Skip to menu Skip to content Skip to footer
Dr Karnaker Reddy Tupally
Dr

Karnaker Reddy Tupally

Email: 

Overview

Background

Karnaker's research interests are natural products, peptide-based drug discovery and development, formulation chemistry and non-viral gene delivery system. Karnaker co-inventor and developed a novel, bioresponsive disulphide-linker technology, which has been used for non-viral vectors, peptide-therapeutics for pain and cancer treatment. Karnaker is also keen interest for topical, mucosal drug delivery using a range of dendrimer, nano and microbubbles, lipid and polymer-based nanoparticle systems in conjugation with both biological and physical stimuli-responsiveness.

Karnaker received a PhD in Pharmaceutical Chemistry from The University Queensland under the supervision of Dr Harendra Parekh and Dr Defang Ouyang. Prior to PhD, he completed a Master degree in Pharmaceutical Analysis and Quality assurance (India). Also worked as analytical research and development chemist for one year in a Pharma company. Since 2016, he his working with Dr Parekh team on a range of Industry-funded research projects and his role involves from ideation, research plan, execution, product delivery to industry partners on major platforms such as peptide-based therapeutics, gene therapy and sol-gel technology.

Availability

Dr Karnaker Reddy Tupally is:
Available for supervision
Media expert

Qualifications

  • Bachelor of Pharmacy, Kakatiya University
  • Masters (Research), unknown
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Non-viral gene delivery

    Bioresponsive peptide & Lipid-based nanoparticle for delivering gene-therapeutics

Research impacts

Karnaker is co-inventor for several patents (PCT, provisional stage) from Dr Parekh and Team, licensed to industry partners which received million dollars in funding for further research and development

Works

Search Professor Karnaker Reddy Tupally’s works on UQ eSpace

25 works between 2013 and 2024

1 - 20 of 25 works

2024

Book Chapter

Integration of dendrimer-based delivery technologies with computational pharmaceutics and their potential in the era of nanomedicine

Tupally, Karnaker Reddy, Seal, Prasenjit, Pandey, Preeti, Lohman, Rink-Jan, Smith, Sean, Ouyang, Defang and Parekh, Haredra (2024). Integration of dendrimer-based delivery technologies with computational pharmaceutics and their potential in the era of nanomedicine. Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0. (pp. 328-378) edited by Defang Ouyang. Hoboken, NJ, United States: Wiley. doi: 10.1002/9781119987260.ch10

Integration of dendrimer-based delivery technologies with computational pharmaceutics and their potential in the era of nanomedicine

2024

Journal Article

Intranasal delivery of imaging agents to the brain

Almahmoud, Abdallah, Parekh, Harendra S., Paterson, Brett M., Tupally, Karnaker Reddy and Vegh, Viktor (2024). Intranasal delivery of imaging agents to the brain. Theranostics, 14 (13), 5022-5101. doi: 10.7150/thno.98473

Intranasal delivery of imaging agents to the brain

2023

Journal Article

Opportunities for bioactive glass in gastrointestinal conditions: a review of production methodologies, morphology, composition, and performance

Harrop, Angus C. F., Tupally, Karnaker R., Pandey, Preeti and Parekh, Harendra S. (2023). Opportunities for bioactive glass in gastrointestinal conditions: a review of production methodologies, morphology, composition, and performance. Molecular Pharmaceutics, 20 (12), 5954-5980. doi: 10.1021/acs.molpharmaceut.3c00188

Opportunities for bioactive glass in gastrointestinal conditions: a review of production methodologies, morphology, composition, and performance

2023

Conference Publication

Bivalent kappa-selective opioid peptides with enhanced metabolic stability and potency

Saifuddin, D., Lohman, R.-J., Tupally, K., Parekh, H. and Cabot, P. (2023). Bivalent kappa-selective opioid peptides with enhanced metabolic stability and potency. 81st FIP World Congress Of Pharmacy And Pharmaceutical Sciences, Brisbane, QLD Australia, 24-28 September 2023. PKP Publishing.

Bivalent kappa-selective opioid peptides with enhanced metabolic stability and potency

2023

Journal Article

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

Lohman, Rink-Jan, Reddy Tupally, Karnaker, Kandale, Ajit, Cabot, Peter J. and Parekh, Harendra S. (2023). Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy. Frontiers in Pharmacology, 14 1150313, 1-16. doi: 10.3389/fphar.2023.1150313

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

2023

Journal Article

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

Lohman, Rink-Jan, Tupally, Karnaker Reddy, Kandale, Ajit, Cabot, Peter J and Parekh, Harendra S (2023). Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy. Frontiers in Pharmacology, 14 1150313, 1150313. doi: 10.3389/fphar.2023.1150313

Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

2023

Journal Article

A systematic review of ultrasound-mediated drug delivery to the eye and critical insights to facilitate a timely path to the clinic

Rad, Isaac J., Chapman, Luke, Tupally, Karnaker Reddy, Veidt, Martin, Al-Sadiq, Hussain, Sullivan, Robert and Parekh, Harendra S (2023). A systematic review of ultrasound-mediated drug delivery to the eye and critical insights to facilitate a timely path to the clinic. Theranostics, 13 (11), 3582-3638. doi: 10.7150/thno.82884

A systematic review of ultrasound-mediated drug delivery to the eye and critical insights to facilitate a timely path to the clinic

2022

Journal Article

Multi-physics study of acoustofluidic delivery agents' clustering behavior

AlSadiq, Hussain, Tupally, Karnaker Reddy, Vogel, Robert, Parekh, Harendra S. and Veidt, Martin (2022). Multi-physics study of acoustofluidic delivery agents' clustering behavior. Physics in Medicine and Biology, 67 (1) 015002, 015002. doi: 10.1088/1361-6560/ac4666

Multi-physics study of acoustofluidic delivery agents' clustering behavior

2021

Conference Publication

Shell properties of a new acoustofluidic delivery agent

AL-Sadiq, H. A., Tupally, K. R., Parekh, H S. and M Veidt, M. (2021). Shell properties of a new acoustofluidic delivery agent. EPSM 2020, Engineering and Physical Sciences in Medicine, Brisbane, QLD Australia, 28-29 October 2020. Dordrecht, Netherlands: Springer Netherlands.

Shell properties of a new acoustofluidic delivery agent

2021

Other Outputs

Peptides and uses thereof

Parekh, Harendra, Tupally, Karnaker, Cabot, Peter and Kandale, Ajit (2021). Peptides and uses thereof. 2021300202.

Peptides and uses thereof

2021

Conference Publication

Novel opioid peptides as allosteric modulators of nociception

Saifuddin, Danial, Lohman, Rink-Jan, Tupally, Karnaker Reddy, Parekh, Harendra S. and Cabot, Peter J. (2021). Novel opioid peptides as allosteric modulators of nociception. ASMR medical research week: Queensland virtual symposium, Online, 9-10 June 2021.

Novel opioid peptides as allosteric modulators of nociception

2021

Journal Article

Shell properties and concentration stability of acoustofluidic delivery agents

Alsadiq, Hussain, Tupally, Karnaker, Vogel, Robert, Kokil, Ganesh, Parekh, Harendra S. and Veidt, Martin (2021). Shell properties and concentration stability of acoustofluidic delivery agents. Physical and Engineering Sciences in Medicine, 44 (1), 79-91. doi: 10.1007/s13246-020-00954-4

Shell properties and concentration stability of acoustofluidic delivery agents

2020

Journal Article

Evaluation of microalgae and cyanobacteria as potential sources of antimicrobial compounds

Alsenani, Faisal, Tupally, Karnaker R., Chua, Elvis T., Eltanahy, Eladl, Alsufyani, Hamed, Parekh, Harendra S. and Schenk, Peer M. (2020). Evaluation of microalgae and cyanobacteria as potential sources of antimicrobial compounds. Saudi Pharmaceutical Journal, 28 (12), 1834-1841. doi: 10.1016/j.jsps.2020.11.010

Evaluation of microalgae and cyanobacteria as potential sources of antimicrobial compounds

2020

Other Outputs

A Cyclic Peptide

Parekh, Harendra, Cabot, Peter, Tupally, Karnaker and Kandale, Ajit (2020). A Cyclic Peptide. US-20220089646-A1.

