Professor Peter Cabot
Professor

Peter Cabot

Email: 
Phone: 
+61 7 334 61854

Background

Peter Cabot is the Professor and Head of School in the School of Pharmacy. He joined the School staff in this position in 1999 after completing postdoctoral positions at Johns Hopkins University, Baltimore USA, The NIH, Baltimore USA and within the School of Pharmacy at UQ.

The primary focus of my research is on the elucidation of the peripheral mechanisms involved in analgesia associated with inflammation. Key discoveries were made in this field that highlighted the importance of the immune system in inflammatory pain. The results of which were published in the notable journals; JBC, PAIN, Nature Medicine and The Journal of Clinical Investigation.

Availability

Professor Peter Cabot is:
Available for supervision
Media expert

Fields of research

Clinical sciences Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor of Applied Science, Charles Sturt University
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Opioids in inflammation

    In the area I work as a translational scientist, exploring drug discovery of novel opioids and inflammatory mechanisms as well as developing new alternatives, paring this with translational work into preclinical and clinical studies looking for better outcomes for patients.

  • Biotransformation of Opioids in Disease

  • Pain in Inflammatory Diseases

  • Natural Products Drug Discovery

Research impacts

Our current research is focussed on novel opioid ligands that target opioid receptors aligned with less addictive properties, bioactivity of endogenous and natural products that may provide insights into better pain therapy or reduction in inflammatory disorders such as sinusitis.

Search Professor Peter Cabot’s works on UQ eSpace

158 works between 1992 and 2024
All (158) Journal Article (92) Book Chapter (1) Conference Publication (61) Other Outputs (4)

21 - 40 of 158 works

2020

Other Outputs

A Cyclic Peptide

Parekh, Harendra, Cabot, Peter, Tupally, Karnaker and Kandale, Ajit (2020). A Cyclic Peptide. US-20220089646-A1.

A Cyclic Peptide

2020

Other Outputs

A cyclic peptide

Parekh, Harendra, Cabot, Peter, Tupally, Karnaker and Kandale, Ajit (2020). A cyclic peptide. 2020212659.

A cyclic peptide

2019

Journal Article

Baltic amber teething necklaces: could succinic acid leaching from beads provide anti-inflammatory effects?

Nissen, Michael D., Lau, Esther T. L., Cabot, Peter J. and Steadman, Kathryn J. (2019). Baltic amber teething necklaces: could succinic acid leaching from beads provide anti-inflammatory effects?. BMC Complementary and Alternative Medicine, 19 (1) 162, 162. doi: 10.1186/s12906-019-2574-9

Baltic amber teething necklaces: could succinic acid leaching from beads provide anti-inflammatory effects?

2019

Journal Article

Toxicity evaluation and nasal mucosal tissue deposition of dexamethasone-infused mucoadhesive in situ nasal gelling systems

Pandey, Preeti, Pandey, Saurabh, Cabot, Peter J., Wallwork, Benjamin, Panizza, Benedict J. and Parekh, Harendra S. (2019). Toxicity evaluation and nasal mucosal tissue deposition of dexamethasone-infused mucoadhesive in situ nasal gelling systems. Saudi Pharmaceutical Journal, 27 (7), 914-919. doi: 10.1016/j.jsps.2019.06.005

Toxicity evaluation and nasal mucosal tissue deposition of dexamethasone-infused mucoadhesive in situ nasal gelling systems

2019

Journal Article

Glucagon-like peptide-1 receptor agonists and strategies to improve their efficiency

Alavi, Seyed Ebrahim, Cabot, Peter J. and Moyle, Peter M. (2019). Glucagon-like peptide-1 receptor agonists and strategies to improve their efficiency. Molecular Pharmaceutics, 16 (6) acs.molpharmaceut.9b00308, 2278-2295. doi: 10.1021/acs.molpharmaceut.9b00308

Glucagon-like peptide-1 receptor agonists and strategies to improve their efficiency

2019

Journal Article

Solid nanoparticles for oral antimicrobial drug delivery: a review

Raza, Aun, Sime, Fekade Bruck, Cabot, Peter J., Maqbool, Faheem, Roberts, Jason A. and Falconer, James Robert (2019). Solid nanoparticles for oral antimicrobial drug delivery: a review. Drug Discovery Today, 24 (3), 858-866. doi: 10.1016/j.drudis.2019.01.004

Solid nanoparticles for oral antimicrobial drug delivery: a review

2018

Journal Article

Bio-Guided Fractionation of Papaya Leaf Juice for Delineating the Components Responsible for the Selective Anti-proliferative Effects on Prostate Cancer Cells

Pandey, Saurabh, Walpole, Carina, Shaw, Paul N., Cabot, Peter J., Hewavitharana, Amitha K. and Batra, Jyotsna (2018). Bio-Guided Fractionation of Papaya Leaf Juice for Delineating the Components Responsible for the Selective Anti-proliferative Effects on Prostate Cancer Cells. Frontiers in Pharmacology, 9 (NOV) 1319, 1319. doi: 10.3389/fphar.2018.01319

Bio-Guided Fractionation of Papaya Leaf Juice for Delineating the Components Responsible for the Selective Anti-proliferative Effects on Prostate Cancer Cells

2018

Journal Article

Effect of perioperative opioids on cancer-relevant circulating parameters: mu opioid receptor and TLR4 activation potential, and proteolytic profile

Xie, Nan, Matigian, Nicholas, Vithanage, Tharindu D., Gregory, Kye, Nassar, Zeyad D., Cabot, Peter J., Shaw, Paul Nicholas, Kirkpatrick, Carl Mj, Lê Cao, Kim-Anh, Sturgess, David and Parat, Marie-Odile (2018). Effect of perioperative opioids on cancer-relevant circulating parameters: mu opioid receptor and TLR4 activation potential, and proteolytic profile. Clinical Cancer Research, 24 (10), 2319-2327. doi: 10.1158/1078-0432.CCR-18-0172

Effect of perioperative opioids on cancer-relevant circulating parameters: mu opioid receptor and TLR4 activation potential, and proteolytic profile

2018

Journal Article

Sustained Simultaneous Delivery of Metronidazole and Doxycycline From Polycaprolactone Matrices Designed for Intravaginal Treatment of Pelvic Inflammatory Disease

Pathak, Meenakshi, Coombes, Allan G. A., Ryu, BoMi, Cabot, Peter J., Turner, Mark S., Palmer, Cheryn, Wang, Dongjie and Steadman, Kathryn J. (2018). Sustained Simultaneous Delivery of Metronidazole and Doxycycline From Polycaprolactone Matrices Designed for Intravaginal Treatment of Pelvic Inflammatory Disease. Journal of Pharmaceutical Sciences, 107 (3), 863-869. doi: 10.1016/j.xphs.2017.09.033

Sustained Simultaneous Delivery of Metronidazole and Doxycycline From Polycaprolactone Matrices Designed for Intravaginal Treatment of Pelvic Inflammatory Disease

2018

Journal Article

Alternative therapies for chronic rhinosinusitis: A review

Griffin, Aaron S., Cabot, Peter, Wallwork, Ben and Panizza, Ben (2018). Alternative therapies for chronic rhinosinusitis: A review. Ear, Nose and Throat Journal, 97 (3), E25-E33. doi: 10.1177/0145561320939415

Alternative therapies for chronic rhinosinusitis: A review

2017

Journal Article

Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment

Morgan, Michael, Deuis, Jennifer R., Frøsig-Jørgensen, Majbrit, Lewis, Richard J., Cabot, Peter J., Gray, Paul D. and Vetter, Irina (2017). Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment. Pain Medicine, 19 (4), 708-734. doi: 10.1093/pm/pnx228

Burn pain: a systematic and critical review of epidemiology, pathophysiology, and treatment

2017

Journal Article

Morphine alters the circulating proteolytic profile in mice: functional consequences on cellular migration and invasion

Xie, Nan, Khabbazi, Samira, Nassar, Zeyad D, Gregory, Kye, Vithanage, Tharindu, Anand-Apte, Bela, Cabot, Peter J, Sturgess, David, Shaw, Paul N and Parat, Marie-Odile (2017). Morphine alters the circulating proteolytic profile in mice: functional consequences on cellular migration and invasion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31 (12), 5208-5216. doi: 10.1096/fj.201700546R

Morphine alters the circulating proteolytic profile in mice: functional consequences on cellular migration and invasion

2017

Journal Article

Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells

Peters, A. A., Jamaludin, S. Y. N., Yapa, K. T. D. S., Chalmers, S., Wiegmans, A. P., Lim, H. F., Milevskiy, M. J. G., Azimi, I., Davis, F. M., Northwood, K. S., Pera, E., Marcial, D. L., Dray, E., Waterhouse, N. J., Cabot, P. J., Gonda, T. J., Kenny, P. A., Brown, M. A., Khanna, K. K., Roberts-Thomson, S. J. and Monteith, G. R. (2017). Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells. Oncogene, 36 (46), 6490-6500. doi: 10.1038/onc.2017.234

Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells

2017

Journal Article

Co-Phenylcaine Spray: can we improve the taste? A randomised, double-blind, crossover study

Bailey, S., Panizza, B., Cabot, P. and Wallwork, B. (2017). Co-Phenylcaine Spray: can we improve the taste? A randomised, double-blind, crossover study. Journal of Laryngology and Otology, 132 (2), 138-142. doi: 10.1017/S0022215117001359

Co-Phenylcaine Spray: can we improve the taste? A randomised, double-blind, crossover study

2017

Journal Article

Selective anti-proliferative activities of Carica papaya leaf juice extracts against prostate cancer

Pandey, Saurabh, Walpole, Carina, Cabot, Peter J., Shaw, Paul N., Batra, Jyotsna and Hewavitharana, Amitha K. (2017). Selective anti-proliferative activities of Carica papaya leaf juice extracts against prostate cancer. Biomedicine & Pharmacotherapy, 89, 515-523. doi: 10.1016/j.biopha.2017.02.050

Selective anti-proliferative activities of Carica papaya leaf juice extracts against prostate cancer

2017

Journal Article

Inhibitory effects of dynorphin 3-14 on the lipopolysaccharide-induced toll-like receptor 4 signalling pathway

Rahiman, Siti Sarah Fazalul, Morgan, Michael, Gray, Paul, Shaw, Paul Nicholas and Cabot, Peter John (2017). Inhibitory effects of dynorphin 3-14 on the lipopolysaccharide-induced toll-like receptor 4 signalling pathway. Peptides, 90, 48-54. doi: 10.1016/j.peptides.2017.02.004

Inhibitory effects of dynorphin 3-14 on the lipopolysaccharide-induced toll-like receptor 4 signalling pathway

2017

Journal Article

Activation of μ-opioid receptor and Toll-like receptor 4 by plasma from morphine-treated mice

Xie, Nan, Gomes, Fabio P., Deora, Vandana, Gregory, Kye, Vithanage, Tharindu, Nassar, Zeyad D., Cabot, Peter J., Sturgess, David, Shaw, Paul N. and Parat, Marie-Odile (2017). Activation of μ-opioid receptor and Toll-like receptor 4 by plasma from morphine-treated mice. Brain, Behavior, and Immunity, 61, 244-258. doi: 10.1016/j.bbi.2016.12.002

Activation of μ-opioid receptor and Toll-like receptor 4 by plasma from morphine-treated mice

2017

Journal Article

Gaq proteins: molecular pharmacology and therapeutic potential

Kamato, Danielle, Mitra, Partha, Davis, Felicity, Osman, Narin, Chaplin, Rebecca, Cabot, Peter J., Afroz, Rizwana, Thomas, Walter, Zheng, Wenhua, Kaur, Harveen, Brimble, Margaret and Little, Peter J. (2017). Gaq proteins: molecular pharmacology and therapeutic potential. Cellular and Molecular Life Sciences, 74 (8), 1379-1390. doi: 10.1007/s00018-016-2405-9

Gaq proteins: molecular pharmacology and therapeutic potential

2017

Journal Article

Bifunctional succinylated ε-polylysine-coated mesoporous silica nanoparticles for pH-responsive and intracellular drug delivery targeting the colon

Nguyen, Chau T. H., Webb, Richard I., Lambert, Lynette K., Strounina, Ekaterina, Lee, Edward C., Parat, Marie-Odile, McGuckin, Michael A., Popat, Amirali, Cabot, Peter J. and Ross, Benjamin P. (2017). Bifunctional succinylated ε-polylysine-coated mesoporous silica nanoparticles for pH-responsive and intracellular drug delivery targeting the colon. ACS Applied Materials and Interfaces, 9 (11), 9470-9483. doi: 10.1021/acsami.7b00411

Bifunctional succinylated ε-polylysine-coated mesoporous silica nanoparticles for pH-responsive and intracellular drug delivery targeting the colon

2017

Journal Article

The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation

Morgan, M., Heffernan, A., Benhabib, F., Wagner, S., Hewavitharana, A. K., Shaw, P. N. and Cabot, P. J. (2017). The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation. Peptides, 89, 9-16. doi: 10.1016/j.peptides.2016.12.019

The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation

Past funding

  • 2022 - 2024
    Development of small nerve fibre pathology in chronic whiplash-associated disorder (RBWH Foundation Grant administered by MNHHS)
    Royal Brisbane and Women's Hospital Foundation
    Open grant
  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Establishing a High-Throughput, Microwave-Assisted Automated Peptide Synthesis Facility at PACE
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    Murine behavioural phenotyping facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    The assessment of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells to identify and characterize new therapeutic targets for diseases
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014
    A medium-throughput cell isolation and analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2015
    Perioperative opioids and tumour growth and metastasis
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2010
    Analytical instrumentation enabling rapid compound separation and chemical structure analysis via mass fingerprinting
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Cost effective acquisition of an LC-MS/MS system to support CIPDD organics analysis and preclinical and clinical operations
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    High content imaging analysis for bioactive and novel therapeutic target evaluation
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Why do people keep hurting their back: A longitudinal study of biological, psychological and social predictors
    NHMRC Project Grant
    Open grant
  • 2009
    A core pharmacy facility for molecular biology, expression and protein post translational modification studies in cancer, cardiovascular, pain and epilepsy research
    UQ School/Centre Co-Funding
    Open grant
  • 2009
    Robotics Instrumentation for High Throughput Sample preparation for Increased Productivity of the CIPDD/TetraQ's HPLC-MS/MS Systems for Quantitative Analysis of Organics in a Quality Systems NATA-Acc
    UQ Faculty Co-Funding
    Open grant
  • 2005
    Establishment of an improved model of relapsing MS and the characterisation of the role of Peroxisome Proliferator - activated receoptors alpha and beta
    Multiple Sclerosis Research Australia
    Open grant
  • 2005
    NHMRC_Equipment Grant = DSI Telemetry System
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2005
    NHMRC_Equipment Grant_HLTH_Pharmacy
    NHMRC Equipment Grant
    Open grant
  • 2001
    Immunosupression and inflammatory Pain: the role of the immune system
    Cancer Bequest Fund
    Open grant
  • 2001
    Mechanical and Thermal Nociceptive thresholds in rats with Immunosuppression and Inflammatory Pain.
    UQ Early Career Researcher
    Open grant
  • 2001 - 2003
    Peripheral Mechanisms of Analgesia in Inflammation
    NHMRC Project Grant
    Open grant
  • 2000
    A pilot study investigating the role of Low Level Laser Therapy (LLLT) in an inflammatory model
    Royal Brisbane & Women's Hospital Research Foundation
    Open grant
  • 2000
    Investigating the role of Low Level Laser Therapy (LLTP) in an inflammatory model
    Centre of Nat. Res. on Disability & Rehab Medicine
    Open grant
  • 1999
    Site-directed trafficking of opioid producing lymphocytes in localised inflammation and the involvement in pain control
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Professor Peter Cabot is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Peripheral Mechanisms of Analgesia and the Involvement of the Immune System

  • Opioid biotransformation and inflammation

  • Novel opioid peptides for the treatment of addiction and tolerance

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Professor Peter Cabot directly for media enquiries about:

  • Inflammation - pharmacology
  • Pain pharmacology
  • Pharmacology - pain

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