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2024 Journal Article Prolonged vs intermittent infusions of β-lactam antibiotics in adults with sepsis or septic shock: a systematic review and meta-analysisAbdul-Aziz, Mohd H., Hammond, Naomi E., Brett, Stephen J., Cotta, Menino O., De Waele, Jan J., Devaux, Anthony, Di Tanna, Gian Luca, Dulhunty, Joel M., Elkady, Hatem, Eriksson, Lars, Hasan, M Shahnaz, Khan, Ayesha Bibi, Lipman, Jeffrey, Liu, Xiaoqiu, Monti, Giacomo, Myburgh, John, Novy, Emmanuel, Omar, Shahed, Rajbhandari, Dorrilyn, Roger, Claire, Sjövall, Fredrik, Zaghi, Irene, Zangrillo, Alberto, Delaney, Anthony and Roberts, Jason A. (2024). Prolonged vs intermittent infusions of β-lactam antibiotics in adults with sepsis or septic shock: a systematic review and meta-analysis. JAMA, 332 (8), 638-648. doi: 10.1001/jama.2024.9803 |
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2023 Journal Article Antimicrobial exposures in critically ill patients receiving extracorporeal membrane oxygenationShekar, Kiran, Abdul-Aziz, Mohd H, Cheng, Vesa, Burrows, Fay, Buscher, Hergen, Cho, Young-Jae, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Jakob, Stephan M, Kim, Hyung-Sook, Levkovich, Bianca J, Lim, Sung Yoon, McGuinness, Shay, Parke, Rachael, Pellegrino, Vincent, Que, Yok-Ai, Reynolds, Claire, Rudham, Sam, Wallis, Steven C, Welch, Susan A, Zacharias, David, Fraser, John F. and Roberts, Jason A (2023). Antimicrobial exposures in critically ill patients receiving extracorporeal membrane oxygenation. American Journal of Respiratory and Critical Care Medicine, 207 (6), 704-720. doi: 10.1164/rccm.202207-1393oc |
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2022 Journal Article Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing softwareRoberts, Jason A., Bellomo, Rinaldo, Cotta, Menino O., Koch, Birgit C. P., Lyster, Haifa, Ostermann, Marlies, Roger, Claire, Shekar, Kiran, Watt, Kevin and Abdul-Aziz, Mohd H. (2022). Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software. Intensive Care Medicine, 48 (10), 1338-1351. doi: 10.1007/s00134-022-06847-2 |
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2020 Journal Article Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#Abdul-Aziz, Mohd H., Alffenaar, Jan-Willem C., Bassetti, Matteo, Bracht, Hendrik, Dimopoulos, George, Marriott, Deborah, Neely, Michael N., Paiva, Jose-Artur, Pea, Federico, Sjovall, Fredrik, Timsit, Jean F., Udy, Andrew A., Wicha, Sebastian G., Zeitlinger, Markus, De Waele, Jan J., Roberts, Jason A., the Infection Section of European Society of Intensive Care Medicine (ESICM), Pharmacokinetic/pharmacodynamic and Critically Ill Patient Study Groups of European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) and Infections in the ICU and Sepsis Working Group of International Society of Antimicrobial Chemotherapy (ISAC) (2020). Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#. Intensive Care Medicine, 46 (6), 1127-1153. doi: 10.1007/s00134-020-06050-1 |
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2016 Journal Article Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsisAbdul-Aziz, Mohd H., Sulaiman, Helmi, Mat-Nor, Mohd-Basri, Rai, Vineya, Wong, Kang K., Hasan, Mohd S., Abd Rahman, Azrin N., Jamal, Janattul A., Wallis, Steven C., Lipman, Jeffrey, Staatz, Christine E. and Roberts, Jason A. (2016). Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis. Intensive Care Medicine, 42 (10), 1535-1545. doi: 10.1007/s00134-015-4188-0 |
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2025 Journal Article Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot studyRoberts, J. A., Heffernan, A. J., Chai, M. G., Harris, P. N. A., Legg, A., Farkas, A., Laupland, K., Dhanani, J., Fourie, C., Murray, L., Abdul-Aziz, H., Ungerer, J., McWhinney, B., Lipman, J. and Cotta, M. O. (2025). Resistance Optimised Antibiotic Dosing (The ROAD Study): Is dosing of meropenem and piperacillin-tazobactam optimised to prevent the emergence of antibiotic resistance safe and feasible in the ICU? A pilot study. CMI Communications, 2 (1) 105051, 105051. doi: 10.1016/j.cmicom.2024.105051 |
