
Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
-
calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
-
High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2005
Conference Publication
High throughput calcium assays: From discovery to understanding
Monteith, G. R. (2005). High throughput calcium assays: From discovery to understanding. Joint Meeting of ASCEPT and APSA, Melbourne, Vic, Australia, 4-7 December, 2005. Melbourne, Vic, Australia: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists.
2005
Conference Publication
Blockade of relapse with pioglitazone in a multiple relapsing-remitting experimental autoimmune encephalomyelitis in C57BL/6 mice
Peiris, M., Roberts-Thomson, S. J., Monteith, G. R. and Cabot, P. J. (2005). Blockade of relapse with pioglitazone in a multiple relapsing-remitting experimental autoimmune encephalomyelitis in C57BL/6 mice. 5th Annual Health & Medical Research Conference of Queensland, Brisbane, Qld, Australia, 3-4 November, 2005. Brisbane, Qld, Australia: Queensland Health.
2005
Conference Publication
Consumers on the map: Australia's QUM map
Tett, S. E., Roughead, E. E., Monteith, G. R. and Kirkpatrick, C. M. J. (2005). Consumers on the map: Australia's QUM map. The Society of Hospital Pharmacists of Australia 27th Federal Conference, Brisbane, Qld, Australia, 10-13 November, 2005. Brisbane, Qld, Australia: Event Planners Australia.
2005
Conference Publication
Expression of plasma membrane calcium pump isoforms in a colon cancer cell line
Aung, C. S., Roberts-Thomson, S. J. and Monteith, G. R. (2005). Expression of plasma membrane calcium pump isoforms in a colon cancer cell line. Joint Meeting of ASCEPT and APSA, Melbourne, Vic, Australia, 4-7 December, 2005. Australia: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists.
2005
Conference Publication
Anti-proliferative effects of novel glyco-lipoaminoacid-modified arsenicals (III) on MCF-7 human breast cancer cells
Wimmer, N., Robinson, J. A., Thomson, S. J., Monteith, G. R. and Toth, I. (2005). Anti-proliferative effects of novel glyco-lipoaminoacid-modified arsenicals (III) on MCF-7 human breast cancer cells. 19th American Peptide Symposium, San Diego, U.S., 18-23 June, 2005. Hoboken, U.S.: Wiley Interscience.
2005
Journal Article
Antisense-mediated inhibition of the plasma membrane Calcium-ATPase suppresses proliferation of MCF-7 cells
Lee, W. J., Robinson, J. A., Holman, N. A., McCall, M. N., Roberts-Thomson, S. J. and Monteith, G. R. (2005). Antisense-mediated inhibition of the plasma membrane Calcium-ATPase suppresses proliferation of MCF-7 cells. Journal of Biological Chemistry, 280 (29), 27076-27084. doi: 10.1074/jbc.M414142200
2005
Conference Publication
Opioid inhibition of TRPV1-mediated calcium currents in cultured dorsal root ganglion neurones and a HEK293 cell line stably expressing TRPV1 and MOR
Vetter, I., Wyse, B. D., Monteith, G. R., Roberts-Thomson, S. J. and Cabot, P. J. (2005). Opioid inhibition of TRPV1-mediated calcium currents in cultured dorsal root ganglion neurones and a HEK293 cell line stably expressing TRPV1 and MOR. 11th World Congress on Pain, Sydney, NSW, Australia, 21-26 August, 2005. Seattle, WA, U.S.A.: International Association for the Study of Pain (IASP) Press.
2005
Conference Publication
Peroxisome proliferator activated receptor (PPAR) isoform expression during differentiation of HT-29 colon cancer cells
Lister, E. J., Faddy, H. M., Aung, C. S., Monteith, G. R. and Roberts-Thomson, S. J. (2005). Peroxisome proliferator activated receptor (PPAR) isoform expression during differentiation of HT-29 colon cancer cells. Joint Meeting of ASCEPT and APSA, Melbourne, Vic, Australia, 4-7 December, 2005. Melbourne, Vic, Australia: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists.
2005
Conference Publication
Development and application of a liposome delivery method to enhance the bioavailability of antioxidants and evaluate cytotoxicity in colon and breast cancer in vitro models
Sutherland, A., Hewavitharana, A., Flanagan, B. M., Monteith, G. R., Shaw, N., Roberts-Thomson, S. J. and Gidley, M. (2005). Development and application of a liposome delivery method to enhance the bioavailability of antioxidants and evaluate cytotoxicity in colon and breast cancer in vitro models. 29th Annual Scientific Meeting of Nutrition Society of Australia, Melbourne, Vic, Australia, 30 November-3 December, 2005. Clayton, Vic., Australia: Blackwell Science Asia.
2005
Journal Article
Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines
Lee, WJ, Roberts-Thomson, SJ and Monteith, GR (2005). Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines. Biochemical And Biophysical Research Communications, 337 (3), 779-783. doi: 10.1016/j.bbrc.2005.09.119
2005
Conference Publication
Pioglitazone treatment prevents relapse in a multiple relapsing-remitting experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice
Peiris, M., Roberts-Thomson, S. J., Monteith, G. R. and Cabot, P. J. (2005). Pioglitazone treatment prevents relapse in a multiple relapsing-remitting experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. Joint Meeting of ASCEPT and APSA, Melbourne, Vic, Australia, 4-7 December, 2005. Melbourne, Vic, Australia: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists.
2004
Journal Article
Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons
Smith, Steven A., Monteith, Gregory R., Robinson, Jodie A., Gopisetty Venkata, Nagaraj, May, Fiona J. and Roberts-Thomson, Sarah J. (2004). Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons. Journal of Neuroscience Research, 77 (2), 240-249. doi: 10.1002/jnr.20153
2004
Conference Publication
A novel multiple relapsing model of multiple sclerosis: Experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice
Roberts-Thomson, S. J., Peiris, M., Monteith, G. R. and Cabot, P. J. (2004). A novel multiple relapsing model of multiple sclerosis: Experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. Melbourne Regional Meeting of ASCEPT, Melbourne University, 30 November, 2004. Melbourne, Vic, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT).
2004
Conference Publication
Beta -endorphin inhibition of capsaicin induced calcium responses in cultured dorsal root ganglion neurones is enhanced at acidic pH's
Vetter, I., Hermanussen, S. F., Monteith, G. R. and Cabot, P. J. (2004). Beta -endorphin inhibition of capsaicin induced calcium responses in cultured dorsal root ganglion neurones is enhanced at acidic pH's. CPT2004: 8th World Conference on Clinical Pharmacology & Therapeutics 2004, Brisbane, Qld, Australia, 1-6 August, 2004. Melbourne, Vic, Australia: Blackwell Publishing.
2004
Conference Publication
Fluorescence probes for the assessment of calcium in sub-cellular organelles: Implications for microplate readers
Monteith, G. R., Robinson, J. A., Jenkins, N. and Roberts-Thomson, S. J. (2004). Fluorescence probes for the assessment of calcium in sub-cellular organelles: Implications for microplate readers. SBS 10th Anniversary Conference and Exhibition, Orlando, Florida, U.S.A., 11-15 September, 2004. Florida, U.S.A.: Society for Biomolecular Screening.
2004
Conference Publication
Phthalates: A possible peroxisome proliferator-activated receptor mediated effect in breast cancer cell lines
Gopisetty Venkata, N., Robinson, J. A., Davis, B.J., Monteith, G. R. and Roberts-Thomson, S. J. (2004). Phthalates: A possible peroxisome proliferator-activated receptor mediated effect in breast cancer cell lines. 4th Annual Queensland Health and Medical Scientific Meeting, Brisbane, 30 Nov - 1 Dec 2004. Brisbane: Qld. Government.
2004
Conference Publication
Assessment of the expression of a calcium transporter in cancer cells exposed to conditions which promote differentiation
Aung, C. S., Lee, W. J., Huynh, H., Tran, K. M., Robinson, J. A., Faddy, H. M., Gopisetty Venkata, N., Roberts-Thomson, S. J. and Monteith, G. R. (2004). Assessment of the expression of a calcium transporter in cancer cells exposed to conditions which promote differentiation. 4th Annual Queensland Health and Medical Scientific Meeting, Brisbane, 30 November - 1 December 2004. Brisbane: Qld Government.
2004
Journal Article
Ratiometric and nonratiometric Ca2+ indicators for the assessment of intracellular free Ca2+ in a breast cancer cell line using a fluorescence microplate reader
Robinson, J. A., Jenkins, N. S., Holman, N. A., Roberts-Thomson, S. J. and Monteith, G. R. (2004). Ratiometric and nonratiometric Ca2+ indicators for the assessment of intracellular free Ca2+ in a breast cancer cell line using a fluorescence microplate reader. Journal of Biochemical And Biophysical Methods, 58 (3), 227-237. doi: 10.1016/j.jbbm.2003.11.002
2004
Conference Publication
Peroxisome proliferator-activated receptor a in human breast cancer cell lines
Faddy, H. M., Robinson, J. A., Holman, N. A., Monteith, G. R. and Roberts-Thomson, S. J. (2004). Peroxisome proliferator-activated receptor a in human breast cancer cell lines. 4th Annual Queensland Health and Medical Scientific Meeting, Brisbane, 30 November - 1 December, 2004. Brisbane: Qld Government.
2004
Conference Publication
Phthalate ester toxicity in the human breast: A possible role of peroxisome proliferator-activated receptors A,b/d and g
Gopisetty Venkata, N., Robinson, J. A., Davis, B.J., Monteith, G. R. and Roberts-Thomson, S. J. (2004). Phthalate ester toxicity in the human breast: A possible role of peroxisome proliferator-activated receptors A,b/d and g. CPT2004: 8th World Conference on Clinical Pharmacology & Therapeutics, Brisbane, Qld, Australia, 1-6 Aug 2004. Melbourne, Vic, Australia: Blackwell Publishing.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Calcium signalling pathways in cancer progression
-
Calcium signalling changes associated with viral infection
-
Calcium channels and pumps as drug targets
-
Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
-
Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
-
Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
-
Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
Completed supervision
-
2025
Doctor Philosophy
Calcium signalling in the context of cell-in-cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
-
2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
-
2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
-
-
2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
-
2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
-
2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
-
2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
-
2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
-
2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
-
2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
-
2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
-
2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
-
2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
-
-
2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
-
2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
-
2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
-
-
2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
-
2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
-
2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
-
2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
-
2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
-
2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
-
-
2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
-
2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
-
2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
-
2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
-
2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
-
Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
Media
Enquiries
For media enquiries about Professor Gregory Monteith's areas of expertise, story ideas and help finding experts, contact our Media team: