
Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
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High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2006
Journal Article
Calcium transport and signaling in the mammary gland: Targets for breast cancer
Lee, W. J., Monteith, G. R. and Roberts-Thomson, S. J. (2006). Calcium transport and signaling in the mammary gland: Targets for breast cancer. Biochimica Et Biophysica Acta-reviews On Cancer, 1765 (2), 235-255. doi: 10.1016/j.bbcan.2005.12.001
2006
Journal Article
Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast
Gopisetty Venkata, Nagaraj, Robinson, Jodie A., Cabot, Peter J., Davis, Barbara, Monteith, Greg R. and Roberts-Thomson, Sarah J. (2006). Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast. Toxicology Letters, 163 (3), 224-234. doi: 10.1016/j.toxlet.2005.11.001
2006
Conference Publication
Isoform specific changes in calcium transporters in colon and breast cancer cell lines
Faddy, H. M., Aung, C. S., Lee, W. J., Roberts-Thomson, S. J. and Monteith, G. R. (2006). Isoform specific changes in calcium transporters in colon and breast cancer cell lines. AACR 97th Annual Meeting 2006: Driving the science: From bench to bedside...and back, Washington, D.C. U.S.A., 1-5 April, 2006. Philadelphia, PA, U.S.A.: American Association for Cancer Research.
2006
Conference Publication
Peroxisome-proliferator activated receptors modulate inflammation in relapsing-remitting experimental autoimmune encephalomyelitis
Peiris, M., Monteith, G. R., Roberts-Thomson, S. J. and Cabot, P. J. (2006). Peroxisome-proliferator activated receptors modulate inflammation in relapsing-remitting experimental autoimmune encephalomyelitis. ComBio 2006, Brisbane Convention Centre, Brisbane, Australia, 24-28 September, 2006. Kent Town, South Australia: Australian Society for Biochemistry and Molecular Biology.
2006
Conference Publication
Effects of the Mu opioid receptor agonist morphine on TRPV1-mediated capsaicin responses potentiated through PKC and cAMP-dependent PKA pathways
Vetter, I., Wyse, B. D., Monteith, G. R., Roberts-Thomson, S. J. and Cabot, P. J. (2006). Effects of the Mu opioid receptor agonist morphine on TRPV1-mediated capsaicin responses potentiated through PKC and cAMP-dependent PKA pathways. 2006 Neuroscience, Georgia World Congress Center / Altana, Georgia, U.S.A., 11-18 October, 2006. Washington DC, U.S.A.: Society for Neuroscience.
2006
Conference Publication
Revamped, redeveloped, relaunched...the new QUMmap
Tett, S. E., Roughead, E. E., Monteith, G. R. and Kirkpatrick, C. M. J. (2006). Revamped, redeveloped, relaunched...the new QUMmap. Quality use of medicines: Balancing beliefs, benefits and harms, National Convention Centre, Canberrra, Australia, 7-9 June, 2006. Brisbane, Qld, Australia: National Prescribing Service.
2006
Conference Publication
TRP channels in colon cancer
Chowdhury, M. A., Aung, C. S., Monteith, G. R. and Roberts-Thomson, S. J. (2006). TRP channels in colon cancer. The 3rd Australian Health & Medical Research Congress, Melbourne Convention Centre, Melbourne, Australia, 26 November-1 December, 2006. National Health and Medical Research Council.
2006
Conference Publication
Preliminary evaluation of cultured embryonic rat midbrain neurons as an in vitro model of diabetic neuropathy
Tsui, D. Y., Monteith, G. R., Wyse, B. D. and Smith, M. T. (2006). Preliminary evaluation of cultured embryonic rat midbrain neurons as an in vitro model of diabetic neuropathy. 11th World Congress on Pain, Sydney, Australia, 21-26 August 2005. Seattle, Wa.: IASP Press.
2006
Journal Article
Isoform specific changes in PPAR alpha and beta in colon and breast cancer with differentiation
Aung, CS, Faddy, HM, Lister, EJ, Monteith, GR and Roberts-Thomson, SJ (2006). Isoform specific changes in PPAR alpha and beta in colon and breast cancer with differentiation. Biochemical And Biophysical Research Communications, 340 (2), 656-660. doi: 10.1016/j.bbrc.2005.12.061
2006
Conference Publication
Muscarinic agonist-induced recruitment of PMCA to themembrance involves the PDZ scaffold NA+ H+ exchanger regulatory factor 2 (NHERF-2)
Kruger, W. A., Monteith, G R and Poronnik, P (2006). Muscarinic agonist-induced recruitment of PMCA to themembrance involves the PDZ scaffold NA+ H+ exchanger regulatory factor 2 (NHERF-2). ComBio 2006, Brisbane Convention Centre, Brisbane, Australia, 24-28 September, 2006. Kent Town, South Australia: Australian Society for Biochemistry and Molecular Biology.
2006
Conference Publication
Plasma membrane calcium pump (PMCA) expression in a colon cancer cell line during differentiation
Aung, C. S., Monteith, G. R. and Roberts-Thomson, S. J. (2006). Plasma membrane calcium pump (PMCA) expression in a colon cancer cell line during differentiation. ComBio 2006, Brisbane Convention Centre, Brisbane, Australia, 24-28 September, 2006. Kent Town, South Australia: Australian Society for Biochemistry and Molecular Biology.
