
Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
-
calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
-
High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2014
Conference Publication
Tumour microenvironment factors and the promotion of epithelial to mesenchymal transition in MDA-MB-468 breast cancer cells
Mitchell, Marnie E., Azimi, Iman , Davis, Felicity M., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2014). Tumour microenvironment factors and the promotion of epithelial to mesenchymal transition in MDA-MB-468 breast cancer cells. ASCEPT-MPGPCR Joint Scientific Meeting, Melbourne, VIC Australia, 7-11 December 2014.
2014
Conference Publication
Calcium efflux pump, PMCA2, in human breast tissue with lactational change and as a therapeutic target in breast cancer
Peters, Amelia A., Lee, Wei C., Dray, Eloise, Smart, Chanel E., Reid, Lynne , da Silva, Leonard , Lakhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2014). Calcium efflux pump, PMCA2, in human breast tissue with lactational change and as a therapeutic target in breast cancer. 2nd Annual Congress of The European Society for Translational Medicine Medicine, Vienna, Austria, 22-25 September 2014.
2014
Conference Publication
Assessment of Janus protein tyrosine kinases as potential regulators of epithelial-mesenchymal transition using a model of epidermal growth factor induced breast cancer epithelial-mesenchymal transition
Bassett, John J., Stewart, Teneale A., Azimi, Iman , Davis, Felicity M., Thompson, Erik W., Brooks, Andrew J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2014). Assessment of Janus protein tyrosine kinases as potential regulators of epithelial-mesenchymal transition using a model of epidermal growth factor induced breast cancer epithelial-mesenchymal transition. ASCEPT-MPGPCR Joint Scientific Meeting, Melbourne, VIC Australia, 7-11 December 2014.
2014
Conference Publication
Inhibition of the secretory pathway calcium ATPase 1 (SPCA1) in MDA-MB-231 breast cancer cells and the effect on protein expression
Lee, Jane M., Ross, Diana G., Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2014). Inhibition of the secretory pathway calcium ATPase 1 (SPCA1) in MDA-MB-231 breast cancer cells and the effect on protein expression. 105th Annual Meeting of the American Association for Cancer Research (AACR), San Diego, CA United States, 05-09 April 2014. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2014-3301
2014
Conference Publication
PMCA2 in human breast tissue with lactational change and in human breast cancer cells
Peters, Amelia A., Lee, Wei C., Dray, Eloise , Smart, Chanel E., Reid, Lynne , da Silva, Leonard , Lakhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2014). PMCA2 in human breast tissue with lactational change and in human breast cancer cells. 13th International Meeting of the European Calcium Society, Aix-en-Provence, France, 13-17 September 2014.
2014
Journal Article
Phytochemical extraction, characterisation and comparative distribution across four mango (Mangifera indica L.) fruit varieties
Pierson, Jean T., Monteith, Gregory R., Roberts-Thomson, Sarah J., Dietzgen, Ralf G., Gidley, Michael J. and Shaw, Paul N. (2014). Phytochemical extraction, characterisation and comparative distribution across four mango (Mangifera indica L.) fruit varieties. Food Chemistry, 149, 253-263. doi: 10.1016/j.foodchem.2013.10.108
2014
Conference Publication
Assessment of the consequences of silencing of the secretory pathway calcium ATPase 1 in MDA-MB-231 breast cancer cells
Chaw, Lisa Y. Y., Peters, Amelia A., Lee, Jane M., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2014). Assessment of the consequences of silencing of the secretory pathway calcium ATPase 1 in MDA-MB-231 breast cancer cells. ASCEPT-MPGPCR Joint Scientific Meeting, Melbourne, Vic, Australia, 7-11 December 2014.
2014
Conference Publication
The expression of plasma membrane Ca2+ ATPase isoform, PMCA2, in breast tissue with lactational change and in breast cancer cells and the consequences of its silencing in MDA-MB-231 breast cancer cells
Peters, Amelia A., Lee, Wei C., Dray, Eloise , Smart, Chanel E., Reid, Lynne , da Silva, Leonard , Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2014). The expression of plasma membrane Ca2+ ATPase isoform, PMCA2, in breast tissue with lactational change and in breast cancer cells and the consequences of its silencing in MDA-MB-231 breast cancer cells. ASCEPT-MPGPCR Joint Scientific Meeting, Melbourne, VIC, Australia, 7-11 December 2014.
2014
Conference Publication
Genetically-encoded calcium indicators for the assessment of intracellular calcium signalling in MDA-MB-231 breast cancer cells
Janke, Ellen K., Peters, Amelia A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2014). Genetically-encoded calcium indicators for the assessment of intracellular calcium signalling in MDA-MB-231 breast cancer cells. ASCEPT-MPGPCR Joint Scientific Meeting, Melbourne, VIC, Australia, 7-11 December 2014.
2013
Journal Article
Assessment of ORAI1-mediated basal calcium influx in mammary epithelial cells
Ross, Diana G. F., Smart, Chanel E., Azimi, Iman, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Assessment of ORAI1-mediated basal calcium influx in mammary epithelial cells. BMC Cell Biology, 14 (1) 57, 57.1-57.10. doi: 10.1186/1471-2121-14-57
2013
Journal Article
Effects of differentiation on purinergic and neurotensin-mediated calcium signaling in human HT-29 colon cancer cells
Chowdhury, Mohammad A., Peters, Amelia A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Effects of differentiation on purinergic and neurotensin-mediated calcium signaling in human HT-29 colon cancer cells. Biochemical and Biophysical Research Communications, 429 (1), 35-39. doi: 10.1016/j.bbrc.2013.08.034
2013
Journal Article
Assessment of gene expression of intracellular calcium channels, pumps and exchangers with epidermal growth factor-induced epithelial-mesenchymal transition in a breast cancer cell line
Davis, Felicity M., Parsonage, Michelle T., Cabot, Peter J., Parat, Marie-Odile, Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Assessment of gene expression of intracellular calcium channels, pumps and exchangers with epidermal growth factor-induced epithelial-mesenchymal transition in a breast cancer cell line. Cancer Cell International, 13 (76) 76, 1-7. doi: 10.1186/1475-2867-13-76
2013
Journal Article
Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells
Curry, Merril C., Peters, Amelia A., Kenny, Paraic A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Mitochondrial calcium uniporter silencing potentiates caspase-independent cell death in MDA-MB-231 breast cancer cells. Biochemical and Biophysical Research Communications, 434 (3), 695-700. doi: 10.1016/j.bbrc.2013.04.015
2013
Journal Article
NHERF-1 regulation of EGF and neurotensin signalling in HT-29 epithelial cells
Kruger, Wade A., Monteith, Gregory R. and Poronnik, Philip (2013). NHERF-1 regulation of EGF and neurotensin signalling in HT-29 epithelial cells. Biochemical and Biophysical Research Communications, 432 (4), 568-573. doi: 10.1016/j.bbrc.2013.02.047
2013
Journal Article
Mango (Mangifera indica L.) peel extract fractions from different cultivars differentially affect lipid accumulation in 3T3-L1 adipocyte cells
Taing, Meng-Wong, Pierson, Jean-Thomas, Shaw, Paul N., Dietzgen, Ralf G., Roberts-Thomson, Sarah J., Gidley, Michael J. and Monteith, Gregory R. (2013). Mango (Mangifera indica L.) peel extract fractions from different cultivars differentially affect lipid accumulation in 3T3-L1 adipocyte cells. Food & Function, 4 (3), 481-491. doi: 10.1039/c2fo30224a
2013
Journal Article
pH-Responsive Nutraceutical-Mesoporous Silica Nanoconjugates with Enhanced Colloidal Stability
Guillet-Nicolas, Rémy, Popat, Amirali, Bridot, Jean-Luc, Monteith, Gregory, Qiao, Shi Zhang and Kleitz, Freddy (2013). pH-Responsive Nutraceutical-Mesoporous Silica Nanoconjugates with Enhanced Colloidal Stability. Angewandte Chemie, 125 (8), 2374-2378. doi: 10.1002/ange.201208840
2013
Conference Publication
Development of a fluorescent imaging plate reader (FLIPR TETRA) based screen to identify regulators of store operated calcium entry in breast cancer cells
Azimi, Iman, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Development of a fluorescent imaging plate reader (FLIPR TETRA) based screen to identify regulators of store operated calcium entry in breast cancer cells. SLAS 2nd Annual Conference & Exhibition 2013 (Slas2013), Orlando, FL, United States, 12-16 January 2013.
2013
Conference Publication
Reactive oxygen species alters the expression of specific calcium channels during hypoxia-mediated epithelial-mesenchymal transition in breast cancer cells
Azimi, Iman, Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Reactive oxygen species alters the expression of specific calcium channels during hypoxia-mediated epithelial-mesenchymal transition in breast cancer cells. 2013 8th International Human Peroxidase Meeting & 6th Joint Meeting of the Societies for Free Radical Research Australasia and Japan, Sydney, NSW, Australia, 9-14 September, 2013.
2013
Journal Article
pH-responsive nutraceutical-mesoporous silica nanoconjugates with enhanced colloidal stability
Guillet-Nicolas, Remy, Popat, Amirali, Bridot, Jean-Luc, Monteith, Gregory, Qiao, Shi Zhang and Kleitz, Freddy (2013). pH-responsive nutraceutical-mesoporous silica nanoconjugates with enhanced colloidal stability. Angewandte Chemie International Edition, 52 (8), 2318-2322. doi: 10.1002/anie.201208840
2013
Conference Publication
Calcium transporters and modulator profiling in trastuzumab-resistant SKBR3R breast cancer cells
Pera, Elena, Peters, Amelia A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2013). Calcium transporters and modulator profiling in trastuzumab-resistant SKBR3R breast cancer cells. ASCEPT 2013: Annual Scientific Meeting, Melbourne, VIC, Australia, 1-4 December, 2013. Hamilton Central, QLD, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Calcium signalling pathways in cancer progression
-
Calcium signalling changes associated with viral infection
-
Calcium channels and pumps as drug targets
-
Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
-
Doctor Philosophy
Calcium signalling and cell death pathways in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
-
Doctor Philosophy
Calcium signalling in the context of cell in cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
-
Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
-
Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
-
Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
-
Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
-
Master Philosophy
Investigating the role of exosomes in cancer progression and immunology
Associate Advisor
Other advisors: Dr Sherry Wu
-
Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
Completed supervision
-
2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
-
2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
-
-
2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
-
2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
-
2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
-
2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
-
2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
-
2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
-
2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
-
2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
-
2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
-
2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
-
-
2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
-
2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
-
2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
-
-
2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
-
2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
-
2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
-
2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
-
2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
-
2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
-
-
2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
-
2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
-
2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
-
2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
-
2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
-
Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
Media
Enquiries
For media enquiries about Professor Gregory Monteith's areas of expertise, story ideas and help finding experts, contact our Media team: