Overview
Background
Dr. Mohd Hafiz Abdul-Aziz is an incoming National Health and Medical Research Council (NHMRC) Emerging Leadership Fellow EL2 (2026) and Clinical Research Pharmacist at the University of Queensland Centre for Clinical Research (UQCCR), Australia. He currently leads the Clinical Dosing Studies and Knowledge Translation Workstream within the Antimicrobial Optimisation Group and the Centre for Research Excellence for Personalising Antimicrobial Dosing to Reduce Resistance (CRE RESPOND) at UQCCR. Dr. Abdul-Aziz holds a Bachelor of Pharmacy (IIUM) and a Master of Clinical Pharmacy (UKM) from Malaysia and completed his PhD at the University of Queensland in 2016. His doctoral thesis focused on pharmacokinetic/pharmacodynamic (PK/PD)-optimised beta-lactam dosing in critically ill patients.
As a clinical pharmacist with a strong interest in clinical research, Dr. Abdul-Aziz is particularly focused on multi-centre and multi-national collaborations. His current research program aims to develop innovative methods for optimising antimicrobial dosing and delivery to improve patient outcomes in the ICU. His current areas of interest include: (1) antimicrobial pharmacokinetics/pharmacodynamics (PK/PD); (2) antimicrobial dosing in special patient population groups (e.g. critically ill, pneumonia, extracorporeal membrane oxygenation (ECMO), renal replacement therapy (RRT) patients; (3) prolonged infusions of beta-lactam antibiotics; (4) antimicrobial therapeutic drug monitoring (TDM); (5) ex-vivo pharmacokinetic ECMO and RRT model experiments; (6) model-informed precision antimicrobial dosing; and (7) multi-centre population pharmacokinetic studies. He has authored over 80 peer-reviewed papers and book chapters in this research area. His publications have been cited more than 4800 times. He has extensive experience in designing and conducting multi-national clinical pharmacokinetic studies in the ICU. Over the past five years, he has led or coordinated eight multi-national antimicrobial pharmacokinetic studies, including the ASAP ECMO, BLING 3, BLING 3 PK/PD, and PNEUDOS studies.
Dr. Abdul-Aziz is a Fellow of the International Society of Antimicrobial Chemotherapy (ISAC) and currently serves as the Chair of the Infections in the ICU and Sepsis Working Group of ISAC. He maintains active collaborations with more than 100 researchers across 36 countries.
Information for Potential Students
Dr. Abdul-Aziz welcomes expressions of interest from prospective postgraduate students. Interested applicants are encouraged to contact him via email to discuss potential research opportunities. Please include an up-to-date CV and a brief research proposal outlining the project you wish to undertake. Dr. Abdul-Aziz is also open to developing projects that address research questions specific to your clinical practice, particularly those related to optimising antimicrobial dosing and delivery.
Availability
- Dr Hafiz Abdul-Aziz is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
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Antimicrobial pharmacokinetics/pharmacodynamics (PK/PD) in critically ill patients
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Antimicrobial therapeutic drug monitoring (TDM) in the intensive care unit (ICU)
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Ex-vivo pharmacokinetic ECMO and RRT model experiments
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Antimicrobial dosing in special patient population groups (e.g. critically ill, pneumonia, extracorporeal membrane oxygenation (ECMO), renal replacement therapy (RRT) patients
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Prolonged infusions of beta-lactam antibiotics in critically ill patients
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Model-informed precision antimicrobial dosing in the intensive care unit (ICU)
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Multi-centre population pharmacokinetic studies
Works
Search Professor Hafiz Abdul-Aziz’s works on UQ eSpace
2020
Journal Article
What are the current approaches to optimising antimicrobial dosing in the intensive care unit?
