Overview
Background
Dr Melanie Robitaille is a Senior Post-Doctoral Researcher working with the Calcium Signalling in Therapeutics Team (CaSTT) in the School of Pharmacy. This team specializes in the development and application of novel methodologies and cellular assays in drug discovery, including the use of genetically encoded indicator for high-content imaging in live cells.
Her interests are to elucidate how calcium signals are remodelled in disease states, to identify calcium transporters as new therapeutic targets and to develop molecular and cellular screening tools to be used in drug development programs. She has an established profile in cellular and molecular biology, with high expertise in plasmid cloning, lentiviral transduction and the use of CRISPR/Cas9 to modulate gene expression.
Availability
- Dr Melanie Robitaille is:
- Not available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, Université de Montréal
Works
Search Professor Melanie Robitaille’s works on UQ eSpace
2022
Conference Publication
The role of RunX2 in calcium-related signaling pathways in breast cancer cells
Zhang, Junkai, Monteith, Gregory R., Roberts-Thomson, Sarah and Robitaille, Mélanie (2022). The role of RunX2 in calcium-related signaling pathways in breast cancer cells. APSA-ASCEPT 2022 Joint Conference, Perth, WA Australia, 29 November- 2 December 2022.
2022
Journal Article
AKT regulation of ORAI1-mediated calcium influx in breast cancer cells
Bong, Alice Hui Li, Hua, Trinh, So, Choon Leng, Peters, Amelia A., Robitaille, Mélanie, Tan, Yin Yi, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2022). AKT regulation of ORAI1-mediated calcium influx in breast cancer cells. Cancers, 14 (19) 4794, 1-14. doi: 10.3390/cancers14194794
2022
Conference Publication
Use of genetically-encoded calcium indicators to measure intracellular calcium signalling dynamics between cell-in-cell structures
Janke, Ellen, Sadras, Francisco, Robitaille, Melanie, Roberts-Thomson, Sarah and Monteith, Gregory R. (2022). Use of genetically-encoded calcium indicators to measure intracellular calcium signalling dynamics between cell-in-cell structures. 16th International Meeting of the European Calcium Society, Cork, Ireland, 21-25 August 2022.
2022
Journal Article
Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells
So, Choon Leng, Meinert, Christoph, Xia, Qing, Robitaille, Mélanie, Roberts-Thomson, Sarah J and Monteith, Gregory R (2022). Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells. Cell Calcium, 104 102569, 1-10. doi: 10.1016/j.ceca.2022.102569
2022
Journal Article
ORAI1-regulated gene expression in breast cancer cells: Roles for STIM1 binding, calcium influx and transcription factor translocation
Robitaille, Mélanie, Chan, Shao Ming, Peters, Amelia A., Dai, Limin, So, Choon Leng, Bong, Alice H. L., Sadras, Francisco, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2022). ORAI1-regulated gene expression in breast cancer cells: Roles for STIM1 binding, calcium influx and transcription factor translocation. International Journal of Molecular Sciences, 23 (11) 5867, 1-14. doi: 10.3390/ijms23115867
2022
Journal Article
Uncoiling the link between STIM1 and metastatic pathways in estrogen receptor negative breast cancer cells
Monteith, Prof. Gregory R, Robitaille, Mélanie and Roberts-Thomson, Sarah J. (2022). Uncoiling the link between STIM1 and metastatic pathways in estrogen receptor negative breast cancer cells. Cell Calcium, 103 102563, 102563. doi: 10.1016/j.ceca.2022.102563
2022
Journal Article
ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway
Bassett, John J., Robitaille, Mélanie, Peters, Amelia A., Bong, Alice H. L., Taing, Meng‐Wong, Wood, Ian A., Sadras, Francisco, Roberts‐Thomson, Sarah J. and Monteith, Gregory R. (2022). ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway. The FASEB Journal, 36 (1) e22108, e22108. doi: 10.1096/fj.202002031rr
2021
Conference Publication
Incomplete apoptosis in non-stimulated MDA-MB-468 breast cancer cells
Hua, Trinh N., Sadras, Francisco, Robitaille, Mélanie, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2021). Incomplete apoptosis in non-stimulated MDA-MB-468 breast cancer cells. ASCEPT 2021 Virtual Scientific Meeting, Virtual, 29 November- 2 December 2021.
2021
Conference Publication
ORAI1-dependant IL6 Gene Regulation via Store-operated Calcium Entry in Triple-negative Breast Cancer
Chan, Shao Ming, Robitaille, Mélanie, Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2021). ORAI1-dependant IL6 Gene Regulation via Store-operated Calcium Entry in Triple-negative Breast Cancer. AuPS Meeting, Gold Coast, QLD Australia, 21-24 November 2021.
2021
Conference Publication
CRISPR/Cas9 and lentiviral rescue methods to study ORAI1 function in transcription activation
Robitaille, Mélanie, Chan, Shao Ming, Peters, Amelia A., Dai, Limin, Bong, Alice H.L., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2021). CRISPR/Cas9 and lentiviral rescue methods to study ORAI1 function in transcription activation. AuPS Meeting, Gold Coast, QLD Australia, 21-24 November 2021.
2021
Conference Publication
MetaXpress analysis – Ca2+, transcription factors and using IF after live imaging
Sadras, Francisco, So, Choon Leng, Robitaille, Melanie, Roberts-Thomson, Sarah and Monteith, Gregory (2021). MetaXpress analysis – Ca2+, transcription factors and using IF after live imaging. High Content 2021 SBI2’s 8th Annual Conference, Online, 4-6 October 2021.
2021
Journal Article
Altered calcium influx pathways in cancer-associated fibroblasts
Sadras, Francisco, Stewart, Teneale A., Robitaille, Mélanie, Peters, Amelia A., Croft, Priyakshi Kalita-de, Soon, Patsy S., Saunus, Jodi M., Lakhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2021). Altered calcium influx pathways in cancer-associated fibroblasts. Biomedicines, 9 (6) 680, 1-13. doi: 10.3390/biomedicines9060680
2021
Conference Publication
High-throughput assessment of calcium signaling in MCF-7 breast cancer cells adopting various cellular geometry
So, Choon Leng, Sadras, Francisco, Robitaille, Melanie, Roberts-Thomson, Sarah and Monteith, Gregory (2021). High-throughput assessment of calcium signaling in MCF-7 breast cancer cells adopting various cellular geometry. SLAS 2021 Virtual Conference, Virtual, 25-27 January 2021.
2020
Journal Article
Activation of the ion channel TRPV4 induces epithelial to mesenchymal transition in breast cancer cells
Azimi, Iman, Robitaille, Mélanie, Armitage, Kaela, So, Choon Leng, Milevskiy, Michael J. G., Northwood, Korinne, Lim, Huai Fang, Thompson, Erik W., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2020). Activation of the ion channel TRPV4 induces epithelial to mesenchymal transition in breast cancer cells. International Journal of Molecular Sciences, 21 (24) 9417, 1-14. doi: 10.3390/ijms21249417
2020
Conference Publication
Matrix Stiffness effects on calcium signaling in GCaMP6m-MDA-MB-231 breast cancer cells
So, Choon Leng, Meinert, Christoph, Robitaille, Melanie, Roberts-Thomson, Sarah and Monteith, Gregory (2020). Matrix Stiffness effects on calcium signaling in GCaMP6m-MDA-MB-231 breast cancer cells. 7th Society of Biomolecular Imaging and Informatics (SBI2) High Content Meeting, Virtual, 16-17 September 2020.
2020
Conference Publication
High-throughput assessment of calcium signalling in MDa-MB-231 breast cancer cells expressing the genetically encoded calcium indicator GCaMP6m and cultured in different matrix stiffness
So, Choon Leng, Meinert, Christoph, Robitaille, Melanie, Roberts-Thomson, Sarah and Monteith, Gregory (2020). High-throughput assessment of calcium signalling in MDa-MB-231 breast cancer cells expressing the genetically encoded calcium indicator GCaMP6m and cultured in different matrix stiffness. SLAS2020, San Diego, CA United States, 25-29 January 2020.
