
Overview
Background
Karnaker's research interests are natural products, peptide-based drug discovery and development, formulation chemistry and non-viral gene delivery system. Karnaker co-inventor and developed a novel, bioresponsive disulphide-linker technology, which has been used for non-viral vectors, peptide-therapeutics for pain and cancer treatment. Karnaker is also keen interest for topical, mucosal drug delivery using a range of dendrimer, nano and microbubbles, lipid and polymer-based nanoparticle systems in conjugation with both biological and physical stimuli-responsiveness.
Karnaker received a PhD in Pharmaceutical Chemistry from The University Queensland under the supervision of Dr Harendra Parekh and Dr Defang Ouyang. Prior to PhD, he completed a Master degree in Pharmaceutical Analysis and Quality assurance (India). Also worked as analytical research and development chemist for one year in a Pharma company. Since 2016, he his working with Dr Parekh team on a range of Industry-funded research projects and his role involves from ideation, research plan, execution, product delivery to industry partners on major platforms such as peptide-based therapeutics, gene therapy and sol-gel technology.
Availability
- Dr Karnaker Reddy Tupally is:
- Available for supervision
- Media expert
Fields of research
Qualifications
- Bachelor of Pharmacy, Kakatiya University
- Masters (Research), Jawharlal Nehru Technological University
- Doctor of Philosophy, The University of Queensland
Research interests
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Non-viral gene delivery
Bioresponsive peptide & Lipid-based nanoparticle for delivering gene-therapeutics
Research impacts
Karnaker is co-inventor for several patents (PCT, provisional stage) from Dr Parekh and Team, licensed to industry partners which received million dollars in funding for further research and development
Works
Search Professor Karnaker Reddy Tupally’s works on UQ eSpace
2016
Other Outputs
Engineering novel, steric stabilized disulfide-containing amino acids and their application in carrier system, therapeutic peptide and FRET-probe synthesis
Tupally, Karnaker Reddy (2016). Engineering novel, steric stabilized disulfide-containing amino acids and their application in carrier system, therapeutic peptide and FRET-probe synthesis. PhD Thesis, School of Pharmacy, The University of Queensland. doi: 10.14264/390469
2016
Book Chapter
Introduction to diabetes and type 1 diabetes
Singh, Prachi, Kokil, Ganesh R., Tupally, Karnaker R., Poddar, Kingshuk, Tan, Aaron, Venkatesan, Venky, Parekh, Harendra S. and Pastorin, Giorgia (2016). Introduction to diabetes and type 1 diabetes. Therapeutic perspectives in type-1 diabetes. (pp. 1-6) edited by Prachi Singh, Ganesh R. Kokil, Karnaker R. Tupally, Kingshuk Poddar, Aaron Tan, Venky Venkatesan, Harendra S. Parekh and Giorgia Pastorin. Singapore, Singapore: Springer. doi: 10.1007/978-981-10-0602-9_1
2016
Book
Therapeutic perspectives in Type-1 Diabetes
Singh, Prachi, Kokil, Ganesh R., Tupally, Karnaker R., Poddar, Kingshuk, Tan, Aaron, Venkatesan, Venky, Parekh, Harendra S. and Pastorin, Giorgia (2016). Therapeutic perspectives in Type-1 Diabetes. Singapore: Springer. doi: 10.1007/978-981-10-0602-9
2015
Book Chapter
Dendrimers
Tupally, Karnaker R., Kokil, Ganesh K., Thakur, Sachin S., Singh, Prachi and Parekh, Harendra S. (2015). Dendrimers. Controlled release systems: advances in nanobottles and active nanoparticles. (pp. 259-286) edited by Alexander van Herk, Jacqueline Forcada and Giorgia Pastorin. Boca Raton, FL, United States: Taylor & Francis. doi: 10.1201/b19860-15
2013
Book Chapter
Fluorescent nucleic acid probes in living cells
Seefeld, Anne, Kokil, Ganesh R., Tupally, Karnaker R., Parekh, Harendra S. and Herten, Dirk-Peter (2013). Fluorescent nucleic acid probes in living cells. DNA and RNA nanobiotechnologies in medicine: diagnosis and treatment of diseases. (pp. 291-328) edited by Volker A. Erdmann and Jan Barciszewski. Berlin, Germany: Springer. doi: 10.1007/978-3-642-36853-0_12
Supervision
Availability
- Dr Karnaker Reddy Tupally is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Development of an acoustofluidic ocular drug delivery platform: Preparations for clinical translation
Associate Advisor
Other advisors: Professor Martin Veidt, Dr Harendra Parekh
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Doctor Philosophy
Design, synthesis and pharmacological evaluation of KOPr/NOPr opioid peptides for the treatment of pain and opioid use disorder
Associate Advisor
Other advisors: Dr Harendra Parekh, Professor Peter Cabot
-
Doctor Philosophy
The pharmacological evaluation of beta-endorphin analogues: opioid-based bivalent peptide DB1-7 targeting multiple opioid receptors.
Associate Advisor
Other advisors: Dr Harendra Parekh, Professor Peter Cabot
-
Doctor Philosophy
Bivalent opioid constructs as allosteric modulators of nociception
Associate Advisor
Other advisors: Dr Harendra Parekh, Professor Peter Cabot
-
Doctor Philosophy
Development of an acoustofluidic ocular drug delivery platform: Preparations for clinical translation
Associate Advisor
Other advisors: Professor Martin Veidt, Dr Harendra Parekh
-
Doctor Philosophy
Gel-based drug delivery monitored via medical imaging
Associate Advisor
Other advisors: Dr Harendra Parekh, Dr Brett Paterson
-
Doctor Philosophy
the role of TLR4 in the effect of opioids on tumour growth and metastasis
Associate Advisor
Other advisors: Dr Harendra Parekh, Professor Peter Cabot
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Doctor Philosophy
The pharmacological evaluation of beta-endorphin analogues: opioid-based bivalent peptide DB1-7 targeting multiple opioid receptors.
Associate Advisor
Other advisors: Dr Harendra Parekh, Dr Danial Saifuddin, Professor Peter Cabot
Completed supervision
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2025
Doctor Philosophy
Development of an acoustofluidic ocular drug delivery platform: Preparations for clinical translation
Associate Advisor
Other advisors: Professor Martin Veidt, Dr Harendra Parekh
-
2024
Doctor Philosophy
Bivalent opioid constructs as allosteric modulators of nociception
Associate Advisor
Other advisors: Dr Harendra Parekh, Professor Peter Cabot
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2019
Doctor Philosophy
IDENTIFICATION AND INDUCED BIOSYNTHESIS OF NATURAL HEALTH COMPOUNDS IN MICROALGAE
Associate Advisor
Other advisors: Dr Michael Netzel, Dr Harendra Parekh
Media
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