
Overview
Background
Greg studies cellular signalling in disease and the identification of new drug targets. Greg leads the Calcium Signalling Therapeutics Team (CaSTT) in the School of Pharmacy at UQ.
His lab specializes in the development and application of genetically encoded calcium indicators for high-content imaging in live cells. His team focuses on integrating these technologies into high-throughput assays that are critical for drug discovery efforts targeting calcium-mediated signaling pathways. The group has developed and utilized high-content imaging platforms to investigate calcium signaling in various cell types. These platforms enable the team to conduct large-scale screenings and these have been instrumental in identifying novel therapeutic targets.
Greg has established a research program with research funding via NHMRC, ARC, Queensland Cancer Council, Society of Biomolecular Screening, Department of Defense (USA) and other grants and collaboration with Pharmaceutical companies. His interests are signal transduction in disease, calcium transporters as drug targets and biomolecular screening. His work has led to patents and projects towards commercialization for new therapies for cancer.
In 2006 he received a UQ Foundation research excellence award and in 2016 he received the UQ Research Higher Degree Supervision Excellence Award - video link. Greg has also recieved a Research Mentorship Award (HaBS, 2017) and an award for Excellence in Leadership (UQ, 2016).
Availability
- Professor Gregory Monteith is:
- Available for supervision
Fields of research
Qualifications
- Bachelor (Honours), University of Sydney
- Doctor of Philosophy, University of Sydney
Research interests
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calcium regulation in disease and cell signalling
Our current projects are focussed on the study of a variety of calcium transporters in disease for the identification of novel drug targets. PhD and Post-doctoral opportunities may be available, contact - gregm@uq.edu.au and see the "available projects" link.
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High throughput calcium assays for biomolecular screening and cancer research
Our laboratory has the the first FLIPR-tetra system in Australia, allowing high throughput measurement of intracellular calcium in living cells.
Works
Search Professor Gregory Monteith’s works on UQ eSpace
2012
Conference Publication
Assessment of mango peel and flesh extract effects on adipogenesis using the high-content ImageXpresss(R) Micro System
Taing, Meng-Wong, Pierson, Jean-Thomas, Shaw, Paul Nicholas, Roberts-Thomson, Sarah J., Dietzgen, Ralf G., Gidley, Mike and Monteith, Gregory R. (2012). Assessment of mango peel and flesh extract effects on adipogenesis using the high-content ImageXpresss(R) Micro System. SLAS 1st Annual Conference and Exhibition (SLAS2012), San Diego, United States, 4-8 February 2012. St. Charles, IL, United States: Society for Laboratory Automation & Screening.
2012
Conference Publication
Altered purinergic receptor calcium signalling associated with hypoxia in MDA-MB-468 breast cancer cells
Azimi, Iman, Beilby, Hannah, Davis, Felicity M., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Altered purinergic receptor calcium signalling associated with hypoxia in MDA-MB-468 breast cancer cells. Joint ASCEPT-APSA 2012 Conference, Medication Safety, Sydney, Australia, 2 - 5 December 2012.
2012
Conference Publication
Calcium channel transient receptor potential V6 (TRPV6) as a potential therapeutic target for some breast cancers
Peters, A. A., Simpson, P. T., Bassett, J. J., Lee, J. M., Song, S., Parat, M. O., Lakhani, S. R., Kenny, P. A., Roberts-Thomson, S. J. and Monteith, G. R. (2012). Calcium channel transient receptor potential V6 (TRPV6) as a potential therapeutic target for some breast cancers. 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin, Ireland, 6-9 November 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/S0959-8049(12)72328-6
2012
Conference Publication
Differential effects of store operated calcium entry proteins on the calcium-mediated transcription factor NFkB in MDA-MB-231 breast cancer cells
Luk, Nicole, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Differential effects of store operated calcium entry proteins on the calcium-mediated transcription factor NFkB in MDA-MB-231 breast cancer cells. International Meeting on Ion Transport and Cancer 2012, Wurzburg, Germany, 9-12 September 2012.
2012
Conference Publication
Alteration of SKBR3 cancer cell proliferation by silencing specific calcium pumps, channels and channel modulatiors
Pera, Elena, Peters, Amelia, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Alteration of SKBR3 cancer cell proliferation by silencing specific calcium pumps, channels and channel modulatiors. Joint ASCEPT-APSA 2012 Conference, Sydney, Australia, 2-5 December 2012.