Chai, Ming G., Cotta, Menino O., Abdul-Aziz, Mohd H. and Roberts, Jason A. (2020). What are the current approaches to optimising antimicrobial dosing in the intensive care unit?. Pharmaceutics, 12 (7) 638, 1-22. doi: 10.3390/pharmaceutics12070638
2020
Journal Article
Pharmacokinetics of sulfamethoxazole and trimethoprim during veno-venous extracorporeal membrane oxygenation: a case report
Dhanani, Jayesh A., Lipman, Jeffrey, Pincus, Jason, Townsend, Shane, Livermore, Amelia, Wallis, Steven C., Abdul-Aziz, Mohd H. and Roberts, Jason A. (2020). Pharmacokinetics of sulfamethoxazole and trimethoprim during veno-venous extracorporeal membrane oxygenation: a case report. Pharmacotherapy, 40 (7) phar.2413, 713-717. doi: 10.1002/phar.2413
2020
Conference Publication
The DECISIVE study: defining beta-lactam concentration in intensive care unit patients – the pharmacokinetics of piperacillin and meropenem in critically ill patients with conserved renal function
Abdul-Aziz, M., Rozali, M., Othman-Jailani, M., Rahman, A. Abd, Sulaiman, H., Atiya, N., Adiraju, S., Wallis, S., Mat, W. Wan, Mazlan, M., Jamaluddin, M., Hasan, M., Mat-Nor, M. and Roberts, J. (2020). The DECISIVE study: defining beta-lactam concentration in intensive care unit patients – the pharmacokinetics of piperacillin and meropenem in critically ill patients with conserved renal function. 31st ICC - 4th GCCMID 2019, Dubai, United Arab Emirates, 6 - 9 November 2019. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jiph.2020.01.129
2019
Journal Article
Pharmacokinetics of enteric coated mycophenolate sodium in lupus nephritis (POEMSLUN)
Ranganathan, Dwarakanathan, Abdul-Aziz, Mohd H., John, George T., McWhinney, Brett C., Fassett, Robert G., Healy, Helen, Kubler, Paul, Lim, Aaron, Lipman, Jeffrey, Purvey, Megan, Roberts, Matthew, Reyaldeen, Reza, Ungerer, Jacobus and Roberts, Jason A. (2019). Pharmacokinetics of enteric coated mycophenolate sodium in lupus nephritis (POEMSLUN). Therapeutic Drug Monitoring, 41 (6), 703-713. doi: 10.1097/ftd.0000000000000658
2019
Journal Article
Antibiotic dosing during extracorporeal membrane oxygenation: does the system matter?
Abdul-Aziz, Mohd H. and Roberts, Jason A. (2019). Antibiotic dosing during extracorporeal membrane oxygenation: does the system matter?. Current Opinion in Anaesthesiology, 33 (1), 1-82. doi: 10.1097/aco.0000000000000810
2019
Journal Article
Pharmacokinetics of total and unbound cefazolin during veno-arterial extracorporeal membrane oxygenation: a case report
Dhanani, Jayesh A., Lipman, Jeffrey, Pincus, Jason, Townsend, Shane, Livermore, Amelia, Wallis, Steven C., Abdul-Aziz, Mohd H. and Roberts, Jason A. (2019). Pharmacokinetics of total and unbound cefazolin during veno-arterial extracorporeal membrane oxygenation: a case report. Chemotherapy, 64 (3), 1-4. doi: 10.1159/000502474
2019
Journal Article
Antimicrobial therapy during ECMO – customised dosing with therapeutic drug monitoring: the way to go?
Abdul-Aziz, Mohd H., Shekar, Kiran and Roberts, Jason A. (2019). Antimicrobial therapy during ECMO – customised dosing with therapeutic drug monitoring: the way to go?. Anaesthesia Critical Care and Pain Medicine, 38 (5), 451-453. doi: 10.1016/j.accpm.2019.07.005
2019
Journal Article
Implementasi Antimicrobial Stewardship Program di Kawasan Asia: Sebuah Kajian Sistematis
Setiawan, Eko, Wibowo, Yosi I., Setiadi, Adji P., Nurpatria, Yul'aini, Sosilya, Hernycane, Wardhani, Dian K., Cotta, Menino O., Abdul-Aziz, Mohd-Hafiz and Roberts, Jason (2019). Implementasi Antimicrobial Stewardship Program di Kawasan Asia: Sebuah Kajian Sistematis. Indonesian Journal of Clinical Pharmacy, 8 (2), 141-156. doi: 10.15416/ijcp.2019.8.2.141
2019
Journal Article
Narrative study on pharmacokinetics of antibiotics among critically ill patients: the implication on the pharmacokinetics-pharmacodynamics target attainment
Setiawan, Eko, Widyati, Marpaung, Ferdy Royland, Sukandar, Edy, Susaniwati, Lukas, Dwi Lily, Wijono, Heru, Warindra, Taufin, Kurniawan, Roni, Wibowo, Tjipto, Hendradi, Wahyu, Cotta, Menino Osbert, Abdul-Aziz, Mohd-Hafiz and Roberts, Jason (2019). Narrative study on pharmacokinetics of antibiotics among critically ill patients: the implication on the pharmacokinetics-pharmacodynamics target attainment. Pharmaceutical Sciences and Research, 6 (1). doi: 10.7454/psr.v6i1.4274
2019
Journal Article
Overcoming barriers to optimal drug dosing during ECMO in critically ill adult patients
Cheng, Vesa, Abdul-Aziz, Mohd H., Roberts, Jason A. and Shekar, Kiran (2019). Overcoming barriers to optimal drug dosing during ECMO in critically ill adult patients. Expert Opinion on Drug Metabolism & Toxicology, 15 (2), 103-112. doi: 10.1080/17425255.2019.1563596
2019
Book Chapter
Clinical Pharmacy Considerations in ICU
Jamal, Janattul-Ain, Abdul-Aziz, Mohd-Hafiz, Levkovich, Bianca and Roberts, Jason A. (2019). Clinical Pharmacy Considerations in ICU. Encyclopedia of Pharmacy Practice and Clinical Pharmacy. (pp. 849-865) Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-812735-3.00576-8
2019
Journal Article
Infections by multidrug-resistant gram-negative bacteria: what's new in our arsenal and what's in the pipeline?
Koulenti, Despoina, Song, Andrew, Ellingboe, Aaron, Abdul-Aziz, Mohd Hafiz, Harris, Patrick, Gavey, Emile and Lipman, Jeffrey (2019). Infections by multidrug-resistant gram-negative bacteria: what's new in our arsenal and what's in the pipeline?. International Journal of Antimicrobial Agents, 53 (3), 211-224. doi: 10.1016/j.ijantimicag.2018.10.011
2018
Journal Article
New paradigm for rapid achievement of appropriate therapy in special populations: coupling antibiotic dose optimisation rapid microbiological methods
Abdul-Aziz, Mohd H., Driver, Elicia, Lipman, Jeffrey and Roberts, Jason A. (2018). New paradigm for rapid achievement of appropriate therapy in special populations: coupling antibiotic dose optimisation rapid microbiological methods. Expert Opinion on Drug Metabolism and Toxicology, 14 (7), 1-16. doi: 10.1080/17425255.2018.1484452
2018
Journal Article
Optimising drug dosing in patients receiving extracorporeal membrane oxygenation
Cheng, Vesa, Abdul-Aziz, Mohd-Hafiz, Roberts, Jason A. and Shekar, Kiran (2018). Optimising drug dosing in patients receiving extracorporeal membrane oxygenation. Journal of Thoracic Disease, 10 (Suppl 5), S629-S641. doi: 10.21037/jtd.2017.09.154
2018
Journal Article
Prolonged Infusion Piperacillin-Tazobactam Decreases Mortality and Improves Outcomes in Severely Ill Patients: Results of a Systematic Review and Meta-Analysis
Rhodes, Nathaniel J., Liu, Jiajun, O'Donnell, J. Nicholas, Dulhunty, Joel M., Abdul-Aziz, Mohd H., Berko, Patsy Y., Nadler, Barbara, Lipman, Jeffery and Roberts, Jason A. (2018). Prolonged Infusion Piperacillin-Tazobactam Decreases Mortality and Improves Outcomes in Severely Ill Patients: Results of a Systematic Review and Meta-Analysis. Critical Care Medicine, 46 (2), 236-243. doi: 10.1097/CCM.0000000000002836
2018
Conference Publication
Does dosing of piperacillin-tazobactam in critically ill patients on ECMO need to change? A pharmacokinetics study
Cheng, V., Shekar, K., Abdul-Aziz, M.H., Buscher, H., Corley, A., Diehl, A., Gilder, E., Jarrett, P., Lye, I., McGuinness, S., Parke, R., Pellegrino, V., Reynolds, C., Wallis, S. C., Welch, S., Zacharias, D., Fraser, J. F. and Roberts, J. A. (2018). Does dosing of piperacillin-tazobactam in critically ill patients on ECMO need to change? A pharmacokinetics study. European Society of Intensive Care Medicine Annual Congress, Paris, France, 20-24 October 2018. Heidelberg, Germany: Springer.
2018
Book Chapter
Antibiotic dosing during extracorporeal membrane oxygenation
Abdul-Aziz, M. H., Shekar, Kiran and Roberts, Jason A. (2018). Antibiotic dosing during extracorporeal membrane oxygenation. Antibiotic Pharmacokinetic/Pharmacodynamic Considerations in the Critically Ill. (pp. 151-171) edited by Andrew A. Udy, Jason A. Roberts and Jeffrey Lipman. Gateway East, Singapore: Springer . doi: 10.1007/978-981-10-5336-8_8
2018
Conference Publication
Does dosing of ceftriaxone in critically ill patients on ECMO need to change? A pharmacokinetics study
Cheng, V., Shekar, K., Abdul-Aziz, M. H., Buscher, H., Corley, A., Diehl, A., Gilder, A., Jarrett, P., Lye, I., McGuinness, S., Parke, R., Pellegrino, V., Reynolds, C., Wallis, S. C., Welch, S., Zacharias, D., Fraser, J. F. and Roberts, J. A. (2018). Does dosing of ceftriaxone in critically ill patients on ECMO need to change? A pharmacokinetics study. European Society of Intensive Care Medicine Annual Congress, Paris, France, 20-24 October 2018. Heidelberg, Germany: Springer.
2017
Journal Article
Identifying "at-risk" patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections
Abdul-Aziz, Mohd H., Lipman, Jeffrey and Roberts, Jason A. (2017). Identifying "at-risk" patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections. Critical Care, 21 (1) 283, 1-3. doi: 10.1186/s13054-017-1871-2
2017
Journal Article
Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation
Sinnah, Fabrice, Shekar, Kiran, Abdul-Aziz, Mohd H, Buscher, Hergen, Diab, Sara D., Fisquet, Stephanie, Fung, Yoke L., McDonald, Charles I., Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan, Xie, Jiao, Fraser, John F., Roberts, Jason A. and ASAP ECMO investigators (2017). Incremental research approach to describing the pharmacokinetics of ciprofloxacin during extracorporeal membrane oxygenation. Critical Care and Resuscitation, 19 (Suppl 1), 8-14.
Funding
Current funding
Past funding
Supervision
Availability
- Dr Hafiz Abdul-Aziz is:
- Available for supervision
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Supervision history
Current supervision
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Master Philosophy
Determining bEta-lactam Exposure targets in Patients with deep-seated infections.
Principal Advisor
Other advisors: Dr Robert Horvath
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Doctor Philosophy
Establishing effective antibiotic and sedative dosing in paediatrics with extracorporeal therapies (including extracorporeal membrane oxygenation and renal replacement therapies)
Associate Advisor
Other advisors: Honorary Professor Luregn Schlapbach, Professor Jason Roberts
Completed supervision
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2024
Doctor Philosophy
Defining Optimal Dosing Regimens of Colistin and Polymyxin B in Malaysian Patient Populations
Associate Advisor
Other advisors: Dr Fekade Sime, Professor Jason Roberts
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2023
Doctor Philosophy
Strategies to improve the use of antimicrobials in hospitalised Indonesian patients
Associate Advisor
Other advisors: Professor Jeffrey Lipman, Professor Jason Roberts
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2021
Doctor Philosophy
Optimising antimicrobial dosing in critically ill patients on extracorporeal membrane oxygenation (ECMO)
Associate Advisor
Other advisors: Professor Kiran Shekar, Professor Jason Roberts
Media
Enquiries
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