug resistant Pseudomonas aeruginosa: a systematic review and meta-analysis

2024

Conference Publication

The fusion study – Compatibility of antibiotics with commonly used medication infusions in a paediatric intensive care unit

Tu, Quyen, Won, Hayoung Helen, Sime, Fekade, Wallis, Steven, Raman, Sainath, Stacey, Sonya, Cotta, Menino, Schlapbach, Luregn and Roberts, Jason (2024). The fusion study – Compatibility of antibiotics with commonly used medication infusions in a paediatric intensive care unit. Australian and New Zealand Intensive Care Society/Australian College of Critical Care Nursing Intensive Care Annual Scientific meeting, Brisbane, QLD Australia, 10-12 April 2024. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.aucc.2024.07.037

The fusion study – Compatibility of antibiotics with commonly used medication infusions in a paediatric intensive care unit

2023

Journal Article

Evaluation of the stability of aciclovir in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy

Sime, Fekade Bruck, Wallis, Steven, Jamieson, Conor, Hills, Tim, Gilchrist, Mark, Santillo, Mark, Seaton, R Andrew, Drummond, Felicity and Roberts, Jason (2023). Evaluation of the stability of aciclovir in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy. European Journal of Hospital Pharmacy ejhpharm-2023-003784, ejhpharm-2023. doi: 10.1136/ejhpharm-2023-003784

Evaluation of the stability of aciclovir in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy

2023

Journal Article

An in vitro dynamic bioreactor model for evaluating antimicrobial effectiveness on periodontal polymicrobial biofilms: a proof-of-concept study

Ramachandra, Srinivas Sulugodu, Sime, Fekade Bruck, Naicker, Saiyuri, Han, Pingping, Lee, Ryan S.B., Wallis, Steven C., Roberts, Jason A. and Ivanovski, Sašo (2023). An in vitro dynamic bioreactor model for evaluating antimicrobial effectiveness on periodontal polymicrobial biofilms: a proof-of-concept study. Journal of Periodontology, 95 (4), 384-396. doi: 10.1002/JPER.23-0086

An in vitro dynamic bioreactor model for evaluating antimicrobial effectiveness on periodontal polymicrobial biofilms: a proof-of-concept study

2023

Journal Article

A protocol for an international, multicentre pharmacokinetic study for Screening Antifungal Exposure in Intensive Care Units: The SAFE-ICU study

Roberts, Jason A., Sime, Fekade, Lipman, Jeffrey, Hernández-Mitre, Maria Patricia, Baptista, João Pedro, Brüggemann, Roger J., Darvall, Jai, De Waele, Jan J., Dimopoulos, George, Lefrant, Jean-Yves, Mat Nor, Mohd Basri, Rello, Jordi, Seoane, Leonardo, Slavin, Monica A., Valkonen, Miia, Venditti, Mario, Wong, Wai Tat, Zeitlinger, Markus and Roger, Claire (2023). A protocol for an international, multicentre pharmacokinetic study for Screening Antifungal Exposure in Intensive Care Units: The SAFE-ICU study. Critical Care and Resuscitation, 25 (1), 1-5. doi: 10.1016/j.ccrj.2023.04.002

A protocol for an international, multicentre pharmacokinetic study for Screening Antifungal Exposure in Intensive Care Units: The SAFE-ICU study

2023

Journal Article

Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae—authors’ response

Sumi, Chandra Datta, Roberts, Jason A and Sime, Fekade B (2023). Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae—authors’ response. Journal of Antimicrobial Chemotherapy, 78 (3), 854-857. doi: 10.1093/jac/dkad017

Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae—authors’ response

2022

Journal Article

Current and emerging treatment options for multidrug resistant Escherichia coli urosepsis: a review

Walker, Mikaela M., Roberts, Jason A., Rogers, Benjamin A., Harris, Patrick N. A. and Sime, Fekade B. (2022). Current and emerging treatment options for multidrug resistant Escherichia coli urosepsis: a review. Antibiotics, 11 (12) 1821, 1-20. doi: 10.3390/antibiotics11121821

Current and emerging treatment options for multidrug resistant Escherichia coli urosepsis: a review

2022

Conference Publication

Evaluating mono- and combination therapy of meropenem and amikacin against Pseudomonas aeruginosa bacteremia in the hollow-fiber infection model

Avent, Minyon, Mccarthy, Kate, Sime, Fekade, Naickera, Saiyuri, Heffernan, Aaron, Wallis, Steven, Paterson, David and Roberts, Jason A (2022). Evaluating mono- and combination therapy of meropenem and amikacin against Pseudomonas aeruginosa bacteremia in the hollow-fiber infection model. 32nd International Congress of Antimicrobial Chemotherapy (ICC), Perth, WA, Australia, 27-30 November 2022. Amsterdam, Netherlands: Elsevier . doi: 10.1016/s2213-7165(22)00314-9

Evaluating mono- and combination therapy of meropenem and amikacin against Pseudomonas aeruginosa bacteremia in the hollow-fiber infection model

2022

Conference Publication

Pharmacokinetics of polymyxin B and the pharmacokinetic/pharmacodynamic target attainment in hospitalised adult patients with multidrug-resistant gram-negative infections

Zamri, Puteri Juanita, Abdul-Aziz, Mohd-Hafiz, Hernandez-Mitre, Maria Patricia, Hasan, Mohd Shahnaz, Shariff, Izyani Md, Sulaiman, Helmi, Wallis, Steve, Sumi, Chandra Datta, Sime, Fekade Bruck and Roberts, Jason A (2022). Pharmacokinetics of polymyxin B and the pharmacokinetic/pharmacodynamic target attainment in hospitalised adult patients with multidrug-resistant gram-negative infections. 32nd International Congress of Antimicrobial Chemotherapy (ICC), Perth, Australia, 27-30 November 2022. Amsterdam, Netherlands: Elsevier . doi: 10.1016/s2213-7165(22)00339-3

Pharmacokinetics of polymyxin B and the pharmacokinetic/pharmacodynamic target attainment in hospitalised adult patients with multidrug-resistant gram-negative infections

2022

Journal Article

Evaluation of fosfomycin-sulbactam combination therapy against carbapenem-resistant Acinetobacter baumannii isolates in a hollow-fibre infection model

Mohd Sazlly Lim, Sazlyna, Heffernan, Aaron, Naicker, Saiyuri, Wallis, Steven, Roberts, Jason A. and Sime, Fekade Bruck (2022). Evaluation of fosfomycin-sulbactam combination therapy against carbapenem-resistant Acinetobacter baumannii isolates in a hollow-fibre infection model. Antibiotics, 11 (11) 1578, 1-11. doi: 10.3390/antibiotics11111578

Evaluation of fosfomycin-sulbactam combination therapy against carbapenem-resistant Acinetobacter baumannii isolates in a hollow-fibre infection model

2022

Journal Article

Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Escherichia coli clinical isolates

Sumi, Chandra Datta, Heffernan, Aaron J., Naicker, Saiyuri, Cottrell, Kyra, Wallis, Steven C., Lipman, Jeffrey, Harris, Patrick N. A., Sime, Fekade B. and Roberts, Jason A. (2022). Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Escherichia coli clinical isolates. Journal of Antimicrobial Chemotherapy, 77 (11), 3026-3034. doi: 10.1093/jac/dkac273

Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Escherichia coli clinical isolates

2022

Journal Article

Pharmacodynamics of Piperacillin-Tazobactam/Amikacin Combination versus Meropenem against Extended-Spectrum β-Lactamase-Producing Escherichia coli in a Hollow Fiber Infection Model

Islam, Kamrul, Sime, Fekade B., Wallis, Steven C., Bauer, Michelle J., Naicker, Saiyuri, Won, Hayoung, Zowawi, Hosam M., Choudhury, Md Abu, Shirin, Tahmina, Habib, Zakir H., Harris, Patrick N. A., Flora, Meerjady S. and Roberts, Jason A. (2022). Pharmacodynamics of Piperacillin-Tazobactam/Amikacin Combination versus Meropenem against Extended-Spectrum β-Lactamase-Producing Escherichia coli in a Hollow Fiber Infection Model. Antimicrobial Agents and Chemotherapy, 66 (9), e0016222. doi: 10.1128/aac.00162-22

