Overview
Background
Dr. Mohd Hafiz Abdul-Aziz is an Early Career Research Fellow and Clinical Research Pharmacist at the University of Queensland Centre for Clinical Research (UQCCR), Australia. He currently leads the Clinical Dosing Studies and Knowledge Translation Workstream within the Antimicrobial Optimisation Group and the Centre for Research Excellence for Personalising Antimicrobial Dosing to Reduce Resistance (CRE RESPOND) at UQCCR. Dr. Abdul-Aziz holds a Bachelor of Pharmacy (IIUM) and a Master of Clinical Pharmacy (UKM) from Malaysia and completed his PhD at the University of Queensland in 2016. His doctoral thesis focused on pharmacokinetic/pharmacodynamic-optimised beta-lactam dosing in critically ill patients.
As a clinical pharmacist with a strong interest in clinical research, Dr. Abdul-Aziz is particularly focused on multi-centre and multi-national collaborations. His current research program aims to develop innovative methods for optimising antimicrobial dosing and delivery to improve patient outcomes in the ICU. He has extensive experience in designing and conducting multi-national clinical pharmacokinetic studies in the ICU. Over the past five years, he has led or coordinated eight multi-national antimicrobial pharmacokinetic studies, including the ASAP ECMO, BLING 3, BLING 3 PK/PD, and PNEUDOS studies.
Dr. Abdul-Aziz is a Fellow of the International Society of Antimicrobial Chemotherapy (ISAC) and serves as the Chair of the Infections in the ICU and Sepsis Working Group of ISAC. He has maintained active collaborations with over 100 collaborators from 36 countries.
Availability
- Dr Hafiz Abdul-Aziz is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Hafiz Abdul-Aziz’s works on UQ eSpace
Featured
2024
Journal Article
Prolonged vs intermittent infusions of β-lactam antibiotics in adults with sepsis or septic shock: a systematic review and meta-analysis
Abdul-Aziz, Mohd H., Hammond, Naomi E., Brett, Stephen J., Cotta, Menino O., De Waele, Jan J., Devaux, Anthony, Di Tanna, Gian Luca, Dulhunty, Joel M., Elkady, Hatem, Eriksson, Lars, Hasan, M Shahnaz, Khan, Ayesha Bibi, Lipman, Jeffrey, Liu, Xiaoqiu, Monti, Giacomo, Myburgh, John, Novy, Emmanuel, Omar, Shahed, Rajbhandari, Dorrilyn, Roger, Claire, Sjövall, Fredrik, Zaghi, Irene, Zangrillo, Alberto, Delaney, Anthony and Roberts, Jason A. (2024). Prolonged vs intermittent infusions of β-lactam antibiotics in adults with sepsis or septic shock: a systematic review and meta-analysis. JAMA, 332 (8), 638-648. doi: 10.1001/jama.2024.9803
Featured
2023
Journal Article
Antimicrobial exposures in critically ill patients receiving extracorporeal membrane oxygenation
Shekar, Kiran, Abdul-Aziz, Mohd H, Cheng, Vesa, Burrows, Fay, Buscher, Hergen, Cho, Young-Jae, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Jakob, Stephan M, Kim, Hyung-Sook, Levkovich, Bianca J, Lim, Sung Yoon, McGuinness, Shay, Parke, Rachael, Pellegrino, Vincent, Que, Yok-Ai, Reynolds, Claire, Rudham, Sam, Wallis, Steven C, Welch, Susan A, Zacharias, David, Fraser, John F. and Roberts, Jason A (2023). Antimicrobial exposures in critically ill patients receiving extracorporeal membrane oxygenation. American Journal of Respiratory and Critical Care Medicine, 207 (6), 704-720. doi: 10.1164/rccm.202207-1393oc
Featured
2022
Journal Article
Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software
Roberts, Jason A., Bellomo, Rinaldo, Cotta, Menino O., Koch, Birgit C. P., Lyster, Haifa, Ostermann, Marlies, Roger, Claire, Shekar, Kiran, Watt, Kevin and Abdul-Aziz, Mohd H. (2022). Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software. Intensive Care Medicine, 48 (10), 1338-1351. doi: 10.1007/s00134-022-06847-2
Featured
2020
Journal Article
Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#
Abdul-Aziz, Mohd H., Alffenaar, Jan-Willem C., Bassetti, Matteo, Bracht, Hendrik, Dimopoulos, George, Marriott, Deborah, Neely, Michael N., Paiva, Jose-Artur, Pea, Federico, Sjovall, Fredrik, Timsit, Jean F., Udy, Andrew A., Wicha, Sebastian G., Zeitlinger, Markus, De Waele, Jan J., Roberts, Jason A., the Infection Section of European Society of Intensive Care Medicine (ESICM), Pharmacokinetic/pharmacodynamic and Critically Ill Patient Study Groups of European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) and Infections in the ICU and Sepsis Working Group of International Society of Antimicrobial Chemotherapy (ISAC) (2020). Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#. Intensive Care Medicine, 46 (6), 1127-1153. doi: 10.1007/s00134-020-06050-1
Featured
2016
Journal Article
Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis
Abdul-Aziz, Mohd H., Sulaiman, Helmi, Mat-Nor, Mohd-Basri, Rai, Vineya, Wong, Kang K., Hasan, Mohd S., Abd Rahman, Azrin N., Jamal, Janattul A., Wallis, Steven C., Lipman, Jeffrey, Staatz, Christine E. and Roberts, Jason A. (2016). Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis. Intensive Care Medicine, 42 (10), 1535-1545. doi: 10.1007/s00134-015-4188-0
2025
Journal Article
Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot study
Roberts, J. A., Heffernan, A. J., Chai, M. G., Harris, P. N. A., Legg, A., Farkas, A., Laupland, K., Dhanani, J., Fourie, C., Murray, L., Abdul-Aziz, H., Ungerer, J., McWhinney, B., Lipman, J. and Cotta, M. O. (2025). Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot study. CMI Communications, 2 (1) 105051, 105051. doi: 10.1016/j.cmicom.2024.105051
2025
Journal Article
Propofol and fentanyl pharmacokinetics and pharmacodynamics in extracorporeal membrane oxygenation
Morales Castro, Diana, Balzani, Eleonora, Abdul-Aziz, M. Hafiz, Hernandez-Mitre, Maria Patricia, Wong, Irene, Turgeon, Julien, Tisminetzky, Manuel, Jurado-Camacho, Felipe, Morris, Idunn, Dresser, Linda, Granton, John, Uetrecht, Jack, Pang, K. Sandy, Chen, Eric, Shekar, Kiran and Fan, Eddy (2025). Propofol and fentanyl pharmacokinetics and pharmacodynamics in extracorporeal membrane oxygenation. Annals of the American Thoracic Society, 22 (1), 121-129. doi: 10.1513/annalsats.202407-795oc
2024
Journal Article
Prolonged vs intermittent infusions of β-lactam antibiotics-reply
Roberts, Jason A., Devaux, Anthony and Abdul-Aziz, Mohd H. (2024). Prolonged vs intermittent infusions of β-lactam antibiotics-reply. JAMA-Journal of the American Medical Association. doi: 10.1001/jama.2024.23728
2024
Journal Article
Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study
Abdul-Aziz, Mohd H., Diehl, Arne, Liu, Xin, Cheng, Vesa, Corley, Amanda, Gilder, Eileen, Levkovich, Bianca, McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Pellegrino, Vincent, Wallis, Steven C., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2024). Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study. Antimicrobial Agents and Chemotherapy. doi: 10.1128/aac.01435-24
2024
Journal Article
Is it time to implement prolonged infusions of beta-lactam antibiotics in and beyond critical care settings?
Abdul-Aziz, Mohd H., Dulhunty, Joel M., Rajbhandari, Dorrilyn, Roberts, Jason A. and Lipman, Jeffrey (2024). Is it time to implement prolonged infusions of beta-lactam antibiotics in and beyond critical care settings?. Internal Medicine Journal, 54 (12), 1931-1934. doi: 10.1111/imj.16584
2024
Journal Article
The impact of extracorporeal support on antimicrobial pharmacokinetics in critically ill neonatal and paediatric patients: a systematic review
Cree, Michele L., Abdul-Aziz, Mohd Hafiz, Schlapbach, Luregn J., Roberts, Jason A. and Parker, Suzanne (2024). The impact of extracorporeal support on antimicrobial pharmacokinetics in critically ill neonatal and paediatric patients: a systematic review. International Journal of Antimicrobial Agents, 64 (4) 107311, 1-16. doi: 10.1016/j.ijantimicag.2024.107311
2024
Journal Article
COVID-19 Drug Treatments Are Prone to Sequestration in Extracorporeal Membrane Oxygenation Circuits: An Ex Vivo Extracorporeal Membrane Oxygenation Study
Dhanani, Jayesh A., Shekar, Kiran, Parmar, Dinesh, Lipman, Jeffrey, Bristow, Debra, Wallis, Steven C., Won, Hayoung, Sumi, Chandra D., Abdul-Aziz, Mohd H. and Roberts, Jason A. (2024). COVID-19 Drug Treatments Are Prone to Sequestration in Extracorporeal Membrane Oxygenation Circuits: An Ex Vivo Extracorporeal Membrane Oxygenation Study. ASAIO journal (American Society for Artificial Internal Organs : 1992), 70 (6), 546-552. doi: 10.1097/MAT.0000000000002120
2024
Conference Publication
Sedative Pharmacodynamics in Patients Supported With Extracorporeal Membrane Oxygenation
Morales Castro, D., Balzani, E., Abdul-Aziz, M.H., Wong, I., Turgeon, J., Tisminetzky, M., Jurado-Camacho, L.F., Morris, I., Dresser, L., Granton, J.T., Pang, K.S., Uetrecht, J., Chen, E., Shekar, K. and Fan, E. (2024). Sedative Pharmacodynamics in Patients Supported With Extracorporeal Membrane Oxygenation. American Thoracic Society 2024 International Conference, San Diego, CA United States, 17-22 May 2024. New York, NY United States: American Thoracic Society. doi: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a5531
2023
Journal Article
Population pharmacokinetics of fluconazole in critically ill patients receiving extracorporeal membrane oxygenation and continuous renal replacement therapy: an ASAP ECMO study
Novy, Emmanuel, Abdul-Aziz, Mohd H., Cheng, Vesa, Burrows, Fay, Buscher, Hergen, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Levkovich, Bianca J., McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Parker, Suzanne, Pellegrino, Vincent, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2023). Population pharmacokinetics of fluconazole in critically ill patients receiving extracorporeal membrane oxygenation and continuous renal replacement therapy: an ASAP ECMO study. Antimicrobial Agents and Chemotherapy, 68 (1) e0120123, e0120123. doi: 10.1128/aac.01201-23
2023
Journal Article
In silico evaluation of a beta‐lactam dosing guideline among adults with serious infections
Williams, Paul, Cotta, Menino Osbert, Abdul‐Aziz, Mohd H., Wilks, Kathryn, Farkas, Andras and Roberts, Jason A. (2023). In silico evaluation of a beta‐lactam dosing guideline among adults with serious infections. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 43 (11), 1121-1130. doi: 10.1002/phar.2753
2023
Journal Article
In silico evaluation of a vancomycin dosing guideline among adults with serious infections
Williams, Paul, Cotta, Menino Osbert, Abdul-Aziz, Mohd H., Wilks, Kathryn, Farkas, Andras and Roberts, Jason A (2023). In silico evaluation of a vancomycin dosing guideline among adults with serious infections. Therapeutic Drug Monitoring, 45 (5), 631-636. doi: 10.1097/FTD.0000000000001102
2023
Journal Article
Why is the implementation of beta-lactam therapeutic drug monitoring for the critically ill falling short? A multicenter mixed-methods study
Barreto, Erin F., Chitre, Pooja N., Pine, Kathleen H., Shepel, Kathryn K., Rule, Andrew D., Alshaer, Mohammad H., Abdul Aziz, Mohd Hafiz, Roberts, Jason A., Scheetz, Marc H., Ausman, Sara E., Moreland-Head, Lindsay N., Rivera, Christina G., Jannetto, Paul J., Mara, Kristin C. and Boehmer, Kasey R. (2023). Why is the implementation of beta-lactam therapeutic drug monitoring for the critically ill falling short? A multicenter mixed-methods study. Therapeutic Drug Monitoring, 45 (4), 508-518. doi: 10.1097/FTD.0000000000001059
2023
Journal Article
Dalbavancin as suppressive antibiotic therapy in patients with prosthetic infections: efficacy and safety
Ruiz-Sancho, Andrés, Núñez-Núñez, María, Castelo-Corral, Laura, Martínez-Marcos, Francisco Javier, Lois-Martínez, Nagore, Abdul-Aziz, Mohd Hafiz and Vinuesa-García, David (2023). Dalbavancin as suppressive antibiotic therapy in patients with prosthetic infections: efficacy and safety. Frontiers in Pharmacology, 14 1185602, 1185602. doi: 10.3389/fphar.2023.1185602
2023
Journal Article
Antifungal dosing in critically ill patients on extracorporeal membrane oxygenation
Lyster, Haifa, Shekar, Kiran, Watt, Kevin, Reed, Anna, Roberts, Jason A. and Abdul-Aziz, Mohd-Hafiz (2023). Antifungal dosing in critically ill patients on extracorporeal membrane oxygenation. Clinical Pharmacokinetics, 62 (7), 931-942. doi: 10.1007/s40262-023-01264-0
2023
Journal Article
A systematic review on antimicrobial pharmacokinetic differences between Asian and non-Asian adult populations
Setiawan, Eko, Cotta, Menino Osbert, Roberts, Jason A. and Abdul-Aziz, Mohd Hafiz (2023). A systematic review on antimicrobial pharmacokinetic differences between Asian and non-Asian adult populations. Antibiotics, 12 (5) 803, 1-23. doi: 10.3390/antibiotics12050803
Funding
Current funding
Past funding
Supervision
Availability
- Dr Hafiz Abdul-Aziz is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Establishing effective antibiotic and sedative dosing in paediatrics with extracorporeal therapies (including extracorporeal membrane oxygenation and renal replacement therapies)
Associate Advisor
Other advisors: Honorary Professor Luregn Schlapbach, Professor Jason Roberts
-
Master Philosophy
Determining bEta-lactam Exposure targets in Patients with deep-seated infections.
Associate Advisor
Other advisors: Dr Robert Horvath
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Master Philosophy
Determining bEta-lactam Exposure targets in Patients with deep-seated infections.
Associate Advisor
Other advisors: Dr Robert Horvath
Completed supervision
-
2024
Doctor Philosophy
Defining Optimal Dosing Regimens of Colistin and Polymyxin B in Malaysian Patient Populations
Associate Advisor
Other advisors: Dr Fekade Sime, Professor Jason Roberts
-
2023
Doctor Philosophy
Strategies to improve the use of antimicrobials in hospitalised Indonesian patients
Associate Advisor
Other advisors: Professor Jeffrey Lipman, Professor Jason Roberts
-
2021
Doctor Philosophy
Optimising antimicrobial dosing in critically ill patients on extracorporeal membrane oxygenation (ECMO)
Associate Advisor
Other advisors: Professor Kiran Shekar, Professor Jason Roberts
Media
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