2020
Conference Publication
Remodelling of calcium influx pathways in breast cancer associated fibroblasts
Sadras, Francisco, Stewart, Teneale A., Robitaille, Melanie, Peters, Amelia A., Kalita-de Croft, Priyakshi, Soon, Patsy, Saunus, Jodi M., Lakhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2020). Remodelling of calcium influx pathways in breast cancer associated fibroblasts. 2019 San Antonio Breast Cancer Symposium, San Antonio, TX United States, 10-14 December 2019. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.sabcs19-p6-06-15
2019
Journal Article
NCS-1 expression is higher in basal breast cancers and regulates calcium influx and cytotoxic responses to doxorubicin
Bong, Alice H. L., Robitaille, Mélanie, Milevskiy, Michael J. G., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2019). NCS-1 expression is higher in basal breast cancers and regulates calcium influx and cytotoxic responses to doxorubicin. Molecular Oncology, 14 (1) 1878-0261.12589, 87-104. doi: 10.1002/1878-0261.12589
2019
Journal Article
ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development
Magomedova, Lilia, Tiefenbach, Jens, Zilberman, Emma, Le Billan, Florian, Voisin, Veronique, Saikali, Michael, Boivin, Vincent, Robitaille, Melanie, Gueroussov, Serge, Irimia, Manuel, Ray, Debashish, Patel, Rucha, Xu, ChangJiang, Jeyasuria, Pancharatnam, Bader, Gary D, Hughes, Timothy R, Morris, Quaid D, Scott, Michelle S, Krause, Henry, Angers, Stephane, Blencowe, Benjamin J and Cummins, Carolyn L (2019). ARGLU1 is a transcriptional coactivator and splicing regulator important for stress hormone signaling and development. Nucleic Acids Research, 47 (6), 2856-2870. doi: 10.1093/nar/gkz010
2019
Journal Article
ORAI1 and ORAI3 in breast cancer molecular subtypes and the identification of ORAI3 as a hypoxia sensitive gene and a regulator of hypoxia responses
Azimi, Iman, Milevskiy, Michael J. G., Chalmers, Silke B., Yapa, Kunsala T. D. S., Robitaille, Mélanie, Henry, Christopher, Baillie, Gregory J., Thompson, Erik W., Roberts-Thomson, Sarah J and Monteith, Gregory R (2019). ORAI1 and ORAI3 in breast cancer molecular subtypes and the identification of ORAI3 as a hypoxia sensitive gene and a regulator of hypoxia responses. Cancers, 11 (2) 208, 208. doi: 10.3390/cancers11020208
Supervision
Availability
- Dr Melanie Robitaille is:
- Not available for supervision
Supervision history
Current supervision
-
Doctor Philosophy
he intersection between calcium signaling pathways and viral infection
Principal Advisor
Other advisors: Professor Gregory Monteith, Dr Larisa Labzin
-
Doctor Philosophy
The intersection between calcium signaling pathways and coronavirus infection
Principal Advisor
Other advisors: Professor Gregory Monteith, Dr Larisa Labzin
-
Doctor Philosophy
Calcium signalling in the context of cell in cell structures in a model of entosis in breast cancer cells
Associate Advisor
Other advisors: Professor Gregory Monteith
-
Doctor Philosophy
Targeting peripheral kappa and mu bivalent opioid receptors with bivalent opioid peptides for inflammatory pain
Associate Advisor
Other advisors: Dr Ben Ross, Dr Danial Saifuddin, Professor Peter Cabot
-
Doctor Philosophy
Designing novel bivalent ligands that target the mu and nociceptin opioid receptors for reduced side effects
Associate Advisor
Other advisors: Professor Peter Cabot
-
Doctor Philosophy
Calcium signalling and cell death pathways in breast cancer cells
Associate Advisor
Other advisors: Professor Gregory Monteith
-
Doctor Philosophy
Engineering a recombinant targeted delivery platform for nucleic acid-based therapeutics
Associate Advisor
Other advisors: Associate Professor Peter Moyle
-
Doctor Philosophy
Targeting peripheral kappa and mu bivalent opioid receptors with bivalent opioid peptides for inflammatory pain
Associate Advisor
Other advisors: Dr Ben Ross, Professor Peter Cabot
-
Doctor Philosophy
Designing novel bivalent ligands that target the mu and nociceptin opioid receptors for reduced side effects
Associate Advisor
Other advisors: Dr Danial Saifuddin, Professor Peter Cabot
Completed supervision
-
2022
Doctor Philosophy
Shape- and matrix-density mediated changes in calcium signalling in breast cancer cells
Associate Advisor
Other advisors: Professor Gregory Monteith
Media
Enquiries
For media enquiries about Dr Melanie Robitaille's areas of expertise, story ideas and help finding experts, contact our Media team: