
Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
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High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2000
Conference Publication
The expression of the plasma membrane Ca2+-ATPase isoforms in human mammary gland epithelial cell lines
Lee, W. J., Holman, N. A., Roberts-Thomson, S. J. and Monteith, G. R. (2000). The expression of the plasma membrane Ca2+-ATPase isoforms in human mammary gland epithelial cell lines. International Congress on Differentiation & Cell Biology, Gold Coast, Australia, 24-28 September 2000. UK: Academic Press.
2000
Journal Article
PMCA1 mRNA expression in rat aortic myocytes: A real-time RT-PCR study
Mamic, TM, Holman, NA, Roberts-Thomson, SJ and Monteith, GR (2000). PMCA1 mRNA expression in rat aortic myocytes: A real-time RT-PCR study. Biochemical And Biophysical Research Communications, 276 (3), 1024-1027. doi: 10.1006/bbrc.2000.3578
2000
Conference Publication
Morphine-3-glucuronide (M3G) evoked increases in [Ca2+]cyt oscillations in cultured rat embryonic hippocampal neurones
Hemstapat, K., Monteith, G. R. and Smith, M. T. (2000). Morphine-3-glucuronide (M3G) evoked increases in [Ca2+]cyt oscillations in cultured rat embryonic hippocampal neurones. Australasian Pharmaceutical Science Association 2000 Annual Conference, Newcastle, Australia, 6 - 8 December, 2000. University of Qld: Australasian Pharmaceutical Science Association.
2000
Conference Publication
Evaluating Australia's national medicines policy using geographical mapping: qummap.health.gov.au
Roughead, E. E., Tett, S. E., Monteith, G. R. and Harvey, K. J. (2000). Evaluating Australia's national medicines policy using geographical mapping: qummap.health.gov.au. 6th Pharmacy Australia Congress, Sydney, 27-30 Oct. 2000. Australia: PAC/FAPA.
2000
Conference Publication
Changes in plasma membrane Ca2+- ATPase isoform 1 (PMCA1) mRNA levels in serum deprived primary cultured rat aoritic smooth muscle cells after stimulation with foetal bovine serum
Mamic, T. M., Roberts-Thomson, S. J., Holman, N. A. and Monteith, G. R. (2000). Changes in plasma membrane Ca2+- ATPase isoform 1 (PMCA1) mRNA levels in serum deprived primary cultured rat aoritic smooth muscle cells after stimulation with foetal bovine serum. International Congress on Differentiation & Cell Biology, Gold Coast, 24-28 Sept. 2000. UK: Academic Press.
2000
Conference Publication
Using the internet to evaluate national medicines policy : Aummap.health.gov.au
Tett, S. E., Overland, V., Roughead, E. E., Monteith, G. R. and Harvey, K. J. (2000). Using the internet to evaluate national medicines policy : Aummap.health.gov.au. Joint Meeting of ASCEPT and the British Pharmacological Society, Monash University, 25-28 April 2000. Australia: ASCEPT.
2000
Conference Publication
The peroxisome proliferator-activated receptor alpha (PPARa ) promotes cell death in cerebellar granule cells in vitro
Smith, S. A., May, F. J., Monteith, G. R. and Roberts-Thomson, S. J. (2000). The peroxisome proliferator-activated receptor alpha (PPARa ) promotes cell death in cerebellar granule cells in vitro. APSA 2000 Annual Conference, Newcastle, 6-8 Dec. 2000. Brisbane: School of Pharmacy, UQ.
2000
Book Chapter
Calcium complexities: new fluorescence techniques for probing mitochondria and other subcellular compartments
Monteith, Gregory R., Dedov, Vadim N. and Roufogalis, Basil D. (2000). Calcium complexities: new fluorescence techniques for probing mitochondria and other subcellular compartments. Calcium: the molecular basis of calcium action in biology and medicine. (pp. 697-713) edited by Roland Pochet, Rosario Donato, Jacques Haiech, Claus Heizmann and Volker Gerke. Dordrecht, Netherlands: Kluwer Academic Publishers. doi: 10.1007/978-94-010-0688-0_42
2000
Journal Article
PMCA1 mRNA expression in rat aortic myocytes: A real time RT-PCR study
Mamic, T. M., Holman, N. A., Roberts-Thomson, S. J. and Monteith, G. R. (2000). PMCA1 mRNA expression in rat aortic myocytes: A real time RT-PCR study. Biochemical & Biophysical Research Communications, 276 (3), 1024-1027. doi: 10.1006/bbrc.2000.3578
2000
Conference Publication
Spontaneous oscillations in neuronal cytosolic free Ca2+ ([Ca2+]cyt ) in rat cultured embryonic hippocampal neurons maintained in serum-free neurobasal medium
Hemstapat, K., Monteith, G. R. and Smith, M. T. (2000). Spontaneous oscillations in neuronal cytosolic free Ca2+ ([Ca2+]cyt ) in rat cultured embryonic hippocampal neurons maintained in serum-free neurobasal medium. Joint Meeting of ASCEPT and the British Pharmacological Society, Melbourne, Australia, 26 - 28 April, 2000. Melbourne, Vic.: Blackwell Scientific Publications.
