
Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
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High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2016
Journal Article
The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin
Peters, Amelia A., Milevskiy, Michael J. G., Lee, WeiC., Curry, Merril C., Smart, Chanel E., Saunus, Jodi M., Reid, Lynne, da Silva, Leonard, Marcial, Daneth L., Dray, Eloise, Brown, Melissa A., Lakhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin. Scientific Reports, 6 (1) 25505, 25505. doi: 10.1038/srep25505
2016
Journal Article
The voltage gated Ca2+-channel Cav3.2 and therapeutic responses in breast cancer
Pera, Elena, Kaemmerer, Elke, Milevskiy, Michael J. G., Yapa, Kunsala T. D. S., O'Donnell, Jake S., Brown, Melissa A., Simpson, Fiona, Peters, Amelia A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). The voltage gated Ca2+-channel Cav3.2 and therapeutic responses in breast cancer. Cancer Cell International, 16 (24) 24, 24. doi: 10.1186/s12935-016-0299-0
2016
Conference Publication
An Assessment of the effects of doxorubicin on calcium signalling in MDA-MB-231 breast cancer cells
Bong, Alice H. L., Bassett, John J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). An Assessment of the effects of doxorubicin on calcium signalling in MDA-MB-231 breast cancer cells. ASCEPT-MPGPCR, Melbourne, Australia, 27–30 November 2016.
2016
Conference Publication
Assessment of cytosolic free calcium levels in MDA-MB-231 breast cancer cells undergoing cell death following treatment with ceramide and staurosporine
Bassett, John J., Peters, Amelia A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). Assessment of cytosolic free calcium levels in MDA-MB-231 breast cancer cells undergoing cell death following treatment with ceramide and staurosporine. ASCEPT-MPGPCR, Melbourne, VIC, Australia, 27–30 November, 2016.
2016
Conference Publication
Changes in calcium signalling as a consequence of doxorubicin treatment in MDA-MB-231 breast cancer cells expressing a genetically-encoded calcium indicator
Bong, Alice H. I., Bassett, John J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). Changes in calcium signalling as a consequence of doxorubicin treatment in MDA-MB-231 breast cancer cells expressing a genetically-encoded calcium indicator. 14th International Meeting of the European Calcium Society, Valladolid, Spain, 25-29 September 2016.
2016
Conference Publication
Effects of transient receptor potential cation channel V4 (TRPV4) Activation on MDA-MB-468 breast cancer cells
Yappa, K. T. D. S. , Peters, A. A ., Chalmers, S., Marical, D., Robert-Thomson, S. J. and Monteith, Gregory R. (2016). Effects of transient receptor potential cation channel V4 (TRPV4) Activation on MDA-MB-468 breast cancer cells. Australian Society for Medical Research (ASMR), Brisbane, QLD, Australia, 1 June 2016.
2016
Journal Article
Altered purinergic receptor-Ca2+ signaling associated with hypoxia-induced epithelial-mesenchymal transition in breast cancer cells
Azimi, Iman, Beilby, Hannah, Davis, Felicity M., Marcial, Daneth L., Kenny, Paraic A., Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). Altered purinergic receptor-Ca2+ signaling associated with hypoxia-induced epithelial-mesenchymal transition in breast cancer cells. Molecular Oncology, 10 (1), 166-178. doi: 10.1016/j.molonc.2015.09.006
2016
Conference Publication
Golgi calcium pump secretory pathway Ca2+ ATPase 1 (SPCA1) in breast cancer cells
Peters, A. A. , Lee, J. M. H. , Marcial, D. , Kenny, P. , Hu, W. , Kineav, I. , Roberts-Thomson, S. J. and Monteith, Gregory R. (2016). Golgi calcium pump secretory pathway Ca2+ ATPase 1 (SPCA1) in breast cancer cells. AuPS/ABS Conference 2016, Adelaide, SA, Australia, 4-7 December 2016.
2016
Conference Publication
Assessment of cytosolic free calcium levles in GCaMP6m expressing MDA-MB-231 breast cancer cells undergoing cell death using time-lapse high-content imaging
Bassett, John, Peters, Amelia, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). Assessment of cytosolic free calcium levles in GCaMP6m expressing MDA-MB-231 breast cancer cells undergoing cell death using time-lapse high-content imaging. 14th International Meeting of the European Calcium Society, Valladolid, Spain, 25-29 September 2016.
2016
Conference Publication
Assessment of TRPV4-mediated calcium influx induced by receptor activiation in MDA-MB-468 breast cancer cells
Armitage, Kaela, Azimi, Iman , McIntyre, Peter , Bunnett, Nigel , Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). Assessment of TRPV4-mediated calcium influx induced by receptor activiation in MDA-MB-468 breast cancer cells. ASCEPT-MPGPCR, Melbourne, Australia, 27–30 November 2016. ASCEPT.
2016
Conference Publication
Calcium permeable ion channel remodelling in breast cancer
Monteith, Gregory R. (2016). Calcium permeable ion channel remodelling in breast cancer. HH3-08 3rd floor, Sir Hans Heysen Bldg, Adelaide, Australia, 4-7 December 2016.
2016
Conference Publication
Changes in calcium signaling as a consequence of doxorubicin treatment in MDA-MB-231 breast cancer cells expressing a genetically-encoded calcium indicator
Bong, Alice H. L. , Bassett, John J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). Changes in calcium signaling as a consequence of doxorubicin treatment in MDA-MB-231 breast cancer cells expressing a genetically-encoded calcium indicator. 14th International Meeting of the European Calcium Society, Valladolid, Spain, 25-29 September 2016.
2016
Journal Article
Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay
Azimi, Iman, Flanagan, Jack U., Stevenson, Ralph J., Inserra, Marco, Vetter, Irina, Monteith, Gregory R. and Denny, William A. (2016). Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca2+ entry in MDA-MB-231 breast cancer cells using a Fluorescence Imaging Plate Reader assay. Bioorganic and Medicinal Chemistry, 25 (1), 440-449. doi: 10.1016/j.bmc.2016.11.007
2015
Journal Article
Altered calcium signaling in cancer cells
Stewart, Teneale A., Yapa, Kunsala T. D. S. and Monteith, Gregory R. (2015). Altered calcium signaling in cancer cells. Biochimica et Biophysica Acta - Biomembranes, 1848 (10), 2502-2511. doi: 10.1016/j.bbamem.2014.08.016
2015
Journal Article
Sequence diversity and differential expression of major phenylpropanoid-flavonoid biosynthetic genes among three mango varieties
Hoang, Van L. T., Innes, David J., Shaw, P. Nicholas, Monteith, Gregory R., Gidley, Michael J. and Dietzgen, Ralf G. (2015). Sequence diversity and differential expression of major phenylpropanoid-flavonoid biosynthetic genes among three mango varieties. BMC Genomics, 16 (561) 561, 561. doi: 10.1186/s12864-015-1784-x
2015
Journal Article
Estrogen modulation properties of mangiferin and quercetin and the mangiferin metabolite norathyriol
Wilkinson, Ashley S., Taing, Meng-Wong, Pierson, Jean Thomas, Lin, Chun-Nam, Dietzgen, Ralf G., Shaw, P. Nicholas, Gidley, Michael J., Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2015). Estrogen modulation properties of mangiferin and quercetin and the mangiferin metabolite norathyriol. Food and Function, 6 (6), 1847-1854. doi: 10.1039/c5fo00133a
2015
Journal Article
Essential role of Orai1 store-operated calcium channels in lactation
Davis, Felicity M., Janoshazi, Agnes, Janardhan, Kyathanahalli S., Steinckwich, Natacha, D'Agostin, Diane M., Petranka, John G., Desai, Pooja N., Roberts-Thomson, Sarah J., Bird, Gary S., Tucker, Deirdre K., Fenton, Suzanne E., Feske, Stefan, Monteith, Gregory R. and Putney, James W. (2015). Essential role of Orai1 store-operated calcium channels in lactation. Proceedings of the National Academy of Sciences of the United States of America, 112 (18), 5827-5832. doi: 10.1073/pnas.1502264112
2015
Journal Article
A role for calcium in the regulation of ATP-binding cassette, sub-family C, member 3 (ABCC3) gene expression in a model of epidermal growth factor-mediated breast cancer epithelial-mesenchymal transition
Stewart, Teneale Amber, Azimi, Iman, Thompson, Erik W, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2015). A role for calcium in the regulation of ATP-binding cassette, sub-family C, member 3 (ABCC3) gene expression in a model of epidermal growth factor-mediated breast cancer epithelial-mesenchymal transition. Biochemical and Biophysical Research Communication, 458 (3), 509-514. doi: 10.1016/j.bbrc.2015.01.141
2015
Journal Article
Polyphenolic contents and the effects of methanol extracts from mango varieties on breast cancer cells
Hoang, Van Le Thu, Pierson, Jean-Thomas, Curry, Merril Carmel, Shaw, Paul Nicholas, Dietzgen, Ralf Georg, Gidley, Michael John, Roberts-Thomson, Sarah Jane and Monteith, Gregory Raymond (2015). Polyphenolic contents and the effects of methanol extracts from mango varieties on breast cancer cells. Food Science and Biotechnology, 24 (1), 265-271. doi: 10.1007/s10068-015-0035-x
2015
Journal Article
Mango fruit extracts differentially affect proliferation and intracellular calcium signalling in MCF-7 human breast cancer cells
Taing, Meng-Wong, Pierson, Jean-Thomas, Shaw, Paul N., Dietzgen, Ralf G., Roberts-Thomson, Sarah J., Gidley, Michael J. and Monteith, Gregory R. (2015). Mango fruit extracts differentially affect proliferation and intracellular calcium signalling in MCF-7 human breast cancer cells. Journal of Chemistry, 2015 613268, 613268.1-613268.10. doi: 10.1155/2015/613268
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
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Available projects
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Calcium signalling pathways in cancer progression
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Calcium signalling changes associated with viral infection
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Calcium channels and pumps as drug targets
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Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
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Doctor Philosophy
Calcium signalling and cell death pathways in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
Calcium signalling in the context of cell in cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Master Philosophy
Investigating the role of exosomes in cancer progression and immunology
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
Completed supervision
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2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
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2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
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2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
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2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
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2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
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2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
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2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
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2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
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2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
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2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
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2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
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2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
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2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
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2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
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2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
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2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
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2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
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2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
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2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
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Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
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