Overview
Background
Karnaker's research interests are natural products, peptide-based drug discovery and development, formulation chemistry and non-viral gene delivery system. Karnaker co-inventor and developed a novel, bioresponsive disulphide-linker technology, which has been used for non-viral vectors, peptide-therapeutics for pain and cancer treatment. Karnaker is also keen interest for topical, mucosal drug delivery using a range of dendrimer, nano and microbubbles, lipid and polymer-based nanoparticle systems in conjugation with both biological and physical stimuli-responsiveness.
Karnaker received a PhD in Pharmaceutical Chemistry from The University Queensland under the supervision of Dr Harendra Parekh and Dr Defang Ouyang. Prior to PhD, he completed a Master degree in Pharmaceutical Analysis and Quality assurance (India). Also worked as analytical research and development chemist for one year in a Pharma company. Since 2016, he his working with Dr Parekh team on a range of Industry-funded research projects and his role involves from ideation, research plan, execution, product delivery to industry partners on major platforms such as peptide-based therapeutics, gene therapy and sol-gel technology.
Availability
- Dr Karnaker Reddy Tupally is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Pharmacy, Kakatiya University
- Masters (Research), unknown
- Doctor of Philosophy, The University of Queensland
Research interests
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Non-viral gene delivery
Bioresponsive peptide & Lipid-based nanoparticle for delivering gene-therapeutics
Research impacts
Karnaker is co-inventor for several patents (PCT, provisional stage) from Dr Parekh and Team, licensed to industry partners which received million dollars in funding for further research and development
Works
Search Professor Karnaker Reddy Tupally’s works on UQ eSpace
2024
Book Chapter
Integration of dendrimer-based delivery technologies with computational pharmaceutics and their potential in the era of nanomedicine
Tupally, Karnaker Reddy, Seal, Prasenjit, Pandey, Preeti, Lohman, Rink-Jan, Smith, Sean, Ouyang, Defang and Parekh, Haredra (2024). Integration of dendrimer-based delivery technologies with computational pharmaceutics and their potential in the era of nanomedicine. Exploring Computational Pharmaceutics - AI and Modeling in Pharma 4.0. (pp. 328-378) edited by Defang Ouyang. Hoboken, NJ, United States: Wiley. doi: 10.1002/9781119987260.ch10
2024
Journal Article
Intranasal delivery of imaging agents to the brain
Almahmoud, Abdallah, Parekh, Harendra S., Paterson, Brett M., Tupally, Karnaker Reddy and Vegh, Viktor (2024). Intranasal delivery of imaging agents to the brain. Theranostics, 14 (13), 5022-5101. doi: 10.7150/thno.98473
2023
Journal Article
Opportunities for bioactive glass in gastrointestinal conditions: a review of production methodologies, morphology, composition, and performance
Harrop, Angus C. F., Tupally, Karnaker R., Pandey, Preeti and Parekh, Harendra S. (2023). Opportunities for bioactive glass in gastrointestinal conditions: a review of production methodologies, morphology, composition, and performance. Molecular Pharmaceutics, 20 (12), 5954-5980. doi: 10.1021/acs.molpharmaceut.3c00188
2023
Conference Publication
Bivalent kappa-selective opioid peptides with enhanced metabolic stability and potency
Saifuddin, D., Lohman, R.-J., Tupally, K., Parekh, H. and Cabot, P. (2023). Bivalent kappa-selective opioid peptides with enhanced metabolic stability and potency. 81st FIP World Congress Of Pharmacy And Pharmaceutical Sciences, Brisbane, QLD Australia, 24-28 September 2023. PKP Publishing.
2023
Journal Article
Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy
Lohman, Rink-Jan, Reddy Tupally, Karnaker, Kandale, Ajit, Cabot, Peter J. and Parekh, Harendra S. (2023). Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy. Frontiers in Pharmacology, 14 1150313, 1-16. doi: 10.3389/fphar.2023.1150313
2023
Journal Article
Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy
Lohman, Rink-Jan, Tupally, Karnaker Reddy, Kandale, Ajit, Cabot, Peter J and Parekh, Harendra S (2023). Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy. Frontiers in Pharmacology, 14 1150313, 1150313. doi: 10.3389/fphar.2023.1150313
2023
Journal Article
A systematic review of ultrasound-mediated drug delivery to the eye and critical insights to facilitate a timely path to the clinic
Rad, Isaac J., Chapman, Luke, Tupally, Karnaker Reddy, Veidt, Martin, Al-Sadiq, Hussain, Sullivan, Robert and Parekh, Harendra S (2023). A systematic review of ultrasound-mediated drug delivery to the eye and critical insights to facilitate a timely path to the clinic. Theranostics, 13 (11), 3582-3638. doi: 10.7150/thno.82884
2022
Journal Article
Multi-physics study of acoustofluidic delivery agents' clustering behavior
AlSadiq, Hussain, Tupally, Karnaker Reddy, Vogel, Robert, Parekh, Harendra S. and Veidt, Martin (2022). Multi-physics study of acoustofluidic delivery agents' clustering behavior. Physics in Medicine and Biology, 67 (1) 015002, 015002. doi: 10.1088/1361-6560/ac4666
2021
Conference Publication
Shell properties of a new acoustofluidic delivery agent
AL-Sadiq, H. A., Tupally, K. R., Parekh, H S. and M Veidt, M. (2021). Shell properties of a new acoustofluidic delivery agent. EPSM 2020, Engineering and Physical Sciences in Medicine, Brisbane, QLD Australia, 28-29 October 2020. Dordrecht, Netherlands: Springer Netherlands.
2021
Other Outputs
Peptides and uses thereof
Parekh, Harendra, Tupally, Karnaker, Cabot, Peter and Kandale, Ajit (2021). Peptides and uses thereof. 2021300202.
2021
Conference Publication
Novel opioid peptides as allosteric modulators of nociception
Saifuddin, Danial, Lohman, Rink-Jan, Tupally, Karnaker Reddy, Parekh, Harendra S. and Cabot, Peter J. (2021). Novel opioid peptides as allosteric modulators of nociception. ASMR medical research week: Queensland virtual symposium, Online, 9-10 June 2021.
2021
Journal Article
Shell properties and concentration stability of acoustofluidic delivery agents
Alsadiq, Hussain, Tupally, Karnaker, Vogel, Robert, Kokil, Ganesh, Parekh, Harendra S. and Veidt, Martin (2021). Shell properties and concentration stability of acoustofluidic delivery agents. Physical and Engineering Sciences in Medicine, 44 (1), 79-91. doi: 10.1007/s13246-020-00954-4
2020
Journal Article
Evaluation of microalgae and cyanobacteria as potential sources of antimicrobial compounds
Alsenani, Faisal, Tupally, Karnaker R., Chua, Elvis T., Eltanahy, Eladl, Alsufyani, Hamed, Parekh, Harendra S. and Schenk, Peer M. (2020). Evaluation of microalgae and cyanobacteria as potential sources of antimicrobial compounds. Saudi Pharmaceutical Journal, 28 (12), 1834-1841. doi: 10.1016/j.jsps.2020.11.010
2020
Other Outputs
A Cyclic Peptide
Parekh, Harendra, Cabot, Peter, Tupally, Karnaker and Kandale, Ajit (2020). A Cyclic Peptide. US-20220089646-A1.
2020
Other Outputs
A cyclic peptide
Parekh, Harendra, Cabot, Peter, Tupally, Karnaker and Kandale, Ajit (2020). A cyclic peptide. 2020212659.
2020
Journal Article
Cell membrane penetration without pore formation: chameleonic properties of dendrimers in response to hydrophobic and hydrophilic environments
de Luca, Sergio, Seal, Prasenjit, Parekh, Harendra S., Tupally, Karnaker R. and Smith, Sean C. (2020). Cell membrane penetration without pore formation: chameleonic properties of dendrimers in response to hydrophobic and hydrophilic environments. Advanced Theory and Simulations, 3 (7) 1900152, 1900152. doi: 10.1002/adts.201900152
2019
Journal Article
Development of a hybrid peptide dendrimer micellar carrier system and its application in the reformulation of a hydrophobic therapeutic agent derived from traditional Chinese medicine
Jing, Jing, Tupally, Karnaker R., Kokil, Ganesh R., Qu, Zhi, Chen, Sibao and Parekh, Harendra S. (2019). Development of a hybrid peptide dendrimer micellar carrier system and its application in the reformulation of a hydrophobic therapeutic agent derived from traditional Chinese medicine. RSC Advances, 9 (5), 2458-2463. doi: 10.1039/c8ra09606f
2019
Conference Publication
Concentration stability of monolayer and bilayer lipid microbubbles–a precursor for new drug delivery applications
Alsadiq, H., Tupally, K. R., Kokil, G. R., Vogel, R., Parekh, H. S. and Veidt, M. (2019). Concentration stability of monolayer and bilayer lipid microbubbles–a precursor for new drug delivery applications. Drug Delivery Australia 2019 Conference, Brisbane, QLD Australia, 18-19 November 2019.
2018
Conference Publication
Influence of acoustofluidic parameters on velocity streaming of sonicated medical microbubbles
Alsadiq, Hussain, Reddy, Karnaker, Parekh, Harendra and Veidt, Martin (2018). Influence of acoustofluidic parameters on velocity streaming of sonicated medical microbubbles. AAS2018: Acoustics 2018: Hear to Listen, Adelaide, SA Australia, 6-9 November 2018. Adelaide, SA Australia: Australian Acoustical Society.
2017
Journal Article
Skin delivery of EGCG and silibinin: potential of peptide dendrimers for enhanced skin permeation and deposition
Shetty, Pallavi Krishna, Manikkath, Jyothsna, Tupally, Karnaker, Kokil, Ganesh, Hegde, Aswathi R., Raut, Sushil Y., Parekh, Harendra S. and Mutalik, Srinivas (2017). Skin delivery of EGCG and silibinin: potential of peptide dendrimers for enhanced skin permeation and deposition. AAPS PharmSciTech, 18 (6), 2346-2357. doi: 10.1208/s12249-017-0718-0
Supervision
Availability
- Dr Karnaker Reddy Tupally is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The pharmacological evaluation of beta-endorphin analogues: opioid-based bivalent peptide DB1-7 targeting multiple opioid receptors.
Associate Advisor
Other advisors: Dr Harendra Parekh, Dr Danial Saifuddin, Professor Peter Cabot
-
Doctor Philosophy
the role of TLR4 in the effect of opioids on tumour growth and metastasis
Associate Advisor
Other advisors: Dr Harendra Parekh, Professor Peter Cabot
-
Doctor Philosophy
Development of an acoustofluidic ocular drug delivery platform: Preparations for clinical translation
Associate Advisor
Other advisors: Professor Martin Veidt, Dr Harendra Parekh
-
Doctor Philosophy
The pharmacological evaluation of beta-endorphin analogues: opioid-based bivalent peptide DB1-7 targeting multiple opioid receptors.
Associate Advisor
Other advisors: Dr Harendra Parekh, Professor Peter Cabot
-
Doctor Philosophy
Design, synthesis and pharmacological evaluation of KOPr/NOPr opioid peptides for the treatment of pain and opioid use disorder
Associate Advisor
Other advisors: Dr Harendra Parekh, Professor Peter Cabot
-
Doctor Philosophy
Bivalent opioid constructs as allosteric modulators of nociception
Associate Advisor
Other advisors: Dr Harendra Parekh, Professor Peter Cabot
-
Doctor Philosophy
Gel-based drug delivery monitored via medical imaging
Associate Advisor
Other advisors: Dr Harendra Parekh, Dr Brett Paterson, Dr Viktor Vegh
Completed supervision
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2024
Doctor Philosophy
Bivalent opioid constructs as allosteric modulators of nociception
Associate Advisor
Other advisors: Dr Harendra Parekh, Professor Peter Cabot
-
2019
Doctor Philosophy
IDENTIFICATION AND INDUCED BIOSYNTHESIS OF NATURAL HEALTH COMPOUNDS IN MICROALGAE
Associate Advisor
Other advisors: Dr Michael Netzel, Dr Harendra Parekh
Media
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