
Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
-
calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
-
High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2011
Conference Publication
Remodelling of calcium release channels in basal breast cancer cells undergoing egf-induced emt
Parsonage, Michelle T., Davis, Felicity M., Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2011). Remodelling of calcium release channels in basal breast cancer cells undergoing egf-induced emt. ASCEPT-AUPS-HBPRCA Joint Meeting, Perth, Australia, 4-9 December 2011. ASCEPT.
2011
Conference Publication
Remodelling of calcium homeostasis in tumor progression
Monteith, Gregory R. (2011). Remodelling of calcium homeostasis in tumor progression. 17th International Symposium on Calcium-Binding Proteins and Calcium Function in Health and Disease (CaBP17), Beijing, China, 16-21 July 2011.
2011
Conference Publication
The transient receptor potential V6 (TRPV6) calcium channel in breast cancer cell lines and clinical breast cancer tissues
Peters, Amelia, Simpson, Peter T., Bassett, Johnathon, Lakhani, Sunil, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). The transient receptor potential V6 (TRPV6) calcium channel in breast cancer cell lines and clinical breast cancer tissues. American Association for Cancer Research 102nd Annual Meeting, Orlando, United States, 2 - 6 April 2011. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.AM2011-2954
2011
Conference Publication
The role of the secretory pathway Ca2+ ATPase (SPCAs) in breast cancer
Lee, Jane, Grice, Desma, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). The role of the secretory pathway Ca2+ ATPase (SPCAs) in breast cancer. 13th International P-type ATPase meeting: Na, K-ATPases and Related P-ATPases: Structure, Biology and Medicine, Pacific Grove, CA, United States, 27 September - 2 October 2011.
2011
Conference Publication
Expression of the calcium pump PMCA2 in lactating breast and breast cancer
Lee, W. C., Reid, L., Smart, Chanel, Simpson, P. T., Da Silva, L., Peters, Amelia, Lakhani, Sunil, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Expression of the calcium pump PMCA2 in lactating breast and breast cancer. ComBio 2011, Cairns, Australia, 25-29 September 2011.
2011
Conference Publication
The impact of plasma membrane calcium ATPase 1 silencing on GPCR-mediated Ca2+ signaling in MDA-MB-231 breast cancer cells
Curry, Merril, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). The impact of plasma membrane calcium ATPase 1 silencing on GPCR-mediated Ca2+ signaling in MDA-MB-231 breast cancer cells. Calcium Signalling Gordon-Merck Research Seminar, Waterville, ME, United States, 25-26 June 2011.
2011
Conference Publication
Calcium Channel Transient Receptor Potential V6 (TRPV6) in Breast Cancer Cell Lines and in Breast Tumours
Peters Amelia A., Simpson, Peter T., Bassett ,John J., Da Silva Leo, Reid, Lynne, Lakhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Calcium Channel Transient Receptor Potential V6 (TRPV6) in Breast Cancer Cell Lines and in Breast Tumours. 5th PacRim Breast and Prostate Cancer Meeting, Kingscliffe, NSW, Australia, 3-7 May 2011.
2011
Conference Publication
In-vitro assessment of the phytochemicals resveratrol, quercetin, mangiferin and epigallocatechin gallate on lipid accumulation in the 3T3-L1 cell line
Taing, Meng-Wong, Shaw, Paul N., Roberts-Thomson, Sarah J., Gidley, Mike, Dietzgen, Ralf G. and Monteith, Gregory R. (2011). In-vitro assessment of the phytochemicals resveratrol, quercetin, mangiferin and epigallocatechin gallate on lipid accumulation in the 3T3-L1 cell line. Experimental Biology 2011, Washington, United States, 9-13 April 2011. Bethesda, MD, United States: Federation of American Societies for Experimental Biology.
2011
Conference Publication
Inhibition of PMCA4 as a strategy to increase the effectiveness of Bcl-2 inhibitor-mediated cell death in breast cancer cells
Roberts-Thomson, Sarah J., Curry, Merril, Luk, Nicole A. and Monteith, Gregory R. (2011). Inhibition of PMCA4 as a strategy to increase the effectiveness of Bcl-2 inhibitor-mediated cell death in breast cancer cells. AACR-NCI-EORTC International Conference, San Francisco, United States, 12-16 November 2011. Philadelphia, United States: American Association for Cancer Research. doi: 10.1158/1535-7163.TARG-11-A30
2011
Conference Publication
Two-pore channels in breast cancer cell lines
Jahidin, Aisyah H., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Two-pore channels in breast cancer cell lines. ASCEPT-AUPS-HBPRCA Joint Meeting, Perth, Australia, 4-9 December 2011. ASCEPT.
2011
Conference Publication
Consequences of plasma membrane calcium ATPase isoforms 1 and 4 silencing on ionomy-cin-induced cell death in MDA-MB-231 breast cancer cells
Curry, Merril, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Consequences of plasma membrane calcium ATPase isoforms 1 and 4 silencing on ionomy-cin-induced cell death in MDA-MB-231 breast cancer cells. 17th International Symposium on Calcium-Binding Proteins and Calcium Function in Health and Disease (CaBP17), Beijing, China, 16-21 July 2011.
2011
Journal Article
Plasma membrane calcium ATPases and cancer
Curry, Merril C., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Plasma membrane calcium ATPases and cancer. BioFactors, 37 (3), 132-138. doi: 10.1002/biof.146
2011
Conference Publication
Calcium pumps and channels in lactation and in breast cancer
Monteith, Gregory R. (2011). Calcium pumps and channels in lactation and in breast cancer. 5th PACRIM Breast and Prostate Cancer Meeting, Kingscliffe, NSW, Australia, 3-7 May 2011.
2011
Conference Publication
The physiology and pathophysiology of clacium ATPases in the breast
Monteith, Gregory R. (2011). The physiology and pathophysiology of clacium ATPases in the breast. 13th International P-type ATPase meeting: Na, K-ATPases and Related P-ATPases: Structure, Biology and Medicine, Pacific Grove, CA, United States, 27 September - 2 October 2011.
2011
Conference Publication
Alterations in purinergic receptor-mediated signalling as a consequence of epidermal growth factor-induced epithelial mesenchymal transition (EMT) in breast cancer cells
Davis, Felicity, Kenny, P. A., Soo, E. T. L., van Denderen, B. J., Thompson, E. W., Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Alterations in purinergic receptor-mediated signalling as a consequence of epidermal growth factor-induced epithelial mesenchymal transition (EMT) in breast cancer cells. 3rd EMBO Meeting, Vienna, Austria, 10-13 September 2011.
2011
Conference Publication
ORAI calcium channels and their regulators in breast cancer
Monteith, Gregory R. (2011). ORAI calcium channels and their regulators in breast cancer. 84th Annual Meeting of the Japanese Pharmacological Society, Yokohama, Japan, 22-24 March 2011. Kyoto-shi, Japan: Nihon Yakuri Gakkai Henshuubu.
2011
Conference Publication
In-vitro assessment of mango extracts from four phylogentically diverse cultivars on lipid accumulation in a mouse adipocyte cell line
Taing, Meng-Wong, Roberts-Thomson, Sarah J., Shaw, Paul N., Gidley, Mike, Dietzgen, Ralf G. and Monteith, Gregory R. (2011). In-vitro assessment of mango extracts from four phylogentically diverse cultivars on lipid accumulation in a mouse adipocyte cell line. Australian Food Science Summer School 2011, Brisbane, Australia, 9-11 February 2011.
2011
Conference Publication
The role of plasma membrane calcium ATPase isoforms on caspase-dependent and independent cell death mechanisms in MDA-MD-231 breast cancer cells
Curry, Merril, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). The role of plasma membrane calcium ATPase isoforms on caspase-dependent and independent cell death mechanisms in MDA-MD-231 breast cancer cells. The 1st Australian Workshop on Cell Death, Lindeman Island, QLD, Australia, 21-25 August 2011.
2011
Conference Publication
CXCL12-Induced calcium release in breast cancer cells
Jamaludin, Siti Y. N., Davis, Felicity, Peters, Amelia, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). CXCL12-Induced calcium release in breast cancer cells. ASCEPT-AUPS-HBPRCA Joint Meeting, Perth, Australia, 4-9 December 2011. ASCEPT.
2011
Journal Article
Bioactivity of mango flesh and peel extracts on peroxisome proliferator-activated receptor gamma [PPARgamma] activation and MCF-7 cell proliferation: Fraction and fruit variability
Wilkinson, Ashley, Flanagan, Bernadine M., Pierson, Jean-Thomas, Hewavitharana, Amitha, Dietzgen, Ralf G., Shaw, Paul N., Roberts-Thomson, Sarah J., Monteith, Gregory R. and Gidley, Mike (2011). Bioactivity of mango flesh and peel extracts on peroxisome proliferator-activated receptor gamma [PPARgamma] activation and MCF-7 cell proliferation: Fraction and fruit variability. Journal of Food Science, 76 (1), 11-18. doi: 10.1111/j.1750-3841.2010.01899.x
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Calcium signalling pathways in cancer progression
-
Calcium signalling changes associated with viral infection
-
Calcium channels and pumps as drug targets
-
Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
-
Doctor Philosophy
Calcium signalling and cell death pathways in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
-
Doctor Philosophy
Calcium signalling in the context of cell in cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
-
Master Philosophy
Investigating the role of exosomes in cancer progression and immunology
Associate Advisor
Other advisors: Dr Sherry Wu
-
Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
-
Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
-
Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
-
Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
-
Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
Completed supervision
-
2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
-
2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
-
-
2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
-
2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
-
2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
-
2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
-
2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
-
2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
-
2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
-
2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
-
2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
-
2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
-
-
2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
-
2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
-
2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
-
-
2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
-
2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
-
2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
-
2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
-
2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
-
2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
-
-
2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
-
2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
-
2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
-
2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
-
2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
-
Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
Media
Enquiries
For media enquiries about Professor Gregory Monteith's areas of expertise, story ideas and help finding experts, contact our Media team: