Professor Peter Cabot
Professor

Peter Cabot

Email: 
Phone: 
+61 7 334 61854

Background

Peter Cabot is the Professor and Head of School in the School of Pharmacy. He joined the School staff in this position in 1999 after completing postdoctoral positions at Johns Hopkins University, Baltimore USA, The NIH, Baltimore USA and within the School of Pharmacy at UQ.

The primary focus of my research is on the elucidation of the peripheral mechanisms involved in analgesia associated with inflammation. Key discoveries were made in this field that highlighted the importance of the immune system in inflammatory pain. The results of which were published in the notable journals; JBC, PAIN, Nature Medicine and The Journal of Clinical Investigation.

Availability

Professor Peter Cabot is:
Available for supervision
Media expert

Fields of research

Clinical sciences Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor of Applied Science, Charles Sturt University
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Opioids in inflammation

    In the area I work as a translational scientist, exploring drug discovery of novel opioids and inflammatory mechanisms as well as developing new alternatives, paring this with translational work into preclinical and clinical studies looking for better outcomes for patients.

  • Biotransformation of Opioids in Disease

  • Pain in Inflammatory Diseases

  • Natural Products Drug Discovery

Research impacts

Our current research is focussed on novel opioid ligands that target opioid receptors aligned with less addictive properties, bioactivity of endogenous and natural products that may provide insights into better pain therapy or reduction in inflammatory disorders such as sinusitis.

Search Professor Peter Cabot’s works on UQ eSpace

158 works between 1992 and 2024
All (158) Journal Article (92) Book Chapter (1) Conference Publication (61) Other Outputs (4)

61 - 80 of 158 works

2013

Journal Article

Analgesic treatment of ciguatoxin-induced cold allodynia

Zimmermann, Katharina, Deuis, Jennifer R., Inserra, Marco C., Collins, Lindon S., Namer, Barbara, Cabot, Peter J., Reeh, Peter W., Lewis, Richard J. and Vetter, Irina (2013). Analgesic treatment of ciguatoxin-induced cold allodynia. Pain, 154 (10), 1999-2006. doi: 10.1016/j.pain.2013.06.015

Analgesic treatment of ciguatoxin-induced cold allodynia

2013

Journal Article

Morphine and breast tumor metastasis: the role of matrix-degrading enzymes

Afsharimani, Banafsheh, Baran, JoAnne, Watanabe, Satoshi, Lindner, Daniel, Cabot, Peter J. and Parat, Marie-Odile (2013). Morphine and breast tumor metastasis: the role of matrix-degrading enzymes. Clinical and Experimental Metastasis, Online First (2), 1-10. doi: 10.1007/s10585-013-9616-3

Morphine and breast tumor metastasis: the role of matrix-degrading enzymes

2013

Journal Article

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na(v)1.6 in peripheral pain pathways

Deuis, Jennifer R., Zimmermann, Katharina, Romanovsky, Andrej A., Possani, Lourival D., Cabot, Peter J., Lewis, Richard J. and Vetter, Irina (2013). An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na(v)1.6 in peripheral pain pathways. Pain, 154 (9), 1749-1757. doi: 10.1016/j.pain.2013.05.032

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na(v)1.6 in peripheral pain pathways

2013

Journal Article

Inaccuracies in the quantification of peptides - A case study using beta-endorphin assay

Herath, H. M. D. R., Kim, R-R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2013). Inaccuracies in the quantification of peptides - A case study using beta-endorphin assay. LCGC Europe, 26 (8), 435-437.

Inaccuracies in the quantification of peptides - A case study using beta-endorphin assay

2013

Journal Article

Assessment of gene expression of intracellular calcium channels, pumps and exchangers with epidermal growth factor-induced epithelial-mesenchymal transition in a breast cancer cell line

Davis, Felicity M., Parsonage, Michelle T., Cabot, Peter J., Parat, Marie-Odile, Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Assessment of gene expression of intracellular calcium channels, pumps and exchangers with epidermal growth factor-induced epithelial-mesenchymal transition in a breast cancer cell line. Cancer Cell International, 13 (76) 76, 1-7. doi: 10.1186/1475-2867-13-76

Assessment of gene expression of intracellular calcium channels, pumps and exchangers with epidermal growth factor-induced epithelial-mesenchymal transition in a breast cancer cell line

2013

Journal Article

Targeted nanoparticles that mimic immune cells in pain control inducing analgesic and anti-inflammatory actions: a potential novel treatment of acute and chronic pain conditions

Hua, Susan and Cabot, Peter J. (2013). Targeted nanoparticles that mimic immune cells in pain control inducing analgesic and anti-inflammatory actions: a potential novel treatment of acute and chronic pain conditions. Pain Physician, 16 (3), E199-E216. doi: 10.36076/ppj.2013/16/e199

Targeted nanoparticles that mimic immune cells in pain control inducing analgesic and anti-inflammatory actions: a potential novel treatment of acute and chronic pain conditions

2013

Conference Publication

Biotransformation within inflamed tissue of beta-endorphin 1-31 and three major N-terminal fragments; beta-endorphin 1-17, beta-endorphin 1-13, and beta-endorphin 1-11

Asvadi, Naghmeh Hajarol, Morgan, Michael, Hewavitharana, Amitha, Shaw, P. Nicholas and Cabot, Peter J. (2013). Biotransformation within inflamed tissue of beta-endorphin 1-31 and three major N-terminal fragments; beta-endorphin 1-17, beta-endorphin 1-13, and beta-endorphin 1-11. HPLC 2013: 40th International Symposium on High Performance Liquid Phase Separations and Related Techniques, Hobart, TAS, Australia, 18-21 November, 2013. Royal Australian Chemical Institute (raci).

Biotransformation within inflamed tissue of beta-endorphin 1-31 and three major N-terminal fragments; beta-endorphin 1-17, beta-endorphin 1-13, and beta-endorphin 1-11

2013

Journal Article

Inaccuracies in the quantification of peptides - a case study using beta-endorphin assay

Herath, H. M. D. R., Kim, R. -R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2013). Inaccuracies in the quantification of peptides - a case study using beta-endorphin assay. LCGC North America, 31 (1), 58-61.

Inaccuracies in the quantification of peptides - a case study using beta-endorphin assay

2013

Conference Publication

Morphine modulates the paracrine interaction between breast tumor cells and macrophages

Imani, Banafsheh Afshar, Baran, JoAnne, Cabot, Peter J. and Parat, Marie-Odile (2013). Morphine modulates the paracrine interaction between breast tumor cells and macrophages. 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington Dc, 6 - 10 April 2013. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2013-2808

Morphine modulates the paracrine interaction between breast tumor cells and macrophages

2013

Conference Publication

The biotransformation of beta-endorphin in the rat brain after a single sedating dose of ethanol

Morgan, Michael, Holgate, Jan, Hewavitharana, Amitha K., Shaw, Nick, Cabot, Peter and Bartlett, Selena E. (2013). The biotransformation of beta-endorphin in the rat brain after a single sedating dose of ethanol. Australasian Professional Society on Alcohol and other Drugs Conference, Brisbane, QLD, Australia, 24-27 November 2013. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. doi: 10.1111/dar.12077

The biotransformation of beta-endorphin in the rat brain after a single sedating dose of ethanol

2012

Journal Article

Dynorphin A 1–17 biotransformation in inflamed tissue, serum and trypsin solution analysed by liquid chromatography–tandem mass spectrometry

Morgan, M., Herath, H. M. D. R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2012). Dynorphin A 1–17 biotransformation in inflamed tissue, serum and trypsin solution analysed by liquid chromatography–tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 404 (10), 3111-3121. doi: 10.1007/s00216-012-6406-8

Dynorphin A 1–17 biotransformation in inflamed tissue, serum and trypsin solution analysed by liquid chromatography–tandem mass spectrometry

