Overview
Background
Dr. Mohd Hafiz Abdul-Aziz is an incoming National Health and Medical Research Council (NHMRC) Emerging Leadership Fellow EL2 (2026) and Clinical Research Pharmacist at the University of Queensland Centre for Clinical Research (UQCCR), Australia. He currently leads the Clinical Dosing Studies and Knowledge Translation Workstream within the Antimicrobial Optimisation Group and the Centre for Research Excellence for Personalising Antimicrobial Dosing to Reduce Resistance (CRE RESPOND) at UQCCR. Dr. Abdul-Aziz holds a Bachelor of Pharmacy (IIUM) and a Master of Clinical Pharmacy (UKM) from Malaysia and completed his PhD at the University of Queensland in 2016. His doctoral thesis focused on pharmacokinetic/pharmacodynamic (PK/PD)-optimised beta-lactam dosing in critically ill patients.
As a clinical pharmacist with a strong interest in clinical research, Dr. Abdul-Aziz is particularly focused on multi-centre and multi-national collaborations. His current research program aims to develop innovative methods for optimising antimicrobial dosing and delivery to improve patient outcomes in the ICU. His current areas of interest include: (1) antimicrobial pharmacokinetics/pharmacodynamics (PK/PD); (2) antimicrobial dosing in special patient population groups (e.g. critically ill, pneumonia, extracorporeal membrane oxygenation (ECMO), renal replacement therapy (RRT) patients; (3) prolonged infusions of beta-lactam antibiotics; (4) antimicrobial therapeutic drug monitoring (TDM); (5) ex-vivo pharmacokinetic ECMO and RRT model experiments; (6) model-informed precision antimicrobial dosing; and (7) multi-centre population pharmacokinetic studies. He has authored over 80 peer-reviewed papers and book chapters in this research area. His publications have been cited more than 4800 times. He has extensive experience in designing and conducting multi-national clinical pharmacokinetic studies in the ICU. Over the past five years, he has led or coordinated eight multi-national antimicrobial pharmacokinetic studies, including the ASAP ECMO, BLING 3, BLING 3 PK/PD, and PNEUDOS studies.
Dr. Abdul-Aziz is a Fellow of the International Society of Antimicrobial Chemotherapy (ISAC) and currently serves as the Chair of the Infections in the ICU and Sepsis Working Group of ISAC. He maintains active collaborations with more than 100 researchers across 36 countries.
Information for Potential Students
Dr. Abdul-Aziz welcomes expressions of interest from prospective postgraduate students. Interested applicants are encouraged to contact him via email to discuss potential research opportunities. Please include an up-to-date CV and a brief research proposal outlining the project you wish to undertake. Dr. Abdul-Aziz is also open to developing projects that address research questions specific to your clinical practice, particularly those related to optimising antimicrobial dosing and delivery.
Availability
- Dr Hafiz Abdul-Aziz is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Antimicrobial pharmacokinetics/pharmacodynamics (PK/PD) in critically ill patients
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Antimicrobial therapeutic drug monitoring (TDM) in the intensive care unit (ICU)
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Ex-vivo pharmacokinetic ECMO and RRT model experiments
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Antimicrobial dosing in special patient population groups (e.g. critically ill, pneumonia, extracorporeal membrane oxygenation (ECMO), renal replacement therapy (RRT) patients
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Prolonged infusions of beta-lactam antibiotics in critically ill patients
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Model-informed precision antimicrobial dosing in the intensive care unit (ICU)
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Multi-centre population pharmacokinetic studies
Works
Search Professor Hafiz Abdul-Aziz’s works on UQ eSpace
2022
Journal Article
Population pharmacokinetics of vancomycin in critically ill adult patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study)
Cheng, Vesa, Abdul-Aziz, Mohd H., Burrows, Fay, Buscher, Hergen, Cho, Young-Jae, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Jakob, Stephan M., Kim, Hyung-Sook, Levkovich, Bianca J., Lim, Sung Yoon, McGuinness, Shay, Parke, Rachael, Pellegrino, Vincent, Que, Yok-Ai, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Zacharias, David, Fraser, John F., Shekar, Kiran, Roberts, Jason A. and on behalf of ASAP ECMO Investigators (2022). Population pharmacokinetics of vancomycin in critically ill adult patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study). Antimicrobial Agents and Chemotherapy, 66 (1) AAC0137721, 1-10. doi: 10.1128/aac.01377-21
2021
Journal Article
Population pharmacokinetics of cefepime in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study)
Cheng, Vesa, Abdul-Aziz, Mohd H., Burrows, Fay, Buscher, Hergen, Corley, Amanda, Diehl, Arne, Jakob, Stephan M., Levkovich, Bianca J., Pellegrino, Vincent, Que, Yok-Ai, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Zacharias, David, Roberts, Jason A., Shekar, Kiran, Fraser, John F. and on behalf ofASAP ECMO Investigators (2021). Population pharmacokinetics of cefepime in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study). International Journal of Antimicrobial Agents, 58 (6) 106466, 1-8. doi: 10.1016/j.ijantimicag.2021.106466
2021
Journal Article
Therapeutic drug monitoring of antibiotics: defining the therapeutic range
Abdul–Aziz, Mohd H., Brady, Kara, Cotta, Menino Osbert and Roberts, Jason A. (2021). Therapeutic drug monitoring of antibiotics: defining the therapeutic range. Therapeutic Drug Monitoring, 44 (1), 19-31. doi: 10.1097/ftd.0000000000000940
2021
Journal Article
Population pharmacokinetics of piperacillin and tazobactam in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study)
Cheng, Vesa, Abdul-Aziz, Mohd H., Burrows, Fay, Buscher, Hergen, Cho, Young-Jae, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Jakob, Stephan M, Kim, Hyung-Sook, Levkovich, Bianca J., Lim, Sung Yoon, McGuinness, Shay, Parke, Rachael, Pellegrino, Vincent, Que, Yok-Ai, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Zacharias, David, Fraser, John F., Shekar, Kiran, Roberts, Jason A. and on behalf of ASAP ECMO Investigators (2021). Population pharmacokinetics of piperacillin and tazobactam in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study). Antimicrobial Agents and Chemotherapy, 65 (11) e01438-21, 1-11. doi: 10.1128/aac.01438-21
2021
Journal Article
Pharmacokinetics of fluconazole and ganciclovir as combination antimicrobial chemotherapy on ECMO- A case report
Dhanani, Jayesh A., Lipman, Jeffrey, Pincus, Jason, Townsend, Shane, Livermore, Amelia, Wallis, Steven C., Abdul-Aziz, Mohd H. and Roberts, Jason A. (2021). Pharmacokinetics of fluconazole and ganciclovir as combination antimicrobial chemotherapy on ECMO- A case report. International Journal of Antimicrobial Agents, 58 (5) 106431, 106431. doi: 10.1016/j.ijantimicag.2021.106431
2021
Journal Article
Applying antimicrobial pharmacokinetic principles for complex patients: critically ill adult patients receiving extracorporeal membrane oxygenation and renal replacement therapy
Cheng, Vesa, Abdul-Aziz, Mohd H. and Roberts, Jason A. (2021). Applying antimicrobial pharmacokinetic principles for complex patients: critically ill adult patients receiving extracorporeal membrane oxygenation and renal replacement therapy. Current Infectious Disease Reports, 23 (9) 13. doi: 10.1007/s11908-021-00757-y
2021
Journal Article
Provider perspectives on beta-lactam therapeutic drug monitoring programs in the critically ill: a protocol for a multicenter mixed-methods study
Barreto, Erin F., Rule, Andrew D., Alshaer, Mohammad H., Roberts, Jason A., Abdul Aziz, Mohd Hafiz, Scheetz, Marc H., Mara, Kristin C., Jannetto, Paul J., Gajic, Ognjen, O'Horo, John C and Boehmer, Kasey R (2021). Provider perspectives on beta-lactam therapeutic drug monitoring programs in the critically ill: a protocol for a multicenter mixed-methods study. Implementation science communications, 2 (1) 34, 34-1. doi: 10.1186/s43058-021-00134-9
2020
Conference Publication
Knowledge and practice survey of clinicians on the management of ventilator-associated pneumonia (VAP) in Malaysia
Sulaiman, H., Salihah, A., Mazhar, A., Aziz, M. H. Abdul, Hasan, M. S., Hairi, F., Nor, B. Mat, Kamarulzaman, A. and Roberts, J. (2020). Knowledge and practice survey of clinicians on the management of ventilator-associated pneumonia (VAP) in Malaysia. London: ELSEVIER SCI LTD. doi: 10.1016/j.ijid.2020.09.274
2020
Journal Article
Knowledge, perception, and antibiotic prescribing practice in the intensive care unit: findings from the Malaysian public setting
Rozali, Muhammad Azrai, Abd Rahman, Norny Syafinaz, Sulaiman, Helmi, Abd Rahman, Azrin Nurul, Atiya, Nadia, Wan Mat, Wan Rahiza, Jamaluddin, Mohd Fadhil, Mazlan, Muhd Zulfakar, Mat Nor, Mohd Basri, Hasan, Mohd Shahnaz and Abdul-Aziz, Mohd Hafiz (2020). Knowledge, perception, and antibiotic prescribing practice in the intensive care unit: findings from the Malaysian public setting. Journal of Pharmacy And Bioallied Sciences, 12 (6), 804-809. doi: 10.4103/jpbs.jpbs_266_19
2020
Journal Article
A case report: community-acquired Pseudomonas aeruginosa necrotizing fasciitis in a morbidly obese diabetic young man can be fatal
Mazlan, Mohd Zulfakar, Abidin, Huda Zainal, Hassan, Wan Mohd. Nazaruddin Wan, Mohamad, Nik Abdullah Nik, Salmuna, Zeti Norfidiyati, Ibrahim, Kamaruddin, Omar, Mahamarowi and Abdul-Aziz, Mohd Hafiz (2020). A case report: community-acquired Pseudomonas aeruginosa necrotizing fasciitis in a morbidly obese diabetic young man can be fatal. IDCases, 22 e01001, e01001. doi: 10.1016/j.idcr.2020.e01001
2020
Journal Article
Prolonged infusion of beta-lactam antibiotics for Gram-negative infections: rationale and evidence base
Abdul-Aziz, Mohd H., Portunato, Federica and Roberts, Jason A. (2020). Prolonged infusion of beta-lactam antibiotics for Gram-negative infections: rationale and evidence base. Current Opinion in Infectious Diseases, 33 (6), 501-510. doi: 10.1097/qco.0000000000000681
2020
Journal Article
The role of antibiotic pharmacokinetic studies performed post-licensing
Parker, Suzanne L., Abdul-Aziz, Mohd Hafiz and Roberts, Jason A. (2020). The role of antibiotic pharmacokinetic studies performed post-licensing. International Journal of Antimicrobial Agents, 56 (6) 106165, 106165. doi: 10.1016/j.ijantimicag.2020.106165
2020
Journal Article
Increasing ventilator surge capacity in COVID 19 pandemic: design, manufacture and in vitro-in vivo testing in anaesthetized healthy pigs of a rapid prototyped mechanical ventilator
Dhanani, Jayesh, Pang, George, Pincus, Jason, Ahern, Benjamin, Goodwin, Wendy, Cowling, Nicholas, Whitten, Grant, Abdul-Aziz, Mohd H., Martin, Steven, Corke, Peter and Laupland, Kevin B. (2020). Increasing ventilator surge capacity in COVID 19 pandemic: design, manufacture and in vitro-in vivo testing in anaesthetized healthy pigs of a rapid prototyped mechanical ventilator. BMC Research Notes, 13 (1) 421, 421. doi: 10.1186/s13104-020-05259-z
2020
Journal Article
What are the predictors for achieving therapeutic levetiracetam serum concentrations in adult neurological patients?
Cotta, Menino Osbert, Abdul-Aziz, Mohd Hafiz, Frey, Otto R., Sime, Fekade Bruck, Roberts, Jason A. and Roehr, Anka C. (2020). What are the predictors for achieving therapeutic levetiracetam serum concentrations in adult neurological patients?. Therapeutic Drug Monitoring, 42 (4), 626-630. doi: 10.1097/ftd.0000000000000731
2020
Journal Article
Prolonged versus intermittent infusion of β-Lactam antibiotics: a systematic review and meta-regression of bacterial killing in preclinical infection models
Dhaese, Sofie, Heffernan, Aaron, Liu, David, Abdul-Aziz, Mohd Hafiz, Stove, Veronique, Tam, Vincent H., Lipman, Jeffrey, Roberts, Jason A. and De Waele, Jan J. (2020). Prolonged versus intermittent infusion of β-Lactam antibiotics: a systematic review and meta-regression of bacterial killing in preclinical infection models. Clinical Pharmacokinetics, 59 (10), 1237-1250. doi: 10.1007/s40262-020-00919-6
2020
Journal Article
Comparative plasma pharmacokinetics of ceftriaxone and ertapenem between normoalbuminemia, hypoalbuminemia and with albumin replacement in a sheep model
Dhanani, Jayesh A., Ahern, Benjamin, Lupinsky, Liad, Jackson, Karen, Wallis, Steven C., Abdul-Aziz, Mohd H., Lipman, Jeffrey and Roberts, Jason A. (2020). Comparative plasma pharmacokinetics of ceftriaxone and ertapenem between normoalbuminemia, hypoalbuminemia and with albumin replacement in a sheep model. Antimicrobial Agents and Chemotherapy, 64 (7) e02584-19. doi: 10.1128/aac.02584-19
2020
Journal Article
What are the current approaches to optimising antimicrobial dosing in the intensive care unit?
Chai, Ming G., Cotta, Menino O., Abdul-Aziz, Mohd H. and Roberts, Jason A. (2020). What are the current approaches to optimising antimicrobial dosing in the intensive care unit?. Pharmaceutics, 12 (7) 638, 1-22. doi: 10.3390/pharmaceutics12070638
2020
Journal Article
Pharmacokinetics of sulfamethoxazole and trimethoprim during veno-venous extracorporeal membrane oxygenation: a case report
Dhanani, Jayesh A., Lipman, Jeffrey, Pincus, Jason, Townsend, Shane, Livermore, Amelia, Wallis, Steven C., Abdul-Aziz, Mohd H. and Roberts, Jason A. (2020). Pharmacokinetics of sulfamethoxazole and trimethoprim during veno-venous extracorporeal membrane oxygenation: a case report. Pharmacotherapy, 40 (7) phar.2413, 713-717. doi: 10.1002/phar.2413
2020
Conference Publication
The DECISIVE study: defining beta-lactam concentration in intensive care unit patients – the pharmacokinetics of piperacillin and meropenem in critically ill patients with conserved renal function
Abdul-Aziz, M., Rozali, M., Othman-Jailani, M., Rahman, A. Abd, Sulaiman, H., Atiya, N., Adiraju, S., Wallis, S., Mat, W. Wan, Mazlan, M., Jamaluddin, M., Hasan, M., Mat-Nor, M. and Roberts, J. (2020). The DECISIVE study: defining beta-lactam concentration in intensive care unit patients – the pharmacokinetics of piperacillin and meropenem in critically ill patients with conserved renal function. 31st ICC - 4th GCCMID 2019, Dubai, United Arab Emirates, 6 - 9 November 2019. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jiph.2020.01.129
2019
Journal Article
Pharmacokinetics of enteric coated mycophenolate sodium in lupus nephritis (POEMSLUN)
Ranganathan, Dwarakanathan, Abdul-Aziz, Mohd H., John, George T., McWhinney, Brett C., Fassett, Robert G., Healy, Helen, Kubler, Paul, Lim, Aaron, Lipman, Jeffrey, Purvey, Megan, Roberts, Matthew, Reyaldeen, Reza, Ungerer, Jacobus and Roberts, Jason A. (2019). Pharmacokinetics of enteric coated mycophenolate sodium in lupus nephritis (POEMSLUN). Therapeutic Drug Monitoring, 41 (6), 703-713. doi: 10.1097/ftd.0000000000000658
Funding
Current funding
Past funding
Supervision
Availability
- Dr Hafiz Abdul-Aziz is:
- Available for supervision
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Supervision history
Current supervision
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Master Philosophy
Determining bEta-lactam Exposure targets in Patients with deep-seated infections.
Principal Advisor
Other advisors: Dr Robert Horvath
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Doctor Philosophy
Establishing effective antibiotic and sedative dosing in paediatrics with extracorporeal therapies (including extracorporeal membrane oxygenation and renal replacement therapies)
Associate Advisor
Other advisors: Honorary Professor Luregn Schlapbach, Professor Jason Roberts
Completed supervision
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2024
Doctor Philosophy
Defining Optimal Dosing Regimens of Colistin and Polymyxin B in Malaysian Patient Populations
Associate Advisor
Other advisors: Dr Fekade Sime, Professor Jason Roberts
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2023
Doctor Philosophy
Strategies to improve the use of antimicrobials in hospitalised Indonesian patients
Associate Advisor
Other advisors: Professor Jeffrey Lipman, Professor Jason Roberts
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2021
Doctor Philosophy
Optimising antimicrobial dosing in critically ill patients on extracorporeal membrane oxygenation (ECMO)
Associate Advisor
Other advisors: Professor Kiran Shekar, Professor Jason Roberts
Media
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