Overview
Availability
- Dr Fekade Sime is:
- Available for supervision
Qualifications
- Doctor of Philosophy, University of South Australia
Works
Search Professor Fekade Sime’s works on UQ eSpace
2021
Journal Article
Microfluidic assembly of pomegranate-like hierarchical microspheres for efflux regulation in oral drug delivery
Raza, Aun, Alavi, Seyed Ebrahim, Sime, Fekade Bruck, Han, Felicity Y., Roberts, Jason A., Popat, Amirali, Falconer, James R. and Kumeria, Tushar (2021). Microfluidic assembly of pomegranate-like hierarchical microspheres for efflux regulation in oral drug delivery. Acta Biomaterialia, 126, 277-290. doi: 10.1016/j.actbio.2021.03.042
2021
Journal Article
Semi-mechanistic PK/PD modelling of meropenem and sulbactam combination against carbapenem-resistant strains of Acinetobacter baumannii
Mohd Sazlly Lim, Sazlyna, Heffernan, Aaron J., Zowawi, Hosam M., Roberts, Jason A. and Sime, Fekade B. (2021). Semi-mechanistic PK/PD modelling of meropenem and sulbactam combination against carbapenem-resistant strains of Acinetobacter baumannii. European Journal of Clinical Microbiology and Infectious Diseases, 40 (9), 1943-1952. doi: 10.1007/s10096-021-04252-z
2021
Journal Article
Semi-mechanistic PK/PD modelling of fosfomycin and sulbactam combination against carbapenem-resistant Acinetobacter baumannii
Mohd Sazlly Lim, S., Heffernan, A.J., Roberts, J.A. and Sime, F.B. (2021). Semi-mechanistic PK/PD modelling of fosfomycin and sulbactam combination against carbapenem-resistant Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 65 (5) e02472-20. doi: 10.1128/aac.02472-20
2021
Journal Article
Impact of the epithelial lining fluid milieu on amikacin pharmacodynamics against Pseudomonas aeruginosa
Heffernan, Aaron J., Sime, Fekade B., Lim, Sazlyna Mohd Sazlly, Naicker, Saiyuri, Andrews, Katherine T., Ellwood, David, Lipman, Jeffrey, Grimwood, Keith and Roberts, Jason A. (2021). Impact of the epithelial lining fluid milieu on amikacin pharmacodynamics against Pseudomonas aeruginosa. Drugs in R&D, 21 (2), 203-215. doi: 10.1007/s40268-021-00344-5
2021
Journal Article
PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery
Raza, Aun, Miles, Jared A., Bruck Sime, Fekade, Ross, Benjamin P., Roberts, Jason A., Popat, Amirali, Kumeria, Tushar and Falconer, James R. (2021). PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery. International Journal of Pharmaceutics, 597 120280, 120280. doi: 10.1016/j.ijpharm.2021.120280
2021
Journal Article
Pharmacodynamics of once- versus twice-daily dosing of nebulized amikacin in an in vitro Hollow-Fiber Infection Model against 3 clinical isolates of Pseudomonas aeruginosa
Heffernan, Aaron James, Sime, Fekade Bruck, Naicker, Saiyuri, Andrews, Katherine, Ellwood, David, Guerra-Valero, Yarmarly, Wallis, Steven, Lipman, Jeffrey, Grimwood, Keith and Roberts, Jason Alexander (2021). Pharmacodynamics of once- versus twice-daily dosing of nebulized amikacin in an in vitro Hollow-Fiber Infection Model against 3 clinical isolates of Pseudomonas aeruginosa. Diagnostic microbiology and infectious disease, 100 (2) 115329, 115329. doi: 10.1016/j.diagmicrobio.2021.115329
2021
Journal Article
Population pharmacokinetics of levetiracetam in patients with traumatic brain injury and subarachnoid hemorrhage exhibiting augmented renal clearance
Sime, Fekade Bruck, Roberts, Jason A., Jeffree, Rosalind L., Pandey, Saurabh, Adiraju, Santosh, Livermore, Amelia, Butler, Jenie, Parker, Suzanne L., Wallis, Steven C., Lipman, Jeffrey and Cotta, Menino Osbert (2021). Population pharmacokinetics of levetiracetam in patients with traumatic brain injury and subarachnoid hemorrhage exhibiting augmented renal clearance. Clinical Pharmacokinetics, 60 (5), 655-664. doi: 10.1007/s40262-020-00979-8
2021
Journal Article
Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem
Raza, Aun, Sime, Fekade Bruck, Cabot, Peter J., Roberts, Jason A., Falconer, James R., Kumeria, Tushar and Popat, Amirali (2021). Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem. ACS Biomaterials Science and Engineering, 7 (5) acsbiomaterials.0c01284, 1836-1853. doi: 10.1021/acsbiomaterials.0c01284
2021
Book Chapter
PK/PD and the drug delivery regimen for infusion in the critical care setting
Sime, Fekade B. and Roberts, Jason A. (2021). PK/PD and the drug delivery regimen for infusion in the critical care setting. Drug delivery approaches: perspectives from pharmacokinetics and pharmacodynamics. (pp. 355-374) edited by Bret Berner, Toufigh Gordi, Heather A. E. Benson and Michael S.Roberts. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/9781119772767.ch10
2020
Journal Article
Cerebrospinal fluid penetration of ceftolozane/tazobactam in critically ill patients with an indwelling external ventricular drain
Sime, Fekade B, Lassig-Smith, Melissa, Starr, Therese, Stuart, Janine, Pandey, Saurabh, Parker, Suzanne L., Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2020). Cerebrospinal fluid penetration of ceftolozane/tazobactam in critically ill patients with an indwelling external ventricular drain. Antimicrobial Agents and Chemotherapy, 65 (1) e01698-20, 1-11. doi: 10.1128/aac.01698-20
2020
Journal Article
A validated LC-MS/MS method for the simultaneous quantification of the novel combination antibiotic, ceftolozane–tazobactam, in plasma (total and unbound), CSF, urine and renal replacement therapy effluent: application to pilot pharmacokinetic studies
Parker, Suzanne L., Pandey, Saurabh, Sime, Fekade B., Stuart, Janine, Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2020). A validated LC-MS/MS method for the simultaneous quantification of the novel combination antibiotic, ceftolozane–tazobactam, in plasma (total and unbound), CSF, urine and renal replacement therapy effluent: application to pilot pharmacokinetic studies. Clinical Chemistry and Laboratory Medicine (CCLM), 59 (5), 921-933. doi: 10.1515/cclm-2020-1196
2020
Journal Article
Oral meropenem for superbugs: challenges and opportunities
Raza, Aun, Ngieng, Shih Chen, Sime, Fekade Bruck, Cabot, Peter J., Roberts, Jason A., Popat, Amirali, Kumeria, Tushar and Falconer, James R. (2020). Oral meropenem for superbugs: challenges and opportunities. Drug Discovery Today, 26 (2), 551-560. doi: 10.1016/j.drudis.2020.11.004
2020
Journal Article
Ceftriaxone dosing in patients admitted from the emergency department with sepsis
Heffernan, Aaron J., Curran, Rebecca A., Denny, Kerina J., Sime, Fekade B., Stanford, Claire L., McWhinney, Brett, Ungerer, Jacobus, Roberts, Jason A. and Lipman, Jeffrey (2020). Ceftriaxone dosing in patients admitted from the emergency department with sepsis. European Journal of Clinical Pharmacology, 77 (2), 207-214. doi: 10.1007/s00228-020-03001-z
2020
Journal Article
Pharmacodynamic Analysis of Meropenem and Fosfomycin Combination Against Carbapenem-Resistant in Patients with Normal Renal Clearance: Can It Be a Treatment Option?
Mohd Sazlly Lim, Sazlyna, Heffernan, Aaron J., Roberts, Jason A. and Sime, Fekade B. (2020). Pharmacodynamic Analysis of Meropenem and Fosfomycin Combination Against Carbapenem-Resistant in Patients with Normal Renal Clearance: Can It Be a Treatment Option?. Microbial drug resistance (Larchmont, N.Y.), 27 (4) mdr.2020.0197, 546-552. doi: 10.1089/mdr.2020.0197
2020
Journal Article
Challenges in antifungal therapy in diabetes mellitus
Mohd Sazlly Lim, Sazlyna, Sinnollareddy, Mahipal and Sime, Fekade Bruck (2020). Challenges in antifungal therapy in diabetes mellitus. Journal of Clinical Medicine, 9 (9) 2878, 2878-9. doi: 10.3390/jcm9092878
2020
Journal Article
Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae
Sumi, Chandra Datta, Heffernan, Aaron J., Naicker, Saiyuri, Islam, Kamrul, Cottrell, Kyra, Wallis, Steven C., Lipman, Jeffrey, Harris, Patrick N. A., Sime, Fekade B. and Roberts, Jason A. (2020). Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae. Journal of Antimicrobial Chemotherapy, 75 (9), 2633-2640. doi: 10.1093/jac/dkaa211
2020
Journal Article
What are the predictors for achieving therapeutic levetiracetam serum concentrations in adult neurological patients?
Cotta, Menino Osbert, Abdul-Aziz, Mohd Hafiz, Frey, Otto R., Sime, Fekade Bruck, Roberts, Jason A. and Roehr, Anka C. (2020). What are the predictors for achieving therapeutic levetiracetam serum concentrations in adult neurological patients?. Therapeutic Drug Monitoring, 42 (4), 626-630. doi: 10.1097/ftd.0000000000000731
2020
Journal Article
Pharmacodynamic evaluation of plasma and epithelial lining fluid exposures of amikacin against in a dynamic hollow-fibre infection model
Heffernan, Aaron J., Sime, Fekade B., Sarovich, Derek S., Neely, Michael, Guerra-Valero, Yarmarly, Naicker, Saiyuri, Cottrell, Kyra, Harris, Patrick, Andrews, Katherine T., Ellwood, David, Wallis, Steven C., Lipman, Jeffrey, Grimwood, Keith and Roberts, Jason A. (2020). Pharmacodynamic evaluation of plasma and epithelial lining fluid exposures of amikacin against in a dynamic hollow-fibre infection model. Antimicrobial Agents and Chemotherapy, 64 (9) e00879-20. doi: 10.1128/aac.00879-20
2020
Journal Article
Non-polymyxin based combinations as potential alternatives in treatment against carbapenem-resistant Acinetobacter baumannii infections
Mohd Sazlly Lim, S., Naicker, S., Ayfan, A. K., Zowawi, H., Roberts, J. A. and Sime, F. B. (2020). Non-polymyxin based combinations as potential alternatives in treatment against carbapenem-resistant Acinetobacter baumannii infections. International Journal of Antimicrobial Agents, 56 (4) 106115, 106115. doi: 10.1016/j.ijantimicag.2020.106115
2020
Journal Article
Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime
Liu, Jiajun, Neely, Michael, Lipman, Jeffrey, Sime, Fekade, Roberts, Jason A., Kiel, Patrick J., Avedissian, Sean N., Rhodes, Nathaniel J. and Scheetz, Marc H. (2020). Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime. Clinical Pharmacokinetics, 59 (8), 1027-1036. doi: 10.1007/s40262-020-00873-3
Funding
Current funding
Supervision
Availability
- Dr Fekade Sime is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Supervision history
Current supervision
-
Doctor Philosophy
Optimising infusion regimens for outpatient parenteral antimicrobial therapy
Principal Advisor
Other advisors: Professor Jason Roberts
-
Doctor Philosophy
Pharmacodynamic evaluation of the effect of aminoglycoside antimicrobial duration of therapy in ß-lactam/aminoglycoside combination regimens against Pseudomonas aeruginosa
Principal Advisor
Other advisors: Professor Jason Roberts
-
Doctor Philosophy
In vitro evaluation of the impact of different durations of exposure of fast-acting antimicrobials in combination with beta-lactams
Principal Advisor
Other advisors: Professor Jason Roberts
-
Doctor Philosophy
Barriers and facilitators of the implementation and expansion of outpatient parenteral antimicrobial therapy program
Principal Advisor
Other advisors: Dr Kate McCarthy
Completed supervision
-
2026
Doctor Philosophy
Pharmacodynamics of intermittent versus prolonged infusion of beta-lactam antibiotics in the treatment of Gram-negative bacterial pneumonia
Principal Advisor
Other advisors: Professor Jason Roberts
-
2026
Doctor Philosophy
Evaluation of combination antibiotic regimens as carbapenem-sparing alternatives for ceftazidime/avibactam-resistant Enterobacterales infections
Principal Advisor
Other advisors: Professor Jason Roberts
-
2025
Doctor Philosophy
Suitability of ß-lactam and ß-lactamase inhibitor combinations for use in outpatient parenteral antimicrobial therapy
Associate Advisor
Other advisors: Professor Jason Roberts
-
2024
Doctor Philosophy
Defining Optimal Dosing Regimens of Colistin and Polymyxin B in Malaysian Patient Populations
Associate Advisor
Other advisors: Dr Hafiz Abdul-Aziz, Professor Jason Roberts
-
2022
Doctor Philosophy
Evaluation of combination antibiotic regimens for the treatment of multidrug-resistant Acinetobacter baumannii infections
Associate Advisor
Other advisors: Professor Jason Roberts
-
2022
Doctor Philosophy
Microbiological evaluation of piperacillin/tazobactam versus meropenem against extended-spectrum ß-lactamase-producing Escherichia coli
Associate Advisor
Other advisors: Professor Jason Roberts
-
2021
Doctor Philosophy
Advanced Oral Antibiotic Formulations
Associate Advisor
Other advisors: Professor Jason Roberts, Professor Peter Cabot, Professor Amirali Popat, Dr James Robert Falconer
-
2020
Doctor Philosophy
Optimisation of alternative antibiotic dosing regimens for maximal antibacterial activity and suppression of emergence of resistance
Associate Advisor
Other advisors: Professor Jason Roberts
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