
Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
-
calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
-
High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2004
Conference Publication
The effect of acidic pH on morphine inhibition of high-K+ induced CA2+ responses in dorsal root ganglion neurons
Kapitzke, D., Hermanussen, S. F., Monteith, G. R., Brown, L. C. and Cabot, P. J. (2004). The effect of acidic pH on morphine inhibition of high-K+ induced CA2+ responses in dorsal root ganglion neurons. 4th Annual Queensland Health and Medical Scientific Meeting, Brisbane, 30 Nov - 1 Dec 2004. Brisbane: Qld. Government.
2004
Conference Publication
Beta-endorphin inhibition of capsaicin induced calcium responses in cultured dorsal root ganglion neurones is enhanced at acidic pH
Vetter, I., Hermanussen, S. F., Monteith, G. R. and Cabot, P. J. (2004). Beta-endorphin inhibition of capsaicin induced calcium responses in cultured dorsal root ganglion neurones is enhanced at acidic pH. 4th Annual Queensland Health and Medical Scientific Meeting, Brisbane, 30th November - 1st December, 2004. Brisbane: Queensland Government.
2004
Conference Publication
Characterisation of the plasma membrane calcium pump in breast and colon cancer cell lines
Roberts-Thomson, S. J., Aung, C. S., Lee, W. J., Robinson, J. A. and Monteith, G. R. (2004). Characterisation of the plasma membrane calcium pump in breast and colon cancer cell lines. Melbourne Regional Meeting of ASCEPT, Melbourne University, 30 November, 2004. Melbourne, Vic, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT).
2004
Conference Publication
Differential expression of MRNA encoding plasma membrane calcium atpase isoform two in human breast epithelial cell lines
Lee, W. J., Robinson, J. A., Holman, N. A., Roberts-Thomson, S. J. and Monteith, G. R. (2004). Differential expression of MRNA encoding plasma membrane calcium atpase isoform two in human breast epithelial cell lines. CTP 2004: 8th World Congress on Clinical Pharmacology & Therapeutics, Brisbane, Qld, Australia, 1-6 August, 2004. Melbourne, Vic, Australia: Blackwell Publishing Asia.
2004
Conference Publication
Consequences of peroxisome proliferator-activated receptor A in human breast cancer cell lines
Faddy, H. M., Robinson, J. A., Holman, N. A., Davis, B.J., Monteith, G. R. and Roberts-Thomson, S. J. (2004). Consequences of peroxisome proliferator-activated receptor A in human breast cancer cell lines. 8th World Conference on Clinical Pharmacology and Therapeutics, Brisbane, Qld, Australia, 1-6 August, 2004. Melbourne, Vic, Australia: Blackwell Publishing.
2004
Conference Publication
Experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice: A multiple relapsing model of multiple sclerosis
Peiris, M., Roberts-Thomson, S. J., Monteith, G. R. and Cabot, P. J. (2004). Experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice: A multiple relapsing model of multiple sclerosis. 4th Annual Queensland Health and Medical Scientific Meeting, Brisbane, 30 Nov - 1 Dec 2004. Brisbane: Qld Government.
2004
Journal Article
Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: Potential application to biomolecular screening
Hemstapat, K, Smith, M. T. and Monteith, G. R. (2004). Measurement of intracellular Ca2+ in cultured rat embryonic hippocampal neurons using a fluorescence microplate reader: Potential application to biomolecular screening. Journal of Pharmacological and Toxicological Methods, 49 (2), 81-87. doi: 10.1016/j.vascn.2003.10.002
2003
Journal Article
Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones
Hemstapat, K., Monteith, G. R., Smith, D. and Smith, M. T. (2003). Morphine-3-glucuronide's neuro-excitatory effects are mediated via indirect activation of N-methyl-D-aspartic acid receptors: Mechanistic studies in embryonic cultured hippocampal neurones. Anesthesia & Analgesia, 97 (2), 494-505. doi: 10.1213/01.ANE.0000059225.40049.99
2003
Journal Article
Effects of peroxisome proliferator-activated receptor gamma ligands ciglitazone and 15-deoxy-delta 12,14-prostaglandin J2 on rat cultured cerebellar granule neuronal viability Steven A. Smith, Gregory R. Monteith, Nicola A. Holman, Jodie A. Robinson, Fion
Smith, Steven A., Monteith, Gregory R., Holman, Nicola A., Robinson, Jodie A., May, Fiona J. and Roberts-Thomson, Sarah J. (2003). Effects of peroxisome proliferator-activated receptor gamma ligands ciglitazone and 15-deoxy-delta 12,14-prostaglandin J2 on rat cultured cerebellar granule neuronal viability Steven A. Smith, Gregory R. Monteith, Nicola A. Holman, Jodie A. Robinson, Fion. Journal of Neuroscience Research, 72 (6), 747-755. doi: 10.1002/jnr.10613
2003
Conference Publication
Characterisation of peroxisome proliferator-activated receptor a and its effects on MCF-7 breast cancer cells
Faddy, H. M., Robinson, J. A., Holman, N. A., Davis, B.J., Monteith, G. R. and Roberts-Thomson, S. J. (2003). Characterisation of peroxisome proliferator-activated receptor a and its effects on MCF-7 breast cancer cells. ASCEPT 2003, Sydney, NSW, Australia, December, 2003. Melbourne, Vic, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT).
2003
Conference Publication
Peroxisome proliferator-activated receptors (PPAR) and breast cancer
Roberts-Thomson, S. J., Robinson, J. A., Faddy, H. M., Holman, N. A., Davis, B.J., Gopisetty Venkata, N., Suchanek, K. M., May, F. J., Lee, W. J. and Monteith, G. R. (2003). Peroxisome proliferator-activated receptors (PPAR) and breast cancer. Annual Queensland Health & Medical Scientific Meeting 2003, Brisbane, Qld, Australia, 25-26 November, 2003. Brisbane, Qld, Australia: Queensland Health.
2003
Conference Publication
Generation of a tetracycline-regulated stable MCF-7 breast cancer cell line expressing human peroxisome proliferator-activated receptor alpha
Holman, N. A., Davis, B.J., Monteith, G. R., Roberts-Thomson, S. J. and Robinson, J. A. (2003). Generation of a tetracycline-regulated stable MCF-7 breast cancer cell line expressing human peroxisome proliferator-activated receptor alpha. ASCEPT 2003, Sydney, NSW, Australia, December, 2003. Melbourne, Vic, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT).
2003
Conference Publication
Environmental pollutant phthalate esters: Investigation into possible activation of peroxisome proliferator-activated receptor ? (PPAR?)
Gopisetty Venkata, N., Robinson, J. A., Davis, B.J., Monteith, G. R. and Roberts-Thomson, S. J. (2003). Environmental pollutant phthalate esters: Investigation into possible activation of peroxisome proliferator-activated receptor ? (PPAR?). ASCEPT 2003, Sydney, NSW, Australia, December, 2003. Melbourne, Vic, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT).
2003
Conference Publication
Cell adhesion molecules mediate adhesion between immune cells and sensory neurones invitro: A role in inflammatory hyperalgesia
Cabot, P. J., Hermanussen, S. F., Tang, L.W.C. and Monteith, G. R. (2003). Cell adhesion molecules mediate adhesion between immune cells and sensory neurones invitro: A role in inflammatory hyperalgesia. Annual Queensland Health and Medical Scientific Meeting, Brisbane, Qld, Australia, 25-26 November, 2003. Brisbane, Qld, Australia: Queensland Health.
2003
Book Chapter
Recent developments in calcium signaling
Monteith, G. R. (2003). Recent developments in calcium signaling. Molecular Pathomechanisms and New Trends in Drug Research. (pp. 114-119) edited by G. Keri and I. Toth. London & New York: Taylor & Francis.
2003
Conference Publication
Generation of a stable MCF-7 cell line expressing tetracycline-regulated antisense towards the plasma membrane calcium
Lee, W.J., Robinson, J. A., Holman, N. A., McCall, M., Roberts-Thomson, S. J. and Monteith, G. R. (2003). Generation of a stable MCF-7 cell line expressing tetracycline-regulated antisense towards the plasma membrane calcium. ASCEPT 2003, Sydney, NSW, Australia, December, 2003. Melbourne, Vic, Australia: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (ASCEPT).
2003
Journal Article
The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones
Hemstapat, K., Smith, S. A., Monteith, G. R. and Smith, M. T. (2003). The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones. Pharmacology & Toxicology, 93 (4), 197-200. doi: 10.1034/j.1600-0773.2003.930408.x
2002
Journal Article
Expression of plasma membrane calcium pump isoform mRNAs in breast cancer cell lines.
Lee, W. J., Roberts-Thomson, S. J., Holman, N. A., May, F. J., Lehrbach, G. M. and Monteith, G. R. (2002). Expression of plasma membrane calcium pump isoform mRNAs in breast cancer cell lines.. Cellular Signalling, 14 (12), 1015-1022. doi: 10.1016/S0898-6568(02)00049-9
2002
Journal Article
Peroxisome proliferator-activated receptor alpha in the human breast cancer cell lines MCF-7 and MDA-MB-231
Suchanek, Kate M., May, Fiona J., Robinson, Jodie A., Lee, Won Jae, Holman, Nicola A., Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2002). Peroxisome proliferator-activated receptor alpha in the human breast cancer cell lines MCF-7 and MDA-MB-231. Molecular Carcinogenesis, 34 (4), 165-171. doi: 10.1002/mc.10061
2002
Journal Article
Evaluating Australia's National Medicines Policy using geographical mapping
Roughead, E. E., Monteith, G. R., Harvey, K. J. and Tett, S. E. (2002). Evaluating Australia's National Medicines Policy using geographical mapping. Internal Medicine Journal, 32 (3), 66-71. doi: 10.1046/j.1445-5994.2002.00166.x
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
Calcium signalling pathways in cancer progression
-
Calcium signalling changes associated with viral infection
-
Calcium channels and pumps as drug targets
-
Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
-
Doctor Philosophy
Calcium signalling and cell death pathways in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
-
Doctor Philosophy
Calcium signalling in the context of cell in cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
-
Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
-
Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
-
Master Philosophy
Investigating the role of exosomes in cancer progression and immunology
Associate Advisor
Other advisors: Dr Sherry Wu
-
Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
-
Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
-
Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
Completed supervision
-
2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
-
-
2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
-
2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
-
2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
-
2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
-
2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
-
2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
-
2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
-
2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
-
2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
-
2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
-
2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
-
-
2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
-
2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
-
2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
-
-
2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
-
2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
-
2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
-
2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
-
2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
-
2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
-
-
2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
-
2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
-
2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
-
2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
-
2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
-
Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
Media
Enquiries
For media enquiries about Professor Gregory Monteith's areas of expertise, story ideas and help finding experts, contact our Media team: