
Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
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High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2017
Conference Publication
Phosphatase and Tensin Homolog (PTEN) loss is associated with changes in Ca2+ signalling in MDA-MB-231 cells
Bong, Alice H.L., Hua, Trinh, Bassett, John J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2017). Phosphatase and Tensin Homolog (PTEN) loss is associated with changes in Ca2+ signalling in MDA-MB-231 cells. 20th International Symposium on Calcium Binding Proteins and Calcium Function in Health and Disease, Awaji City, Japan, 22-26 October 2017.
2017
Conference Publication
Assessment of calcium responses induced by the transient receptor potential cation channel subfamily V member 4 (TRPV4) activator GSK1016790A in MDA-MD-468 breast cancer cells using automated epifluorescence microscopy
Wagner, Zara N., Azimi, Iman, Bassett, Johnathon J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2017). Assessment of calcium responses induced by the transient receptor potential cation channel subfamily V member 4 (TRPV4) activator GSK1016790A in MDA-MD-468 breast cancer cells using automated epifluorescence microscopy. APSA-ASCEPT Joint Scientific Meeting, Brisbane, Australia , 5-8 December 2017.
2017
Conference Publication
Phosphatase and tensin homolog (PTEN) silencing suppresses Ca2+ responses in MDA-MB-231 breast cancer cells
Hua, Trin N., Bong, Alice H.L., Bassett, John J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2017). Phosphatase and tensin homolog (PTEN) silencing suppresses Ca2+ responses in MDA-MB-231 breast cancer cells. APSA-ASCEPT Joint Scientific Meeting, Brisbane, QLD, Australia, 5-8 December 2017.
2017
Conference Publication
TRPV4 in breast cancer of the basal molecular subtype
Monteith, Gregory R. (2017). TRPV4 in breast cancer of the basal molecular subtype. Calcium Signalling Gordon Research Conference: Intracellular Calcium Signals: Generation, Function and Therapeutic Intervention, Lucca, Italy, 18-23 June 2017.
2017
Conference Publication
Imaging intracellular Ca2+ dynamics in breast cancer using automated high-content fluorescence imaging
Bong, Alice, Bassett, John J, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2017). Imaging intracellular Ca2+ dynamics in breast cancer using automated high-content fluorescence imaging. SLAS2017, Washington, DC, United States, 4-8 February 2017.
2017
Book Chapter
Calcium channels and pumps: importance during lactation as potential targets for breast cancer
Monteith, Gregory R. and Stewart, Teneale A. (2017). Calcium channels and pumps: importance during lactation as potential targets for breast cancer. Essential and Non-essential Metals: Carcinogenesis, Prevention and Cancer Therapeutics. (pp. 1-17) edited by Mudipalli, Anuradha and Zelikoff, Judith T.. Cham, Switzerland: Springer. doi: 10.1007/978-3-319-55448-8_1
2017
Conference Publication
Monitoring altered Ca2+ signalling in breast cancer cells with a high-content imaging model of intracellular Ca2+ dynamics using genetically encoded calcium indicators expressed in MDA-MB-231 breast cancer cells
Bassett, John, Peters, Amelia, Roberts-Thomson, Sarah and Monteith, Gregory (2017). Monitoring altered Ca2+ signalling in breast cancer cells with a high-content imaging model of intracellular Ca2+ dynamics using genetically encoded calcium indicators expressed in MDA-MB-231 breast cancer cells. SLAS High-content screening conference, Madrid, Spain, 19-21 September, 2017.
2017
Conference Publication
Identification of TRPC1 as a modulator of AKT phosphorylation in HCC1569 breast cancer cells
Turner, Dane, Kaemmerer, Elke, Azimi, Iman, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2017). Identification of TRPC1 as a modulator of AKT phosphorylation in HCC1569 breast cancer cells. ASCEPT-MPGPCR, Melbourne, Australia, 27–30 November 2016. Hamilton Central QLD Australia: ASCEPT.
2017
Conference Publication
Consequences of pharmacological inhibition of store-operated calcium entry on calcium signalling in MDA-MB-468 breast cancer cells
Poo, Greta X. H., Azimi, Iman, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2017). Consequences of pharmacological inhibition of store-operated calcium entry on calcium signalling in MDA-MB-468 breast cancer cells. APSA-ASCEPT Joint Scientific Meeting, Brisbane, Australia, 5-8 December 2017.
2017
Conference Publication
Monitoring altered Ca2+ signalling in breast cancer cells with a high-throughput model of intracellular Ca2+ dynamics using genetically encoded calcium indicators expressed in MDA-MB-231 breast cancer cells
Bassett, John J., Peters, Amelia A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2017). Monitoring altered Ca2+ signalling in breast cancer cells with a high-throughput model of intracellular Ca2+ dynamics using genetically encoded calcium indicators expressed in MDA-MB-231 breast cancer cells. Society for Laboratory Automation and Screening annual meeting, Washington DC, United States, 4-8 February 2017.
2017
Conference Publication
Neuronal calcium sensor-1 (NCS-1) in the regulation of calcium homeostasis and cell death in MDA-MB-231 basal breast cancer cells
Bong, Alice H. L., Bassett, John J., Roberts-Thomson, Sarah J., Milevskiy, Michael J. G. and Monteith, Gregory R. (2017). Neuronal calcium sensor-1 (NCS-1) in the regulation of calcium homeostasis and cell death in MDA-MB-231 basal breast cancer cells. APSA-ASCEPT Joint Scientific Meeting, Brisbane, Australia, 5-8 December 2017.
2017
Book Chapter
Genetically encoded calcium indicators as probes to assess the role of calcium channels in disease and for high-throughput drug discovery
Bassett, J. J. and Monteith, G. R. (2017). Genetically encoded calcium indicators as probes to assess the role of calcium channels in disease and for high-throughput drug discovery. Ion Channels DownUnder. (pp. 141-171) Maryland Heights, MO, United States: Academic Press. doi: 10.1016/bs.apha.2017.01.001
2017
Conference Publication
ER-LAR-GEC01 and R-CEPIA1er as tools to measure endoplasmic reticulum calcium in breast cancer cells
El Washahy, Mohamed, Marcial, Daneth L., Bassett, John, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2017). ER-LAR-GEC01 and R-CEPIA1er as tools to measure endoplasmic reticulum calcium in breast cancer cells. ASCEPT-MPGPCR, Melbourne, VIC, Australia, 27–30 November 2016. Hamilton Central QLD Australia: ASCEPT.
2017
Conference Publication
TRPC1 regulates hypoxia associated events in PTEN-deficient breast cancer cells
Azimi, I., Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2017). TRPC1 regulates hypoxia associated events in PTEN-deficient breast cancer cells. Calcium Signalling Gordon Research Conference: Intracellular calcium signals: Generation, Function and Therapeutic Intervention, Lucca, Italy, 18-23 June 2017.
2017
Conference Publication
Ion channels and promotion of cell death pathways in triple negative breast cancer cells
Monteith, Gregory R. (2017). Ion channels and promotion of cell death pathways in triple negative breast cancer cells. 20th International Symposium on Calcium Binding Proteins and Calcium Function in Health and Disease, Awaji, Japan, 22-26 October 2017.
2016
Journal Article
Plasma membrane ion channels and epithelial to mesenchymal transition in cancer cells
Azimi, Iman and Monteith, Gregory R. (2016). Plasma membrane ion channels and epithelial to mesenchymal transition in cancer cells. Endocrine-Related Cancer, 23 (11), R517-R525. doi: 10.1530/ERC-16-0334
2016
Journal Article
PMCA2 silencing potentiates MDA-MB-231 breast cancer cell death initiated with the Bcl-2 inhibitor ABT-263
Curry, Merril, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). PMCA2 silencing potentiates MDA-MB-231 breast cancer cell death initiated with the Bcl-2 inhibitor ABT-263. Biochemical and Biophysical Research Communications, 478 (4), 1792-1797. doi: 10.1016/j.bbrc.2016.09.030
2016
Journal Article
GAG mimetic functionalised solid and mesoporous silica nanoparticles as viral entry inhibitors of herpes simplex type 1 and type 2 viruses
Lee, Edward C., Davis-Poynter, Nicholas, Nguyen, Chau T. H., Peters, Amelia A., Monteith, Gregory R., Strounina, Ekaterina, Popat, Amirali and Ross, Benjamin P. (2016). GAG mimetic functionalised solid and mesoporous silica nanoparticles as viral entry inhibitors of herpes simplex type 1 and type 2 viruses. Nanoscale, 8 (36), 16192-16196. doi: 10.1039/c6nr03878f
2016
Journal Article
Differential effects of two-pore channel protein 1 and 2 silencing in MDA-MB-468 breast cancer cells
Jahidin, Aisyah H., Stewart, Teneale A., Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). Differential effects of two-pore channel protein 1 and 2 silencing in MDA-MB-468 breast cancer cells. Biochemical and Biophysical Research Communications, 477 (4), 731-736. doi: 10.1016/j.bbrc.2016.06.127
2016
Journal Article
Janus kinases and Src family kinases in the regulation of EGF-induced vimentin expression in MDA-MB-468 breast cancer cells
Stewart, Teneale A., Azimi, Iman, Brooks, Andrew J., Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). Janus kinases and Src family kinases in the regulation of EGF-induced vimentin expression in MDA-MB-468 breast cancer cells. The International Journal of Biochemistry and Cell Biology, 76, 64-74. doi: 10.1016/j.biocel.2016.05.007
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Calcium signalling pathways in cancer progression
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Calcium signalling changes associated with viral infection
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Calcium channels and pumps as drug targets
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Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
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Doctor Philosophy
Calcium signalling and cell death pathways in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
Calcium signalling in the context of cell in cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Master Philosophy
Investigating the role of exosomes in cancer progression and immunology
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
Completed supervision
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2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
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2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
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2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
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2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
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2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
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2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
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2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
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2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
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2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
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2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
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2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
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2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
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2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
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2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
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2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
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2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
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2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
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2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
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2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
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Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
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