Multiphoton microscopy of living animals as a tool for immunology and cell biology studies (2009-2010)

This application is for a single item of equipment, a multiphoton microscope with split beam scanning capacity designed particularly for rapid imaging of living animal tissues to maintain the examination as physiologically relevant as practical and to allow repeated examinations of the same living animal over time. Aim is to enable observation of interaction over time between tumour cells, immune cells, and host stroma which will significantly advance our understanding of these interactions at the cellular and sub-cellular level. Outcome will be better insights into the physiology and pathophysiology of the immune system and of regulation of cell growth and division, which may underpin the development of new therapy for disease.