Professor Peter Cabot
Professor

Peter Cabot

Email: 
Phone: 
+61 7 334 61854

Background

Peter Cabot is the Professor and Head of School in the School of Pharmacy. He joined the School staff in this position in 1999 after completing postdoctoral positions at Johns Hopkins University, Baltimore USA, The NIH, Baltimore USA and within the School of Pharmacy at UQ.

The primary focus of my research is on the elucidation of the peripheral mechanisms involved in analgesia associated with inflammation. Key discoveries were made in this field that highlighted the importance of the immune system in inflammatory pain. The results of which were published in the notable journals; JBC, PAIN, Nature Medicine and The Journal of Clinical Investigation.

Availability

Professor Peter Cabot is:
Available for supervision
Media expert

Fields of research

Clinical sciences Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor of Applied Science, Charles Sturt University
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Opioids in inflammation

    In the area I work as a translational scientist, exploring drug discovery of novel opioids and inflammatory mechanisms as well as developing new alternatives, paring this with translational work into preclinical and clinical studies looking for better outcomes for patients.

  • Biotransformation of Opioids in Disease

  • Pain in Inflammatory Diseases

  • Natural Products Drug Discovery

Research impacts

Our current research is focussed on novel opioid ligands that target opioid receptors aligned with less addictive properties, bioactivity of endogenous and natural products that may provide insights into better pain therapy or reduction in inflammatory disorders such as sinusitis.

Search Professor Peter Cabot’s works on UQ eSpace

158 works between 1992 and 2024
All (158) Journal Article (92) Book Chapter (1) Conference Publication (61) Other Outputs (4)

81 - 100 of 158 works

2011

Journal Article

Targeting of ICAM-1-directed immunoliposomes specifically to activated endothelial cells with low cellular uptake: use of an optimized procedure for the coupling of low concentrations of antibody to liposomes

Hua, Susan, Chang, Hsin-I, Davies, Nigel M. and Cabot, Peter J. (2011). Targeting of ICAM-1-directed immunoliposomes specifically to activated endothelial cells with low cellular uptake: use of an optimized procedure for the coupling of low concentrations of antibody to liposomes. Journal of Liposome Research, 21 (2), 95-105. doi: 10.3109/08982101003754401

Targeting of ICAM-1-directed immunoliposomes specifically to activated endothelial cells with low cellular uptake: use of an optimized procedure for the coupling of low concentrations of antibody to liposomes

2011

Journal Article

Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats

Otto, Kathleen J., Wyse, Bruce D., Cabot, Peter J. and Smith, Maree T. (2011). Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats. Pain Medicine, 12 (5), 782-793. doi: 10.1111/j.1526-4637.2011.01102.x

Insulin implants prevent the temporal development of mechanical allodynia and opioid hyposensitivity for 24-wks in streptozotocin (STZ)-diabetic wistar rats

2011

Journal Article

Longitudinal study of painful diabetic neuropathy in the Zucker diabetic fatty rat model of type 2 diabetes: Impaired basal G-protein activity appears to underpin marked morphine hyposensitivity at 6 months

Otto, Kathleen J., Wyse, Bruce D., Cabot, Peter J. and Smith, Maree T. (2011). Longitudinal study of painful diabetic neuropathy in the Zucker diabetic fatty rat model of type 2 diabetes: Impaired basal G-protein activity appears to underpin marked morphine hyposensitivity at 6 months. Pain Medicine, 12 (3), 437-450. doi: 10.1111/j.1526-4637.2011.01067.x

Longitudinal study of painful diabetic neuropathy in the Zucker diabetic fatty rat model of type 2 diabetes: Impaired basal G-protein activity appears to underpin marked morphine hyposensitivity at 6 months

2011

Conference Publication

Identification of enzyme-sensitive cleavage sites of beta endorphin (beta- END) using serum and inflamed tissue

Herath, Dilanthi, Hewavitharana, Amitha K., Cabot, Peter J. and Shaw, P. Nicholas (2011). Identification of enzyme-sensitive cleavage sites of beta endorphin (beta- END) using serum and inflamed tissue. American Peptide Symposium (22nd, 2011), San Diego, CA, U.S.A., 25-30 June 2011. Hoboken, NJ, U.S.A.: John Wiley & Sons. doi: 10.1002/bip.21670

Identification of enzyme-sensitive cleavage sites of beta endorphin (beta- END) using serum and inflamed tissue

2011

Conference Publication

Remodeling of purinergic receptor-mediated calcium signalling during epidermal growth factor-induced EMT in a breast cancer cell line

Davis, Felicity, Kenny, Paraic A., Soo, Eliza T.-L., van Denderen, Bryce J. W., Thompson, Erik W., Cabot, Peter J., Marie-Odile Parat, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Remodeling of purinergic receptor-mediated calcium signalling during epidermal growth factor-induced EMT in a breast cancer cell line. 5th International Epithelial-Mesenchymal Transition Meeting, Singapore, 10-13 October 2011.

Remodeling of purinergic receptor-mediated calcium signalling during epidermal growth factor-induced EMT in a breast cancer cell line

2011

Conference Publication

Effect of interferential therapy on serum beta endorphin level in rat

Beatti, A., Cabot, P. and Chipchase, L. S. (2011). Effect of interferential therapy on serum beta endorphin level in rat. World Physical Therapy 2011, Amsterdam, Netherlands, 20-23 June 2011. Amsterdam , Netherlands:

Effect of interferential therapy on serum beta endorphin level in rat

2011

Conference Publication

Alterations in purinergic receptor-mediated signalling as a consequence of epidermal growth factor-induced epithelial mesenchymal transition (EMT) in breast cancer cells

Davis, Felicity, Kenny, P. A., Soo, E. T. L., van Denderen, B. J., Thompson, E. W., Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Alterations in purinergic receptor-mediated signalling as a consequence of epidermal growth factor-induced epithelial mesenchymal transition (EMT) in breast cancer cells. 3rd EMBO Meeting, Vienna, Austria, 10-13 September 2011.

Alterations in purinergic receptor-mediated signalling as a consequence of epidermal growth factor-induced epithelial mesenchymal transition (EMT) in breast cancer cells

2010

Journal Article

Effect of solvent and electrospray mass spectrometer parameters on the charge state distribution of peptides - a case study using liquid chromatography/mass spectrometry method development for beta-endorphin assay

Hewavitharana, A. K., Herath, H. M. D. R., Shaw, P. N., Cabot, P. N. and Kebarle, P. (2010). Effect of solvent and electrospray mass spectrometer parameters on the charge state distribution of peptides - a case study using liquid chromatography/mass spectrometry method development for beta-endorphin assay. Rapid Communications in Mass Spectrometry, 24 (24), 3510-3514. doi: 10.1002/rcm.4806

Effect of solvent and electrospray mass spectrometer parameters on the charge state distribution of peptides - a case study using liquid chromatography/mass spectrometry method development for beta-endorphin assay

2010

Journal Article

Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: Clinical and therapeutic implications

Hua, Susan and Cabot, Peter J. (2010). Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: Clinical and therapeutic implications. Trends in Pharmacolgical Sciences, 31 (9), 427-433. doi: 10.1016/j.tips.2010.05.008

Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: Clinical and therapeutic implications

2010

Journal Article

Effect of ionization suppression by trace impurities in mobile phase water on the accuracy of quantification by high-performance liquid chromatography/mass spectrometry

Herath, H. M. D. R., Shaw, Paul N., Cabot, Peter and Hewavitharana, Amitha (2010). Effect of ionization suppression by trace impurities in mobile phase water on the accuracy of quantification by high-performance liquid chromatography/mass spectrometry. Rapid Communications in Mass Spectrometry, 24 (11), 1502-1506. doi: 10.1002/rcm.4549

Effect of ionization suppression by trace impurities in mobile phase water on the accuracy of quantification by high-performance liquid chromatography/mass spectrometry

2010

Conference Publication

Growth factor-mediated changes in receptor-stimulated calcium signaling in breast cancer cells

Davis, Felicity, Paraic, Kenny A, Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2010). Growth factor-mediated changes in receptor-stimulated calcium signaling in breast cancer cells. New Horizons in Calcium Signaling, Beijiing, China, October 10-13 2010.

Growth factor-mediated changes in receptor-stimulated calcium signaling in breast cancer cells

2010

Conference Publication

Growth factor-mediated changes in purinergic receptor signaling in breast cancer cells

Davis, Felicity, Paraic, Kenny A, Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2010). Growth factor-mediated changes in purinergic receptor signaling in breast cancer cells. ASCEPT Annual Scientific Meeting 2010, Melbourne, 28 November - 1 December 2010.

Growth factor-mediated changes in purinergic receptor signaling in breast cancer cells

2010

Conference Publication

Altered receptor-mediated calcium signaling in breast cancer cells after growth factor stimuli

Davis, Felicity, Paraic, Kenny A, Cabot, Peter J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2010). Altered receptor-mediated calcium signaling in breast cancer cells after growth factor stimuli. 11th Meeting of the European Calcium Society, Warszawa, Poland, September 6-9 2010.

Altered receptor-mediated calcium signaling in breast cancer cells after growth factor stimuli

2009

Journal Article

[Flavonoids from Diospyros kaki inhibit the adhesion between lymphocyte and dorsal root ganglion]

Bei, Wei-Jian, Cabot, Peter J., Hermanussen, Siobhan, Li, Chu-Yuan and Xu, An-Long (2009). [Flavonoids from Diospyros kaki inhibit the adhesion between lymphocyte and dorsal root ganglion]. Zhong Yao Cai, 32 (5), 740-744.

[Flavonoids from Diospyros kaki inhibit the adhesion between lymphocyte and dorsal root ganglion]

2008

Journal Article

Rapid, Opiod-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization

Vetter, Irina, Cheung, Wei, Peiris, Madusha, Wyse, Bruce D., Roberts-Thomson, Sarah J., Zheng, Jie, Monteith, Gregory R. and Cabot, Peter J (2008). Rapid, Opiod-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization. Journal of Biological Chemistry, 283 (28), 19540-19550. doi: 10.1074/jbc.M707865200

Rapid, Opiod-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization

2008

Journal Article

PPARα and PPARß are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line

Gopisetty Venkata, Nagaraj, Aung, Cho S., Cabot, Peter J., Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2008). PPARα and PPARß are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. Toxicological Sciences, 102 (1), 120-128. doi: 10.1093/toxsci/kfm281

PPARα and PPARß are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line

2008

Journal Article

Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol

Vetter, Irina, Wyse, Bruce D., Roberts-Thomson, Sarah J., Monteith, Gregory R. and Cabot, Peter J. (2008). Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol. European Journal of Pain, 12 (4), 441-454. doi: 10.1016/j.ejpain.2007.07.001

Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol

2008

Conference Publication

Influence of diet on the longitudinal temporal development of opioid hyposensitivity and tactile allodynia in the Zucker Diabetic Fatty (ZDF) rat

Cabot, P.J., Otto, K., Smith, M.T., South, S.M. and Wyse, B.D. (2008). Influence of diet on the longitudinal temporal development of opioid hyposensitivity and tactile allodynia in the Zucker Diabetic Fatty (ZDF) rat. 28th Annual Scientific Meeting of the Australian Pain Society: The Spectrum of Pain, Perth, Australia, 30 March – 2 April, 2008.

Influence of diet on the longitudinal temporal development of opioid hyposensitivity and tactile allodynia in the Zucker Diabetic Fatty (ZDF) rat

2008

Conference Publication

Targeting of ICAM-1-directed immunoliposomes specifically to activated endothelial cells - A potential tool for specific drug delivery to inflammatory pathologies

Hua, Susan, Davies, Nigel M. and Cabot, Peter J. (2008). Targeting of ICAM-1-directed immunoliposomes specifically to activated endothelial cells - A potential tool for specific drug delivery to inflammatory pathologies. Neuroscience 2008: 38th Annual Meeting of the Society for Neuroscience, Washington D.C., U.S., 15-19 November, 2008.

Targeting of ICAM-1-directed immunoliposomes specifically to activated endothelial cells - A potential tool for specific drug delivery to inflammatory pathologies

2008

Conference Publication

Influence of diet on the longitudinal temporal development of opioid hyposensitivity and tactile allodynia in the Zucker Diabetic Fatty (ZDF) rat

Otto, K., Wyse, B. D., South, S. M., Cabot, P. J. and Smith, M. T. (2008). Influence of diet on the longitudinal temporal development of opioid hyposensitivity and tactile allodynia in the Zucker Diabetic Fatty (ZDF) rat. 12th World Congress on Pain, Glasgow, Scotland, 17-22 August 2008.

Influence of diet on the longitudinal temporal development of opioid hyposensitivity and tactile allodynia in the Zucker Diabetic Fatty (ZDF) rat

Past funding

  • 2022 - 2024
    Development of small nerve fibre pathology in chronic whiplash-associated disorder (RBWH Foundation Grant administered by MNHHS)
    Royal Brisbane and Women's Hospital Foundation
    Open grant
  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Establishing a High-Throughput, Microwave-Assisted Automated Peptide Synthesis Facility at PACE
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    Murine behavioural phenotyping facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    The assessment of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells to identify and characterize new therapeutic targets for diseases
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014
    A medium-throughput cell isolation and analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2015
    Perioperative opioids and tumour growth and metastasis
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2010
    Analytical instrumentation enabling rapid compound separation and chemical structure analysis via mass fingerprinting
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Cost effective acquisition of an LC-MS/MS system to support CIPDD organics analysis and preclinical and clinical operations
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    High content imaging analysis for bioactive and novel therapeutic target evaluation
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Why do people keep hurting their back: A longitudinal study of biological, psychological and social predictors
    NHMRC Project Grant
    Open grant
  • 2009
    A core pharmacy facility for molecular biology, expression and protein post translational modification studies in cancer, cardiovascular, pain and epilepsy research
    UQ School/Centre Co-Funding
    Open grant
  • 2009
    Robotics Instrumentation for High Throughput Sample preparation for Increased Productivity of the CIPDD/TetraQ's HPLC-MS/MS Systems for Quantitative Analysis of Organics in a Quality Systems NATA-Acc
    UQ Faculty Co-Funding
    Open grant
  • 2005
    Establishment of an improved model of relapsing MS and the characterisation of the role of Peroxisome Proliferator - activated receoptors alpha and beta
    Multiple Sclerosis Research Australia
    Open grant
  • 2005
    NHMRC_Equipment Grant = DSI Telemetry System
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2005
    NHMRC_Equipment Grant_HLTH_Pharmacy
    NHMRC Equipment Grant
    Open grant
  • 2001
    Immunosupression and inflammatory Pain: the role of the immune system
    Cancer Bequest Fund
    Open grant
  • 2001
    Mechanical and Thermal Nociceptive thresholds in rats with Immunosuppression and Inflammatory Pain.
    UQ Early Career Researcher
    Open grant
  • 2001 - 2003
    Peripheral Mechanisms of Analgesia in Inflammation
    NHMRC Project Grant
    Open grant
  • 2000
    A pilot study investigating the role of Low Level Laser Therapy (LLLT) in an inflammatory model
    Royal Brisbane & Women's Hospital Research Foundation
    Open grant
  • 2000
    Investigating the role of Low Level Laser Therapy (LLTP) in an inflammatory model
    Centre of Nat. Res. on Disability & Rehab Medicine
    Open grant
  • 1999
    Site-directed trafficking of opioid producing lymphocytes in localised inflammation and the involvement in pain control
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Professor Peter Cabot is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Peripheral Mechanisms of Analgesia and the Involvement of the Immune System

  • Opioid biotransformation and inflammation

  • Novel opioid peptides for the treatment of addiction and tolerance

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Professor Peter Cabot directly for media enquiries about:

  • Inflammation - pharmacology
  • Pain pharmacology
  • Pharmacology - pain

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