Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy and Pharmaceutical Sciences at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "supervision availability" link.
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High throughput calcium assays for biomolecular screening and cancer research
Our laboratory uses a suite of genetically encoded calcium indicators in FLIPR and high content imaging systems, allowing high throughput measurement of intracellular calcium in living cells. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "supervision availability" link.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2003
Journal Article
Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones
Hemstapat, K., Monteith, G. R., Smith, D. and Smith, M. T. (2003). Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones. Anesthesia & Analgesia, 97 (2), 494-505. doi: 10.1213/01.ANE.0000059225.40049.99
2003
Journal Article
Effects of peroxisome proliferator-activated receptor gamma ligands ciglitazone and 15-deoxy-delta 12,14-prostaglandin J2 on rat cultured cerebellar granule neuronal viability Steven A. Smith, Gregory R. Monteith, Nicola A. Holman, Jodie A. Robinson, Fion
Smith, Steven A., Monteith, Gregory R., Holman, Nicola A., Robinson, Jodie A., May, Fiona J. and Roberts-Thomson, Sarah J. (2003). Effects of peroxisome proliferator-activated receptor gamma ligands ciglitazone and 15-deoxy-delta 12,14-prostaglandin J2 on rat cultured cerebellar granule neuronal viability Steven A. Smith, Gregory R. Monteith, Nicola A. Holman, Jodie A. Robinson, Fion. Journal of Neuroscience Research, 72 (6), 747-755. doi: 10.1002/jnr.10613
2003
Conference Publication
Generation of a tetracycline-regulated stable MCF-7 breast cancer cell line expressing human peroxisome proliferator-activated receptor alpha
Holman, N. A., Davis, B.J., Monteith, G. R., Roberts-Thomson, S. J. and Robinson, J. A. (2003). Generation of a tetracycline-regulated stable MCF-7 breast cancer cell line expressing human peroxisome proliferator-activated receptor alpha. ASCEPT 2003, Sydney, NSW, Australia, December, 2003. Melbourne, Vic, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT).
2003
Conference Publication
Environmental pollutant phthalate esters: Investigation into possible activation of peroxisome proliferator-activated receptor ? (PPAR?)
Gopisetty Venkata, N., Robinson, J. A., Davis, B.J., Monteith, G. R. and Roberts-Thomson, S. J. (2003). Environmental pollutant phthalate esters: Investigation into possible activation of peroxisome proliferator-activated receptor ? (PPAR?). ASCEPT 2003, Sydney, NSW, Australia, December, 2003. Melbourne, Vic, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT).
2003
Conference Publication
Cell adhesion molecules mediate adhesion between immune cells and sensory neurones invitro: A role in inflammatory hyperalgesia
Cabot, P. J., Hermanussen, S. F., Tang, L.W.C. and Monteith, G. R. (2003). Cell adhesion molecules mediate adhesion between immune cells and sensory neurones invitro: A role in inflammatory hyperalgesia. Annual Queensland Health and Medical Scientific Meeting, Brisbane, Qld, Australia, 25-26 November, 2003. Brisbane, Qld, Australia: Queensland Health.
2003
Book Chapter
Recent developments in calcium signaling
Monteith, G. R. (2003). Recent developments in calcium signaling. Molecular Pathomechanisms and New Trends in Drug Research. (pp. 114-119) edited by G. Keri and I. Toth. London & New York: Taylor & Francis.
2003
Conference Publication
Generation of a stable MCF-7 cell line expressing tetracycline-regulated antisense towards the plasma membrane calcium
Lee, W.J., Robinson, J. A., Holman, N. A., McCall, M., Roberts-Thomson, S. J. and Monteith, G. R. (2003). Generation of a stable MCF-7 cell line expressing tetracycline-regulated antisense towards the plasma membrane calcium. ASCEPT 2003, Sydney, NSW, Australia, December, 2003. Melbourne, Vic, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT).
2003
Journal Article
The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones
Hemstapat, K., Smith, S. A., Monteith, G. R. and Smith, M. T. (2003). The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones. Pharmacology & Toxicology, 93 (4), 197-200. doi: 10.1034/j.1600-0773.2003.930408.x
2003
Conference Publication
Peroxisome proliferator-activated receptors (PPAR) and breast cancer
Roberts-Thomson, S. J., Robinson, J. A., Faddy, H. M., Holman, N. A., Davis, B.J., Gopisetty Venkata, N., Suchanek, K. M., May, F. J., Lee, W. J. and Monteith, G. R. (2003). Peroxisome proliferator-activated receptors (PPAR) and breast cancer. Annual Queensland Health & Medical Scientific Meeting 2003, Brisbane, Qld, Australia, 25-26 November, 2003. Brisbane, Qld, Australia: Queensland Health.
2003
Conference Publication
Characterisation of peroxisome proliferator-activated receptor a and its effects on MCF-7 breast cancer cells
Faddy, H. M., Robinson, J. A., Holman, N. A., Davis, B.J., Monteith, G. R. and Roberts-Thomson, S. J. (2003). Characterisation of peroxisome proliferator-activated receptor a and its effects on MCF-7 breast cancer cells. ASCEPT 2003, Sydney, NSW, Australia, December, 2003. Melbourne, Vic, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT).
2002
Journal Article
Expression of plasma membrane calcium pump isoform mRNAs in breast cancer cell lines.
Lee, W. J., Roberts-Thomson, S. J., Holman, N. A., May, F. J., Lehrbach, G. M. and Monteith, G. R. (2002). Expression of plasma membrane calcium pump isoform mRNAs in breast cancer cell lines.. Cellular Signalling, 14 (12), 1015-1022. doi: 10.1016/S0898-6568(02)00049-9
2002
Journal Article
Peroxisome proliferator-activated receptor alpha in the human breast cancer cell lines MCF-7 and MDA-MB-231
Suchanek, Kate M., May, Fiona J., Robinson, Jodie A., Lee, Won Jae, Holman, Nicola A., Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2002). Peroxisome proliferator-activated receptor alpha in the human breast cancer cell lines MCF-7 and MDA-MB-231. Molecular Carcinogenesis, 34 (4), 165-171. doi: 10.1002/mc.10061
2002
Journal Article
Evaluating Australia's National Medicines Policy using geographical mapping
Roughead, E. E., Monteith, G. R., Harvey, K. J. and Tett, S. E. (2002). Evaluating Australia's National Medicines Policy using geographical mapping. Internal Medicine Journal, 32 (3), 66-71. doi: 10.1046/j.1445-5994.2002.00166.x
2002
Conference Publication
www.qummap.health.gov.au: What's happening where? Who's involved? What's missing?
Roughead, E. E., Monteith, G. R. and Tett, S.E. (2002). www.qummap.health.gov.au: What's happening where? Who's involved? What's missing?. National Medicines Symposium 2002, Canberra, 20-22 March 2002. Canberra: NPS.
2002
Conference Publication
P/Q and L-type calcium channel blockers abolish morphine-3-glucuronide (M3G)-induced indirect activation of the NMDA receptor
Hemstapat, K., Monteith, G. R. and Smith, M. T. (2002). P/Q and L-type calcium channel blockers abolish morphine-3-glucuronide (M3G)-induced indirect activation of the NMDA receptor. AHMR Congress 2002, Melbourne, 24-29 Nov. 2002. Melbourne: NHMRC.
2002
Conference Publication
Peroxisome proliferator-activated receptors in rat cerebellar granule neuronal cultures
Smith, S. A., Monteith, G. R. and Roberts-Thomson, S. J. (2002). Peroxisome proliferator-activated receptors in rat cerebellar granule neuronal cultures. Neuroscience 2002, Florida, 2-7 Nov. 2002. Washington, DC: ScholarOne.
2002
Conference Publication
Expression and function of the peroxisome proliferator-activated receptor in human breast cancer cell lines.
Roberts-Thomson, S. J., May, F. J., Suchanek, K. M., Lee, W.J., Holman, N. A. and Monteith, G. R. (2002). Expression and function of the peroxisome proliferator-activated receptor in human breast cancer cell lines.. American Association for Cancer Research 93rd Annual Meeting, San Francisco, 6-10 Apr. 2002. Linthicum, USA: Cadmus.
2002
Conference Publication
Investigation of the role of dynorphin-A in mediating morphine-3-glucuronide's neuro-excitatory effects
Hemstapat, K., Monteith, G. R. and Smith, M. T. (2002). Investigation of the role of dynorphin-A in mediating morphine-3-glucuronide's neuro-excitatory effects. 10th World Congress on Pain, San Diego, 17-22 Aug. 2002. Seattle: IASP Press.
2002
Conference Publication
The plasma membrane Ca2+ ATPase in breast cancer cell lines
Monteith, G. R., Lee, W.J., Holman, N. A., May, F. J., Lehrbach, G.M. and Roberts-Thomson, S. J. (2002). The plasma membrane Ca2+ ATPase in breast cancer cell lines. American Association for Cancer Research 93rd Annual Meeting, San Francisco, 6-10 Apr. 2002. Linthicum, USA: Cadmus.
2001
Conference Publication
Evaluation of the neurotoxic effects of morphine-3-glucuronide (M3G) in neuronal cultures.
Hemstapat, K., Smith, S. A., Monteith, G. R. and Smith, M. T. (2001). Evaluation of the neurotoxic effects of morphine-3-glucuronide (M3G) in neuronal cultures.. Annual Conference of APSA, Melbourne, 24-27 Nov 2001. Melbourne: APSA.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
Looking for a supervisor? Read our advice on how to choose a supervisor.
Available projects
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Calcium signalling pathways in cancer progression
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Calcium signalling changes associated with viral infection
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Calcium channels and pumps as drug targets
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Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
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Doctor Philosophy
Development of novel methods to identify calcium channels and pumps as drug targets in diseases.
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
Calcium-mediated Signaling Pathways in Breast Cancer
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
The intersection between calcium signaling and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Associate Professor Sherry Wu
Completed supervision
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2025
Doctor Philosophy
Calcium signalling in the context of cell-in-cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
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2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
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2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
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2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
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2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
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2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
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2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
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2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
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2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Hon Assoc Professor Ralf Dietzgen, Emeritus Professor Mike Gidley
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2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
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2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Hon Assoc Professor Ralf Dietzgen, Emeritus Professor Mike Gidley
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2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
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2026
Doctor Philosophy
Design and synthesis of novel modulators targeting ORAI channels
Associate Advisor
Other advisors: Dr Ben Ross
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2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
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2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
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2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
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2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
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2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
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2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
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2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
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2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Hon Assoc Professor Ralf Dietzgen, Emeritus Professor Mike Gidley
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2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
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2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
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Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
Media
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