Overview
Background
Dr Melanie Robitaille is a Senior Post-Doctoral Researcher working with the Calcium Signalling in Therapeutics Team (CaSTT) in the School of Pharmacy. This team specializes in the development and application of novel methodologies and cellular assays in drug discovery, including the use of genetically encoded indicator for high-content imaging in live cells.
Her interests are to elucidate how calcium signals are remodelled in disease states, to identify calcium transporters as new therapeutic targets and to develop molecular and cellular screening tools to be used in drug development programs. She has an established profile in cellular and molecular biology, with high expertise in plasmid cloning, lentiviral transduction and the use of CRISPR/Cas9 to modulate gene expression.
Availability
- Dr Melanie Robitaille is:
- Not available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Université de Montréal
Works
Search Professor Melanie Robitaille’s works on UQ eSpace
2013
Conference Publication
Unraveling 7tm receptor protein interaction landscape by proximity-depdendent biotin-labeling
Robitaille, Melanie and Angers, Stephane (2013). Unraveling 7tm receptor protein interaction landscape by proximity-depdendent biotin-labeling. GPCR 2012, -, 2012. London, United Kingdom: Taylor & Francis.
2013
Conference Publication
An unbiased proteomic screen for nuclear G beta gamma subunit interactors
Campden, R., Petrin, D., Robitaille, M., Angers, S. and Hebert, T. E. (2013). An unbiased proteomic screen for nuclear G beta gamma subunit interactors. ASCB Annual Meeting 2013, New Orleans, LA United States, 14-18 December 2013. Bethesda, MD United States: American Society for Cell Biology.
2013
Conference Publication
Sapcd2, a novel G alpha i-interacting protein regulating mitotic spindle orientation
Monat, C., Chiu, C., Robitaille, M., Daulat, A., Zhao, P., Chidiac, P., Cayouette, M. and Angers, S. (2013). Sapcd2, a novel G alpha i-interacting protein regulating mitotic spindle orientation. ASCB Annual Meeting 2013, New Orleans, LA United States, 14-18 December 2013. Bethesda, MD United States: American Society for Cell Biology.
2012
Journal Article
A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression
Anastas, J. N., Biechele, T. L., Robitaille, M., Muster, J., Allison, K. H., Angers, S. and Moon, R. T. (2012). A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression. Oncogene, 31 (32), 3696-3708. doi: 10.1038/onc.2011.528
2011
Book Chapter
Real-time BRET assays to measure G protein/effector interactions
Petrin, Darlaine, Robitaille, Melanie and Hebert, Terence E. (2011). Real-time BRET assays to measure G protein/effector interactions. Signal Transduction Protocols . (pp. 245-261) edited by Louis M. Luttrell and Stephen S. G. Ferguson. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-61779-160-4_13
2010
Journal Article
Gβγ is a negative regulator of AP-1 mediated transcription
Robitaille, Melanie, Gora, Sarah, Wang, Ying, Goupil, Eugenie, Petrin, Darlaine, Del Duca, Danny, Villeneuve, Louis R., Allen, Bruce G., Laporte, Stephane A., Bernard, Daniel J. and Hebert, Terence E. (2010). Gβγ is a negative regulator of AP-1 mediated transcription. Cellular Signalling, 22 (8), 1254-1266. doi: 10.1016/j.cellsig.2010.04.005
2009
Journal Article
The Role of G beta gamma subunits in the organization, assembly, and function of GPCR signaling complexes
Dupre, Denis J., Robitaille, Melanie, Rebois, R. Victor and Hebert, Terence E. (2009). The Role of G beta gamma subunits in the organization, assembly, and function of GPCR signaling complexes. Annual Review of Pharmacology and Toxicology, 49 (1), 31-56. doi: 10.1146/annurev-pharmtox-061008-103038
2009
Journal Article
Fonction des chaperonnes moléculaires dans l’assemblage des protéines G hétérotrimériques
Robitaille, Mélanie, Dupré, Denis J. and Hébert, Terence E. (2009). Fonction des chaperonnes moléculaires dans l’assemblage des protéines G hétérotrimériques. Médecine/Sciences, 25 (10), 821-825. doi: 10.1051/medsci/20092510821
2009
Journal Article
The role of molecular chaperones in the assembly of heterotrimeric G proteins
Robitaille, Melanie, Dupre, Denis J. and Hebert, Terence E. (2009). The role of molecular chaperones in the assembly of heterotrimeric G proteins. M S-Medecine Sciences, 25 (10), 821-825. doi: 10.1051/medsci/20092510821
2009
Journal Article
Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor
Zhang, Xiaoping, Wang, Guansong, Dupre, Denis J., Feng, Yumei, Robitaille, Melanie, Lazartigues, Eric, Feng, Ying-Hong, Hebert, Terence E. and Wu, Guangyu (2009). Rab1 GTPase and dimerization in the cell surface expression of angiotensin II type 2 receptor. Journal of Pharmacology and Experimental Therapeutics, 330 (1), 109-117. doi: 10.1124/jpet.109.153460
2009
Journal Article
A single conserved leucine residue on the first intracellular loop regulates ER export of G protein-coupled receptors
Duvernay, Matthew T., Dong, Chunmin, Zhang, Xiaoping, Robitaille, Melanie, Hebert, Terence E. and Wu, Guangyu (2009). A single conserved leucine residue on the first intracellular loop regulates ER export of G protein-coupled receptors. Traffic, 10 (5), 552-566. doi: 10.1111/j.1600-0854.2009.00890.x
2009
Journal Article
Intracellular trafficking and assembly of specific Kir3 channel/G protein complexes
Robitaille, Melanie, Ramakrishnan, Nitya, Baragli, Alessandra and Hebert, Terence E. (2009). Intracellular trafficking and assembly of specific Kir3 channel/G protein complexes. Cellular Signalling, 21 (4), 488-501. doi: 10.1016/j.cellsig.2008.11.011
2009
Book Chapter
Novel tools for use in Bioluminescence Resonance Energy Transfer (BRET) assays
Robitaille, Melanie, Heroux, Isabelle, Baragli, Alessandra and Hebert, Terence E. (2009). Novel tools for use in Bioluminescence Resonance Energy Transfer (BRET) assays. Bioluminescence: Methods and Protocols. (pp. 215-234) edited by Preston B. Rich and Christelle Douillet. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-60327-321-3_18
2008
Journal Article
Combining protein complementation assays with resonance energy transfer to detect multipartner protein complexes in living cells
Rebois, R. Victor, Robitaille, Melanie, Petrin, Darlaine, Zylbergold, Peter, Trieu, Phan and Hebert, Terence E. (2008). Combining protein complementation assays with resonance energy transfer to detect multipartner protein complexes in living cells. Methods, 45 (3), 214-218. doi: 10.1016/j.ymeth.2008.06.006
2007
Journal Article
Dopamine receptor-interacting protein 78 acts as a molecular chaperone for G gamma subunits before assembly with G beta
Dupre, Denis J., Robitaille, Melanie, Richer, Maxime, Ethier, Nathalie, Mamarbachi, Aida M. and Hebert, Terence E. (2007). Dopamine receptor-interacting protein 78 acts as a molecular chaperone for G gamma subunits before assembly with G beta. Journal of Biological Chemistry, 282 (18), 13703-13715. doi: 10.1074/jbc.M608846200
2006
Journal Article
Seven transmembrane receptor core signaling complexes are assembled prior to plasma membrane trafficking
Dupre, Denis J., Robitaille, Melanie, Ethier, Nathalie, Villeneuve, Louis R., Mamarbachi, Aida M. and Hebert, Terence E. (2006). Seven transmembrane receptor core signaling complexes are assembled prior to plasma membrane trafficking. Journal of Biological Chemistry, 281 (45), 34561-34573. doi: 10.1074/jbc.M605012200
2006
Journal Article
Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells
Rebois, R. Victor, Robitaille, Melanie, Gales, Celine, Dupre, Denis J., Baragli, Alessandra, Trieu, Phan, Ethier, Nathalie, Bouvier, Michel and Hebert, Terence E. (2006). Heterotrimeric G proteins form stable complexes with adenylyl cyclase and Kir3.1 channels in living cells. Journal of Cell Science, 119 (13), 2807-2818. doi: 10.1242/jcs.03021
Supervision
Availability
- Dr Melanie Robitaille is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Principal Advisor
Other advisors: Professor Gregory Monteith, Dr Larisa Labzin
-
Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Principal Advisor
Other advisors: Professor Gregory Monteith, Dr Larisa Labzin
-
Doctor Philosophy
Calcium signalling in the context of cell in cell structures in a model of entosis in breast cancer cells
Associate Advisor
Other advisors: Professor Gregory Monteith
-
Doctor Philosophy
Targeting peripheral kappa and mu bivalent opioid receptors with bivalent opioid peptides for inflammatory pain
Associate Advisor
Other advisors: Dr Ben Ross, Dr Danial Saifuddin, Professor Peter Cabot
-
Doctor Philosophy
Designing novel bivalent ligands that target the mu and nociceptin opioid receptors for reduced side effects
Associate Advisor
Other advisors: Professor Peter Cabot
-
Doctor Philosophy
Calcium signalling and cell death pathways in breast cancer cells
Associate Advisor
Other advisors: Professor Gregory Monteith
-
Doctor Philosophy
Engineering a recombinant targeted delivery platform for nucleic acid-based therapeutics
Associate Advisor
Other advisors: Associate Professor Peter Moyle
-
Doctor Philosophy
Targeting peripheral kappa and mu bivalent opioid receptors with bivalent opioid peptides for inflammatory pain
Associate Advisor
Other advisors: Dr Ben Ross, Professor Peter Cabot
-
Doctor Philosophy
Designing novel bivalent ligands that target the mu and nociceptin opioid receptors for reduced side effects
Associate Advisor
Other advisors: Dr Danial Saifuddin, Professor Peter Cabot
Completed supervision
-
2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Associate Advisor
Other advisors: Professor Gregory Monteith
Media
Enquiries
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