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2024 Journal Article Prolonged vs intermittent infusions of β-lactam antibiotics in adults with sepsis or septic shock: a systematic review and meta-analysisAbdul-Aziz, Mohd H., Hammond, Naomi E., Brett, Stephen J., Cotta, Menino O., De Waele, Jan J., Devaux, Anthony, Di Tanna, Gian Luca, Dulhunty, Joel M., Elkady, Hatem, Eriksson, Lars, Hasan, M Shahnaz, Khan, Ayesha Bibi, Lipman, Jeffrey, Liu, Xiaoqiu, Monti, Giacomo, Myburgh, John, Novy, Emmanuel, Omar, Shahed, Rajbhandari, Dorrilyn, Roger, Claire, Sjövall, Fredrik, Zaghi, Irene, Zangrillo, Alberto, Delaney, Anthony and Roberts, Jason A. (2024). Prolonged vs intermittent infusions of β-lactam antibiotics in adults with sepsis or septic shock: a systematic review and meta-analysis. JAMA, 332 (8), 638-648. doi: 10.1001/jama.2024.9803 |
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2023 Journal Article Antimicrobial exposures in critically ill patients receiving extracorporeal membrane oxygenationShekar, Kiran, Abdul-Aziz, Mohd H, Cheng, Vesa, Burrows, Fay, Buscher, Hergen, Cho, Young-Jae, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Jakob, Stephan M, Kim, Hyung-Sook, Levkovich, Bianca J, Lim, Sung Yoon, McGuinness, Shay, Parke, Rachael, Pellegrino, Vincent, Que, Yok-Ai, Reynolds, Claire, Rudham, Sam, Wallis, Steven C, Welch, Susan A, Zacharias, David, Fraser, John F. and Roberts, Jason A (2023). Antimicrobial exposures in critically ill patients receiving extracorporeal membrane oxygenation. American Journal of Respiratory and Critical Care Medicine, 207 (6), 704-720. doi: 10.1164/rccm.202207-1393oc |
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Featured 2022 Journal Article Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing softwareRoberts, Jason A., Bellomo, Rinaldo, Cotta, Menino O., Koch, Birgit C. P., Lyster, Haifa, Ostermann, Marlies, Roger, Claire, Shekar, Kiran, Watt, Kevin and Abdul-Aziz, Mohd H. (2022). Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software. Intensive Care Medicine, 48 (10), 1338-1351. doi: 10.1007/s00134-022-06847-2 |
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2020 Journal Article Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#Abdul-Aziz, Mohd H., Alffenaar, Jan-Willem C., Bassetti, Matteo, Bracht, Hendrik, Dimopoulos, George, Marriott, Deborah, Neely, Michael N., Paiva, Jose-Artur, Pea, Federico, Sjovall, Fredrik, Timsit, Jean F., Udy, Andrew A., Wicha, Sebastian G., Zeitlinger, Markus, De Waele, Jan J., Roberts, Jason A., the Infection Section of European Society of Intensive Care Medicine (ESICM), Pharmacokinetic/pharmacodynamic and Critically Ill Patient Study Groups of European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) and Infections in the ICU and Sepsis Working Group of International Society of Antimicrobial Chemotherapy (ISAC) (2020). Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#. Intensive Care Medicine, 46 (6), 1127-1153. doi: 10.1007/s00134-020-06050-1 |
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2016 Journal Article Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsisAbdul-Aziz, Mohd H., Sulaiman, Helmi, Mat-Nor, Mohd-Basri, Rai, Vineya, Wong, Kang K., Hasan, Mohd S., Abd Rahman, Azrin N., Jamal, Janattul A., Wallis, Steven C., Lipman, Jeffrey, Staatz, Christine E. and Roberts, Jason A. (2016). Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis. Intensive Care Medicine, 42 (10), 1535-1545. doi: 10.1007/s00134-015-4188-0 |
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2026 Journal Article What every intensivist needs to know about antimicrobial dosing in patients on ECMO, RRT and plasmapheresisSpriet, Isabel, Abdul-Aziz, Mohd Hafiz, Scheetz, Marc and Ostermann, Marlies (2026). What every intensivist needs to know about antimicrobial dosing in patients on ECMO, RRT and plasmapheresis. Journal of Critical Care, 96 155704, 1-5. doi: 10.1016/j.jcrc.2026.155704 |
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2026 Journal Article Optimising tazobactam dosing in critically ill adult patients without renal replacement therapy: a population pharmacokinetic analysis of individual patient data pooled from multiple clinical studiesAssefa, Getnet M, Roberts, Jason A., Pea, Federico, Cojutti, Pier Giorgio, Breilh, Dominique, Carrie, Cedric, Zeitlinger, Markus, Isla, Arantxa, Tamme, Kadri, Wolie, Zenaw T., Walker, Robert J., Ulldemolins, Marta, Abdul-Aziz, Mohd H., Liu, Xin and Sime, Fekade B. (2026). Optimising tazobactam dosing in critically ill adult patients without renal replacement therapy: a population pharmacokinetic analysis of individual patient data pooled from multiple clinical studies. Critical Care. doi: 10.1186/s13054-026-06321-1 |
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2026 Journal Article Protein binding determination of cefepime, flucloxacillin, meropenem, piperacillin and tazobactam by ultrafiltration in critically ill patients: the choice of device mattersGregoire, Matthieu, Wallis, Steven C., Williams, Paul G., Won, Hayoung, Hernández-Mitre, María Patricia, Abdul-Aziz, Mohd H. and Roberts, Jason A. (2026). Protein binding determination of cefepime, flucloxacillin, meropenem, piperacillin and tazobactam by ultrafiltration in critically ill patients: the choice of device matters. Clinical Pharmacokinetics, 1-12. doi: 10.1007/s40262-026-01659-9 |
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2026 Journal Article The effects of continuous venovenous hemofiltration on immunosuppressive drug concentrations in an ex-vivo model of the critically Ill Adult: (CITRIC) studyChumas, Lucy A., Wallis, Steven C., Sumi, Chandra, Abdul-Aziz, Mohd Hafiz, McWhinney, Brett C., Ungerer, Jacobus P. J., Coyer, Fiona, Ranganathan, Dwarakanathan, Roberts, Jason A. and Dhanani, Jayesh (2026). The effects of continuous venovenous hemofiltration on immunosuppressive drug concentrations in an ex-vivo model of the critically Ill Adult: (CITRIC) study. Artificial Organs aor.70211. doi: 10.1111/aor.70211 |
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2026 Journal Article Physiological determinants of piperacillin and cefazolin clearance in septic and trauma patientsUlldemolins, Marta, Abdul-Aziz, Mohd Hafiz, Hernández-Mitre, María Patricia, Mohd Sazlly Lim, Sazlyna, Udy, Andrew A., Colmenero, Manuel, Kruger, Peter, Kirkpatrick, Carl M. J., Roberts, Michael S., Wallis, Steven C., Paterson, David L., Lipman, Jeffrey and Roberts, Jason A. (2026). Physiological determinants of piperacillin and cefazolin clearance in septic and trauma patients. Critical Care. doi: 10.1186/s13054-026-06239-8 |
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2026 Journal Article Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapyUlldemolins, Marta, Lipman, Jeffrey, Liu, Xin, Abdul-Aziz, Mohd-Hafiz, Baptista, João P., Bilgrami, Irma, Bitker, Laurent, Boidin, Clement, Brinkmann, Alexander, Cheng, Vesa, Choi, Gordon, Cole, C. Louise, De Waele, Jan J., Deans, Renae, Eastwood, Glenn M., Escobar, Leslie, Frey, Otto R., Garreau, Romain, Goutelle, Sylvain, Gresham, Rebecca, Hernandez-Mitre, Maria Patricia, Jamal, Janattul Ain, Joynt, Gavin M., Kanji, Salmaan, Kielstein, Jan T., Kluge, Stefan, König, Christina, Koulouras, Vasilios P., Lassig-Smith, Melissa ... and the ESCMID PK/PD of Anti-Infectives Study Group (EPASG) (2026). Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy. Critical Care, 30 (1) 466, 1-12. doi: 10.1186/s13054-026-06226-z |
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2026 Journal Article Emergence of ceftazidime-avibactam-induced KPC variants (KPC-25/127) in intracranial infection and implications for clinical managementLei, Ke, Tian, Ying, Xiong, Chaoliang, Lei, Jing, Chen, Dong, Bai, Xiangni, Abdul-Aziz, Mohd H., Xie, Jiao and Liu, Zeshi (2026). Emergence of ceftazidime-avibactam-induced KPC variants (KPC-25/127) in intracranial infection and implications for clinical management. MicrobiologyOpen, 15 (4) e70363, e70363-e70363. doi: 10.1002/mbo3.70363 |
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2026 Journal Article Population pharmacokinetics of total and free ceftriaxone in critically ill and non-critically ill hospitalised adult patientsSetiawan, Eko, Gonzalez, Alvaro, Wölky, Saskia A., Cotta, Menino Osbert, Liu, Xin, Sosilya, Hernycane, Maresco-Pennisi, Diane, Novy, Emmanuel, Ordonez, Jenny, Lukas, Dwi Lily, Wallis, Steven C., Xie, Jiao, Roberts, Jason A. and Abdul-Aziz, Mohd H. (2026). Population pharmacokinetics of total and free ceftriaxone in critically ill and non-critically ill hospitalised adult patients. International Journal of Antimicrobial Agents, 67 (8) 107817, 1-11. doi: 10.1016/j.ijantimicag.2026.107817 |
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2026 Journal Article Pharmacokinetic and pharmacokinetic/pharmacodynamic (PK/PD) considerations of ceftaroline and ceftobiprole for the treatment of Staphylococcus aureus infections: a systematic reviewGenovese, Camilla, Colaneri, Marta, Sguazzini, Enrico, Maddalena, Donatella, Abdul-Aziz, Mohd-Hafiz, Sime, Fekade B., Soriano, Alex, Gori, Andrea, Roberts, Jason A. and Ulldemolins, Marta (2026). Pharmacokinetic and pharmacokinetic/pharmacodynamic (PK/PD) considerations of ceftaroline and ceftobiprole for the treatment of Staphylococcus aureus infections: a systematic review. International Journal of Antimicrobial Agents 107959, 107959-107959. doi: 10.1016/j.ijantimicag.2026.107959 |
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2026 Journal Article Impact of early dose adjustment of piperacillin/tazobactam on mortality in critically ill patients with acute kidney injury: a retrospective multicenter cohort studySaad, Mohamed Omar, Abdul-Aziz, Mohd Hafiz, Rachid, Ousama and Mohamed Ibrahim, Mohamed Izham (2026). Impact of early dose adjustment of piperacillin/tazobactam on mortality in critically ill patients with acute kidney injury: a retrospective multicenter cohort study. The Annals of Pharmacotherapy 10600280261452547, 10600280261452547-10600280261452547. doi: 10.1177/10600280261452547 |
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2026 Journal Article Population pharmacokinetics of polymyxin B in critically ill patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infectionsZamri, Puteri Juanita, Wölky, Saskia A., Hernandez-Mitre, Maria P., Liu, Xin, Hasan, M. Shahnaz, Shariff, Izyani Md, Sulaiman, Helmi, Wallis, Steven C., Sumi, Chandra Datta, Parker, Suzanne L., Sime, Fekade Bruck, Roberts, Jason A. and Abdul-Aziz, Mohd Hafiz (2026). Population pharmacokinetics of polymyxin B in critically ill patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infections. International Journal of Antimicrobial Agents, 67 (7) 107816, 1-11. doi: 10.1016/j.ijantimicag.2026.107816 |
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2026 Journal Article The impact of an ex vivo paediatric renal replacement therapy circuit on antimicrobial concentrationsCree, Michele L., Abdul-Aziz, Mohd Hafiz, Wallis, Steven C., Won, Hayoung, Sumi, Chandra D., Marjanovic, Dusan, Ordonez, Jenny L., Schlapbach, Luregn J. and Roberts, Jason A. (2026). The impact of an ex vivo paediatric renal replacement therapy circuit on antimicrobial concentrations. Journal of Antimicrobial Chemotherapy, 81 (7) dkag189, 1-11. doi: 10.1093/jac/dkag189 |
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2026 Journal Article A multicentre evaluation of pharmacokinetic/pharmacodynamic target attainment of piperacillin and tazobactam and the association with clinical outcomes in critically ill patients with sepsis and septic shockSulaiman, Helmi, Wölky, Saskia A., Rozali, Muhammad Azrai, Adiraju, Santosh K. S., Hasan, M. Shahnaz, Hernandez-Mitre, Maria Patricia, Liu, Xin, Mat-Nor, Mohd-Basri, Mazlan, Mohd Zulfakar, Salmuna, Zeti Norfidiyati, Wallis, Steven C., Xie, Jiao, Roberts, Jason A. and Abdul-Aziz, Mohd H. (2026). A multicentre evaluation of pharmacokinetic/pharmacodynamic target attainment of piperacillin and tazobactam and the association with clinical outcomes in critically ill patients with sepsis and septic shock. The Journal of Antimicrobial Chemotherapy, 81 (7) dkag199. doi: 10.1093/jac/dkag199 |
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2026 Journal Article Prospective evaluation of therapeutic target attainment with a beta-lactam dosing nomogram in critically ill adult patientsWilliams, Paul, Cotta, Menino Osbert, Abdul-Aziz, Mohd H., Wilks, Kathryn, Murray, Lauren, Wallis, Steven C., Beall, Gareth and Roberts, Jason A. (2026). Prospective evaluation of therapeutic target attainment with a beta-lactam dosing nomogram in critically ill adult patients. International Journal of Antimicrobial Agents, 67 (9) 107883, 1-6. doi: 10.1016/j.ijantimicag.2026.107883 |
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2026 Journal Article Time-series analysis of antimicrobial use and resistance trends in a tertiary hospital in China from 2017 to 2022: implications for national stewardship effortsZhang, Shengmiao, Xie, Jiao, Li, Youjia, Qian, Manqing, Lin, Bin, Abdul-Aziz, Mohd H. and Xu, Haofeng (2026). Time-series analysis of antimicrobial use and resistance trends in a tertiary hospital in China from 2017 to 2022: implications for national stewardship efforts. Journal of Global Antimicrobial Resistance, 49, 1-10. doi: 10.1016/j.jgar.2026.03.010 |
