Professor Peter Cabot
Professor

Peter Cabot

Email: 
Phone: 
+61 7 334 61854

Background

Peter Cabot is the Professor and Head of School in the School of Pharmacy. He joined the School staff in this position in 1999 after completing postdoctoral positions at Johns Hopkins University, Baltimore USA, The NIH, Baltimore USA and within the School of Pharmacy at UQ.

The primary focus of my research is on the elucidation of the peripheral mechanisms involved in analgesia associated with inflammation. Key discoveries were made in this field that highlighted the importance of the immune system in inflammatory pain. The results of which were published in the notable journals; JBC, PAIN, Nature Medicine and The Journal of Clinical Investigation.

Availability

Professor Peter Cabot is:
Available for supervision
Media expert

Fields of research

Clinical sciences Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor of Applied Science, Charles Sturt University
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Opioids in inflammation

    In the area I work as a translational scientist, exploring drug discovery of novel opioids and inflammatory mechanisms as well as developing new alternatives, paring this with translational work into preclinical and clinical studies looking for better outcomes for patients.

  • Biotransformation of Opioids in Disease

  • Pain in Inflammatory Diseases

  • Natural Products Drug Discovery

Research impacts

Our current research is focussed on novel opioid ligands that target opioid receptors aligned with less addictive properties, bioactivity of endogenous and natural products that may provide insights into better pain therapy or reduction in inflammatory disorders such as sinusitis.

Search Professor Peter Cabot’s works on UQ eSpace

158 works between 1992 and 2024
All (158) Journal Article (92) Book Chapter (1) Conference Publication (61) Other Outputs (4)

141 - 158 of 158 works

2002

Journal Article

The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.

Smith, M. T., Cabot, P. J., Ross, F. B., Robertson, A. D. and Lewis, R. J. (2002). The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.. Pain, 96 (1-2), 119-127. doi: 10.1016/S0304-3959(01)00436-5

The novel N-type calcium channel blocker, AM336, produces potent dose-dependent antinociception after intrathecal dosing in rats and inhibits substance P release in rat spinal cord slices.

2001

Journal Article

Methionine-enkephalin-and Dynorphin A-release from immune cells and control of inflammatory pain

Cabot, P. J., Carter, L., Schafer, M. and Stein, C. (2001). Methionine-enkephalin-and Dynorphin A-release from immune cells and control of inflammatory pain. Pain, 93 (3), 207-212. doi: 10.1016/S0304-3959(01)00322-0

Methionine-enkephalin-and Dynorphin A-release from immune cells and control of inflammatory pain

2001

Journal Article

Immune-derived opioids and peripheral antinociception

Cabot, PJ (2001). Immune-derived opioids and peripheral antinociception. Clinical And Experimental Pharmacology And Physiology, 28 (3), 230-232. doi: 10.1046/j.1440-1681.2001.03425.x

Immune-derived opioids and peripheral antinociception

2000

Conference Publication

Donor activated lymphocytes produced potent analgesia in immunosuppressed rats

Do, M. H., Casey, P. M. and Cabot, P. J. (2000). Donor activated lymphocytes produced potent analgesia in immunosuppressed rats. APSA 2000 Annual Conference, Newcastle, 6-8 December 2000. Brisbane: APSA.

Donor activated lymphocytes produced potent analgesia in immunosuppressed rats

2000

Conference Publication

Antinociceptive efficacy of intrathecal AM336 for the relief of adjuvant-induced chronic inflammatory pain in the rat hindpaw

Smith, M. T., Ross, F. B., Lewis, R., Kurek, J. and Cabot, P. J. (2000). Antinociceptive efficacy of intrathecal AM336 for the relief of adjuvant-induced chronic inflammatory pain in the rat hindpaw. Joint Meeting of ASCEPT and the British Pharmacological Society, Melbourne, Australia, 26 - 28 April, 2000. Melbourne, Vic.: Blackwell Scientific Publications.

Antinociceptive efficacy of intrathecal AM336 for the relief of adjuvant-induced chronic inflammatory pain in the rat hindpaw

2000

Conference Publication

Effect of low level laser therapy (LLLT) on resolution of pain in an acute inflammation model

Laakso, E., Do, M. H. and Cabot, P. J. (2000). Effect of low level laser therapy (LLLT) on resolution of pain in an acute inflammation model. Health Care Symposium: In Sickness and in Health, Brisbane, 9-12 October 2000. Brisbane: RBH Foundation.

Effect of low level laser therapy (LLLT) on resolution of pain in an acute inflammation model

2000

Conference Publication

Lack of cross-tolerance between intrathecal AM336 and intravenous morphine in contrast to the marked cross-tolerance between ziconotide and morphine

Smith, M. T., Ross, F. B., Lewis, R., Kurek, J. and Cabot, P. J. (2000). Lack of cross-tolerance between intrathecal AM336 and intravenous morphine in contrast to the marked cross-tolerance between ziconotide and morphine. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, Newcastle, Australia, 3 - 6 December, 2000. Melbourne, Vic.: Blackwell Scientific Publications.

Lack of cross-tolerance between intrathecal AM336 and intravenous morphine in contrast to the marked cross-tolerance between ziconotide and morphine

1999

Conference Publication

Antinociceptive potencies and motor effects of the calcium channel blockers, AM336 and ziconotide, following intrathecal administration to FCA-treated rats

Ross, F. B., Cabot, P. J., Robertson, A. D. and Smith, M. T. (1999). Antinociceptive potencies and motor effects of the calcium channel blockers, AM336 and ziconotide, following intrathecal administration to FCA-treated rats. 9th World Congress on Pain, Vienna, Austria, 22 - 27 August, 1999. Seattle, USA: IASP Press.

Antinociceptive potencies and motor effects of the calcium channel blockers, AM336 and ziconotide, following intrathecal administration to FCA-treated rats

1999

Conference Publication

Inhibition of K+-evoked substance P release from slices of rat spinal cord by the novel calcium channel blockers, AM336 and AM543, relative to ziconotide

Cabot, P. J., Ross, F. B., Robertson, A. D. and Smith, M. T. (1999). Inhibition of K+-evoked substance P release from slices of rat spinal cord by the novel calcium channel blockers, AM336 and AM543, relative to ziconotide. 9th World Congress on Pain, Vienna, Austria, 22 - 27 August, 1999. Seatle, USA: IASP Press.

Inhibition of K+-evoked substance P release from slices of rat spinal cord by the novel calcium channel blockers, AM336 and AM543, relative to ziconotide

1998

Journal Article

Pain control in inflammation governed by selectins

Machelska, H, Cabot, PJ, Mousa, SA, Zhang, Q and Stein, C (1998). Pain control in inflammation governed by selectins. Nature Medicine, 4 (12), 1425-1428. doi: 10.1038/4017

Pain control in inflammation governed by selectins

1997

Journal Article

Peripheral opioid analgesia

Stein, C, Schafer, M, Cabot, PJ, Carter, L, Zhang, Q, Zhou, L and Gasior, M (1997). Peripheral opioid analgesia. Pain Reviews, 4 (3), 173-187.

Peripheral opioid analgesia

1997

Journal Article

Immune cell-derived beta-endorphin - Production, release, and control of inflammatory pain in rats

Cabot, PJ, Carter, L, Gaiddon, C, Zhang, Q, Schafer, M, Loeffler, JP and Stein, C (1997). Immune cell-derived beta-endorphin - Production, release, and control of inflammatory pain in rats. Journal of Clinical Investigation, 100 (1), 142-148. doi: 10.1172/JCI119506

Immune cell-derived beta-endorphin - Production, release, and control of inflammatory pain in rats

1997

Conference Publication

Opioids and inflammation

Stein, C, Schafer, M, Cabot, PJ, Zhang, Q, Zhou, L and Carter, L (1997). Opioids and inflammation. Conference on Molecular Aspects of the Neurobiology of Pain as part of the Celebration to Mark the 150th Anniversary of the First Public Demonstration of Ether, Boston Ma, Oct 15-17, 1996. SEATTLE: INT ASSOC STUDY PAIN (IASP) PRESS.

Opioids and inflammation

1997

Journal Article

Morphine has a dual concentration-dependent effect on K+-evoked substance P release from rat peripheral airways

Cabot, PJ, Cramond, T and Smith, MT (1997). Morphine has a dual concentration-dependent effect on K+-evoked substance P release from rat peripheral airways. Pulmonary Pharmacology & Therapeutics, 10 (4), 215-221. doi: 10.1006/pupt.1997.0094

Morphine has a dual concentration-dependent effect on K+-evoked substance P release from rat peripheral airways

1996

Journal Article

Quantitative autoradiography of peripheral opioid binding sites in rat lung

Cabot, PJ, Cramond, T and Smith, MT (1996). Quantitative autoradiography of peripheral opioid binding sites in rat lung. European Journal of Pharmacology, 310 (1), 47-53. doi: 10.1016/0014-2999(96)00363-9

Quantitative autoradiography of peripheral opioid binding sites in rat lung

1996

Other Outputs

Peripheral opioid binding sites in the rat and human lung : possible explanation for the relief of Dyspnoea by nebulized morphine

Cabot, Peter John (1996). Peripheral opioid binding sites in the rat and human lung : possible explanation for the relief of Dyspnoea by nebulized morphine. PhD Thesis, School of Pharmacy, The University of Queensland. doi: 10.14264/d1194ea

Peripheral opioid binding sites in the rat and human lung : possible explanation for the relief of Dyspnoea by nebulized morphine

1994

Journal Article

Characterization of Nonconventional Opioid Binding-Sites in Rat and Human Lung

Cabot, PJ, Dodd, PR, Cramond, T and Smith, MT (1994). Characterization of Nonconventional Opioid Binding-Sites in Rat and Human Lung. European Journal of Pharmacology-Molecular Pharmacology Section, 268 (2), 247-255. doi: 10.1016/0922-4106(94)90195-3

Characterization of Nonconventional Opioid Binding-Sites in Rat and Human Lung

1992

Conference Publication

Nonconventional Opioid Receptors in Human and Rat Lung

Cabot, PJ, Smith, MT, Cramond, TR and Dodd, PR (1992). Nonconventional Opioid Receptors in Human and Rat Lung. PHILADELPHIA: LIPPINCOTT-RAVEN PUBL.

Nonconventional Opioid Receptors in Human and Rat Lung

Past funding

  • 2022 - 2024
    Development of small nerve fibre pathology in chronic whiplash-associated disorder (RBWH Foundation Grant administered by MNHHS)
    Royal Brisbane and Women's Hospital Foundation
    Open grant
  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Establishing a High-Throughput, Microwave-Assisted Automated Peptide Synthesis Facility at PACE
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    Murine behavioural phenotyping facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2015
    The assessment of mitochondrial oxygen consumption and cytoplasmic glycolysis in cells to identify and characterize new therapeutic targets for diseases
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014
    A medium-throughput cell isolation and analysis suite
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2015
    Perioperative opioids and tumour growth and metastasis
    Australian & New Zealand College of Anaesthetists
    Open grant
  • 2010
    Analytical instrumentation enabling rapid compound separation and chemical structure analysis via mass fingerprinting
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    Cost effective acquisition of an LC-MS/MS system to support CIPDD organics analysis and preclinical and clinical operations
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010
    High content imaging analysis for bioactive and novel therapeutic target evaluation
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Why do people keep hurting their back: A longitudinal study of biological, psychological and social predictors
    NHMRC Project Grant
    Open grant
  • 2009
    A core pharmacy facility for molecular biology, expression and protein post translational modification studies in cancer, cardiovascular, pain and epilepsy research
    UQ School/Centre Co-Funding
    Open grant
  • 2009
    Robotics Instrumentation for High Throughput Sample preparation for Increased Productivity of the CIPDD/TetraQ's HPLC-MS/MS Systems for Quantitative Analysis of Organics in a Quality Systems NATA-Acc
    UQ Faculty Co-Funding
    Open grant
  • 2005
    Establishment of an improved model of relapsing MS and the characterisation of the role of Peroxisome Proliferator - activated receoptors alpha and beta
    Multiple Sclerosis Research Australia
    Open grant
  • 2005
    NHMRC_Equipment Grant = DSI Telemetry System
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2005
    NHMRC_Equipment Grant_HLTH_Pharmacy
    NHMRC Equipment Grant
    Open grant
  • 2001
    Immunosupression and inflammatory Pain: the role of the immune system
    Cancer Bequest Fund
    Open grant
  • 2001
    Mechanical and Thermal Nociceptive thresholds in rats with Immunosuppression and Inflammatory Pain.
    UQ Early Career Researcher
    Open grant
  • 2001 - 2003
    Peripheral Mechanisms of Analgesia in Inflammation
    NHMRC Project Grant
    Open grant
  • 2000
    A pilot study investigating the role of Low Level Laser Therapy (LLLT) in an inflammatory model
    Royal Brisbane & Women's Hospital Research Foundation
    Open grant
  • 2000
    Investigating the role of Low Level Laser Therapy (LLTP) in an inflammatory model
    Centre of Nat. Res. on Disability & Rehab Medicine
    Open grant
  • 1999
    Site-directed trafficking of opioid producing lymphocytes in localised inflammation and the involvement in pain control
    UQ New Staff Research Start-Up Fund
    Open grant

Availability

Professor Peter Cabot is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Peripheral Mechanisms of Analgesia and the Involvement of the Immune System

  • Opioid biotransformation and inflammation

  • Novel opioid peptides for the treatment of addiction and tolerance

Supervision history

Current supervision

Completed supervision

Enquiries

Contact Professor Peter Cabot directly for media enquiries about:

  • Inflammation - pharmacology
  • Pain pharmacology
  • Pharmacology - pain

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au