Dr Fekade Sime
Dr

Fekade Sime

Email: 
Phone: 
+61 7 334 65023

Availability

Dr Fekade Sime is:
Available for supervision

Qualifications

  • Doctor of Philosophy, University of South Australia

Search Professor Fekade Sime’s works on UQ eSpace

95 works between 2012 and 2025
All (95) Journal Article (85) Book Chapter (3) Conference Publication (6) Other Outputs (1)

61 - 80 of 95 works

2020

Journal Article

A population pharmacokinetic model-guided evaluation of ceftolozane/tazobactam dosing in critically ill patients undergoing continuous venovenous hemodiafiltration

Sime, Fekade B., Lassig-Smith, Melissa, Starr, Therese, Stuart, Janine, Pandey, Saurabh, Parker, Suzanne L., Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2020). A population pharmacokinetic model-guided evaluation of ceftolozane/tazobactam dosing in critically ill patients undergoing continuous venovenous hemodiafiltration. Antimicrobial Agents and Chemotherapy, 64 (1) e01655. doi: 10.1128/aac.01655-19

A population pharmacokinetic model-guided evaluation of ceftolozane/tazobactam dosing in critically ill patients undergoing continuous venovenous hemodiafiltration

2019

Journal Article

Ceftolozane–tazobactam in an elastomeric infusion device for ambulatory care: an in vitro stability study

Raby, Edward, Naicker, Saiyuri, Sime, Fekade Bruck, Manning, Laurens, Wallis, Steven C., Pandey, Saurabh and Roberts, Jason A. (2019). Ceftolozane–tazobactam in an elastomeric infusion device for ambulatory care: an in vitro stability study. European Journal of Hospital Pharmacy, 27 (e1) e19002093, e84-e86. doi: 10.1136/ejhpharm-2019-002093

Ceftolozane–tazobactam in an elastomeric infusion device for ambulatory care: an in vitro stability study

2019

Journal Article

A validated LC-MSMS method for the simultaneous quantification of meropenem and vaborbactam in human plasma and renal replacement therapy effluent and its application to a pharmacokinetic study

Parker, Suzanne L., Pandey, Saurabh, Sime, Fekade B., Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2019). A validated LC-MSMS method for the simultaneous quantification of meropenem and vaborbactam in human plasma and renal replacement therapy effluent and its application to a pharmacokinetic study. Analytical and Bioanalytical Chemistry, 411 (29), 7831-7840. doi: 10.1007/s00216-019-02184-4

A validated LC-MSMS method for the simultaneous quantification of meropenem and vaborbactam in human plasma and renal replacement therapy effluent and its application to a pharmacokinetic study

2019

Other Outputs

Development of population and Bayesian models for applied use in patients receiving cefepime

Liu, Jiajun, Neely, Michael, Lipman, Jeffrey, Sime, Fekade, Roberts, Jason, Kiel, Patrick J, Avedissian, Sean N., Rhodes, Nathaniel J. and Scheetz, Marc H. (2019). Development of population and Bayesian models for applied use in patients receiving cefepime. doi: 10.1101/19009647

Development of population and Bayesian models for applied use in patients receiving cefepime

2019

Journal Article

The global prevalence of multidrug-resistance among Acinetobacter baumannii causing hospital-acquired and ventilator-associated pneumonia and its associated mortality: A systematic review and meta-analysis

Mohd Sazlly, Lim S, Zainal Abidin, A., Liew, S.M., Roberts, J.A. and Sime, FB (2019). The global prevalence of multidrug-resistance among Acinetobacter baumannii causing hospital-acquired and ventilator-associated pneumonia and its associated mortality: A systematic review and meta-analysis. Journal of Infection, 79 (6), 593-600. doi: 10.1016/j.jinf.2019.09.012

The global prevalence of multidrug-resistance among Acinetobacter baumannii causing hospital-acquired and ventilator-associated pneumonia and its associated mortality: A systematic review and meta-analysis

2019

Journal Article

Population pharmacokinetics of unbound ceftolozane and tazobactam in critically ill patients without renal dysfunction

Sime, Fekade B., Lassig-Smith, Melissa, Starr, Therese, Stuart, Janine, Pandey, Saurabh, Parker, Suzanne L., Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2019). Population pharmacokinetics of unbound ceftolozane and tazobactam in critically ill patients without renal dysfunction. Antimicrobial Agents and Chemotherapy, 63 (10) e01265-19. doi: 10.1128/aac.01265-19

Population pharmacokinetics of unbound ceftolozane and tazobactam in critically ill patients without renal dysfunction

2019

Journal Article

What antibiotic exposures are required to suppress the emergence of resistance for gram‑negative bacteria? A systematic review

Sumi, Chandra Datta, Heffernan, Aaron J., Lipman, Jeffery, Roberts, Jason A. and Sime, Fekade B. (2019). What antibiotic exposures are required to suppress the emergence of resistance for gram‑negative bacteria? A systematic review. Clinical Pharmacokinetics, 58 (11), 1407-1443. doi: 10.1007/s40262-019-00791-z

What antibiotic exposures are required to suppress the emergence of resistance for gram‑negative bacteria? A systematic review

2019

Journal Article

Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients

Sime, Fekade B., Byrn, Catherine J., Parker, Suzanne, Stuart, Janine, Butler, Jenie, Starr, Therese, Pandey, Saurabh, Wallis, Steven C., Lipman, Jeffery and Roberts, Jason A. (2019). Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients. Critical Care, 23 (1) 205, 205. doi: 10.1186/s13054-019-2483-9

Population pharmacokinetics of total and unbound concentrations of intravenous posaconazole in adult critically ill patients

2019

Journal Article

Vancomycin population pharmacokinetics for adult patients with sepsis or septic shock: are current dosing regimens sufficient?

Heffernan, A. J., Germano, A., Sime, F. B., Roberts, Jason A. and Kimura, E. (2019). Vancomycin population pharmacokinetics for adult patients with sepsis or septic shock: are current dosing regimens sufficient?. European Journal of Clinical Pharmacology, 75 (9), 1219-1226. doi: 10.1007/s00228-019-02694-1

Vancomycin population pharmacokinetics for adult patients with sepsis or septic shock: are current dosing regimens sufficient?

2019

Journal Article

Multidrug-resistant Acinetobacter baumannii infections: current evidence on treatment options and role of PK/PD in dose optimization

Lim, Sazlyna Mohd Sazlly, Sime, Fekade Bruck and Roberts, Jason (2019). Multidrug-resistant Acinetobacter baumannii infections: current evidence on treatment options and role of PK/PD in dose optimization. International Journal of Antimicrobial Agents, 53 (6), 726-745. doi: 10.1016/j.ijantimicag.2019.02.016

Multidrug-resistant Acinetobacter baumannii infections: current evidence on treatment options and role of PK/PD in dose optimization

2019

Journal Article

Intrapulmonary pharmacokinetics of antibiotics used to treat nosocomial pneumonia caused by gram-negative bacilli: a systematic review

Heffernan, Aaron J., Sime, Fekade B., Lipman, Jeffrey, Dhanani, Jayesh, Andrews, Katherine, Ellwood, David, Grimwood, Keith and Roberts, Jason A. (2019). Intrapulmonary pharmacokinetics of antibiotics used to treat nosocomial pneumonia caused by gram-negative bacilli: a systematic review. International Journal of Antimicrobial Agents, 53 (3), 234-245. doi: 10.1016/j.ijantimicag.2018.11.011

Intrapulmonary pharmacokinetics of antibiotics used to treat nosocomial pneumonia caused by gram-negative bacilli: a systematic review

2019

Journal Article

Solid nanoparticles for oral antimicrobial drug delivery: a review

Raza, Aun, Sime, Fekade Bruck, Cabot, Peter J., Maqbool, Faheem, Roberts, Jason A. and Falconer, James Robert (2019). Solid nanoparticles for oral antimicrobial drug delivery: a review. Drug Discovery Today, 24 (3), 858-866. doi: 10.1016/j.drudis.2019.01.004

Solid nanoparticles for oral antimicrobial drug delivery: a review

2018

Journal Article

How to optimize antibiotic pharmacokinetic/pharmacodynamics for Gram-negative infections in critically ill patients

Heffernan, Aaron J., Sime, Fekade B., Taccone, Fabio S. and Roberts, Jason A. (2018). How to optimize antibiotic pharmacokinetic/pharmacodynamics for Gram-negative infections in critically ill patients. Current Opinion in Infectious Diseases, 31 (6), 1-565. doi: 10.1097/QCO.0000000000000494

How to optimize antibiotic pharmacokinetic/pharmacodynamics for Gram-negative infections in critically ill patients

2018

Journal Article

A pharmacokinetic case study of intravenous posaconazole in a critically ill patient with hypoalbuminemia receiving continuous venovenous hemodiafiltration

Sime, Fekade B., Stuart, Janine, Butler, Jenie, Starr, Therese, Wallis, Steven C., Pandey, Saurabh, Lipman, Jeffrey and Roberts, Jason A. (2018). A pharmacokinetic case study of intravenous posaconazole in a critically ill patient with hypoalbuminemia receiving continuous venovenous hemodiafiltration. International Journal of Antimicrobial Agents, 52 (4), 506-509. doi: 10.1016/j.ijantimicag.2018.07.008

A pharmacokinetic case study of intravenous posaconazole in a critically ill patient with hypoalbuminemia receiving continuous venovenous hemodiafiltration

2018

Journal Article

Ex vivo characterisation of effects of renal replacement therapy modalities and settings on pharmacokinetics of meropenem and vaborbactam

Sime, Fekade B., Pandey, Saurabh, Karamujic, Nermin, Parker, Suzanne, Alexander, Elizabeth, Loutit, Jeffery, Durso, Stephanie, Griffith, David, Lipman, Jeffrey, Wallis, Steven C. and Roberts, Jason A. (2018). Ex vivo characterisation of effects of renal replacement therapy modalities and settings on pharmacokinetics of meropenem and vaborbactam. Antimicrobial Agents and Chemotherapy, 62 (10) e01306, AAC.01306-18. doi: 10.1128/AAC.01306-18

Ex vivo characterisation of effects of renal replacement therapy modalities and settings on pharmacokinetics of meropenem and vaborbactam

2018

Journal Article

Pharmacokinetics of intravenous posaconazole in critically ill patients

Sime, Fekade B., Stuart, Janine, Butler, Jenie, Starr, Therese, Wallis, Steven C., Pandey, Saurabh, Lipman, Jeffrey and Roberts, Jason A. (2018). Pharmacokinetics of intravenous posaconazole in critically ill patients. Antimicrobial Agents and Chemotherapy, 62 (6) e00242-18, e00242-18. doi: 10.1128/AAC.00242-18

Pharmacokinetics of intravenous posaconazole in critically ill patients

2018

Journal Article

Individualising therapy to minimize bacterial multidrug resistance

Heffernan, A. J., Sime, F. B., Lipman, J. and Roberts, J. A. (2018). Individualising therapy to minimize bacterial multidrug resistance. Drugs, 78 (6), 621-641. doi: 10.1007/s40265-018-0891-9

Individualising therapy to minimize bacterial multidrug resistance

2018

Journal Article

Differences in suppression of regrowth and resistance despite similar initial bacterial killing for meropenem and piperacillin/tazobactam against Pseudomonas aeruginosa and Escherichia coli

Bergen, Phillip J., Bulitta, Jürgen B., Sime, Fekade B., Lipman, Jeffrey, McGregor, Megan J., Millen, Nada, Paterson, David L., Kirkpatrick, Carl M. J., Roberts, Jason A. and Landersdorfer, Cornelia B. (2018). Differences in suppression of regrowth and resistance despite similar initial bacterial killing for meropenem and piperacillin/tazobactam against Pseudomonas aeruginosa and Escherichia coli. Diagnostic Microbiology and Infectious Disease, 91 (1), 69-76. doi: 10.1016/j.diagmicrobio.2017.12.019

Differences in suppression of regrowth and resistance despite similar initial bacterial killing for meropenem and piperacillin/tazobactam against Pseudomonas aeruginosa and Escherichia coli

2018

Book Chapter

Antibiotic pharmacodynamics

Sime, Fekade B. and Roberts, Jason A. (2018). Antibiotic pharmacodynamics. Antibiotic pharmacokinetic/pharmacodynamic considerations in the critically ill. (pp. 17-29) edited by Andrew Udy, Jason A. Roberts and Jeffrey Lipman. Singapore, Singapore: Springer Nature. doi: 10.1007/978-981-10-5336-8_2

Antibiotic pharmacodynamics

2018

Book Chapter

Appropriate antimicrobial therapy in critically ill patients

Sime, Fekade B. and Roberts, Jason A. (2018). Appropriate antimicrobial therapy in critically ill patients. Abdominal Sepsis: a multidisciplinary approach. (pp. 319-342) edited by Massimo Sartelli, Matteo Bassetti and Ignacio Martin-Loeches. Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-319-59704-1_21

Appropriate antimicrobial therapy in critically ill patients

Current funding

  • 2021 - 2025
    Optimizing outpatient parenteral antibiotic therapy to support hospital-in-the-home program across the unique environmental conditions of Australia
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2023
    Screening Antifungal Exposure in Intensive Care Units: The SAFE-ICU Study
    Gilead Australia Fellowship
    Open grant
  • 2022 - 2023
    Evaluation of the stability of ceftazidime-avibactam in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy-A regulatory compliance study in accordance with the requireme
    Pfizer Inc Global Medical Grant
    Open grant
  • 2022 - 2023
    Evaluation of the stability of Aciclovir in elastomeric infusion devices used for Outpatient Parenteral Antimicrobial Therapy in accordance with the requirement of the UK NHS Yellow Cover Document
    British Society for Antimicrobial Chemotherapy
    Open grant
  • 2021
    Evaluation of the stability of Aciclovir in elastomeric infusion devises used in Outpatient Parenteral Antimicrobial Therapy in accordance with the requirement of the UK NHS Yellow Cover Document
    British Society for Antimicrobial Chemotherapy
    Open grant
  • 2021 - 2022
    Evaluation of the stability of Amoxicillin in elastomeric infusion devices used for Outpatient Parenteral Antimicrobial Therapy in accordance with the requirement of the UK NHS Yellow Cover Document
    British Society for Antimicrobial Chemotherapy
    Open grant
  • 2019 - 2021
    Screening anti-fungal exposure in intensive care unit
    European Society of Clinical Microbiology and Infectious Diseases Study Group Research Grant
    Open grant
  • 2019
    Preventing bacterial biofilm formation in dialysis and advanced oxygenation therapy machines through optimized dosing of antibiotics
    UQ Early Career Researcher
    Open grant
  • 2016 - 2019
    A translational approach to optimisation of antimicrobial therapy for critically ill patients that prevents the emergence of 'superbugs'
    UQ Fellowships
    Open grant

Availability

Dr Fekade Sime is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    In vitro evaluation of the impact of different durations of exposure of fast-acting antimicrobials in combination with beta-lactams

    Principal Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Optimising the stability and dosing regimens of antibiotics for outpatient parenteral antibiotic therapy

    Principal Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Centre of Research Excellence - REduce the burden of antimicrobial reSistance through oPtimal, persONalised Dosing (RESPOND)

    Principal Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Optimisation of antibiotic regimens for the treatment of resistant infections using dynamic in vitro infections models

    Principal Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Barriers and facilitators of the implementation and expansion of outpatient parenteral antimicrobial therapy program

    Principal Advisor

  • Doctor Philosophy

    Optimisation of antibiotic regimens for the treatment of resistant infections using dynamic in vitro infections models

    Principal Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Centre of Research Excellence - REduce the burden of antimicrobial reSistance through oPtimal, persONalised Dosing (RESPOND)

    Associate Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Stability of cephalosporin/b-lactam with b-lactamase inhibitor combinations for use in OPAT and simulation of OPAT-like drug exposures in a Biofilm model to assess the effect on MDR isolates.

    Associate Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Suitability of ß-lactam and ß-lactamase inhibitor combinations for use in outpatient parenteral antimicrobial therapy

    Associate Advisor

    Other advisors: Professor Jason Roberts

Completed supervision

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