2006
Journal Article
Anti-proliferative effects of novel Glyco-lipid-arsenicals (III) on MCF-7 human breast cancer cells
Wimmer, N., Robinson, J. A., Gopisetty Venkata, N., Roberts-Thomson, S. J., Monteith, G. R. and Toth, I. (2006). Anti-proliferative effects of novel Glyco-lipid-arsenicals (III) on MCF-7 human breast cancer cells. Medicinal Chemistry, 2 (1), 79-87. doi: 10.2174/157340606775197714
2006
Book Chapter
Fluorescence microplate-based techniques for the high-throughput assessment of calcium signaling: The highs and lows for calcium researchers
Monteith, G. R. and Bird, G.S.J. (2006). Fluorescence microplate-based techniques for the high-throughput assessment of calcium signaling: The highs and lows for calcium researchers. Calcium Signaling. (pp. 85-99) edited by J.W. Putney Jr. USA: CRC Press. doi: 10.1201/9781420038231
2006
Conference Publication
Peroxisome-proliferator activated receptor (PPAR) beta/delta and its role inr elapsing-remitting experimental autoimmune encephalomyelitis (RR-EAE)
Peiris, M., Monteith, G. R., Roberts-Thomson, S. J. and Cabot, P. J. (2006). Peroxisome-proliferator activated receptor (PPAR) beta/delta and its role inr elapsing-remitting experimental autoimmune encephalomyelitis (RR-EAE). Neuroscience 2006, Georgia World Congress Center / Altana, Georgia, U.S.A., 11-18 October, 2006. Washington, D.C. U.S.A.: Society for Neuroscience.
2006
Conference Publication
Characterization of transient receptor potential cation channels V1 and V6 in human breast cancer cells
McAndrew, D. V., Roberts-Thomson, S. J. and Monteith, G. R. (2006). Characterization of transient receptor potential cation channels V1 and V6 in human breast cancer cells. The 3rd Australian Health & Medical Research Congress, Melbourne Convention Centre, Melbourne, Australia, 26 November-1 December, 2006. Sydney, N.S.W., Australia: National Health and Medical Research Council.
2005
Journal Article
Consumer involvement in quality use of medicines (QUM) projects - lessons from Australia
Kirkpatrick, Carl M. J., Roughead, Elizabeth E., Monteith, Gregory R. and Tett, Susan E. (2005). Consumer involvement in quality use of medicines (QUM) projects - lessons from Australia. BMC Health Services Research, 5 (1) 75, 75.1-75.7. doi: 10.1186/1472-6963-5-75
2005
Journal Article
Techniques: High-throughput measurement of intracellular Ca2+ – back to basics
Monteith, Gregory R. and Bird, Gary St J. (2005). Techniques: High-throughput measurement of intracellular Ca2+ – back to basics. Trends in Pharmacological Sciences, 26 (4), 218-223. doi: 10.1016/j.tips.2005.02.002
2005
Conference Publication
Peroxisome proliferator activated receptor (PPAR) isoform expression during differentiation of HT-29 colon cancer cells
Lister, E. J., Faddy, H. M., Aung, C. S., Monteith, G. R. and Roberts-Thomson, S. J. (2005). Peroxisome proliferator activated receptor (PPAR) isoform expression during differentiation of HT-29 colon cancer cells. Joint Meeting of ASCEPT and APSA, Melbourne, Vic, Australia, 4-7 December, 2005. Melbourne, Vic, Australia: Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists.
2005
Conference Publication
Development and application of a liposome delivery method to enhance the bioavailability of antioxidants and evaluate cytotoxicity in colon and breast cancer in vitro models
Sutherland, A., Hewavitharana, A., Flanagan, B. M., Monteith, G. R., Shaw, N., Roberts-Thomson, S. J. and Gidley, M. (2005). Development and application of a liposome delivery method to enhance the bioavailability of antioxidants and evaluate cytotoxicity in colon and breast cancer in vitro models. 29th Annual Scientific Meeting of Nutrition Society of Australia, Melbourne, Vic, Australia, 30 November-3 December, 2005. Clayton, Vic., Australia: Blackwell Science Asia.
2005
Journal Article
Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines
Lee, WJ, Roberts-Thomson, SJ and Monteith, GR (2005). Plasma membrane calcium-ATPase 2 and 4 in human breast cancer cell lines. Biochemical And Biophysical Research Communications, 337 (3), 779-783. doi: 10.1016/j.bbrc.2005.09.119
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
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Available projects
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Calcium signalling pathways in cancer progression
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Calcium signalling changes associated with viral infection
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Calcium channels and pumps as drug targets
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Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
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Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
Completed supervision
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2025
Doctor Philosophy
Calcium signalling in the context of cell-in-cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
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2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
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2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
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2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
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2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
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2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
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2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
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2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
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2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
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2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
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2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
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2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
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2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
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2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
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2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
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2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
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2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
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2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
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2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
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Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
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