
Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
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High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2011
Conference Publication
Alterations in purinergic receptor-mediated signalling as a consequence of epidermal growth factor-induced epithelial mesenchymal transition (EMT) in breast cancer cells
Davis, Felicity, Kenny, P. A., Soo, E. T. L., van Denderen, B. J., Thompson, E. W., Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Alterations in purinergic receptor-mediated signalling as a consequence of epidermal growth factor-induced epithelial mesenchymal transition (EMT) in breast cancer cells. 3rd EMBO Meeting, Vienna, Austria, 10-13 September 2011.
2011
Conference Publication
ORAI calcium channels and their regulators in breast cancer
Monteith, Gregory R. (2011). ORAI calcium channels and their regulators in breast cancer. 84th Annual Meeting of the Japanese Pharmacological Society, Yokohama, Japan, 22-24 March 2011. Kyoto-shi, Japan: Nihon Yakuri Gakkai Henshuubu.
2010
Journal Article
Golgi calcium pump secretory Pathway calcium ATPase 1 (SPCA1) is a key regulator of Insulin-like Growth Factor Receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231
Grice, Desma M., Vetter, Irina, Faddy, Helen M., Kenny, Paraic A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2010). Golgi calcium pump secretory Pathway calcium ATPase 1 (SPCA1) is a key regulator of Insulin-like Growth Factor Receptor (IGF1R) processing in the basal-like breast cancer cell line MDA-MB-231. Journal of Biological Chemistry, 285 (48), 37458-37466. doi: 10.1074/jbc.M110.163329
2010
Other Outputs
Quality use of medicines: the appropriateness of medicine naming and labelling; sound-alike, look-alike medicine names
Ostini, R., Roughead, E. E., Kirkpatrick, C. M. J., Monteith, G. and Tett, S. E. (2010). Quality use of medicines: the appropriateness of medicine naming and labelling; sound-alike, look-alike medicine names. Not available: National Medicines Policy Committee.
2010
Journal Article
Plasma membrane calcium pumps and their emerging roles in cancer
Roberts-Thomson, Sarah J., Curry, Merril C. and Monteith, Gregory R. (2010). Plasma membrane calcium pumps and their emerging roles in cancer. World Journal of Biological Chemistry, 1 (8), 248-253. doi: 10.4331/wjbc.v1.i8.248
2010
Journal Article
ORAI-mediated calcium entry: Mechanism and roles, diseases and pharmacology
Roberts-Thomson, Sarah J., Peters, Amelia A., Grice, Desma M. and Monteith, Gregory R. (2010). ORAI-mediated calcium entry: Mechanism and roles, diseases and pharmacology. Pharmacology and Therapeutics, 127 (2), 121-130. doi: 10.1016/j.pharmthera.2010.04.016
2010
Journal Article
The plasma membrane Ca2+-ATPase: Regulation by SD-95/Dlg/Zo-1 scaffolds
Kruger, Wade A., Monteith, Gregory R. and Poronnik, Philip (2010). The plasma membrane Ca2+-ATPase: Regulation by SD-95/Dlg/Zo-1 scaffolds. International Journal of Biochemistry and Cell Biology, 42 (6), 805-808. doi: 10.1016/j.biocel.2010.01.023
2010
Journal Article
Mango extracts and the mango component mangiferin promote endothelial cell migration
Daud, Noor Huda, Aung, Cho Sanda, Hewavitharana, Amitha K., Wilkinson, Ashley S., Pierson, Jean-Thomas, Roberts-Thomson, Sarah J., Shaw, P. Nicholas, Monteith, Gregory R., Gidley, Michael J. and Parat, Marie-Odile (2010). Mango extracts and the mango component mangiferin promote endothelial cell migration. Journal of Agricultural and Food Chemistry, 58 (8), 5181-5186. doi: 10.1021/jf100249s
2010
Conference Publication
Growth factor-mediated changes in receptor-stimulated calcium signaling in breast cancer cells
Davis, Felicity, Paraic, Kenny A, Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2010). Growth factor-mediated changes in receptor-stimulated calcium signaling in breast cancer cells. New Horizons in Calcium Signaling, Beijiing, China, October 10-13 2010.
2010
Conference Publication
Alternative splicing of SPCA1 in breast cancer cell lines
Rizk, Mariam, Grice, Desma, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2010). Alternative splicing of SPCA1 in breast cancer cell lines. ASCEPT Annual Scientific Meeting 2010, Melbourne, 28 November - 1 December 2010.
2010
Conference Publication
Development of a TRPV1 inducible expression model in MCF-7 breast cancer cells and its potential role in the evaluation of calcium channels as viable therapeutic targets in cancer
Wu,Tina, Robinson, Jodie A., Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2010). Development of a TRPV1 inducible expression model in MCF-7 breast cancer cells and its potential role in the evaluation of calcium channels as viable therapeutic targets in cancer. AACR 101st Annual Meeting 2010, Washington, DC, April 17-21 2010. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.AM10-3594
2010
Conference Publication
In-vitro effects of the phytochemicals resveratrol, quercetin, mangiferin and epigallocatechin gallate on lipid accumulation in the 3T3-L1 cell line
Taing, Meng-Wong, Shaw, Paul N., Roberts-Thomson, Sarah J., Gidley, Mike, Dietzgen, Ralf G. and Monteith, Gregory R. (2010). In-vitro effects of the phytochemicals resveratrol, quercetin, mangiferin and epigallocatechin gallate on lipid accumulation in the 3T3-L1 cell line. Australasian Pharmaceutical Science Association (APSA) Focus on the Future, Brisbane, December 6-9 2010.
2010
Conference Publication
IP3R-binding protein released with IP3 (IRBIT) in breast cancer cell lines
Jahidin, Aisyah Hasyila, Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2010). IP3R-binding protein released with IP3 (IRBIT) in breast cancer cell lines. ASCEPT Annual Scientific Meeting 2010, Melbourne, 28 November - 1 December 2010.
2010
Conference Publication
Characterization of TRPV1 channel over-expressed in breast cancer cell line using FLIPR calcium and MTS cell viability assays
Wu, Tina, Robinson, Jodie A., Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2010). Characterization of TRPV1 channel over-expressed in breast cancer cell line using FLIPR calcium and MTS cell viability assays. SBS 16th Annual Conference & Exhibition: Advancing the Science of Drug Discovery, Phoenix, Arizona, U.S.A., 11-15 April 2010.
2010
Conference Publication
An unconventional role in store-independent constitutive calcium signaling by the secretory pathway calcium - atpases in mammary tumors
Feng, Mingye, Grice, Desma, Faddy, Helen, Nguyen Nguyen, Leitch, Sharon, Muend, Sabina, Kenny, Paraic, Sukumar, Sara, Roberts-Thomson, Sarah, Monteith, Gregory and Rao, Rajini (2010). An unconventional role in store-independent constitutive calcium signaling by the secretory pathway calcium - atpases in mammary tumors. A, A, 20 - 24 February 2010. St. Louis, MO, United States: Cell Press. doi: 10.1016/j.bpj.2009.12.681
2010
Conference Publication
Consequences of siRNA-mediated inhibition of the secretory pathway calcium ATPase 1 in human breast cancer cell line
Grice, Desma, Vetter, Irina, Faddy, Helen, Paraic, Kenny A, Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2010). Consequences of siRNA-mediated inhibition of the secretory pathway calcium ATPase 1 in human breast cancer cell line. New Horizons in Calcium Signaling, Beijiing, China, October 10-13 2010.
2010
Conference Publication
Altered receptor-mediated calcium signaling in breast cancer cells after growth factor stimuli
Davis, Felicity, Paraic, Kenny A, Cabot, Peter J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2010). Altered receptor-mediated calcium signaling in breast cancer cells after growth factor stimuli. 11th Meeting of the European Calcium Society, Warszawa, Poland, September 6-9 2010.
2010
Conference Publication
Characterisation of nutritional bioactives from mango fruit using cell-based assay
Wilkinson, Ashley, Dietzgen, Ralf G., Shaw, Paul N., Monteith, Gregory R., Gidley, Mike and Roberts-Thomson, Sarah J. (2010). Characterisation of nutritional bioactives from mango fruit using cell-based assay. ASMR Postgraduate Student Conference, Brisbane, 2nd June 2010.
2010
Conference Publication
The golgi-localised calcium atpase in breast cancer
Grice, Desma, Vetter, Irina, Faddy, Helen, Kenny, P.A, Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2010). The golgi-localised calcium atpase in breast cancer. OzBio 2010 - The Molecules of Life - from Discovery to Biotechnology, Melbourne, 26th September to 1st October 2010.
2010
Conference Publication
Growth factor-mediated changes in purinergic receptor signaling in breast cancer cells
Davis, Felicity, Paraic, Kenny A, Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2010). Growth factor-mediated changes in purinergic receptor signaling in breast cancer cells. ASCEPT Annual Scientific Meeting 2010, Melbourne, 28 November - 1 December 2010.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
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Available projects
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Calcium signalling pathways in cancer progression
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Calcium signalling changes associated with viral infection
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Calcium channels and pumps as drug targets
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Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
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Doctor Philosophy
Calcium signalling and cell death pathways in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
Calcium signalling in the context of cell in cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Master Philosophy
Investigating the role of exosomes in cancer progression and immunology
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
Completed supervision
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2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
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2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
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2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
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2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
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2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
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2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
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2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
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2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
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2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
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2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
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2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
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2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
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2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
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2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
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2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
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2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
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2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
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2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
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2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
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Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
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