2012

Journal Article

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling

Vetter, Irina, Touska, Filip, Hess, Andreas, Hinsbey, Rachel, Sattler, Simon, Lampert, Angelika, Sergejeva, Marina, Sharov, Anastasia, Collins, Lindon S., Eberhardt, Mirjam, Engel, Matthias, Cabot, Peter J., Wood, John N., Vlachova, Viktorie, Reeh, Peter W., Lewis, Richard J. and Zimmermann, Katharina (2012). Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. EMBO Journal, 31 (19), 3795-3808. doi: 10.1038/emboj.2012.207

Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling

2012

Journal Article

Spinal manual therapy produces rapid onset analgesia in a rodent model

Grayson, Jane E., Barton, Tom, Cabot, Peter J. and Souvlis, Tina (2012). Spinal manual therapy produces rapid onset analgesia in a rodent model. Manual Therapy, 17 (4), 292-297. doi: 10.1016/j.math.2012.02.004

Spinal manual therapy produces rapid onset analgesia in a rodent model

2012

Journal Article

Non-stimulated, agonist-stimulated and store-operated ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF-induced EMT on calcium entry

Davis, Felicity M., Peters, Amelia A., Grice, Desma M., Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Non-stimulated, agonist-stimulated and store-operated ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF-induced EMT on calcium entry. PLoS One, 7 (5) e36923, e36923.1-e36923.11. doi: 10.1371/journal.pone.0036923

Non-stimulated, agonist-stimulated and store-operated ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF-induced EMT on calcium entry

2012

Journal Article

Study of beta endorphin metabolism in inflamed tissue, serum and trypsin solution by liquid chromatography-tandem mass spectrometric analysis

Dilanthi, H. M. D. R., Cabot, P. J., Shaw, P. N. and Hewavitharana, A. K. (2012). Study of beta endorphin metabolism in inflamed tissue, serum and trypsin solution by liquid chromatography-tandem mass spectrometric analysis. Analytical and Bioanalytical Chemistry, 402 (6), 2089-2100. doi: 10.1007/s00216-011-5686-8

Study of beta endorphin metabolism in inflamed tissue, serum and trypsin solution by liquid chromatography-tandem mass spectrometric analysis

2012

Journal Article

Effect of low frequency of interferential therapy on plasma beta-endorphin levels in rats

Beatti, A., Cabot, P. J. and Chipchase, L. S. (2012). Effect of low frequency of interferential therapy on plasma beta-endorphin levels in rats. Physiotherapy Practice and Research, 33 (2), 97-104. doi: 10.3233/PPR-2012-0002

Effect of low frequency of interferential therapy on plasma beta-endorphin levels in rats

2011

Journal Article

Morphine use in cancer surgery

Afsharimani, Banafsheh, Cabot, Peter J. and Parat, Marie-Odile (2011). Morphine use in cancer surgery. Frontiers in Pharmacology, 2 (46) Article 46, 1-8. doi: 10.3389/fphar.2011.00046

Morphine use in cancer surgery

2011

Journal Article

Remodeling of purinergic receptor-mediated Ca(2+) signaling as a consequence of EGF-induced epithelial-mesenchymal transition in breast cancer cells

Davis, Felicity M., Kenny, Paraic A., Soo, Eliza T.-L., van Denderen, Bryce J. W., Thompson, Erik W., Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Remodeling of purinergic receptor-mediated Ca(2+) signaling as a consequence of EGF-induced epithelial-mesenchymal transition in breast cancer cells. PLoS One, 6 (8) e23464, e23464.1-e23464.9. doi: 10.1371/journal.pone.0023464

Remodeling of purinergic receptor-mediated Ca(2+) signaling as a consequence of EGF-induced epithelial-mesenchymal transition in breast cancer cells

2011

Journal Article

Targeting of ICAM-1-directed immunoliposomes specifically to activated endothelial cells with low cellular uptake: use of an optimized procedure for the coupling of low concentrations of antibody to liposomes

Hua, Susan, Chang, Hsin-I, Davies, Nigel M. and Cabot, Peter J. (2011). Targeting of ICAM-1-directed immunoliposomes specifically to activated endothelial cells with low cellular uptake: use of an optimized procedure for the coupling of low concentrations of antibody to liposomes. Journal of Liposome Research, 21 (2), 95-105. doi: 10.3109/08982101003754401

Targeting of ICAM-1-directed immunoliposomes specifically to activated endothelial cells with low cellular uptake: use of an optimized procedure for the coupling of low concentrations of antibody to liposomes

2011

Journal Article

Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial

Gray, Paul, Kirby, Julie, Smith, Maree T., Cabot, Peter J., Williams, Bronwyn, Doecke, James and Cramond, Tess (2011). Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial. Pain, 152 (6), 1279-1288. doi: 10.1016/j.pain.2011.01.055

Pregabalin in severe burn injury pain: A double-blind, randomised placebo-controlled trial

Past funding

  • 2022 - 2024
    Development of small nerve fibre pathology in chronic whiplash-associated disorder (RBWH Foundation Grant administered by MNHHS)
    Royal Brisbane and Women's Hospital Foundation
    Open grant
  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Establishing a High-Throughput, Microwave-Assisted Automated Peptide Synthesis Facility at PACE
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    Murine behavioural phenotyping facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    The assessment of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells to identify and characterize new therapeutic targets for diseases
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014
    A medium-throughput cell isolation and analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2015
    Perioperative opioids and tumour growth and metastasis
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2010
    Analytical instrumentation enabling rapid compound separation and chemical structure analysis via mass fingerprinting
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Cost effective acquisition of an LC-MS/MS system to support CIPDD organics analysis and preclinical and clinical operations
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    High content imaging analysis for bioactive and novel therapeutic target evaluation
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Why do people keep hurting their back: A longitudinal study of biological, psychological and social predictors
    NHMRC Project Grant
    Open grant
  • 2009
    A core pharmacy facility for molecular biology, expression and protein post translational modification studies in cancer, cardiovascular, pain and epilepsy research
    UQ School/Centre Co-Funding
    Open grant
  • 2009
    Robotics Instrumentation for High Throughput Sample preparation for Increased Productivity of the CIPDD/TetraQ's HPLC-MS/MS Systems for Quantitative Analysis of Organics in a Quality Systems NATA-Acc
    UQ Faculty Co-Funding
    Open grant
  • 2005
    Establishment of an improved model of relapsing MS and the characterisation of the role of Peroxisome Proliferator - activated receoptors alpha and beta
    Multiple Sclerosis Research Australia
    Open grant
  • 2005
    NHMRC_Equipment Grant = DSI Telemetry System
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2005
    NHMRC_Equipment Grant_HLTH_Pharmacy
    NHMRC Equipment Grant
    Open grant
  • 2001
    Immunosupression and inflammatory Pain: the role of the immune system
    Cancer Bequest Fund
    Open grant
  • 2001
    Mechanical and Thermal Nociceptive thresholds in rats with Immunosuppression and Inflammatory Pain.
    UQ Early Career Researcher
    Open grant
  • 2001 - 2003
    Peripheral Mechanisms of Analgesia in Inflammation
    NHMRC Project Grant
    Open grant
  • 2000
    A pilot study investigating the role of Low Level Laser Therapy (LLLT) in an inflammatory model
    Royal Brisbane & Women's Hospital Research Foundation
    Open grant
  • 2000
    Investigating the role of Low Level Laser Therapy (LLTP) in an inflammatory model
    Centre of Nat. Res. on Disability & Rehab Medicine
    Open grant
  • 1999
    Site-directed trafficking of opioid producing lymphocytes in localised inflammation and the involvement in pain control
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Professor Peter Cabot is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Peripheral Mechanisms of Analgesia and the Involvement of the Immune System

  • Opioid biotransformation and inflammation

  • Novel opioid peptides for the treatment of addiction and tolerance

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Professor Peter Cabot directly for media enquiries about:

  • Inflammation - pharmacology
  • Pain pharmacology
  • Pharmacology - pain

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