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2025 Journal Article Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO studyAbdul-Aziz, Mohd H., Diehl, Arne, Liu, Xin, Cheng, Vesa, Corley, Amanda, Gilder, Eileen, Levkovich, Bianca, McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Pellegrino, Vincent, Wallis, Steven C., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2025). Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study. Antimicrobial Agents and Chemotherapy, 69 (2) e0143524, 1-15. doi: 10.1128/aac.01435-24 |
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2025 Journal Article Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infectionGiuliano, Simone, Angelini, Jacopo, Campanile, Floriana, Conti, Paola, Flammini, Sarah, Pagotto, Alberto, Sbrana, Francesco, Martini, Luca, D'Elia, Denise, Abdul-Aziz, Mohd H., Cotta, Menino O., Roberts, Jason A., Bonomo, Robert A. and Tascini, Carlo (2025). Evaluation of ampicillin plus ceftobiprole combination therapy in treating Enterococcus faecalis infective endocarditis and bloodstream infection. Scientific Reports, 15 (1) 3519, 1-16. doi: 10.1038/s41598-025-87512-8 |
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2025 Journal Article Propofol and fentanyl pharmacokinetics and pharmacodynamics in extracorporeal membrane oxygenationMorales Castro, Diana, Balzani, Eleonora, Abdul-Aziz, M. Hafiz, Hernandez-Mitre, Maria Patricia, Wong, Irene, Turgeon, Julien, Tisminetzky, Manuel, Jurado-Camacho, Felipe, Morris, Idunn, Dresser, Linda, Granton, John, Uetrecht, Jack, Pang, K. Sandy, Chen, Eric, Shekar, Kiran and Fan, Eddy (2025). Propofol and fentanyl pharmacokinetics and pharmacodynamics in extracorporeal membrane oxygenation. Annals of the American Thoracic Society, 22 (1), 121-129. doi: 10.1513/annalsats.202407-795oc |
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2024 Journal Article Prolonged vs intermittent infusions of β-lactam antibiotics-replyRoberts, Jason A., Devaux, Anthony and Abdul-Aziz, Mohd H. (2024). Prolonged vs intermittent infusions of β-lactam antibiotics-reply. JAMA-Journal of the American Medical Association, 333 (3), 259. doi: 10.1001/jama.2024.23728 |
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2024 Journal Article Is it time to implement prolonged infusions of beta-lactam antibiotics in and beyond critical care settings?Abdul-Aziz, Mohd H., Dulhunty, Joel M., Rajbhandari, Dorrilyn, Roberts, Jason A. and Lipman, Jeffrey (2024). Is it time to implement prolonged infusions of beta-lactam antibiotics in and beyond critical care settings?. Internal Medicine Journal, 54 (12), 1931-1934. doi: 10.1111/imj.16584 |
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2024 Journal Article The impact of extracorporeal support on antimicrobial pharmacokinetics in critically ill neonatal and paediatric patients: a systematic reviewCree, Michele L., Abdul-Aziz, Mohd Hafiz, Schlapbach, Luregn J., Roberts, Jason A. and Parker, Suzanne (2024). The impact of extracorporeal support on antimicrobial pharmacokinetics in critically ill neonatal and paediatric patients: a systematic review. International Journal of Antimicrobial Agents, 64 (4) 107311, 1-16. doi: 10.1016/j.ijantimicag.2024.107311 |
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2024 Journal Article COVID-19 drug treatments are prone to sequestration in extracorporeal membrane oxygenation circuits: an ex vivo extracorporeal membrane oxygenation studyDhanani, Jayesh A., Shekar, Kiran, Parmar, Dinesh, Lipman, Jeffrey, Bristow, Debra, Wallis, Steven C., Won, Hayoung, Sumi, Chandra D., Abdul-Aziz, Mohd H. and Roberts, Jason A. (2024). COVID-19 drug treatments are prone to sequestration in extracorporeal membrane oxygenation circuits: an ex vivo extracorporeal membrane oxygenation study. ASAIO Journal, 70 (6), 546-552. doi: 10.1097/MAT.0000000000002120 |
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2023 Journal Article Population pharmacokinetics of fluconazole in critically ill patients receiving extracorporeal membrane oxygenation and continuous renal replacement therapy: an ASAP ECMO studyNovy, Emmanuel, Abdul-Aziz, Mohd H., Cheng, Vesa, Burrows, Fay, Buscher, Hergen, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Levkovich, Bianca J., McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Parker, Suzanne, Pellegrino, Vincent, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2023). Population pharmacokinetics of fluconazole in critically ill patients receiving extracorporeal membrane oxygenation and continuous renal replacement therapy: an ASAP ECMO study. Antimicrobial Agents and Chemotherapy, 68 (1) e0120123, e0120123. doi: 10.1128/aac.01201-23 |
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2023 Journal Article In silico evaluation of a beta‐lactam dosing guideline among adults with serious infectionsWilliams, Paul, Cotta, Menino Osbert, Abdul‐Aziz, Mohd H., Wilks, Kathryn, Farkas, Andras and Roberts, Jason A. (2023). In silico evaluation of a beta‐lactam dosing guideline among adults with serious infections. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 43 (11), 1121-1130. doi: 10.1002/phar.2753 |
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2023 Journal Article In silico evaluation of a vancomycin dosing guideline among adults with serious infectionsWilliams, Paul, Cotta, Menino Osbert, Abdul-Aziz, Mohd H., Wilks, Kathryn, Farkas, Andras and Roberts, Jason A (2023). In silico evaluation of a vancomycin dosing guideline among adults with serious infections. Therapeutic Drug Monitoring, 45 (5), 631-636. doi: 10.1097/FTD.0000000000001102 |
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2023 Journal Article Why is the implementation of beta-lactam therapeutic drug monitoring for the critically ill falling short? A multicenter mixed-methods studyBarreto, Erin F., Chitre, Pooja N., Pine, Kathleen H., Shepel, Kathryn K., Rule, Andrew D., Alshaer, Mohammad H., Abdul Aziz, Mohd Hafiz, Roberts, Jason A., Scheetz, Marc H., Ausman, Sara E., Moreland-Head, Lindsay N., Rivera, Christina G., Jannetto, Paul J., Mara, Kristin C. and Boehmer, Kasey R. (2023). Why is the implementation of beta-lactam therapeutic drug monitoring for the critically ill falling short? A multicenter mixed-methods study. Therapeutic Drug Monitoring, 45 (4), 508-518. doi: 10.1097/FTD.0000000000001059 |
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2023 Journal Article Dalbavancin as suppressive antibiotic therapy in patients with prosthetic infections: efficacy and safetyRuiz-Sancho, Andrés, Núñez-Núñez, María, Castelo-Corral, Laura, Martínez-Marcos, Francisco Javier, Lois-Martínez, Nagore, Abdul-Aziz, Mohd Hafiz and Vinuesa-García, David (2023). Dalbavancin as suppressive antibiotic therapy in patients with prosthetic infections: efficacy and safety. Frontiers in Pharmacology, 14 1185602, 1185602. doi: 10.3389/fphar.2023.1185602 |
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2023 Journal Article Antifungal dosing in critically ill patients on extracorporeal membrane oxygenationLyster, Haifa, Shekar, Kiran, Watt, Kevin, Reed, Anna, Roberts, Jason A. and Abdul-Aziz, Mohd-Hafiz (2023). Antifungal dosing in critically ill patients on extracorporeal membrane oxygenation. Clinical Pharmacokinetics, 62 (7), 931-942. doi: 10.1007/s40262-023-01264-0 |
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2023 Journal Article A systematic review on antimicrobial pharmacokinetic differences between Asian and non-Asian adult populationsSetiawan, Eko, Cotta, Menino Osbert, Roberts, Jason A. and Abdul-Aziz, Mohd Hafiz (2023). A systematic review on antimicrobial pharmacokinetic differences between Asian and non-Asian adult populations. Antibiotics, 12 (5) 803, 1-23. doi: 10.3390/antibiotics12050803 |
