Overview
Background
Dr Melanie Robitaille is a Senior Research Fellow working with the Calcium Signalling in Therapeutics Team (CaSTT) in the School of Pharmacy and Pharmaceutical Sciences. This team specializes in the development and application of novel methodologies and cellular assays in drug discovery, including the use of genetically encoded indicator for high-content imaging in live cells.
Her interests are to elucidate how calcium signals are remodelled in disease states, to identify calcium transporters as new therapeutic targets and to develop molecular and cellular screening tools to be used in drug development programs. She has an established profile in cellular and molecular biology, with high expertise in plasmid cloning, lentiviral transduction and the use of CRISPR/Cas9 to modulate gene expression.
Availability
- Dr Melanie Robitaille is:
- Not available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Université de Montréal
Works
Search Professor Melanie Robitaille’s works on UQ eSpace
2016
Journal Article
YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells
Dey, A., Robitaille, M., Remke, M., Maier, C., Malhotra, A., Gregorieff, A., Wrana, J. L., Taylor, M. D., Angers, S. and Kenney, A. M. (2016). YB-1 is elevated in medulloblastoma and drives proliferation in Sonic hedgehog-dependent cerebellar granule neuron progenitor cells and medulloblastoma cells. Oncogene, 35 (32), 4256-4268. doi: 10.1038/onc.2015.491
2016
Journal Article
SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the G alpha i-LGN-NuMA Ternary Complex
Chiu, Catherine W. N., Monat, Carine, Robitaille, Melanie, Lacomme, Marine, Daulat, Avais M., Macleod, Graham, McNeill, Helen, Cayouette, Michel and Angers, Stephane (2016). SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the G alpha i-LGN-NuMA Ternary Complex. Developmental Cell, 36 (1), 50-62. doi: 10.1016/j.devcel.2015.12.016
2015
Journal Article
Gβ4γ1 as a modulator of M3 muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation of cellular signalling
Khan, Shahriar M., Min, Adam, Gora, Sarah, Houranieh, Geeda M., Campden, Rhiannon, Robitaille, Melanie, Trieu, Phan, Petrin, Darlaine, Jacobi, Ashley M., Behlke, Mark A., Angers, Stephane and Hebert, Terence E. (2015). Gβ4γ1 as a modulator of M3 muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation of cellular signalling. Cellular Signalling, 27 (8), 1597-1608. doi: 10.1016/j.cellsig.2015.04.007
2015
Journal Article
BioID-based identification of SKP Cullin F-box (SCF)(beta-TrCP1/2) E3 ligase substrates
Coyaud, Etienne, Mis, Monika, Laurent, Estelle M. N., Dunham, Wade H., Couzens, Amber L., Robitaille, Melanie, Gingras, Anne-Claude, Angers, Stephane and Raught, Brian (2015). BioID-based identification of SKP Cullin F-box (SCF)(beta-TrCP1/2) E3 ligase substrates. Molecular & Cellular Proteomics, 14 (7), 1781-1795. doi: 10.1074/mcp.M114.045658
2015
Journal Article
The identification of novel protein-protein interactions in liver that affect glucagon receptor activity
Han, Junfeng, Zhang, Ming, Froese, Sean, Dai, Feihan F., Robitaille, Melanie, Bhattacharjee, Alpana, Huang, Xinyi, Jia, Weiping, Angers, Stephane, Wheeler, Michael B. and Wei, Li (2015). The identification of novel protein-protein interactions in liver that affect glucagon receptor activity. Plos One, 10 (6) e0129226, e0129226. doi: 10.1371/journal.pone.0129226
2015
Conference Publication
Sonic Hedgehog induces YB-1 in a yap-dependent manner to regulate Igf2 expression and proliferation in cerebellar granule neuron progenitors and medulloblastoma cells
Dey, A., Robitaille, M., Remke, M., Maier, C., Malhotra, A., Gregorieff, A., Wrana, J., Taylor, M., Angers, S. and Kenney, A. (2015). Sonic Hedgehog induces YB-1 in a yap-dependent manner to regulate Igf2 expression and proliferation in cerebellar granule neuron progenitors and medulloblastoma cells. 3rd Biennial Conference on Pediatric Neuro-Oncology Basic and Translational Research, San Diego, CA United States, 7-8 May 2015. Cary, NC United States: Oxford University Press. doi: 10.1093/neuonc/nov061.78
2015
Book Chapter
Tandem affinity purification to identify cytosolic and nuclear Gβγ-interacting proteins
Campden, Rhiannon, Petrin, Darlaine, Robitaille, Melanie, Audet, Nicolas, Gora, Sarah, Angers, Stephane and Hebert, Terence E. (2015). Tandem affinity purification to identify cytosolic and nuclear Gβγ-interacting proteins. Nuclear G-protein coupled receptors. (pp. 161-184) edited by Bruce G. Allen and Terence E. Hébert. New York, NY, United States: Humana Press. doi: 10.1007/978-1-4939-1755-6_14
2014
Journal Article
Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic beta cells
Zhang, Ming, Robitaille, Melanie, Showalter, Aaron D., Huang, Xinyi, Liu, Ying, Bhattacharjee, Alpana, Willard, Francis S., Han, Junfeng, Froese, Sean, Wei, Li, Gaisano, Herbert Y., Angers, Stephane, Sloop, Kyle W., Dai, Feihan F. and Wheeler, Michael B. (2014). Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic beta cells. Molecular and Cellular Proteomics, 13 (11), 3049-3062. doi: 10.1074/mcp.M114.040196
2014
Journal Article
Ubiquitylation and activation of a Rab GTPase is promoted by a beta(2)AR-HACE1 complex
Lachance, Veronik, Degrandmaison, Jade, Marois, Sebastien, Robitaille, Melanie, Genier, Samuel, Nadeau, Stephanie, Angers, Stephane and Parent, Jean-Luc (2014). Ubiquitylation and activation of a Rab GTPase is promoted by a beta(2)AR-HACE1 complex. Journal of Cell Science, 127 (1), 111-123. doi: 10.1242/jcs.132944
2013
Conference Publication
Transcriptional regulation at IGF2 promoters and mechanistic insights on induction of IGF2 downstream of yap in SHH medulloblastomas
Dev, Abhinav, Robitaille, Melanie, Remke, Marc, Faury, Damien, Maier, Caroline, Malhotra, Anshu, Jabado, Nada, Taylor, Michael, Angers, Stephane and Kenney, Anna (2013). Transcriptional regulation at IGF2 promoters and mechanistic insights on induction of IGF2 downstream of yap in SHH medulloblastomas. 4th Quadrennial Meeting of the World-Federation-of-Neuro-Oncology (WFNO) held in conjunction with the 18th Annual Meeting of the Society-for-Neuro-Oncology (SNO), San Francisco, CA United States, 21-24 November 2013. Cary, NC United States: Oxford University Press.
2013
Journal Article
Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability
Roy, Sebastien J., Glazkova, Irina, Frechette, Louis, Iorio-Morin, Christian, Binda, Chantal, Petrin, Darlaine, Phan Trieu,, Robitaille, Melanie, Angers, Stephane, Hebert, Terence E. and Parent, Jean-Luc (2013). Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability. Molecular Endocrinology, 27 (8), 1245-1266. doi: 10.1210/me.2013-1091
2013
Conference Publication
Characterization of a novel protein interactor of galphai suggests its involvement in mitotic spindle orientation
Chiu, Catherine, Robitaille, Melanie, Daulat, Avais, Zhao, Peishen, Chidiac, Peter, Obiero, Josiah and Angers, Stephane (2013). Characterization of a novel protein interactor of galphai suggests its involvement in mitotic spindle orientation. GPCR 2012, -, 2012. London, United Kingdom: Taylor & Francis.
2013
Conference Publication
Unraveling 7tm receptor protein interaction landscape by proximity-depdendent biotin-labeling
Robitaille, Melanie and Angers, Stephane (2013). Unraveling 7tm receptor protein interaction landscape by proximity-depdendent biotin-labeling. GPCR 2012, -, 2012. London, United Kingdom: Taylor & Francis.
2013
Conference Publication
An unbiased proteomic screen for nuclear G beta gamma subunit interactors
Campden, R., Petrin, D., Robitaille, M., Angers, S. and Hebert, T. E. (2013). An unbiased proteomic screen for nuclear G beta gamma subunit interactors. ASCB Annual Meeting 2013, New Orleans, LA United States, 14-18 December 2013. Bethesda, MD United States: American Society for Cell Biology.
2013
Conference Publication
Sapcd2, a novel G alpha i-interacting protein regulating mitotic spindle orientation
Monat, C., Chiu, C., Robitaille, M., Daulat, A., Zhao, P., Chidiac, P., Cayouette, M. and Angers, S. (2013). Sapcd2, a novel G alpha i-interacting protein regulating mitotic spindle orientation. ASCB Annual Meeting 2013, New Orleans, LA United States, 14-18 December 2013. Bethesda, MD United States: American Society for Cell Biology.
2012
Journal Article
A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression
Anastas, J. N., Biechele, T. L., Robitaille, M., Muster, J., Allison, K. H., Angers, S. and Moon, R. T. (2012). A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression. Oncogene, 31 (32), 3696-3708. doi: 10.1038/onc.2011.528
2011
Book Chapter
Real-time BRET assays to measure G protein/effector interactions
Petrin, Darlaine, Robitaille, Melanie and Hebert, Terence E. (2011). Real-time BRET assays to measure G protein/effector interactions. Signal Transduction Protocols . (pp. 245-261) edited by Louis M. Luttrell and Stephen S. G. Ferguson. Totowa, NJ, United States: Humana Press. doi: 10.1007/978-1-61779-160-4_13
2010
Journal Article
Gβγ is a negative regulator of AP-1 mediated transcription
Robitaille, Melanie, Gora, Sarah, Wang, Ying, Goupil, Eugenie, Petrin, Darlaine, Del Duca, Danny, Villeneuve, Louis R., Allen, Bruce G., Laporte, Stephane A., Bernard, Daniel J. and Hebert, Terence E. (2010). Gβγ is a negative regulator of AP-1 mediated transcription. Cellular Signalling, 22 (8), 1254-1266. doi: 10.1016/j.cellsig.2010.04.005
2009
Journal Article
The Role of G beta gamma subunits in the organization, assembly, and function of GPCR signaling complexes
Dupre, Denis J., Robitaille, Melanie, Rebois, R. Victor and Hebert, Terence E. (2009). The Role of G beta gamma subunits in the organization, assembly, and function of GPCR signaling complexes. Annual Review of Pharmacology and Toxicology, 49 (1), 31-56. doi: 10.1146/annurev-pharmtox-061008-103038
2009
Journal Article
Fonction des chaperonnes moléculaires dans l’assemblage des protéines G hétérotrimériques
Robitaille, Mélanie, Dupré, Denis J. and Hébert, Terence E. (2009). Fonction des chaperonnes moléculaires dans l’assemblage des protéines G hétérotrimériques. Médecine/Sciences, 25 (10), 821-825. doi: 10.1051/medsci/20092510821
Supervision
Availability
- Dr Melanie Robitaille is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
The intersection between calcium signaling and coronavirus infection
Principal Advisor
Other advisors: Professor Gregory Monteith, Dr Larisa Labzin
-
Doctor Philosophy
Calcium-mediated Signaling Pathways in Breast Cancer
Associate Advisor
Other advisors: Professor Gregory Monteith
-
Doctor Philosophy
Development of novel methods to identify calcium channels and pumps as drug targets in diseases.
Associate Advisor
Other advisors: Professor Gregory Monteith
-
Doctor Philosophy
Designing novel bivalent ligands that target the Kappa and nociceptin opioid receptors for reduced side effects
Associate Advisor
Other advisors: Dr Danial Saifuddin, Dr Rink-Jan Lohman, Professor Peter Cabot
-
Doctor Philosophy
Synthesis and characterisation of dynorphin and hemopressin analogues within novel bivalent constructs to target both CB1 and KOP receptors
Associate Advisor
Other advisors: Dr Rink-Jan Lohman, Dr Danial Saifuddin, Professor Peter Cabot
-
Doctor Philosophy
Mutation Targeting Therapy for Cancer with dCas9
Associate Advisor
Other advisors: Associate Professor Joy Wolfram
-
Doctor Philosophy
Targeting peripheral mu and delta opioid receptors with bivalent opioid peptides for pain treatment
Associate Advisor
Other advisors: Dr Ben Ross, Dr Danial Saifuddin, Professor Peter Cabot
Completed supervision
-
2025
Doctor Philosophy
Calcium signalling in the context of cell-in-cell structures in a model of entosis in breast cancer cells
Associate Advisor
Other advisors: Professor Gregory Monteith
-
2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Associate Advisor
Other advisors: Professor Gregory Monteith
Media
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