
Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
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High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2007
Conference Publication
NHERF2 is a PDZ scaffold for PMCA: Effect of muscarinic activation
Kruger, WA, Monteith, GR and Poronnik, P (2007). NHERF2 is a PDZ scaffold for PMCA: Effect of muscarinic activation. 32nd Congress of the Federation-of-European-Biochemical-Societies (FEBS), Vienna AUSTRIA, JUL 07-12, 2007.
2007
Conference Publication
Calcium transport in the mammary gland: A role for secretory pathway calcium ATPase 2 (SPCA2) in normal physiology and breast cancer
Faddy, H. M., Smart, C. E., Brown, M. A., Feng, M., Rao, R., Roberts-Thomson, S. J. and Monteith, G. R. (2007). Calcium transport in the mammary gland: A role for secretory pathway calcium ATPase 2 (SPCA2) in normal physiology and breast cancer. ComBio 2007, Sydney, 22-26 September 2007.
2007
Conference Publication
Alterations in the transcription of TRPV6, TRPV5 and TRPC1 during the differentiation of HT29 colon cancer cells
Chowdhury, M. A., Aung, C. S., Monteith, G. R. and Roberts-Thomson, S. J. (2007). Alterations in the transcription of TRPV6, TRPV5 and TRPC1 during the differentiation of HT29 colon cancer cells. Joint meeting 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists (SEAWP-RMP ) and Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) with HBPRCA: Drug and Chemical Safety, Adelaide, South Australia, Australia, 2-6 December 2007. Victoria, Australia: ASCEPT.
2007
Conference Publication
Secretory pathway Ca2+_ATPase isoforms in mouse lactation and in human breast cancer
Roberts-Thomson, S. J., Faddy, H. M., Smart, C. E., Brown, M. A., Xu, R., Lee, G. Y., Kenny, P. A., Bissell, M. J., Feng, M., Rao, R. and Monteith, G. R. (2007). Secretory pathway Ca2+_ATPase isoforms in mouse lactation and in human breast cancer. Australian Breast Cancer Conference 2007, Bio 21 Institute, Melbourne, 19-20 November 2007.
2007
Journal Article
Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation
Aung, C. S., Kruger, W. A., Poronnik, P., Roberts-Thomson, S. J. and Monteith, G. R. (2007). Plasma membrane Ca2+-ATPase expression during colon cancer cell line differentiation. Biochemical And Biophysical Research Communications, 355 (4), 932-936. doi: 10.1016/j.bbrc.2007.02.050
2007
Conference Publication
The plasma membrane calcium ATPase (PMCA) in colon cancer
Aung, C. S., Roberts-Thomson, S. J. and Monteith, G. R. (2007). The plasma membrane calcium ATPase (PMCA) in colon cancer. ComBio2007 Combined Conference Abstracts, Sydney, 22-26 September 2007.
2007
Conference Publication
TRPV1 and TRPV6 are upregulated in breast cancer cell lines
McAndrew, D., Roberts-Thomson, S. J. and Monteith, G. R. (2007). TRPV1 and TRPV6 are upregulated in breast cancer cell lines. ComBio 2007, Sydney, Australia, 22-26 September, 2007. South Australia: Australian Society for Biochemistry and Molecular Biology.
2007
Conference Publication
Modulation of PPARα and PPARβ by ethanol in human breast cancer cell lines
Gopisetty Venkata, Nagaraj, Cabot, Peter, Monteith, Greg and Roberts-Thomson, Sarah (2007). Modulation of PPARα and PPARβ by ethanol in human breast cancer cell lines. 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, U.S., 14-18 April, 2007. Philadelphia, U.S.: American Association for Cancer Research.
2006
Journal Article
The neural cell adhesion molecule antibody blocks cold water swim stress-induced analgesia and cell adhesion between lymphocytes and cultured dorsal root ganglion neurons
Hua, S., Hermanussen, S., Tang, L., Monteith, G. R. and Cabot, P. J. (2006). The neural cell adhesion molecule antibody blocks cold water swim stress-induced analgesia and cell adhesion between lymphocytes and cultured dorsal root ganglion neurons. Anesthesia and Analgesia, 103 (6), 1558-1564. doi: 10.1213/01.ane.0000243410.61451.c1
2006
Journal Article
The μ opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway
Vetter, Irina, Wyse, Bruce D., Monteith, Gregory R., Roberts-Thomson, Sarah J. and Cabot, Peter J. (2006). The μ opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway. Molecular Pain, 2 (22) 22, 1-16. doi: 10.1186/1744-8069-2-22
2006
Journal Article
The Effects of pH on Beta-Endorphin and Morphine Inhibition of Calcium Transients in Dorsal Root Ganglion Neurons
Vetter, I., Kapitzke, D., Hermanussen, S., Monteith, G. R. and Cabot, P. J. (2006). The Effects of pH on Beta-Endorphin and Morphine Inhibition of Calcium Transients in Dorsal Root Ganglion Neurons. The Journal of Pain, 7 (7), 488-499. doi: 10.1016/j.jpain.2006.01.456
2006
Journal Article
Peroxisome proliferator-activated receptor alpha expression is regulated by estrogen receptor alpha and modulates the response of MCF-7 cells to sodium butyrate
Faddy, H. M., Robinson, J. A., Lee, W. J., Holman, N. A., Monteith, G. R. and Roberts-Thomson, S. J. (2006). Peroxisome proliferator-activated receptor alpha expression is regulated by estrogen receptor alpha and modulates the response of MCF-7 cells to sodium butyrate. International Journal of Biochemistry & Cell Biology, 38 (2), 255-266. doi: 10.1016/j.biocel.2005.09.002
2006
Conference Publication
The effects of mono (2-ethylhexyl) phthalate, mono-n-butyl phthalate and ethanol on PPARs in MCF-7 human breast cancer cells
Gopisetty Venkata, N., Robinson, J. A., Cabot, P. J., Monteith, G. R. and Roberts-Thomson, S. J. (2006). The effects of mono (2-ethylhexyl) phthalate, mono-n-butyl phthalate and ethanol on PPARs in MCF-7 human breast cancer cells. AACR 97th Annual Meeting 2006: Driving the science: From bench to bedside...and back, Washington, DC, U.S.A., 1-5 April, 2006. Philadelphia, PA, U.S.A.: American Association for Cancer.
2006
Conference Publication
Novel glyco-lipid-arsenicals(III) with anti-proliferative effects on MCF-7 human breast cancer cells
Wimmer, N, Robinson, JA, Gopisetty-Venkatta, N, Roberts-Thomson, SJ, Monteith, GR and Toth, I (2006). Novel glyco-lipid-arsenicals(III) with anti-proliferative effects on MCF-7 human breast cancer cells. 19th American Peptide Symposium, San Diego, CA, United States, June 18-23 2005. New York, N.Y., United States: Springer. doi: 10.1007/978-0-387-26575-9_148
2006
Conference Publication
Modulation of TRPV1-mediated capsaicin responses potentiated through PKC and camp-dependent PKA pathways by the Mu opioid receptor agonist morphine
Vetter, I., Wyse, B. D., Monteith, G. R., Roberts-Thomson, S. J. and Cabot, P. J. (2006). Modulation of TRPV1-mediated capsaicin responses potentiated through PKC and camp-dependent PKA pathways by the Mu opioid receptor agonist morphine. ComBio 2006, Brisbane Convention Centre, Brisbane, Australia, 24-28 September, 2006. Kent Town, South Australia: Australian Society for Biochemistry and Molecular Biology.
2006
Conference Publication
Norathyriol, the active metabolite of mangiferin, modulates PPAR activity and is a potential nutritional bioactive
Wilkinson, A. S., Lin, C. N., Dietzgen, R. G., Monteith, G. R., Shaw, P. N., Roberts-Thomson, S. J. and Gidley, M. (2006). Norathyriol, the active metabolite of mangiferin, modulates PPAR activity and is a potential nutritional bioactive. Annual Conference of the Australasian Pharmaceutical Science Association, Adelaide Hilton, Adelaide, South Australia, 3-5 December, 2006. Malvern,Vic, Australia: Australasian Pharmaceutical Science Association.
2006
Conference Publication
Nutritional bioactives in tropical fruit
Wilkinson, A, Hewavitharana, A, Flanagan, B M, Dietzgen, R G, Monteith, G R, Shaw, P N, Roberts-Thomson, S J and Gidley, M (2006). Nutritional bioactives in tropical fruit. The 3rd Australian Health & Medical Research Congress, Melbourne Convention Centre, Melbourne, Australia, 26 November-1 December, 2006. Melbourne, Vic, Australia: National Health and Medical Research Council.
2006
Conference Publication
The effects of ethanol on PPARS in MCF-7 human breast cancer cells
Gopisetty Venkata, N., Cabot, P. J., Monteith, G. R. and Roberts-Thomson, S. J. (2006). The effects of ethanol on PPARS in MCF-7 human breast cancer cells. ComBio 2006, Brisbane Convention Centre, Brisbane, Australia, 24-28 September, 2006. Kent Town, South Australia: Australian Society for Biochemistry and Molecular Biology.
2006
Conference Publication
PRG100, a novel anti-allodynic agent
Tsui, D. Y. Y., Wyse, B. D., Monteith, G. R. and Smith, M. T. (2006). PRG100, a novel anti-allodynic agent. 26th Annual Scientific Meeting of the Australian Pain Society, Melbourne, Australia, 9-12 April, 2006. Victoria, Australia: Australian Pain Society.
2006
Conference Publication
A role for secretory pathway calcium atpase 2 (SPCA2) in calcium transport, breast cancer and mammary gland development
Faddy, H. M., Smart, C. E., Brown, M. A., Roberts-Thomson, S. J. and Monteith, G. R. (2006). A role for secretory pathway calcium atpase 2 (SPCA2) in calcium transport, breast cancer and mammary gland development. ComBio 2006, Brisbane / Brisbane Convention Centre, 24-28 September 2006. Kent Town, South Australia: Australian Society for Biochemistry and Molecular Biology.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
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Available projects
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Calcium signalling pathways in cancer progression
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Calcium signalling changes associated with viral infection
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Calcium channels and pumps as drug targets
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Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
Completed supervision
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2025
Doctor Philosophy
Calcium signalling in the context of cell-in-cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
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2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
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2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
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2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
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2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
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2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
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2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
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2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
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2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
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2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
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2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
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2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
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2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
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2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
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2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
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2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
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2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
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2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
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2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
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Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
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