
Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
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High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2013
Conference Publication
Development of a fluorescent imaging plate reader (FLIPR TETRA) based screen to identify regulators of store operated calcium entry in breast cancer cells
Azimi, Iman, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Development of a fluorescent imaging plate reader (FLIPR TETRA) based screen to identify regulators of store operated calcium entry in breast cancer cells. SLAS 2nd Annual Conference & Exhibition 2013 (Slas2013), Orlando, FL, United States, 12-16 January 2013.
2013
Conference Publication
Reactive oxygen species alters the expression of specific calcium channels during hypoxia-mediated epithelial-mesenchymal transition in breast cancer cells
Azimi, Iman, Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Reactive oxygen species alters the expression of specific calcium channels during hypoxia-mediated epithelial-mesenchymal transition in breast cancer cells. 2013 8th International Human Peroxidase Meeting & 6th Joint Meeting of the Societies for Free Radical Research Australasia and Japan, Sydney, NSW, Australia, 9-14 September, 2013.
2013
Conference Publication
Calcium transporters and modulator profiling in trastuzumab-resistant SKBR3R breast cancer cells
Pera, Elena, Peters, Amelia A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Calcium transporters and modulator profiling in trastuzumab-resistant SKBR3R breast cancer cells. ASCEPT 2013: Annual Scientific Meeting, Melbourne, VIC, Australia, 1-4 December, 2013. Hamilton Central, QLD, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists.
2013
Conference Publication
A targeted siRNA based screen to identify calcium transporters involved in the calcium-dependent regulation of ABCC3 gene expression in a model of breast cancer epithelial-mesenchymal transition (EMT)
Stewart, Teneale A., Azimi, Iman, Davis, Felicity M., Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). A targeted siRNA based screen to identify calcium transporters involved in the calcium-dependent regulation of ABCC3 gene expression in a model of breast cancer epithelial-mesenchymal transition (EMT). ASCEPT 2013: Annual Scientific Meeting, Melbourne, VIC, Australia, 1-4 December, 2013. Hamilton Central, QLD, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists.
2013
Conference Publication
Design and testing of novel anti-cancer agents targeting secretory pathway calcium ATPase
Lin, Jennifer H., Peters, Amelia A., Monteith, Gregory R., Groundwater, Paul W. and Hibbs, David E. (2013). Design and testing of novel anti-cancer agents targeting secretory pathway calcium ATPase. ASCEPT 2013: Annual Scientific Meeting, Melbourne, VIC, Australia, 1-4 December, 2013. Hamilton Central QLD, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists.
2013
Conference Publication
Calcium pumps, channels and channel modulator profiling in trastuzumab-resistant SKBR3R breast cancer cell
Pera, Elena, Peters, Amelia, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Calcium pumps, channels and channel modulator profiling in trastuzumab-resistant SKBR3R breast cancer cell. Gordon Research Conference - Calcium Signaling, Italy, 16 - 21 June 2013.
2013
Conference Publication
Role of reactive oxygen species in calcium signalling in hypoxia-induced epithelial-mesenchymal transition
Azimi, Iman, Thompson, Erik W, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Role of reactive oxygen species in calcium signalling in hypoxia-induced epithelial-mesenchymal transition. ASCEPT 2013: Annual Scientific Meeting, Melbourne, VIC, Australia, 1-4 December, 2013. Hamilton Central, QLD, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists.
2013
Conference Publication
Calcium signal-dependent up-regulation of ATP binding cassette, subfamily c, member 3 (ABCC3), associated with epithelial-mesenchymal transition (EMT) in MDA-MB-468 breast cancer cells: implications for drug resistance in metastasis
Stewart, Teneale A., Azimi, Iman, Davis, Felicity M., Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Calcium signal-dependent up-regulation of ATP binding cassette, subfamily c, member 3 (ABCC3), associated with epithelial-mesenchymal transition (EMT) in MDA-MB-468 breast cancer cells: implications for drug resistance in metastasis. Nature-CNIO Cancer Symposium on Frontiers in Tumour Heterogeneity and Plasticity, Madrid, Spain, 27-30 October, 2013. Madrid, Spain: Centro Nacional de Investigaciones Oncológicas (CNIO).
2013
Conference Publication
Activation of over-expressed calcium channels as a potential therapeutic strategy for the treatment for breast cancer
Peters, Amelia A., Wu, Tina, Tan, Ping T., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Activation of over-expressed calcium channels as a potential therapeutic strategy for the treatment for breast cancer. ASCEPT 2013: Annual Scientific Meeting, Melbourne, VIC, Australia, 1-4 December, 2013. Hamilton Central, QLD, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists.
2012
Journal Article
Quality use of medicines – Medication safety issues in naming; Look-alike, sound-alike medicine names
Ostini, Remo, Roughead, Elizabeth E., Kirkpatrick, Carl M. J., Monteith, Gregory R. and Tett, Susan E. (2012). Quality use of medicines – Medication safety issues in naming; Look-alike, sound-alike medicine names. International Journal of Pharmacy Practice, 20 (6), 349-357. doi: 10.1111/j.2042-7174.2012.00210.x
2012
Journal Article
Calcium channels and pumps in cancer: changes and consequences
Monteith, Gregory R., Davis, Felicity M. and Roberts-Thomson, Sarah J. (2012). Calcium channels and pumps in cancer: changes and consequences. Journal of Biological Chemistry, 287 (38), 31666-31673. doi: 10.1074/jbc.R112.343061
2012
Journal Article
Distinct regulation of cytoplasmic calcium signals and cell death pathways by different plasma membrane calcium ATPase isoforms in MDA-MB-231 breast cancer cells
Curry, Merril C., Luk, Nicole A., Kenny, Paraic A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Distinct regulation of cytoplasmic calcium signals and cell death pathways by different plasma membrane calcium ATPase isoforms in MDA-MB-231 breast cancer cells. Journal of Biological Chemistry, 287 (34), 28598-28608. doi: 10.1074/jbc.M112.364737
2012
Journal Article
Mango fruit peel and flesh extracts affect adipogenesis in 3T3-L1 cells
Taing, Meng-Wong, Pierson, Jean-Thomas, Hoang, Van L. T., Shaw, Paul N., Dietzgen, Ralf G., Gidley, Michael J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Mango fruit peel and flesh extracts affect adipogenesis in 3T3-L1 cells. Food and Function, 3 (8), 828-836. doi: 10.1039/c2fo30073g
2012
Journal Article
Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor negative breast cancer
Peters, Amelia A., Simpson, Peter T., Bassett, Johnathon J., Lee, Jane M., Da Silva, Leonard, Reid, Lynne E., Song, Sarah, Parat, Marie-Odile, Lakhani, Sunil R., Kenny, Paraic A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Calcium channel TRPV6 as a potential therapeutic target in estrogen receptor negative breast cancer. Molecular Cancer Therapeutics, 11 (10), 2158-2168. doi: 10.1158/1535-7163.MCT-11-0965
2012
Journal Article
Non-stimulated, agonist-stimulated and store-operated ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF-induced EMT on calcium entry
Davis, Felicity M., Peters, Amelia A., Grice, Desma M., Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Non-stimulated, agonist-stimulated and store-operated ca2+ influx in MDA-MB-468 breast cancer cells and the effect of EGF-induced EMT on calcium entry. PLoS One, 7 (5) e36923, e36923.1-e36923.11. doi: 10.1371/journal.pone.0036923
2012
Journal Article
Major Australian tropical fruits biodiversity: Bioactive compounds and their bioactivities
Pierson, Jean T., Dietzgen, Ralf G., Shaw, Paul N., Roberts-Thomson, Sarah J., Monteith, Gregory R. and Gidley, Michael J. (2012). Major Australian tropical fruits biodiversity: Bioactive compounds and their bioactivities. Molecular Nutrition and Food Research, 56 (3), 357-387. doi: 10.1002/mnfr.201100441
2012
Conference Publication
Differential effects of store operated calcium entry proteins on the calcium-mediated transcription factor NFkappaB in MDA-MB-231 breast cancer cells
Luk, N. A., Roberts-Thomson, S. J. and Monteith, G. R. (2012). Differential effects of store operated calcium entry proteins on the calcium-mediated transcription factor NFkappaB in MDA-MB-231 breast cancer cells. 4th EMBO Meeting 2012, Nice, France, 22-25 September 2012.
2012
Conference Publication
The role of the secretory pathway calcium ATPases (SPCAs) in breast cancer
Lee, Jane M., Ross, Diana G. F., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). The role of the secretory pathway calcium ATPases (SPCAs) in breast cancer. Joint ASCEPT-APSA 2012 Conference, Sydney, Australia, 2-5 December 2012.
2012
Conference Publication
Role of hypoxia-induced epithelial-mesenchymal transition in calcium signalling in breast cancer cells
Azimi, I., Beilby, H., Davis, F. M., Roberts-Thomson, S. J. and Monteith, G. R. (2012). Role of hypoxia-induced epithelial-mesenchymal transition in calcium signalling in breast cancer cells. 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin Ireland, 6-9 November 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/S0959-8049(12)72301-8
2012
Conference Publication
Assessment of two-pore channels in MDA-MB-231 breast cancer cells
Jahidin, Aisyah, Curry, Merril, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Assessment of two-pore channels in MDA-MB-231 breast cancer cells. Joint ASCEPT-APSA 2012 Conference, Medication Safety, Sydney, Australia, 2-5 December 2012.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
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Available projects
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Calcium signalling pathways in cancer progression
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Calcium signalling changes associated with viral infection
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Calcium channels and pumps as drug targets
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Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
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Doctor Philosophy
Calcium signalling and cell death pathways in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
Calcium signalling in the context of cell in cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Master Philosophy
Investigating the role of exosomes in cancer progression and immunology
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
Completed supervision
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2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
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2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
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2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
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2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
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2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
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2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
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2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
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2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
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2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
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2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
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2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
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2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
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2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
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2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
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2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
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2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
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2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
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2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
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2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
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Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
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