A Cyclic Peptide

2020

Other Outputs

A cyclic peptide

Parekh, Harendra, Cabot, Peter, Tupally, Karnaker and Kandale, Ajit (2020). A cyclic peptide. 2020212659.

A cyclic peptide

2020

Journal Article

Cell membrane penetration without pore formation: chameleonic properties of dendrimers in response to hydrophobic and hydrophilic environments

de Luca, Sergio, Seal, Prasenjit, Parekh, Harendra S., Tupally, Karnaker R. and Smith, Sean C. (2020). Cell membrane penetration without pore formation: chameleonic properties of dendrimers in response to hydrophobic and hydrophilic environments. Advanced Theory and Simulations, 3 (7) 1900152, 1900152. doi: 10.1002/adts.201900152

Cell membrane penetration without pore formation: chameleonic properties of dendrimers in response to hydrophobic and hydrophilic environments

2019

Journal Article

Development of a hybrid peptide dendrimer micellar carrier system and its application in the reformulation of a hydrophobic therapeutic agent derived from traditional Chinese medicine

Jing, Jing, Tupally, Karnaker R., Kokil, Ganesh R., Qu, Zhi, Chen, Sibao and Parekh, Harendra S. (2019). Development of a hybrid peptide dendrimer micellar carrier system and its application in the reformulation of a hydrophobic therapeutic agent derived from traditional Chinese medicine. RSC Advances, 9 (5), 2458-2463. doi: 10.1039/c8ra09606f

Development of a hybrid peptide dendrimer micellar carrier system and its application in the reformulation of a hydrophobic therapeutic agent derived from traditional Chinese medicine

2019

Conference Publication

Concentration stability of monolayer and bilayer lipid microbubbles–a precursor for new drug delivery applications

Alsadiq, H., Tupally, K. R., Kokil, G. R., Vogel, R., Parekh, H. S. and Veidt, M. (2019). Concentration stability of monolayer and bilayer lipid microbubbles–a precursor for new drug delivery applications. Drug Delivery Australia 2019 Conference, Brisbane, QLD Australia, 18-19 November 2019.

Concentration stability of monolayer and bilayer lipid microbubbles–a precursor for new drug delivery applications

2018

Conference Publication

Influence of acoustofluidic parameters on velocity streaming of sonicated medical microbubbles

Alsadiq, Hussain, Reddy, Karnaker, Parekh, Harendra and Veidt, Martin (2018). Influence of acoustofluidic parameters on velocity streaming of sonicated medical microbubbles. AAS2018: Acoustics 2018: Hear to Listen, Adelaide, SA Australia, 6-9 November 2018. Adelaide, SA Australia: Australian Acoustical Society.

Influence of acoustofluidic parameters on velocity streaming of sonicated medical microbubbles

2017

Journal Article

Skin delivery of EGCG and silibinin: potential of peptide dendrimers for enhanced skin permeation and deposition

Shetty, Pallavi Krishna, Manikkath, Jyothsna, Tupally, Karnaker, Kokil, Ganesh, Hegde, Aswathi R., Raut, Sushil Y., Parekh, Harendra S. and Mutalik, Srinivas (2017). Skin delivery of EGCG and silibinin: potential of peptide dendrimers for enhanced skin permeation and deposition. AAPS PharmSciTech, 18 (6), 2346-2357. doi: 10.1208/s12249-017-0718-0

Skin delivery of EGCG and silibinin: potential of peptide dendrimers for enhanced skin permeation and deposition

Supervision

Availability

Dr Karnaker Reddy Tupally is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

Completed supervision

Media

Enquiries

Contact Dr Karnaker Reddy Tupally directly for media enquiries about their areas of expertise.

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au