Dr Fekade Sime
Dr

Fekade Sime

Email: 
Phone: 
+61 7 334 65023

Availability

Dr Fekade Sime is:
Available for supervision

Qualifications

  • Doctor of Philosophy, University of South Australia

Search Professor Fekade Sime’s works on UQ eSpace

95 works between 2012 and 2025
All (95) Journal Article (85) Book Chapter (3) Conference Publication (6) Other Outputs (1)

41 - 60 of 95 works

2021

Journal Article

Semi-mechanistic PK/PD modelling of fosfomycin and sulbactam combination against carbapenem-resistant Acinetobacter baumannii

Mohd Sazlly Lim, S., Heffernan, A.J., Roberts, J.A. and Sime, F.B. (2021). Semi-mechanistic PK/PD modelling of fosfomycin and sulbactam combination against carbapenem-resistant Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 65 (5) e02472-20. doi: 10.1128/aac.02472-20

Semi-mechanistic PK/PD modelling of fosfomycin and sulbactam combination against carbapenem-resistant Acinetobacter baumannii

2021

Journal Article

Impact of the epithelial lining fluid milieu on amikacin pharmacodynamics against Pseudomonas aeruginosa

Heffernan, Aaron J., Sime, Fekade B., Lim, Sazlyna Mohd Sazlly, Naicker, Saiyuri, Andrews, Katherine T., Ellwood, David, Lipman, Jeffrey, Grimwood, Keith and Roberts, Jason A. (2021). Impact of the epithelial lining fluid milieu on amikacin pharmacodynamics against Pseudomonas aeruginosa. Drugs in R&D, 21 (2), 203-215. doi: 10.1007/s40268-021-00344-5

Impact of the epithelial lining fluid milieu on amikacin pharmacodynamics against Pseudomonas aeruginosa

2021

Journal Article

PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery

Raza, Aun, Miles, Jared A., Bruck Sime, Fekade, Ross, Benjamin P., Roberts, Jason A., Popat, Amirali, Kumeria, Tushar and Falconer, James R. (2021). PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery. International Journal of Pharmaceutics, 597 120280, 120280. doi: 10.1016/j.ijpharm.2021.120280

PLGA encapsulated γ-cyclodextrin-meropenem inclusion complex formulation for oral delivery

2021

Journal Article

Pharmacodynamics of once- versus twice-daily dosing of nebulized amikacin in an in vitro Hollow-Fiber Infection Model against 3 clinical isolates of Pseudomonas aeruginosa

Heffernan, Aaron James, Sime, Fekade Bruck, Naicker, Saiyuri, Andrews, Katherine, Ellwood, David, Guerra-Valero, Yarmarly, Wallis, Steven, Lipman, Jeffrey, Grimwood, Keith and Roberts, Jason Alexander (2021). Pharmacodynamics of once- versus twice-daily dosing of nebulized amikacin in an in vitro Hollow-Fiber Infection Model against 3 clinical isolates of Pseudomonas aeruginosa. Diagnostic microbiology and infectious disease, 100 (2) 115329, 115329. doi: 10.1016/j.diagmicrobio.2021.115329

Pharmacodynamics of once- versus twice-daily dosing of nebulized amikacin in an in vitro Hollow-Fiber Infection Model against 3 clinical isolates of Pseudomonas aeruginosa

2021

Journal Article

Population pharmacokinetics of levetiracetam in patients with traumatic brain injury and subarachnoid hemorrhage exhibiting augmented renal clearance

Sime, Fekade Bruck, Roberts, Jason A., Jeffree, Rosalind L., Pandey, Saurabh, Adiraju, Santosh, Livermore, Amelia, Butler, Jenie, Parker, Suzanne L., Wallis, Steven C., Lipman, Jeffrey and Cotta, Menino Osbert (2021). Population pharmacokinetics of levetiracetam in patients with traumatic brain injury and subarachnoid hemorrhage exhibiting augmented renal clearance. Clinical Pharmacokinetics, 60 (5), 655-664. doi: 10.1007/s40262-020-00979-8

Population pharmacokinetics of levetiracetam in patients with traumatic brain injury and subarachnoid hemorrhage exhibiting augmented renal clearance

2021

Journal Article

Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem

Raza, Aun, Sime, Fekade Bruck, Cabot, Peter J., Roberts, Jason A., Falconer, James R., Kumeria, Tushar and Popat, Amirali (2021). Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem. ACS Biomaterials Science and Engineering, 7 (5) acsbiomaterials.0c01284, 1836-1853. doi: 10.1021/acsbiomaterials.0c01284

Liquid CO2 formulated mesoporous silica nanoparticles for pH-responsive oral delivery of meropenem

2021

Book Chapter

PK/PD and the drug delivery regimen for infusion in the critical care setting

Sime, Fekade B. and Roberts, Jason A. (2021). PK/PD and the drug delivery regimen for infusion in the critical care setting. Drug delivery approaches: perspectives from pharmacokinetics and pharmacodynamics. (pp. 355-374) edited by Bret Berner, Toufigh Gordi, Heather A. E. Benson and Michael S.Roberts. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/9781119772767.ch10

PK/PD and the drug delivery regimen for infusion in the critical care setting

2020

Journal Article

Cerebrospinal fluid penetration of ceftolozane/tazobactam in critically ill patients with an indwelling external ventricular drain

Sime, Fekade B, Lassig-Smith, Melissa, Starr, Therese, Stuart, Janine, Pandey, Saurabh, Parker, Suzanne L., Wallis, Steven C., Lipman, Jeffrey and Roberts, Jason A. (2020). Cerebrospinal fluid penetration of ceftolozane/tazobactam in critically ill patients with an indwelling external ventricular drain. Antimicrobial Agents and Chemotherapy, 65 (1) e01698-20, 1-11. doi: 10.1128/aac.01698-20

Cerebrospinal fluid penetration of ceftolozane/tazobactam in critically ill patients with an indwelling external ventricular drain

2020

Journal Article

A validated LC-MS/MS method for the simultaneous quantification of the novel combination antibiotic, ceftolozane–tazobactam, in plasma (total and unbound), CSF, urine and renal replacement therapy effluent: application to pilot pharmacokinetic studies

Parker, Suzanne L., Pandey, Saurabh, Sime, Fekade B., Stuart, Janine, Lipman, Jeffrey, Roberts, Jason A. and Wallis, Steven C. (2020). A validated LC-MS/MS method for the simultaneous quantification of the novel combination antibiotic, ceftolozane–tazobactam, in plasma (total and unbound), CSF, urine and renal replacement therapy effluent: application to pilot pharmacokinetic studies. Clinical Chemistry and Laboratory Medicine (CCLM), 59 (5), 921-933. doi: 10.1515/cclm-2020-1196

A validated LC-MS/MS method for the simultaneous quantification of the novel combination antibiotic, ceftolozane–tazobactam, in plasma (total and unbound), CSF, urine and renal replacement therapy effluent: application to pilot pharmacokinetic studies

2020

Journal Article

Oral meropenem for superbugs: challenges and opportunities

Raza, Aun, Ngieng, Shih Chen, Sime, Fekade Bruck, Cabot, Peter J., Roberts, Jason A., Popat, Amirali, Kumeria, Tushar and Falconer, James R. (2020). Oral meropenem for superbugs: challenges and opportunities. Drug Discovery Today, 26 (2), 551-560. doi: 10.1016/j.drudis.2020.11.004

Oral meropenem for superbugs: challenges and opportunities

2020

Journal Article

Ceftriaxone dosing in patients admitted from the emergency department with sepsis

Heffernan, Aaron J., Curran, Rebecca A., Denny, Kerina J., Sime, Fekade B., Stanford, Claire L., McWhinney, Brett, Ungerer, Jacobus, Roberts, Jason A. and Lipman, Jeffrey (2020). Ceftriaxone dosing in patients admitted from the emergency department with sepsis. European Journal of Clinical Pharmacology, 77 (2), 207-214. doi: 10.1007/s00228-020-03001-z

Ceftriaxone dosing in patients admitted from the emergency department with sepsis

2020

Journal Article

Pharmacodynamic Analysis of Meropenem and Fosfomycin Combination Against Carbapenem-Resistant in Patients with Normal Renal Clearance: Can It Be a Treatment Option?

Mohd Sazlly Lim, Sazlyna, Heffernan, Aaron J., Roberts, Jason A. and Sime, Fekade B. (2020). Pharmacodynamic Analysis of Meropenem and Fosfomycin Combination Against Carbapenem-Resistant in Patients with Normal Renal Clearance: Can It Be a Treatment Option?. Microbial drug resistance (Larchmont, N.Y.), 27 (4) mdr.2020.0197, 546-552. doi: 10.1089/mdr.2020.0197

Pharmacodynamic Analysis of Meropenem and Fosfomycin Combination Against Carbapenem-Resistant in Patients with Normal Renal Clearance: Can It Be a Treatment Option?

2020

Journal Article

Challenges in antifungal therapy in diabetes mellitus

Mohd Sazlly Lim, Sazlyna, Sinnollareddy, Mahipal and Sime, Fekade Bruck (2020). Challenges in antifungal therapy in diabetes mellitus. Journal of Clinical Medicine, 9 (9) 2878, 2878-9. doi: 10.3390/jcm9092878

Challenges in antifungal therapy in diabetes mellitus

2020

Journal Article

Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae

Sumi, Chandra Datta, Heffernan, Aaron J., Naicker, Saiyuri, Islam, Kamrul, Cottrell, Kyra, Wallis, Steven C., Lipman, Jeffrey, Harris, Patrick N. A., Sime, Fekade B. and Roberts, Jason A. (2020). Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae. Journal of Antimicrobial Chemotherapy, 75 (9), 2633-2640. doi: 10.1093/jac/dkaa211

Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae

2020

Journal Article

What are the predictors for achieving therapeutic levetiracetam serum concentrations in adult neurological patients?

Cotta, Menino Osbert, Abdul-Aziz, Mohd Hafiz, Frey, Otto R., Sime, Fekade Bruck, Roberts, Jason A. and Roehr, Anka C. (2020). What are the predictors for achieving therapeutic levetiracetam serum concentrations in adult neurological patients?. Therapeutic Drug Monitoring, 42 (4), 626-630. doi: 10.1097/ftd.0000000000000731

What are the predictors for achieving therapeutic levetiracetam serum concentrations in adult neurological patients?

2020

Journal Article

Pharmacodynamic evaluation of plasma and epithelial lining fluid exposures of amikacin against in a dynamic hollow-fibre infection model

Heffernan, Aaron J., Sime, Fekade B., Sarovich, Derek S., Neely, Michael, Guerra-Valero, Yarmarly, Naicker, Saiyuri, Cottrell, Kyra, Harris, Patrick, Andrews, Katherine T., Ellwood, David, Wallis, Steven C., Lipman, Jeffrey, Grimwood, Keith and Roberts, Jason A. (2020). Pharmacodynamic evaluation of plasma and epithelial lining fluid exposures of amikacin against in a dynamic hollow-fibre infection model. Antimicrobial Agents and Chemotherapy, 64 (9) e00879-20. doi: 10.1128/aac.00879-20

Pharmacodynamic evaluation of plasma and epithelial lining fluid exposures of amikacin against in a dynamic hollow-fibre infection model

2020

Journal Article

Non-polymyxin based combinations as potential alternatives in treatment against carbapenem-resistant Acinetobacter baumannii infections

Mohd Sazlly Lim, S., Naicker, S., Ayfan, A. K., Zowawi, H., Roberts, J. A. and Sime, F. B. (2020). Non-polymyxin based combinations as potential alternatives in treatment against carbapenem-resistant Acinetobacter baumannii infections. International Journal of Antimicrobial Agents, 56 (4) 106115, 106115. doi: 10.1016/j.ijantimicag.2020.106115

Non-polymyxin based combinations as potential alternatives in treatment against carbapenem-resistant Acinetobacter baumannii infections

2020

Journal Article

Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime

Liu, Jiajun, Neely, Michael, Lipman, Jeffrey, Sime, Fekade, Roberts, Jason A., Kiel, Patrick J., Avedissian, Sean N., Rhodes, Nathaniel J. and Scheetz, Marc H. (2020). Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime. Clinical Pharmacokinetics, 59 (8), 1027-1036. doi: 10.1007/s40262-020-00873-3

Development of Population and Bayesian Models for Applied Use in Patients Receiving Cefepime

2020

Journal Article

β-lactam antibiotic versus combined β-lactam antibiotic and single-daily dosing regimens of aminoglycosides for the treatment of serious infections: a meta-analysis

Heffernan, Aaron James, Sime, Fekade Bruck, Sun, Jing, Lipman, Jeffrey, Kumar, Anand, Andrews, Katherine, Ellwood, David, Grimwood, Keith and Roberts, Jason (2020). β-lactam antibiotic versus combined β-lactam antibiotic and single-daily dosing regimens of aminoglycosides for the treatment of serious infections: a meta-analysis. International Journal of Antimicrobial Agents, 55 (3) 105839, 105839. doi: 10.1016/j.ijantimicag.2019.10.020

β-lactam antibiotic versus combined β-lactam antibiotic and single-daily dosing regimens of aminoglycosides for the treatment of serious infections: a meta-analysis

2020

Conference Publication

Pharmacodynamic evaluation of intermittent versus prolonged infusion dosing regimens of piperacillin/tazobactam in a hollow-fiber infection model against two susceptible Klebsiella pneumoniae clinical isolates

Sumi, Chandra Datta, B.Sime, Fekade, Heffernan, Aaron J., Naicker, Saiyuri, Islam, Kamrul, Cottrell, Kyra, Harris, Patrick N.A. and Roberts, Jason A. (2020). Pharmacodynamic evaluation of intermittent versus prolonged infusion dosing regimens of piperacillin/tazobactam in a hollow-fiber infection model against two susceptible Klebsiella pneumoniae clinical isolates. Federation of Infection Societies Conference 2019, Edinburgh, United Kingdom, 11-14 November 2019. London, United Kingdom: The Microbiology Society. doi: 10.1099/acmi.fis2019.po0103

Pharmacodynamic evaluation of intermittent versus prolonged infusion dosing regimens of piperacillin/tazobactam in a hollow-fiber infection model against two susceptible Klebsiella pneumoniae clinical isolates

Current funding

  • 2021 - 2025
    Optimizing outpatient parenteral antibiotic therapy to support hospital-in-the-home program across the unique environmental conditions of Australia
    NHMRC Investigator Grants
    Open grant

Past funding

  • 2023
    Screening Antifungal Exposure in Intensive Care Units: The SAFE-ICU Study
    Gilead Australia Fellowship
    Open grant
  • 2022 - 2023
    Evaluation of the stability of ceftazidime-avibactam in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy-A regulatory compliance study in accordance with the requireme
    Pfizer Inc Global Medical Grant
    Open grant
  • 2022 - 2023
    Evaluation of the stability of Aciclovir in elastomeric infusion devices used for Outpatient Parenteral Antimicrobial Therapy in accordance with the requirement of the UK NHS Yellow Cover Document
    British Society for Antimicrobial Chemotherapy
    Open grant
  • 2021
    Evaluation of the stability of Aciclovir in elastomeric infusion devises used in Outpatient Parenteral Antimicrobial Therapy in accordance with the requirement of the UK NHS Yellow Cover Document
    British Society for Antimicrobial Chemotherapy
    Open grant
  • 2021 - 2022
    Evaluation of the stability of Amoxicillin in elastomeric infusion devices used for Outpatient Parenteral Antimicrobial Therapy in accordance with the requirement of the UK NHS Yellow Cover Document
    British Society for Antimicrobial Chemotherapy
    Open grant
  • 2019 - 2021
    Screening anti-fungal exposure in intensive care unit
    European Society of Clinical Microbiology and Infectious Diseases Study Group Research Grant
    Open grant
  • 2019
    Preventing bacterial biofilm formation in dialysis and advanced oxygenation therapy machines through optimized dosing of antibiotics
    UQ Early Career Researcher
    Open grant
  • 2016 - 2019
    A translational approach to optimisation of antimicrobial therapy for critically ill patients that prevents the emergence of 'superbugs'
    UQ Fellowships
    Open grant

Availability

Dr Fekade Sime is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Optimising the stability and dosing regimens of antibiotics for outpatient parenteral antibiotic therapy

    Principal Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Centre of Research Excellence - REduce the burden of antimicrobial reSistance through oPtimal, persONalised Dosing (RESPOND)

    Principal Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Optimisation of antibiotic regimens for the treatment of resistant infections using dynamic in vitro infections models

    Principal Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Barriers and facilitators of the implementation and expansion of outpatient parenteral antimicrobial therapy program

    Principal Advisor

  • Doctor Philosophy

    Optimisation of antibiotic regimens for the treatment of resistant infections using dynamic in vitro infections models

    Principal Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    In vitro evaluation of the impact of different durations of exposure of fast-acting antimicrobials in combination with beta-lactams

    Principal Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Suitability of ß-lactam and ß-lactamase inhibitor combinations for use in outpatient parenteral antimicrobial therapy

    Associate Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Centre of Research Excellence - REduce the burden of antimicrobial reSistance through oPtimal, persONalised Dosing (RESPOND)

    Associate Advisor

    Other advisors: Professor Jason Roberts

  • Doctor Philosophy

    Stability of cephalosporin/b-lactam with b-lactamase inhibitor combinations for use in OPAT and simulation of OPAT-like drug exposures in a Biofilm model to assess the effect on MDR isolates.

    Associate Advisor

    Other advisors: Professor Jason Roberts

Completed supervision

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