
Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
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High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2009
Journal Article
Calcium pumps and channels: novel therapeutic targets in cancers
Monteith, G. R. (2009). Calcium pumps and channels: novel therapeutic targets in cancers. Bio Tech International, 21 (4), 22-24.
2008
Journal Article
Rapid, Opiod-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization
Vetter, Irina, Cheung, Wei, Peiris, Madusha, Wyse, Bruce D., Roberts-Thomson, Sarah J., Zheng, Jie, Monteith, Gregory R. and Cabot, Peter J (2008). Rapid, Opiod-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization. Journal of Biological Chemistry, 283 (28), 19540-19550. doi: 10.1074/jbc.M707865200
2008
Journal Article
Localization of plasma membrane and secretory calcium pumps in the mammary gland
Faddy, Helen M., Smart, Chanel E., Xu, Ren, Lee, Genee Y., Kenny, Paraic A., Feng, Mingye, Rao, Rajini, Brown, Melissa A., Bissell, Mina J., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2008). Localization of plasma membrane and secretory calcium pumps in the mammary gland. Biochemical and Biophysical Research Communications, 369 (3), 977-981. doi: 10.1016/j.bbrc.2008.03.003
2008
Conference Publication
Calcium channels in the mammary gland: Expression and function in lactation, and potential breast cancer targets
McAndrew, D., Rice, M. L., Smart, C. E., Brown, M. A., Roberts-Thomson, S. J. and Monteith, G. R. (2008). Calcium channels in the mammary gland: Expression and function in lactation, and potential breast cancer targets. Australian Health and Medical Research Congress (AHMRC) 2008, Brisbane, Australia, 16-21 November 2008. Sydney, Australia: AHMRC.
2008
Conference Publication
Discovery of bioactives in tropical fruits
Monteith, G. R. and Wilkinson, A. S. (2008). Discovery of bioactives in tropical fruits. Australian Tropical Health and Nutrition Conference, Couran Cove, Qld, Australia, 8-11 November 2008.
2008
Conference Publication
Secretory pathway CA2+-AT Pase isoforms in lactation and in breast cancer
Grice, D. M., Faddy, H. M., Roberts-Thomson, S. J. and Monteith, G. R. (2008). Secretory pathway CA2+-AT Pase isoforms in lactation and in breast cancer. 20th Annual Lorne Cancer Conference, Lorne, Victoria, Australia, 14 - 16 February 2008.
2008
Conference Publication
Targeting calcium channels in breast cancer
Wu, T., Robinson, J., McAndrew D., Monteith, G. R. and Roberts-Thomson, S. J. (2008). Targeting calcium channels in breast cancer. Australian Health and Medical Research Congress (AHMRC) 2008, Brisbane, Qld, Australia, 16-21 November, 2008. Sydney, NSW, Australia: The Congress.
2008
Journal Article
Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms
Wilkinson, Ashley S., Monteith, Gregory R., Shaw, P. Nicholas, Lin, Chun-Nam, Gidley, Michael J. and Roberts-Thomson, Sarah J. (2008). Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. Journal of Agricultural and Food Chemistry, 56 (9), 3037-3042. doi: 10.1021/jf800046n
2008
Conference Publication
Plasma Membrane Calcium Pumps during the differentiation of Colon Cancer Cells and the Consequences of their Altered Expression in Colon Cancer
Aung, C., Roberts-Thomson, S. and Monteith, G. (2008). Plasma Membrane Calcium Pumps during the differentiation of Colon Cancer Cells and the Consequences of their Altered Expression in Colon Cancer. The 20th Annual Conference of the Korean Society for Molecular and Cellular Biology, Seoul, Korea, 7-10 October 2008.
2008
Conference Publication
Plasma membrane calcium pump isoform 4 (PMCA4) and colon cancer
Chan, K. F., Aung, C. S., Roberts-Thomson, S. J. and Monteith, G. R. (2008). Plasma membrane calcium pump isoform 4 (PMCA4) and colon cancer. ComBio 2008, Canberra National Convention Centre, 21-25 September, 2008.
2008
Journal Article
Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol
Vetter, Irina, Wyse, Bruce D., Roberts-Thomson, Sarah J., Monteith, Gregory R. and Cabot, Peter J. (2008). Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol. European Journal of Pain, 12 (4), 441-454. doi: 10.1016/j.ejpain.2007.07.001
2008
Journal Article
PPARα and PPARß are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line
Gopisetty Venkata, Nagaraj, Aung, Cho S., Cabot, Peter J., Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2008). PPARα and PPARß are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. Toxicological Sciences, 102 (1), 120-128. doi: 10.1093/toxsci/kfm281
2008
Conference Publication
Nutritional bioactives in tropical fruit
Wilkinson, A. S., Lin, C. N., Flanagan, B., Dietzgen, R., Shaw, P. N., Monteith, G. R., Roberts-Thomson, S. J. and Gidley, M. J. (2008). Nutritional bioactives in tropical fruit. Experimental Biology 2008: Today's Research: Tomorrow's Health, San Diego, U.S., 5-6 April, 2008.
2008
Conference Publication
The golgi associated calcium pump in human breast cancer
Grice, D. M., Faddy, H. M., Kenny, P. A., Bissell, M. J., Thompson, E. W., Roberts-Thomson, S. J. and Monteith, G. R. (2008). The golgi associated calcium pump in human breast cancer. ComBio 2008, Canberra National Convention Centre, 21-25 September, 2008.
2008
Conference Publication
Calcium influx channels in breast cancer: Altered expression of TRPV6 and TRPV1 in a subset of breast cancer cell lines
McAndrew, D., Roberts-Thomson, S. J. and Monteith, G. R. (2008). Calcium influx channels in breast cancer: Altered expression of TRPV6 and TRPV1 in a subset of breast cancer cell lines. The American Society for Cell Biology, 48th Annual Meeting (ASCB 2008), San Francisco, USA, 13-17 December 2008.
2007
Journal Article
A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapies
Peiris, Madusha, Monteith, Gregory R, Roberts-Thomson, Sarah J. and Cabot, Peter J. (2007). A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapies. Journal of Neuroscience Methods, 163 (2), 245-254. doi: 10.1016/j.jneumeth.2007.03.013
2007
Conference Publication
NHERF2 is a PDZ scaffold for PMCA: Effect of muscarinic activation
Kruger, WA, Monteith, GR and Poronnik, P (2007). NHERF2 is a PDZ scaffold for PMCA: Effect of muscarinic activation. 32nd Congress of the Federation-of-European-Biochemical-Societies (FEBS), Vienna AUSTRIA, JUL 07-12, 2007.
2007
Conference Publication
Calcium transport in the mammary gland: A role for secretory pathway calcium ATPase 2 (SPCA2) in normal physiology and breast cancer
Faddy, H. M., Smart, C. E., Brown, M. A., Feng, M., Rao, R., Roberts-Thomson, S. J. and Monteith, G. R. (2007). Calcium transport in the mammary gland: A role for secretory pathway calcium ATPase 2 (SPCA2) in normal physiology and breast cancer. ComBio 2007, Sydney, 22-26 September 2007.
2007
Conference Publication
Alterations in the transcription of TRPV6, TRPV5 and TRPC1 during the differentiation of HT29 colon cancer cells
Chowdhury, M. A., Aung, C. S., Monteith, G. R. and Roberts-Thomson, S. J. (2007). Alterations in the transcription of TRPV6, TRPV5 and TRPC1 during the differentiation of HT29 colon cancer cells. Joint meeting 10th Southeast Asian Western Pacific Regional Meeting of Pharmacologists (SEAWP-RMP ) and Annual Scientific Meeting of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT) with HBPRCA: Drug and Chemical Safety, Adelaide, South Australia, Australia, 2-6 December 2007. Victoria, Australia: ASCEPT.
2007
Conference Publication
Secretory pathway Ca2+_ATPase isoforms in mouse lactation and in human breast cancer
Roberts-Thomson, S. J., Faddy, H. M., Smart, C. E., Brown, M. A., Xu, R., Lee, G. Y., Kenny, P. A., Bissell, M. J., Feng, M., Rao, R. and Monteith, G. R. (2007). Secretory pathway Ca2+_ATPase isoforms in mouse lactation and in human breast cancer. Australian Breast Cancer Conference 2007, Bio 21 Institute, Melbourne, 19-20 November 2007.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Calcium signalling pathways in cancer progression
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Calcium signalling changes associated with viral infection
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Calcium channels and pumps as drug targets
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Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
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Doctor Philosophy
Calcium signalling in the context of cell in cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
Calcium signalling and cell death pathways in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Master Philosophy
Investigating the role of exosomes in cancer progression and immunology
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
Completed supervision
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2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
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2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
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2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
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2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
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2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
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2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
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2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
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2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
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2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
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2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
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2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
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2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
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2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
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2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
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2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
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2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
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2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
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2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
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2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
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Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
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