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2024 Journal Article Prolonged vs intermittent infusions of β-lactam antibiotics in adults with sepsis or septic shock: a systematic review and meta-analysisAbdul-Aziz, Mohd H., Hammond, Naomi E., Brett, Stephen J., Cotta, Menino O., De Waele, Jan J., Devaux, Anthony, Di Tanna, Gian Luca, Dulhunty, Joel M., Elkady, Hatem, Eriksson, Lars, Hasan, M Shahnaz, Khan, Ayesha Bibi, Lipman, Jeffrey, Liu, Xiaoqiu, Monti, Giacomo, Myburgh, John, Novy, Emmanuel, Omar, Shahed, Rajbhandari, Dorrilyn, Roger, Claire, Sjövall, Fredrik, Zaghi, Irene, Zangrillo, Alberto, Delaney, Anthony and Roberts, Jason A. (2024). Prolonged vs intermittent infusions of β-lactam antibiotics in adults with sepsis or septic shock: a systematic review and meta-analysis. JAMA, 332 (8), 638-648. doi: 10.1001/jama.2024.9803 |
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2023 Journal Article Antimicrobial exposures in critically ill patients receiving extracorporeal membrane oxygenationShekar, Kiran, Abdul-Aziz, Mohd H, Cheng, Vesa, Burrows, Fay, Buscher, Hergen, Cho, Young-Jae, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Jakob, Stephan M, Kim, Hyung-Sook, Levkovich, Bianca J, Lim, Sung Yoon, McGuinness, Shay, Parke, Rachael, Pellegrino, Vincent, Que, Yok-Ai, Reynolds, Claire, Rudham, Sam, Wallis, Steven C, Welch, Susan A, Zacharias, David, Fraser, John F. and Roberts, Jason A (2023). Antimicrobial exposures in critically ill patients receiving extracorporeal membrane oxygenation. American Journal of Respiratory and Critical Care Medicine, 207 (6), 704-720. doi: 10.1164/rccm.202207-1393oc |
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2022 Journal Article Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing softwareRoberts, Jason A., Bellomo, Rinaldo, Cotta, Menino O., Koch, Birgit C. P., Lyster, Haifa, Ostermann, Marlies, Roger, Claire, Shekar, Kiran, Watt, Kevin and Abdul-Aziz, Mohd H. (2022). Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software. Intensive Care Medicine, 48 (10), 1338-1351. doi: 10.1007/s00134-022-06847-2 |
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2020 Journal Article Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#Abdul-Aziz, Mohd H., Alffenaar, Jan-Willem C., Bassetti, Matteo, Bracht, Hendrik, Dimopoulos, George, Marriott, Deborah, Neely, Michael N., Paiva, Jose-Artur, Pea, Federico, Sjovall, Fredrik, Timsit, Jean F., Udy, Andrew A., Wicha, Sebastian G., Zeitlinger, Markus, De Waele, Jan J., Roberts, Jason A., the Infection Section of European Society of Intensive Care Medicine (ESICM), Pharmacokinetic/pharmacodynamic and Critically Ill Patient Study Groups of European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) and Infections in the ICU and Sepsis Working Group of International Society of Antimicrobial Chemotherapy (ISAC) (2020). Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#. Intensive Care Medicine, 46 (6), 1127-1153. doi: 10.1007/s00134-020-06050-1 |
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2016 Journal Article Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsisAbdul-Aziz, Mohd H., Sulaiman, Helmi, Mat-Nor, Mohd-Basri, Rai, Vineya, Wong, Kang K., Hasan, Mohd S., Abd Rahman, Azrin N., Jamal, Janattul A., Wallis, Steven C., Lipman, Jeffrey, Staatz, Christine E. and Roberts, Jason A. (2016). Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis. Intensive Care Medicine, 42 (10), 1535-1545. doi: 10.1007/s00134-015-4188-0 |
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2026 Journal Article Emergence of ceftazidime-avibactam-induced KPC variants (KPC-25/127) in intracranial infection and implications for clinical managementLei, Ke, Tian, Ying, Xiong, Chaoliang, Lei, Jing, Chen, Dong, Bai, Xiangni, Abdul-Aziz, Mohd H., Xie, Jiao and Liu, Zeshi (2026). Emergence of ceftazidime-avibactam-induced KPC variants (KPC-25/127) in intracranial infection and implications for clinical management. MicrobiologyOpen, 15 (4) e70363, e70363-e70363. doi: 10.1002/mbo3.70363 |
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2026 Journal Article Population pharmacokinetics of total and free ceftriaxone in critically ill and non-critically ill hospitalised adult patientsSetiawan, Eko, Gonzalez, Alvaro, Wölky, Saskia A., Cotta, Menino Osbert, Liu, Xin, Sosilya, Hernycane, Maresco-Pennisi, Diane, Novy, Emmanuel, Ordonez, Jenny, Lukas, Dwi Lily, Wallis, Steven C., Xie, Jiao, Roberts, Jason A. and Abdul-Aziz, Mohd H. (2026). Population pharmacokinetics of total and free ceftriaxone in critically ill and non-critically ill hospitalised adult patients. International Journal of Antimicrobial Agents, 67 (8) 107817, 1-11. doi: 10.1016/j.ijantimicag.2026.107817 |
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2026 Journal Article Impact of early dose adjustment of piperacillin/tazobactam on mortality in critically ill patients with acute kidney injury: a retrospective multicenter cohort studySaad, Mohamed Omar, Abdul-Aziz, Mohd Hafiz, Rachid, Ousama and Mohamed Ibrahim, Mohamed Izham (2026). Impact of early dose adjustment of piperacillin/tazobactam on mortality in critically ill patients with acute kidney injury: a retrospective multicenter cohort study. The Annals of Pharmacotherapy 10600280261452547, 10600280261452547-10600280261452547. doi: 10.1177/10600280261452547 |
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2026 Journal Article Population pharmacokinetics of polymyxin B in critically ill patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infectionsZamri, Puteri Juanita, Wölky, Saskia A., Hernandez-Mitre, Maria P., Liu, Xin, Hasan, M. Shahnaz, Shariff, Izyani Md, Sulaiman, Helmi, Wallis, Steven C., Sumi, Chandra Datta, Parker, Suzanne L., Sime, Fekade Bruck, Roberts, Jason A. and Abdul-Aziz, Mohd Hafiz (2026). Population pharmacokinetics of polymyxin B in critically ill patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infections. International Journal of Antimicrobial Agents, 67 (7) 107816, 1-11. doi: 10.1016/j.ijantimicag.2026.107816 |
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2026 Journal Article The impact of an ex vivo paediatric renal replacement therapy circuit on antimicrobial concentrationsCree, Michele L., Abdul-Aziz, Mohd Hafiz, Wallis, Steven C., Won, Hayoung, Sumi, Chandra D., Marjanovic, Dusan, Ordonez, Jenny L., Schlapbach, Luregn J. and Roberts, Jason A. (2026). The impact of an ex vivo paediatric renal replacement therapy circuit on antimicrobial concentrations. Journal of Antimicrobial Chemotherapy, 81 (7) dkag189, 1-11. doi: 10.1093/jac/dkag189 |
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2026 Journal Article A multicentre evaluation of pharmacokinetic/pharmacodynamic target attainment of piperacillin and tazobactam and the association with clinical outcomes in critically ill patients with sepsis and septic shockSulaiman, Helmi, Wölky, Saskia A., Rozali, Muhammad Azrai, Adiraju, Santosh K. S., Hasan, M. Shahnaz, Hernandez-Mitre, Maria Patricia, Liu, Xin, Mat-Nor, Mohd-Basri, Mazlan, Mohd Zulfakar, Salmuna, Zeti Norfidiyati, Wallis, Steven C., Xie, Jiao, Roberts, Jason A. and Abdul-Aziz, Mohd H. (2026). A multicentre evaluation of pharmacokinetic/pharmacodynamic target attainment of piperacillin and tazobactam and the association with clinical outcomes in critically ill patients with sepsis and septic shock. The Journal of Antimicrobial Chemotherapy, 81 (7) dkag199. doi: 10.1093/jac/dkag199 |
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2026 Journal Article Prospective evaluation of therapeutic target attainment with a beta-lactam dosing nomogram in critically ill adult patientsWilliams, Paul, Cotta, Menino Osbert, Abdul-Aziz, Mohd H., Wilks, Kathryn, Murray, Lauren, Wallis, Steven C., Beall, Gareth and Roberts, Jason A. (2026). Prospective evaluation of therapeutic target attainment with a beta-lactam dosing nomogram in critically ill adult patients. International Journal of Antimicrobial Agents, 67 (9) 107883, 1-6. doi: 10.1016/j.ijantimicag.2026.107883 |
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2026 Journal Article Time-series analysis of antimicrobial use and resistance trends in a tertiary hospital in China from 2017 to 2022: implications for national stewardship effortsZhang, Shengmiao, Xie, Jiao, Li, Youjia, Qian, Manqing, Lin, Bin, Abdul-Aziz, Mohd H. and Xu, Haofeng (2026). Time-series analysis of antimicrobial use and resistance trends in a tertiary hospital in China from 2017 to 2022: implications for national stewardship efforts. Journal of Global Antimicrobial Resistance, 49, 1-10. doi: 10.1016/j.jgar.2026.03.010 |
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2026 Journal Article Therapeutic drug monitoring and the role of pharmacokinetics/pharmacodynamics in optimizing beta-lactam antibiotic dosing for deep-seated infections: a systematic reviewVale, Cassandra, Sime, Fekade B., Cotta, Menino O., Eriksson, Lars, Roberts, Jason A, Horvath, Robert and Abdul-Aziz, Mohd H. (2026). Therapeutic drug monitoring and the role of pharmacokinetics/pharmacodynamics in optimizing beta-lactam antibiotic dosing for deep-seated infections: a systematic review. Journal of Antimicrobial Chemotherapy, 81 (5) dkag142. doi: 10.1093/jac/dkag142 |
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2026 Journal Article How to perform pharmacokinetic research of antimicrobial drugs in critically ill patients undergoing continuous renal replacement therapy: a scoping review of all relevant pharmacokinetic factorsWieringa, A., Smeets, T. J. L., ter Horst, P. G. J., Hunfeld, N. G. M., Bellomo, R., Prowle, J. R., Elderman, J. H., Valkenburg, A. J., Gommers, D., Zeitlinger, M., Tängdén, T., Abdul-Aziz, M. H., Li, J., Sikma, M.A., Mangalore, R. Pai, Stocker, S.L., Endeman, H., Koch, B.C.P., Haringman, J.J., On behalf of the pharmacokinetics & pharmacodynamics anti-infective study group of the European Society of Clinical Microbiology and Infectious Diseases (EPASG), Acute Kidney Injury section of the European Society of Intensive Care Medicine (ESICM), Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) and Infections in the ICU, Sepsis, and Anti-Infective Pharmacology Working Group of International Society of Antimicrobial Chemotherapy (ISAC) (2026). How to perform pharmacokinetic research of antimicrobial drugs in critically ill patients undergoing continuous renal replacement therapy: a scoping review of all relevant pharmacokinetic factors. Clinical Microbiology and Infection, 32 (4), 560-571. doi: 10.1016/j.cmi.2025.11.033 |
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2026 Journal Article Reply to Lai and Huang, “Which beta-lactam infusion strategy is superior in ICU pneumonia? A Bayesian network meta-analysis of continuous, extended, and intermittent approaches”Li, Yixuan, Roberts, Jason A., Abdul-Aziz, Mohd H. and Sime, Fekade B. (2026). Reply to Lai and Huang, “Which beta-lactam infusion strategy is superior in ICU pneumonia? A Bayesian network meta-analysis of continuous, extended, and intermittent approaches”. Antimicrobial Agents and Chemotherapy, 70 (4) e01859-25, 1-2. doi: 10.1128/aac.01859-25 |
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2026 Journal Article Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation-an ASAP ECMO studyAbdul-Aziz, Mohd H., Cheng, Vesa, Burrows, Fay, Buscher, Hergen, Cho, Young-Jae, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Kim, Hyung-Sook, Levkovich, Bianca J., Lim, Sung Yoon, Liu, Xin, McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Pellegrino, Vincent, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2026). Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation-an ASAP ECMO study. Journal of Antimicrobial Chemotherapy, 81 (4) dkag090, 1-12. doi: 10.1093/jac/dkag090 |
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2026 Journal Article The clinical spectrum and causal relationship assessment of checkpoint inhibitor-associated autoimmune diabetes mellitus (CIADM): a retrospective observational studyLi, Youjia, Qu, Kai, Yang, Qianting, Zhang, Jinming, Xu, Yitao, Wang, Haitao, Zhang, Kanghuai, Wang, Cheng, Abdul-Aziz, Mohd H and Xie, Jiao (2026). The clinical spectrum and causal relationship assessment of checkpoint inhibitor-associated autoimmune diabetes mellitus (CIADM): a retrospective observational study. Diabetic Medicine, 43 (6) e70316, 1-8. doi: 10.1111/dme.70316 |
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2026 Book Chapter Clinical pharmacy considerations in the ICUJamal, Janattul-Ain, Abd-Wahab, Mohd-Shahezwan, Xie, Jiao and Abdul-Aziz, Mohd-Hafiz (2026). Clinical pharmacy considerations in the ICU. Reference module in biomedical sciences. (pp. 849-865) Elsevier. doi: 10.1016/b978-0-443-26472-6.00066-8 |
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2025 Journal Article Antibacterial pharmacokinetics in critically ill patients receiving extracorporeal membrane oxygenation (ECMO): a systematic review of population pharmacokinetic studiesRen, Chanelle, Huang, Frank, Cheng, Vesa, Xie, Jiao, Roberts, Jason A. and Abdul-Aziz, Mohd H. (2025). Antibacterial pharmacokinetics in critically ill patients receiving extracorporeal membrane oxygenation (ECMO): a systematic review of population pharmacokinetic studies. Clinical pharmacokinetics, 65 (2) PMID 7606849, 193-215. doi: 10.1007/s40262-025-01596-z |