Pharmacodynamics of Piperacillin-Tazobactam/Amikacin Combination versus Meropenem against Extended-Spectrum β-Lactamase-Producing Escherichia coli in a Hollow Fiber Infection Model

2022

Journal Article

Pharmacodynamic evaluation of piperacillin/tazobactam against extended-spectrum β-lactamase-producing versus non-producing Escherichia coli in a hollow-fibre infection model

Islam, Kamrul, Sime, Fekade B., Bauer, Michelle J., Forde, Brian M., Wallis, Steven C., Harris, Patrick, Naicker, Saiyuri, Shirin, Tahmina, Habib, Zakir H., Flora, Meerjady S. and Roberts, Jason A. (2022). Pharmacodynamic evaluation of piperacillin/tazobactam against extended-spectrum β-lactamase-producing versus non-producing Escherichia coli in a hollow-fibre infection model. International Journal of Antimicrobial Agents, 60 (2) 106623, 1-7. doi: 10.1016/j.ijantimicag.2022.106623

Pharmacodynamic evaluation of piperacillin/tazobactam against extended-spectrum β-lactamase-producing versus non-producing Escherichia coli in a hollow-fibre infection model

Current funding

  • 2021 - 2025
    Optimizing outpatient parenteral antibiotic therapy to support hospital-in-the-home program across the unique environmental conditions of Australia
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2023
    Screening Antifungal Exposure in Intensive Care Units: The SAFE-ICU Study
    Gilead Australia Fellowship
    Open grant
  • 2022 - 2023
    Evaluation of the stability of ceftazidime-avibactam in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy-A regulatory compliance study in accordance with the requireme
    Pfizer Inc Global Medical Grant
    Open grant
  • 2022 - 2023
    Evaluation of the stability of Aciclovir in elastomeric infusion devices used for Outpatient Parenteral Antimicrobial Therapy in accordance with the requirement of the UK NHS Yellow Cover Document
    British Society for Antimicrobial Chemotherapy
    Open grant
  • 2021
    Evaluation of the stability of Aciclovir in elastomeric infusion devises used in Outpatient Parenteral Antimicrobial Therapy in accordance with the requirement of the UK NHS Yellow Cover Document
    British Society for Antimicrobial Chemotherapy
    Open grant
  • 2021 - 2022
    Evaluation of the stability of Amoxicillin in elastomeric infusion devices used for Outpatient Parenteral Antimicrobial Therapy in accordance with the requirement of the UK NHS Yellow Cover Document
    British Society for Antimicrobial Chemotherapy
    Open grant
  • 2019 - 2021
    Screening anti-fungal exposure in intensive care unit
    European Society of Clinical Microbiology and Infectious Diseases Study Group Research Grant
    Open grant
  • 2019
    Preventing bacterial biofilm formation in dialysis and advanced oxygenation therapy machines through optimized dosing of antibiotics
    UQ Early Career Researcher
    Open grant
  • 2016 - 2019
    A translational approach to optimisation of antimicrobial therapy for critically ill patients that prevents the emergence of 'superbugs'
    UQ Fellowships
    Open grant

Availability

Dr Fekade Sime is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Optimising the stability and dosing regimens of antibiotics for outpatient parenteral antibiotic therapy

    Principal Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Centre of Research Excellence - REduce the burden of antimicrobial reSistance through oPtimal, persONalised Dosing (RESPOND)

    Principal Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Barriers and facilitators of the implementation and expansion of outpatient parenteral antimicrobial therapy program

    Principal Advisor

  • Doctor Philosophy

    Optimisation of antibiotic regimens for the treatment of resistant infections using dynamic in vitro infections models

    Principal Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    In vitro evaluation of the impact of different durations of exposure of fast-acting antimicrobials in combination with beta-lactams

    Principal Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Centre of Research Excellence - REduce the burden of antimicrobial reSistance through oPtimal, persONalised Dosing (RESPOND)

    Associate Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Stability of cephalosporin/b-lactam with b-lactamase inhibitor combinations for use in OPAT and simulation of OPAT-like drug exposures in a Biofilm model to assess the effect on MDR isolates.

    Associate Advisor

    Other advisors: Dr Suzanne Parker, Professor Jason Roberts

Completed supervision

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