2000
Book Chapter
Calcium complexities: new fluorescence techniques for probing mitochondria and other subcellular compartments
Monteith, G. R., Dedov, V. N. and Roufogalis, B. D. (2000). Calcium complexities: new fluorescence techniques for probing mitochondria and other subcellular compartments. Calcium: The Molecular Basis of Calcium Action in Biology and Medicine. (pp. 697-713) edited by R. Pochet, R. Donatok, J. Haiecy, C. Heizxmann and V. Gerke. Netherlands: Kluwer Academic.
2000
Conference Publication
Dynamic regulation of plasma membrane calcium ATPase isoform 1 (PMCA1) mRNA in rat aortic myocytes
Monteith, G. R., Mamic, T. M., Holman, N. A. and Roberts-Thomson, S. J. (2000). Dynamic regulation of plasma membrane calcium ATPase isoform 1 (PMCA1) mRNA in rat aortic myocytes. ASCEPT 2000 Annual Meeting, Newcastle, 3-6 Dec. 2000. Sydney: ASCEPT.
2000
Journal Article
Seeing is believing: Recent trends in the measurement of Ca2+ in subcellular domains and intracellular organelles
Monteith, GR (2000). Seeing is believing: Recent trends in the measurement of Ca2+ in subcellular domains and intracellular organelles. Immunology And Cell Biology, 78 (4), 403-407. doi: 10.1046/j.1440-1711.2000.00920.x
2000
Conference Publication
Australia's national medicines policy: Collating and evaluating the information from qummap.health.gov.au
Tett, S. E., Roughead, E. E., Monteith, G. R. and Harvey, K. J. (2000). Australia's national medicines policy: Collating and evaluating the information from qummap.health.gov.au. SHPA Biennial Clinical Conference/Qld State Branch, Gold Coast, 20-22 Oct. 2000. Australia: SHPA.
2000
Conference Publication
The plasma membrane Ca2+ ATPase (PMCA) isoforms in tumorigenic and non-tumorigenic human mammary gland epithelial cell lines
Lee, W. J., Holman, N. A., May, F. J., Roberts-Thomson, S. J. and Monteith, G. R. (2000). The plasma membrane Ca2+ ATPase (PMCA) isoforms in tumorigenic and non-tumorigenic human mammary gland epithelial cell lines. APSA 2000 Annual Conference, Newcastle, Australia, 6-8 December 2000. Brisbane: School of Pharmacy, UQ.
2000
Book Chapter
Calcium complexities: new fluorescence techniques for probing mitochondria and other subcellular compartments
Monteith, Gregory R. , Dedov, Vadim N. and Roufogalis, Basil D. (2000). Calcium complexities: new fluorescence techniques for probing mitochondria and other subcellular compartments. Calcium: the molecular basis of calcium action in biology and medicine. (pp. 697-713) edited by Richard Pochet. Dordrecht, Netherlands: Springer. doi: 10.1007/978-94-010-0688-0
2000
Journal Article
Calcium signaling in hypertension: A focus on vascular smooth muscle cells
Monteith, G. R. and Roufogalis, B. D. (2000). Calcium signaling in hypertension: A focus on vascular smooth muscle cells. Electronic Journal of Pathology and Histology, 6 (1), 1-9.
2000
Conference Publication
Elucidation of the mechanism underlying the neuro-excitatory effects of morphine-3-glucoronide (M3G): Studies in rat embryonic hippocampal neurones
Hemstapat, K., Smith, D., Monteith, G. R. and Smith, M. T. (2000). Elucidation of the mechanism underlying the neuro-excitatory effects of morphine-3-glucoronide (M3G): Studies in rat embryonic hippocampal neurones. The Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Annual Scientific Meeting, Newcastle, Australia, 3-6 December, 2000. Melbourne, Vic.: Blackwell Scientific Publications.
1999
Journal Article
Heterogeneity of mitochondrial matrix free Ca2+: resolution of Ca2+ dynamics in individual mitochondria in situ
Monteith, G.R. and Blaustein, M.P. (1999). Heterogeneity of mitochondrial matrix free Ca2+: resolution of Ca2+ dynamics in individual mitochondria in situ. American Journal of Physiology - Cell Physiology, 276 (5), C1193-C1204. doi: 10.1152/ajpcell.1999.276.5.c1193
1999
Conference Publication
The plasma membrane calcium ATPase in the human tumorigenic mammary epithelial MCF-7 cell line
Monteith, G. R., Holman, N. A., Lee, W. J. and Roberts-Thomson, S. J. (1999). The plasma membrane calcium ATPase in the human tumorigenic mammary epithelial MCF-7 cell line. ASCEPT 32nd annual scientific meeting, Sydney, 4-8 December 1999. Sydney: ASCEPT.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Calcium signalling pathways in cancer progression
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Calcium signalling changes associated with viral infection
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Calcium channels and pumps as drug targets
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Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
Completed supervision
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2025
Doctor Philosophy
Calcium signalling in the context of cell-in-cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
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2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
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2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
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2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
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2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
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2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
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2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
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2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
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2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
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2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
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2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
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2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
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2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
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2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
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2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
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2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
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2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
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2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
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2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
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Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
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