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2024 Journal Article Prolonged vs intermittent infusions of β-lactam antibiotics in adults with sepsis or septic shock: a systematic review and meta-analysisAbdul-Aziz, Mohd H., Hammond, Naomi E., Brett, Stephen J., Cotta, Menino O., De Waele, Jan J., Devaux, Anthony, Di Tanna, Gian Luca, Dulhunty, Joel M., Elkady, Hatem, Eriksson, Lars, Hasan, M Shahnaz, Khan, Ayesha Bibi, Lipman, Jeffrey, Liu, Xiaoqiu, Monti, Giacomo, Myburgh, John, Novy, Emmanuel, Omar, Shahed, Rajbhandari, Dorrilyn, Roger, Claire, Sjövall, Fredrik, Zaghi, Irene, Zangrillo, Alberto, Delaney, Anthony and Roberts, Jason A. (2024). Prolonged vs intermittent infusions of β-lactam antibiotics in adults with sepsis or septic shock: a systematic review and meta-analysis. JAMA, 332 (8), 638-648. doi: 10.1001/jama.2024.9803 |
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2023 Journal Article Antimicrobial exposures in critically ill patients receiving extracorporeal membrane oxygenationShekar, Kiran, Abdul-Aziz, Mohd H, Cheng, Vesa, Burrows, Fay, Buscher, Hergen, Cho, Young-Jae, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Jakob, Stephan M, Kim, Hyung-Sook, Levkovich, Bianca J, Lim, Sung Yoon, McGuinness, Shay, Parke, Rachael, Pellegrino, Vincent, Que, Yok-Ai, Reynolds, Claire, Rudham, Sam, Wallis, Steven C, Welch, Susan A, Zacharias, David, Fraser, John F. and Roberts, Jason A (2023). Antimicrobial exposures in critically ill patients receiving extracorporeal membrane oxygenation. American Journal of Respiratory and Critical Care Medicine, 207 (6), 704-720. doi: 10.1164/rccm.202207-1393oc |
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Featured 2022 Journal Article Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing softwareRoberts, Jason A., Bellomo, Rinaldo, Cotta, Menino O., Koch, Birgit C. P., Lyster, Haifa, Ostermann, Marlies, Roger, Claire, Shekar, Kiran, Watt, Kevin and Abdul-Aziz, Mohd H. (2022). Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software. Intensive Care Medicine, 48 (10), 1338-1351. doi: 10.1007/s00134-022-06847-2 |
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2020 Journal Article Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#Abdul-Aziz, Mohd H., Alffenaar, Jan-Willem C., Bassetti, Matteo, Bracht, Hendrik, Dimopoulos, George, Marriott, Deborah, Neely, Michael N., Paiva, Jose-Artur, Pea, Federico, Sjovall, Fredrik, Timsit, Jean F., Udy, Andrew A., Wicha, Sebastian G., Zeitlinger, Markus, De Waele, Jan J., Roberts, Jason A., the Infection Section of European Society of Intensive Care Medicine (ESICM), Pharmacokinetic/pharmacodynamic and Critically Ill Patient Study Groups of European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) and Infections in the ICU and Sepsis Working Group of International Society of Antimicrobial Chemotherapy (ISAC) (2020). Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#. Intensive Care Medicine, 46 (6), 1127-1153. doi: 10.1007/s00134-020-06050-1 |
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2016 Journal Article Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsisAbdul-Aziz, Mohd H., Sulaiman, Helmi, Mat-Nor, Mohd-Basri, Rai, Vineya, Wong, Kang K., Hasan, Mohd S., Abd Rahman, Azrin N., Jamal, Janattul A., Wallis, Steven C., Lipman, Jeffrey, Staatz, Christine E. and Roberts, Jason A. (2016). Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis. Intensive Care Medicine, 42 (10), 1535-1545. doi: 10.1007/s00134-015-4188-0 |
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2026 Journal Article Time-series analysis of antimicrobial use and resistance trends in a tertiary hospital in China from 2017 to 2022: implications for national stewardship effortsZhang, Shengmiao, Xie, Jiao, Li, Youjia, Qian, Manqing, Lin, Bin, Abdul-Aziz, Mohd H. and Xu, Haofeng (2026). Time-series analysis of antimicrobial use and resistance trends in a tertiary hospital in China from 2017 to 2022: implications for national stewardship efforts. Journal of Global Antimicrobial Resistance, 49, 1-10. doi: 10.1016/j.jgar.2026.03.010 |
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2026 Journal Article Population pharmacokinetics of total and free ceftriaxone in critically ill and non-critically ill hospitalised adult patientsSetiawan, Eko, Gonzalez, Alvaro, Wölky, Saskia A., Cotta, Menino Osbert, Liu, Xin, Sosilya, Hernycane, Maresco-Pennisi, Diane, Novy, Emmanuel, Ordonez, Jenny, Lukas, Dwi Lily, Wallis, Steven C., Xie, Jiao, Roberts, Jason A. and Abdul-Aziz, Mohd H. (2026). Population pharmacokinetics of total and free ceftriaxone in critically ill and non-critically ill hospitalised adult patients. International Journal of Antimicrobial Agents 107817, 107817. doi: 10.1016/j.ijantimicag.2026.107817 |
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2026 Journal Article Population pharmacokinetics of polymyxin B in critically ill patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infectionsZamri, Puteri Juanita, Wölky, Saskia A., Hernandez-Mitre, Maria P., Liu, Xin, Hasan, M. Shahnaz, Shariff, Izyani Md, Sulaiman, Helmi, Wallis, Steven C., Sumi, Chandra Datta, Parker, Suzanne L., Sime, Fekade Bruck, Roberts, Jason A. and Abdul-Aziz, Mohd Hafiz (2026). Population pharmacokinetics of polymyxin B in critically ill patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa infections. International Journal of Antimicrobial Agents 107816, 107816. doi: 10.1016/j.ijantimicag.2026.107816 |
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2026 Journal Article Therapeutic drug monitoring and the role of pharmacokinetics/pharmacodynamics in optimizing beta-lactam antibiotic dosing for deep-seated infections: a systematic reviewVale, Cassandra, Sime, Fekade B., Cotta, Menino O., Eriksson, Lars, Roberts, Jason A, Horvath, Robert and Abdul-Aziz, Mohd H. (2026). Therapeutic drug monitoring and the role of pharmacokinetics/pharmacodynamics in optimizing beta-lactam antibiotic dosing for deep-seated infections: a systematic review. Journal of Antimicrobial Chemotherapy, 81 (5) dkag142. doi: 10.1093/jac/dkag142 |
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2026 Journal Article How to perform pharmacokinetic research of antimicrobial drugs in critically ill patients undergoing continuous renal replacement therapy: a scoping review of all relevant pharmacokinetic factorsWieringa, A., Smeets, T. J. L., ter Horst, P. G. J., Hunfeld, N. G. M., Bellomo, R., Prowle, J. R., Elderman, J. H., Valkenburg, A. J., Gommers, D., Zeitlinger, M., Tängdén, T., Abdul-Aziz, M. H., Li, J., Sikma, M.A., Mangalore, R. Pai, Stocker, S.L., Endeman, H., Koch, B.C.P., Haringman, J.J., On behalf of the pharmacokinetics & pharmacodynamics anti-infective study group of the European Society of Clinical Microbiology and Infectious Diseases (EPASG), Acute Kidney Injury section of the European Society of Intensive Care Medicine (ESICM), Infectious Diseases Group of International Association of Therapeutic Drug Monitoring and Clinical Toxicology (IATDMCT) and Infections in the ICU, Sepsis, and Anti-Infective Pharmacology Working Group of International Society of Antimicrobial Chemotherapy (ISAC) (2026). How to perform pharmacokinetic research of antimicrobial drugs in critically ill patients undergoing continuous renal replacement therapy: a scoping review of all relevant pharmacokinetic factors. Clinical Microbiology and Infection, 32 (4), 560-571. doi: 10.1016/j.cmi.2025.11.033 |
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2026 Journal Article The clinical spectrum and causal relationship assessment of checkpoint inhibitor-associated autoimmune diabetes mellitus (CIADM): a retrospective observational studyLi, Youjia, Qu, Kai, Yang, Qianting, Zhang, Jinming, Xu, Yitao, Wang, Haitao, Zhang, Kanghuai, Wang, Cheng, Abdul-Aziz, Mohd H and Xie, Jiao (2026). The clinical spectrum and causal relationship assessment of checkpoint inhibitor-associated autoimmune diabetes mellitus (CIADM): a retrospective observational study. Diabetic Medicine e70316. doi: 10.1111/dme.70316 |
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2026 Journal Article Reply to Lai and Huang, “Which beta-lactam infusion strategy is superior in ICU pneumonia? A Bayesian network meta-analysis of continuous, extended, and intermittent approaches”Li, Yixuan, Roberts, Jason A., Abdul-Aziz, Mohd H. and Sime, Fekade B. (2026). Reply to Lai and Huang, “Which beta-lactam infusion strategy is superior in ICU pneumonia? A Bayesian network meta-analysis of continuous, extended, and intermittent approaches”. Antimicrobial Agents and Chemotherapy, 70 (4) e01859-25, 1-2. doi: 10.1128/aac.01859-25 |
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2026 Journal Article Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation-an ASAP ECMO studyAbdul-Aziz, Mohd H., Cheng, Vesa, Burrows, Fay, Buscher, Hergen, Cho, Young-Jae, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Kim, Hyung-Sook, Levkovich, Bianca J., Lim, Sung Yoon, Liu, Xin, McGuinness, Shay, Ordonez, Jenny, Parke, Rachael, Pellegrino, Vincent, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Fraser, John F., Shekar, Kiran and Roberts, Jason A. (2026). Population pharmacokinetics of meropenem in critically ill adult patients receiving extracorporeal membrane oxygenation-an ASAP ECMO study. Journal of Antimicrobial Chemotherapy, 81 (4) dkag090, 1-12. doi: 10.1093/jac/dkag090 |
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2025 Journal Article Antibacterial pharmacokinetics in critically ill patients receiving extracorporeal membrane oxygenation (ECMO): a systematic review of population pharmacokinetic studiesRen, Chanelle, Huang, Frank, Cheng, Vesa, Xie, Jiao, Roberts, Jason A and Abdul-Aziz, Mohd H (2025). Antibacterial pharmacokinetics in critically ill patients receiving extracorporeal membrane oxygenation (ECMO): a systematic review of population pharmacokinetic studies. Clinical pharmacokinetics, 65 (2) PMID 7606849, 193-215. doi: 10.1007/s40262-025-01596-z |
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2025 Journal Article The impact of an ex vivo pediatric extracorporeal membrane oxygenation circuit on sequestration of antimicrobialsCree, Michele L., Abdul-Aziz, Mohd Hafiz, Haisz, Emma, Wallis, Steven C., Won, Hayoung, Sumi, Chandra D., Marjanovic, Dusan, Ordóñez, Jenny L., Schlapbach, Luregn J. and Roberts, Jason A. (2025). The impact of an ex vivo pediatric extracorporeal membrane oxygenation circuit on sequestration of antimicrobials. Critical Care Explorations, 7 (11) e1338, e1338. doi: 10.1097/CCE.0000000000001338 |
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2025 Journal Article Meropenem dosing optimization on day 1 and steady state in critically ill patients without significant renal impairmentSulaiman, Helmi, Rozali, Muhammad Azrai, Adiraju, Santosh K. S., Hasan, M. Shahnaz, Jamal, Janattul A., Liu, Xin, Mat-Nor, Mohd-Basri, Mazlan, Mohd Zulfakar, Othman-Jailani, Mohamad Irfan, Salmuna, Zeti Norfidiyati, Wallis, Steven C., Roberts, Jason A. and Abdul-Aziz, Mohd H. (2025). Meropenem dosing optimization on day 1 and steady state in critically ill patients without significant renal impairment. Scientific Reports, 15 (1) 37781, 1-12. doi: 10.1038/s41598-025-20630-5 |
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2025 Conference Publication Linezolid Pharmacokinetics in Critically Ill ECMO Patients: Implications for Dosing OptimizationXie, Jiao and Abdul–Aziz, Mohd H. (2025). Linezolid Pharmacokinetics in Critically Ill ECMO Patients: Implications for Dosing Optimization. APELSO 2025, Beijing, China, 10-12 July 2025. Philadelphia, PA United States: Lippincott Williams and Wilkins. doi: 10.1097/01.mat.0001171252.32799.67 |
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2025 Journal Article Continuous or extended vs intermittent infusions of beta-lactam antibiotics in ICU patients with pneumonia: a systematic review and meta-analysis of randomized controlled trialsLi, Yixuan, Roberts, Jason A., Abdul-Aziz, Mohd H. and Sime, Fekade B. (2025). Continuous or extended vs intermittent infusions of beta-lactam antibiotics in ICU patients with pneumonia: a systematic review and meta-analysis of randomized controlled trials. Antimicrobial Agents and Chemotherapy, 69 (10) e0073225, 1-13. doi: 10.1128/aac.00732-25 |
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2025 Journal Article Pharmacological research agenda on adult extracorporeal membrane oxygenation using the Delphi method: a position article of the extracorporeal membrane oxygenation pharmacology networkMorales Castro, Diana, Al-Fares, Abdulrahman Abdullah, Paternoster, Gianluca, Lyster, Haifa, Hohlfelder, Benjamin, Arias Ortiz, Julian, Abdul-Aziz, Mohd Hafiz, Herr, Daniel, Alraish, Rawan, Ferre Contreras, Andrés, Palavecino, Marcela, Milella, Luigi, Watt, Kevin, Alkazemi, Afrah, Carini, Federico Carlos, Roberts, Jason A., Riera Del Brio, Jordi, Parra, Alba Pau, Kakar, Vivek, Dureau, Pauline, Duceppe, Marc-Alexandre, Alm, Mark, Cha, Stephanie, Shekar, Kiran, Dzierba, Amy L. and Extracorporeal Membrane Oxygenation Pharmacology Network (ECMOPharm Net) (2025). Pharmacological research agenda on adult extracorporeal membrane oxygenation using the Delphi method: a position article of the extracorporeal membrane oxygenation pharmacology network. Critical Care Medicine, 53 (11), e2246-e2260. doi: 10.1097/CCM.0000000000006806 |
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2025 Journal Article Optimizing antibiotic dosing: a prospective observational study of piperacillin/tazobactam plasma levels in critically ill patients with augmented renal clearanceNegin, Fahima, Abdul Rahim, Shahir Asraf, Mat Nor, Mohd Basri, Mohamad, Fatimah, Nordin, Nur Sazwi and Abdul-Aziz, Mohd Hafiz (2025). Optimizing antibiotic dosing: a prospective observational study of piperacillin/tazobactam plasma levels in critically ill patients with augmented renal clearance. IIUM Medical Journal Malaysia, 24 (3), 48-53. doi: 10.31436/imjm.v24i03.2607 |