2012
Conference Publication
Differential effects of store operated calcium entry proteins on the calcium-mediated transcription factor NFkappaB in MDA-MB-231 breast cancer cells
Luk, N. A., Roberts-Thomson, S. J. and Monteith, G. R. (2012). Differential effects of store operated calcium entry proteins on the calcium-mediated transcription factor NFkappaB in MDA-MB-231 breast cancer cells. 4th EMBO Meeting 2012, Nice, France, 22-25 September 2012.
2012
Conference Publication
The role of the secretory pathway calcium ATPases (SPCAs) in breast cancer
Lee, Jane M., Ross, Diana G. F., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). The role of the secretory pathway calcium ATPases (SPCAs) in breast cancer. Joint ASCEPT-APSA 2012 Conference, Sydney, Australia, 2-5 December 2012.
2012
Conference Publication
Role of hypoxia-induced epithelial-mesenchymal transition in calcium signalling in breast cancer cells
Azimi, I., Beilby, H., Davis, F. M., Roberts-Thomson, S. J. and Monteith, G. R. (2012). Role of hypoxia-induced epithelial-mesenchymal transition in calcium signalling in breast cancer cells. 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin Ireland, 6-9 November 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/S0959-8049(12)72301-8
2012
Conference Publication
Assessment of two-pore channels in MDA-MB-231 breast cancer cells
Jahidin, Aisyah, Curry, Merril, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Assessment of two-pore channels in MDA-MB-231 breast cancer cells. Joint ASCEPT-APSA 2012 Conference, Medication Safety, Sydney, Australia, 2-5 December 2012.
2012
Journal Article
Peroxisome proliferator-activated receptor subtypes in mammary gland development and breast cancer
Falconer, Caitlin, Kenny, Paraic A., Smart, Chanel E., Monteith, Gregory R. and Roberts-Thomson, Sarah J. (2012). Peroxisome proliferator-activated receptor subtypes in mammary gland development and breast cancer. Journal of Cancer Therapeutics and Research, 1 (1). doi: 10.7243/2049-7962-1-14
2012
Conference Publication
Consequences of the silencing of specific calcium pumps, channels and channel modulators on the proliferation of SKBRS HER2-positive breast cancer cells
Pera, E., Peters, A. A., Roberts-Thomson, S. J. and Monteith, G.R. (2012). Consequences of the silencing of specific calcium pumps, channels and channel modulators on the proliferation of SKBRS HER2-positive breast cancer cells. 4th EMBO Meeting 2012, Nice, France, 22-25 September 2012.
2012
Conference Publication
Immunohistochemical analysis of PMCA2 expression in normal and malignant human breast tissues
Peters, Amelia, Lee, Wei C., Smart, Chanel E., Reid, Lynne, da Silva, Leonard, Lakhani, Sunil, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Immunohistochemical analysis of PMCA2 expression in normal and malignant human breast tissues. Joint ASCEPT-APSA 2012 Conference, Medication Safety, Sydney, Australia, 2-5 December 2012.
2012
Conference Publication
Comparison of the bioactivities of peel and flesh extracts of three mango varieties
Hoang, V. L. T., Pierson, J.-T., Curry, M. C., Flanagan, B., Dietzgen, R. G., Gidley, M. J., Roberts-Thomson, S. J., Shaw, P.N. and Monteith, G. R. (2012). Comparison of the bioactivities of peel and flesh extracts of three mango varieties. ComBio 2012, Adealide, Australia, 23-27 September 2012.
2012
Conference Publication
Calcium dependent regulation of multidrug resistance-associated protein 3 (MRP3/ABCC3) gene expression in a model of epithelial-mesenchymal transition (EMT)
Stewart, Teneale A., Azimi, Iman, Davis, Felicity M., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2012). Calcium dependent regulation of multidrug resistance-associated protein 3 (MRP3/ABCC3) gene expression in a model of epithelial-mesenchymal transition (EMT). Joint ASCEPT-APSA 2012 Conference, Medication Safety, Sydney, Australia, 2-5 December 2012.
2012
Conference Publication
TRPV4 channels in Basal-like breast cancer cells
Jamaludin, S. Y. N., Davis, F. M., Peters, A. A., Gonda, T. J., Roberts-Thomson, S. J. and Monteith, G. R. (2012). TRPV4 channels in Basal-like breast cancer cells. 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin Ireland, 6-9 November 2012. Oxford, United Kingdom: Pergamon.
2011
Journal Article
Remodeling of purinergic receptor-mediated Ca(2+) signaling as a consequence of EGF-induced epithelial-mesenchymal transition in breast cancer cells
Davis, Felicity M., Kenny, Paraic A., Soo, Eliza T.-L., van Denderen, Bryce J. W., Thompson, Erik W., Cabot, Peter J., Parat, Marie-Odile, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Remodeling of purinergic receptor-mediated Ca(2+) signaling as a consequence of EGF-induced epithelial-mesenchymal transition in breast cancer cells. PLoS One, 6 (8) e23464, e23464.1-e23464.9. doi: 10.1371/journal.pone.0023464
2011
Journal Article
Ion channels and transporters in cancer. 4. Remodeling of Ca 2+ signaling in tumorigenesis: Role of Ca 2+ transport
Lee, Jane M., Davis, Felicity M., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Ion channels and transporters in cancer. 4. Remodeling of Ca 2+ signaling in tumorigenesis: Role of Ca 2+ transport. American Journal of Physiology - Cell Physiology, 301 (5), C969-C976. doi: 10.1152/ajpcell.00136.2011
2011
Journal Article
ORAI1-mediated calcium influx in lactation and in breast cancer
McAndrew, Damara, Grice, Desma M., Peters, Amelia A., Davis, Felicity M., Stewart, Teneale, Rice, Michelle, Smart, Chanel E., Brown, Melissa A., Kenny, Paraic A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). ORAI1-mediated calcium influx in lactation and in breast cancer. Molecular Cancer Therapeutics, 10 (3), 448-460. doi: 10.1158/1535-7163.MCT-10-0923
2011
Conference Publication
In-vitro assessment of mango extracts and the phytochemicals resveratrol, quercetin, mangiferin and epigallocatechin gallate on lipid accumulation in a mouse adipocyte cell line
Taing, Meng-Wong, Monteith, Gregory, Dietzgen, Ralf, Gidley, Mike, Roberts-Thomson, Sarah and Shaw, Nick (2011). In-vitro assessment of mango extracts and the phytochemicals resveratrol, quercetin, mangiferin and epigallocatechin gallate on lipid accumulation in a mouse adipocyte cell line. SBS 17th Annual Conference and Exhibition, Orlando, United States, 27-31 March 2011.
2011
Conference Publication
Remodeling of purinergic receptor-mediated calcium signalling during epidermal growth factor-induced EMT in a breast cancer cell line
Davis, Felicity, Kenny, Paraic A., Soo, Eliza T.-L., van Denderen, Bryce J. W., Thompson, Erik W., Cabot, Peter J., Marie-Odile Parat, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011). Remodeling of purinergic receptor-mediated calcium signalling during epidermal growth factor-induced EMT in a breast cancer cell line. 5th International Epithelial-Mesenchymal Transition Meeting, Singapore, 10-13 October 2011.
Funding
Current funding
Past funding
Supervision
Availability
- Professor Gregory Monteith is:
- Available for supervision
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Available projects
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Calcium signalling pathways in cancer progression
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Calcium signalling changes associated with viral infection
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Calcium channels and pumps as drug targets
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Design of innovative high throughput methods for drug screening and testing
Supervision history
Current supervision
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Doctor Philosophy
Calcium signalling and cell death pathways in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
Calcium signalling in the context of cell in cell structures in a model of entosis in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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Doctor Philosophy
Development of a new approach to target exosomes for cancer treatment
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Master Philosophy
Investigating the role of exosomes in cancer progression and immunology
Associate Advisor
Other advisors: Dr Sherry Wu
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Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Associate Advisor
Other advisors: Dr Larisa Labzin, Dr Melanie Robitaille
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
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Doctor Philosophy
A Recently Identified Calcium Channel Provides Diverse Opportunities for Pharmacotherapy in Breast Cancer
Associate Advisor
Other advisors: Dr Ben Ross
Completed supervision
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2023
Doctor Philosophy
The relationship between calcium signalling and executioner caspase activity in breast cancer cells
Principal Advisor
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2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Principal Advisor
Other advisors: Dr Melanie Robitaille
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2019
Doctor Philosophy
Calcium channels, pumps and sensors as modulators of therapeutic response in basal breast cancer
Principal Advisor
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2018
Doctor Philosophy
Genetically encoded calcium indicators and the assessment of the hallmarks of cancer in breast cancer cells
Principal Advisor
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2017
Doctor Philosophy
Regulation of MDA-MB-231 breast cancer cell death by plasma membrane calcium ATPase isoforms and the mitochondrial calcium uniporter
Principal Advisor
Other advisors: Professor Peter Cabot
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2016
Doctor Philosophy
Assessment of cellular signaling pathways in processes important in breast cancer metastasis
Principal Advisor
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2016
Doctor Philosophy
Characterisation of calcium pumps and channels as therapeutic targets in breast cancer
Principal Advisor
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2015
Doctor Philosophy
The role of calcium transporting proteins in the acquisition of resistance to trastuzumab
Principal Advisor
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2014
Doctor Philosophy
Nutritional properties of mango fruits: assessing links between genes and bioactivities
Principal Advisor
Other advisors: Dr Ralf Dietzgen, Professor Mike Gidley
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2014
Doctor Philosophy
The Role of the Secretory Pathway Calcium ATPase 1 (SPCA1) in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Characterization of Calcium Store Channels and their Regulators as Potential Pharmacological Targets in Breast Cancer
Principal Advisor
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2014
Doctor Philosophy
Calcium Signalling Modifying Proteins as Targets for Breast Cancer Therapy
Principal Advisor
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2013
Doctor Philosophy
Use of high throughput techniques in the assessment of the bioactivity of mango extracts
Principal Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2006
Doctor Philosophy
THE PLASMA MEMBRANE CALCIUM-ATPase IN MAMMARY GLAND EPITHELIAL CELL LINES AND CONSEQUENCES OF ITS INHIBITION IN A MODEL OF BREAST CANCER
Principal Advisor
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2012
Doctor Philosophy
Remodelling of calcium signalling during colon cancer cell differentiation
Joint Principal Advisor
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2010
Doctor Philosophy
Calcium influx regulators in mammary gland development and breast cancer: Roles of ORAI and STIM isoforms
Joint Principal Advisor
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2009
Doctor Philosophy
Plasma membrane calcium ATPase during colon cancer cell differentiation and in colon cancer
Joint Principal Advisor
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2009
Doctor Philosophy
PPAR isoforms and breast cancer and their regulation by ethanol and plasticizers
Joint Principal Advisor
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2008
Doctor Philosophy
Plasmalemmal and Secretory Pathway Calcium ATPases in the Mammary Gland
Joint Principal Advisor
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2004
Doctor Philosophy
THE ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS IN THE RAT BRAIN
Joint Principal Advisor
Other advisors: Professor Peter Cabot
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2020
Doctor Philosophy
Design, synthesis and evaluation of modulators of calcium-permeable ion channels
Associate Advisor
Other advisors: Dr Ben Ross
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2012
Doctor Philosophy
Intracellular calcium signaling in a model of breast cancer metastasis
Associate Advisor
Other advisors: Professor Peter Cabot, Associate Professor Marie-Odile Parat
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2010
Doctor Philosophy
Characterisation of biological activities of mango fruit components using cell-based assays
Associate Advisor
Other advisors: Professor Nick Shaw, Dr Ralf Dietzgen, Professor Mike Gidley
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2009
Doctor Philosophy
Functional Roles of Peroxisome Proliferator-Activated Receptor B/O in a Model of Relapsing-Remitting Experimental Autoimmune Encephalomyelitis
Associate Advisor
Other advisors: Professor Peter Cabot
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2008
Doctor Philosophy
Preclinical Studies in Painful Diabetic Neuropathy
Associate Advisor
Other advisors: Emeritus Professor Maree Smith, Professor Peter Cabot
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2003
Doctor Philosophy
NEUROPHARMACOLOGY OF MORPHINE-3-glucuronide (M3G)
Associate Advisor
Other advisors: Emeritus Professor Maree Smith
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Doctor Philosophy
MECHANISMS INVOLVED IN FUNCTIONAL INTERACTIONS BETWEEN THE TRANSIENT RECEPTOR POTENTIAL VANILLIOD 1 AND u OPIOID RECEPTOR
Associate Advisor
Other advisors: Professor Peter Cabot
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