Professor Peter Cabot
Professor

Peter Cabot

Email: 
Phone: 
+61 7 334 61854

Background

Peter Cabot is the Professor and Head of School in the School of Pharmacy. He joined the School staff in this position in 1999 after completing postdoctoral positions at Johns Hopkins University, Baltimore USA, The NIH, Baltimore USA and within the School of Pharmacy at UQ.

The primary focus of my research is on the elucidation of the peripheral mechanisms involved in analgesia associated with inflammation. Key discoveries were made in this field that highlighted the importance of the immune system in inflammatory pain. The results of which were published in the notable journals; JBC, PAIN, Nature Medicine and The Journal of Clinical Investigation.

Availability

Professor Peter Cabot is:
Available for supervision
Media expert

Fields of research

Clinical sciences Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor of Applied Science, Charles Sturt University
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Opioids in inflammation

    In the area I work as a translational scientist, exploring drug discovery of novel opioids and inflammatory mechanisms as well as developing new alternatives, paring this with translational work into preclinical and clinical studies looking for better outcomes for patients.

  • Biotransformation of Opioids in Disease

  • Pain in Inflammatory Diseases

  • Natural Products Drug Discovery

Research impacts

Our current research is focussed on novel opioid ligands that target opioid receptors aligned with less addictive properties, bioactivity of endogenous and natural products that may provide insights into better pain therapy or reduction in inflammatory disorders such as sinusitis.

Search Professor Peter Cabot’s works on UQ eSpace

161 works between 1992 and 2024
All (161) Journal Article (92) Other Outputs (5) Conference Publication (63) Book Chapter (1)

41 - 60 of 161 works

2017

Journal Article

Inhibitory effects of dynorphin 3-14 on the lipopolysaccharide-induced toll-like receptor 4 signalling pathway

Rahiman, Siti Sarah Fazalul, Morgan, Michael, Gray, Paul, Shaw, Paul Nicholas and Cabot, Peter John (2017). Inhibitory effects of dynorphin 3-14 on the lipopolysaccharide-induced toll-like receptor 4 signalling pathway. Peptides, 90, 48-54. doi: 10.1016/j.peptides.2017.02.004

Inhibitory effects of dynorphin 3-14 on the lipopolysaccharide-induced toll-like receptor 4 signalling pathway

2017

Journal Article

Bifunctional succinylated ε-polylysine-coated mesoporous silica nanoparticles for pH-responsive and intracellular drug delivery targeting the colon

Nguyen, Chau T. H., Webb, Richard I., Lambert, Lynette K., Strounina, Ekaterina, Lee, Edward C., Parat, Marie-Odile, McGuckin, Michael A., Popat, Amirali, Cabot, Peter J. and Ross, Benjamin P. (2017). Bifunctional succinylated ε-polylysine-coated mesoporous silica nanoparticles for pH-responsive and intracellular drug delivery targeting the colon. ACS Applied Materials and Interfaces, 9 (11), 9470-9483. doi: 10.1021/acsami.7b00411

Bifunctional succinylated ε-polylysine-coated mesoporous silica nanoparticles for pH-responsive and intracellular drug delivery targeting the colon

2017

Journal Article

The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation

Morgan, M., Heffernan, A., Benhabib, F., Wagner, S., Hewavitharana, A. K., Shaw, P. N. and Cabot, P. J. (2017). The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation. Peptides, 89, 9-16. doi: 10.1016/j.peptides.2016.12.019

The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation

2017

Journal Article

Formulation, functional evaluation and ex vivo performance of thermoresponsive soluble gels - a platform for therapeutic delivery to mucosal sinus tissue

Pandey, Preeti, Cabot, Peter J., Wallwork, Benjamin, Panizza, Benedict J. and Parekh, Harendra S. (2017). Formulation, functional evaluation and ex vivo performance of thermoresponsive soluble gels - a platform for therapeutic delivery to mucosal sinus tissue. European Journal of Pharmaceutical Sciences, 96, 499-507. doi: 10.1016/j.ejps.2016.10.017

Formulation, functional evaluation and ex vivo performance of thermoresponsive soluble gels - a platform for therapeutic delivery to mucosal sinus tissue

2016

Journal Article

Corrigendum to “In vitro cytotoxicity of Nicotiana gossei leaves, used in the Australian Aboriginal smokeless tobacco known as pituri or mingkulpa” [Toxicol. Lett. 254 (2016) 45–51]

Moghbel, Nahid, Ryu, BoMi, Cabot, Peter J., Ratsch, Angela and Steadman, Kathryn J. (2016). Corrigendum to “In vitro cytotoxicity of Nicotiana gossei leaves, used in the Australian Aboriginal smokeless tobacco known as pituri or mingkulpa” [Toxicol. Lett. 254 (2016) 45–51]. Toxicology Letters, 259, 156-156. doi: 10.1016/j.toxlet.2016.07.024

Corrigendum to “In vitro cytotoxicity of Nicotiana gossei leaves, used in the Australian Aboriginal smokeless tobacco known as pituri or mingkulpa” [Toxicol. Lett. 254 (2016) 45–51]

2016

Journal Article

Anti-inflammatory and immunomodulatory properties of Carica papaya

Pandey, Saurabh, Cabot, Peter J., Shaw, P. Nicholas and Hewavitharana, Amitha K. (2016). Anti-inflammatory and immunomodulatory properties of Carica papaya. Journal of Immunotoxicology, 13 (4), 590-602. doi: 10.3109/1547691X.2016.1149528

Anti-inflammatory and immunomodulatory properties of Carica papaya

2016

Journal Article

In vitro cytotoxicity of Nicotiana gossei leaves, used in the Australian Aboriginal smokeless tobacco known as pituri or mingkulpa

Moghbel, Nahid, Ryu, BoMi, Cabot, Peter J., Ratsch, Angela and Steadman, Kathryn J. (2016). In vitro cytotoxicity of Nicotiana gossei leaves, used in the Australian Aboriginal smokeless tobacco known as pituri or mingkulpa. Toxicology Letters, 254, 45-51. doi: 10.1016/j.toxlet.2016.05.011

In vitro cytotoxicity of Nicotiana gossei leaves, used in the Australian Aboriginal smokeless tobacco known as pituri or mingkulpa

2016

Journal Article

Serum C-reactive protein levels predict regional brain responses to noxious cold stimulation of the hand in chronic whiplash associated disorders

Sterling, Michele, Head, Jessica, Cabot, Peter J. and Farrell, Michael (2016). Serum C-reactive protein levels predict regional brain responses to noxious cold stimulation of the hand in chronic whiplash associated disorders. Scandinavian Journal of Pain, 11 (1), 19-26. doi: 10.1016/j.sjpain.2015.11.003

Serum C-reactive protein levels predict regional brain responses to noxious cold stimulation of the hand in chronic whiplash associated disorders

2016

Journal Article

Dynorphin 1-17 and Its N-Terminal Biotransformation Fragments Modulate Lipopolysaccharide-Stimulated Nuclear Factor-kappa B Nuclear Translocation, Interleukin-1beta and Tumor Necrosis Factor-alpha in Differentiated THP-1 Cells

Fazalul Rahiman, Siti Sarah, Morgan, Michael, Gray, Paul, Shaw, Paul Nicholas and Cabot, Peter John (2016). Dynorphin 1-17 and Its N-Terminal Biotransformation Fragments Modulate Lipopolysaccharide-Stimulated Nuclear Factor-kappa B Nuclear Translocation, Interleukin-1beta and Tumor Necrosis Factor-alpha in Differentiated THP-1 Cells. PLoS One, 11 (4) e0153005, e0153005.1-e0153005.18. doi: 10.1371/journal.pone.0153005

Dynorphin 1-17 and Its N-Terminal Biotransformation Fragments Modulate Lipopolysaccharide-Stimulated Nuclear Factor-kappa B Nuclear Translocation, Interleukin-1beta and Tumor Necrosis Factor-alpha in Differentiated THP-1 Cells

2016

Conference Publication

Peripheral kappa-opioid receptor (KOR) stimulation exerts anti-inflammatory effects in lipopolysaccharide (LPS)-activated macrophages

Rahiman, Fazalul S. S., Morgan, M., Gray, P., Shaw, P. and Cabot, P. (2016). Peripheral kappa-opioid receptor (KOR) stimulation exerts anti-inflammatory effects in lipopolysaccharide (LPS)-activated macrophages. ICI 2016 International Congress of Immunology, Melbourne, VIC Australia, 21-26 August 2016. Weinheim, Germany: Wiley-Blackwell. doi: 10.1002/eji.201670200

Peripheral kappa-opioid receptor (KOR) stimulation exerts anti-inflammatory effects in lipopolysaccharide (LPS)-activated macrophages

2016

Conference Publication

Medium polarity fraction of papaya leaf juice has selective antiproliferative effects on prostate cancer cells

Pandey, Saurabh, Walpole, Carina, Cabot, Peter J., Shaw, Paul N., Batra, Jyotsna and Hewavitharana, Amitha K. (2016). Medium polarity fraction of papaya leaf juice has selective antiproliferative effects on prostate cancer cells. 17th Asia-Pacific Prostate Cancer Conference, Melbourne, Australia, Aug 31-Sep 03, 2016. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/bju.13567

Medium polarity fraction of papaya leaf juice has selective antiproliferative effects on prostate cancer cells

2016

Conference Publication

Establishment of new methods to quantify the Mu-opioid and Tlr-4 receptor activation potential in biological samples to assess the influence of opioids on tumor metastasis

Xie, Nan, Cabot, Peter, Shaw, Paul N., Sturgess, David and Parat, Marie-Odile (2016). Establishment of new methods to quantify the Mu-opioid and Tlr-4 receptor activation potential in biological samples to assess the influence of opioids on tumor metastasis. COSA's 43rd and ANZBCTG's 38th Annual Scientific Meetings. Partners for Progress in Breast Cancer Research and Care, Gold Coast, QLD, Australia, 15–17 November 2016. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.

Establishment of new methods to quantify the Mu-opioid and Tlr-4 receptor activation potential in biological samples to assess the influence of opioids on tumor metastasis

2015

Journal Article

Activation of k opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia

Deuis, Jennifer, Whately, Ella, Brust, Andreas, Inserra, Marco, Asvadi, Naghmeh Hajarol, Lewis, Richard J., Alewood, Paul F., Cabot, Peter J. and Vetter, Irina (2015). Activation of k opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia. ACS Chemical Neuroscience, 6 (10), 1751-1758. doi: 10.1021/acschemneuro.5b00113

Activation of k opioid receptors in cutaneous nerve endings by conorphin-1, a novel subtype-selective conopeptide, does not mediate peripheral analgesia

2015

Journal Article

Cellular and molecular mechanisms of chronic rhinosinusitis and potential therapeutic strategies: review on cytokines, nuclear factor kappa B and transforming growth factor beta

Phan, N.T., Cabot, P.J., Wallwork, B.D., Cervin, A.U. and Panizza, B.J. (2015). Cellular and molecular mechanisms of chronic rhinosinusitis and potential therapeutic strategies: review on cytokines, nuclear factor kappa B and transforming growth factor beta. Journal of Laryngology and Otology, 129 (S3), S2-S7. doi: 10.1017/S0022215115001322

Cellular and molecular mechanisms of chronic rhinosinusitis and potential therapeutic strategies: review on cytokines, nuclear factor kappa B and transforming growth factor beta

2015

Journal Article

Comparison and analysis of the animal models used to study the effect of morphine on tumour growth and metastasis

Afsharimani, B., Doornebal, C. W., Cabot, P. J., Hollmann, M. W. and Parat, M.-O. (2015). Comparison and analysis of the animal models used to study the effect of morphine on tumour growth and metastasis. British Journal of Pharmacology, 172 (2), 251-259. doi: 10.1111/bph.12589

Comparison and analysis of the animal models used to study the effect of morphine on tumour growth and metastasis

2015

Conference Publication

Carica papaya leaf juice extracts have selective anti-proliferative responses in prostatic disease

Walpole, Carina, Pandey, Saurabh, Cabot, Peter J., Shaw, Paul N., Batra, Jyotsna and Hewavitharana, Amitha K. (2015). Carica papaya leaf juice extracts have selective anti-proliferative responses in prostatic disease. 2nd Prostate Cancer World Congress (PCWC), Cairns, QLD Australia, 17-21 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/bju.13198

Carica papaya leaf juice extracts have selective anti-proliferative responses in prostatic disease

2015

Conference Publication

Quantification the mu-opioid and TLR4 receptor activation potential in the circulation of mice and humans to assess the influence of morphine on tumour metastasis

Parat, M. O., Xie, N., Cabot, P., Shaw, N., Gregory, K. and Sturgess, D. (2015). Quantification the mu-opioid and TLR4 receptor activation potential in the circulation of mice and humans to assess the influence of morphine on tumour metastasis. Australian and New Zealand College of Anaesthetists Annual Scientific Meeting, Adelaide AU, 2-5 May 2015.

Quantification the mu-opioid and TLR4 receptor activation potential in the circulation of mice and humans to assess the influence of morphine on tumour metastasis

2014

Journal Article

Effect of lysine antifibrinolytics and cyclooxygenase inhibitors on the proteolytic profile of breast cancer cells interacting with macrophages or endothelial cells

Afsharimani, B., Cabot, P. J. and Parat, M.-O. (2014). Effect of lysine antifibrinolytics and cyclooxygenase inhibitors on the proteolytic profile of breast cancer cells interacting with macrophages or endothelial cells. British Journal of Anaesthesia, Advance Access (SUPPL. 1), 1-10. doi: 10.1093/bja/aet468

Effect of lysine antifibrinolytics and cyclooxygenase inhibitors on the proteolytic profile of breast cancer cells interacting with macrophages or endothelial cells

2014

Journal Article

Beta-Endorphin 1-31 Biotransformation and cAMP Modulation in Inflammation

Asvadi, Naghmeh Hajarol, Morgan, Michael, Herath, Herath M., Hewavitharana, Amitha K., Shaw, P. Nicholas and Cabot, Peter J. (2014). Beta-Endorphin 1-31 Biotransformation and cAMP Modulation in Inflammation. PLoS One, 9 (3) e90380, e90380.1-e90380.11. doi: 10.1371/journal.pone.0090380

Beta-Endorphin 1-31 Biotransformation and cAMP Modulation in Inflammation

2014

Journal Article

Pain—novel targets and new technologies

Hua, Susan and Cabot, Peter J. (2014). Pain—novel targets and new technologies. Frontiers in Pharmacology, 5 (SEP) Article 211, 211. doi: 10.3389/fphar.2014.00211

Pain—novel targets and new technologies

Past funding

  • 2022 - 2024
    Development of small nerve fibre pathology in chronic whiplash-associated disorder (RBWH Foundation Grant administered by MNHHS)
    Royal Brisbane and Women's Hospital Foundation
    Open grant
  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Establishing a High-Throughput, Microwave-Assisted Automated Peptide Synthesis Facility at PACE
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    Murine behavioural phenotyping facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    The assessment of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells to identify and characterize new therapeutic targets for diseases
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014
    A medium-throughput cell isolation and analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2015
    Perioperative opioids and tumour growth and metastasis
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2010
    Analytical instrumentation enabling rapid compound separation and chemical structure analysis via mass fingerprinting
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Cost effective acquisition of an LC-MS/MS system to support CIPDD organics analysis and preclinical and clinical operations
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    High content imaging analysis for bioactive and novel therapeutic target evaluation
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Why do people keep hurting their back: A longitudinal study of biological, psychological and social predictors
    NHMRC Project Grant
    Open grant
  • 2009
    A core pharmacy facility for molecular biology, expression and protein post translational modification studies in cancer, cardiovascular, pain and epilepsy research
    UQ School/Centre Co-Funding
    Open grant
  • 2009
    Robotics Instrumentation for High Throughput Sample preparation for Increased Productivity of the CIPDD/TetraQ's HPLC-MS/MS Systems for Quantitative Analysis of Organics in a Quality Systems NATA-Acc
    UQ Faculty Co-Funding
    Open grant
  • 2005
    Establishment of an improved model of relapsing MS and the characterisation of the role of Peroxisome Proliferator - activated receoptors alpha and beta
    Multiple Sclerosis Research Australia
    Open grant
  • 2005
    NHMRC_Equipment Grant = DSI Telemetry System
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2005
    NHMRC_Equipment Grant_HLTH_Pharmacy
    NHMRC Equipment Grant
    Open grant
  • 2001
    Immunosupression and inflammatory Pain: the role of the immune system
    Cancer Bequest Fund
    Open grant
  • 2001
    Mechanical and Thermal Nociceptive thresholds in rats with Immunosuppression and Inflammatory Pain.
    UQ Early Career Researcher
    Open grant
  • 2001 - 2003
    Peripheral Mechanisms of Analgesia in Inflammation
    NHMRC Project Grant
    Open grant
  • 2000
    A pilot study investigating the role of Low Level Laser Therapy (LLLT) in an inflammatory model
    Royal Brisbane & Women's Hospital Research Foundation
    Open grant
  • 2000
    Efficacy of oxycodone relative to morphine for the relief of neuropathic pain in rats
    Brain Research Fund
    Open grant
  • 2000
    Investigating the role of Low Level Laser Therapy (LLTP) in an inflammatory model
    Centre of Nat. Res. on Disability & Rehab Medicine
    Open grant
  • 1999
    Site-directed trafficking of opioid producing lymphocytes in localised inflammation and the involvement in pain control
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Professor Peter Cabot is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Peripheral Mechanisms of Analgesia and the Involvement of the Immune System

  • Opioid biotransformation and inflammation

  • Novel opioid peptides for the treatment of addiction and tolerance

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Professor Peter Cabot directly for media enquiries about:

  • Inflammation - pharmacology
  • Pain pharmacology
  • Pharmacology - pain

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