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Dr Melanie White heads the Dynamics of Morphogenesis Lab at the Institute for Molecular Bioscience (IMB), University of Queensland and is an ARC Future Fellow. She completed a PhD in Neuroscience at University College London followed by postdoctoral research at The University of Edinburgh. During this time Mel engineered viruses to modulate gene expression in the brain to investigate neuronal function and as a therapeutic approach for neurodegenerative disease. Her work was published in Neuron and PNAS, featured in Nature Reviews Neuroscience and received extensive international media coverage (including the BBC and The Guardian).

In 2012 Mel switched fields to apply quantitative imaging in developmental biology. Her work revealed key mechanisms driving the earliest morphogenetic events in mammalian embryogenesis and was published in Cell, Science, Nature Cell Biology, Developmental Cell and Nature Protocols. Her research was featured on the cover of multiple journals including Cell and she was awarded the inaugural American Society for Cell Biology Porter Prize for Research Excellence (2018).

In 2020, Mel joined the IMB where she will combine her passion for neuroscience and developmental biology to investigate the dynamics of neural tube morphogenesis.

Research overview

The brain and the spinal cord control most of the functions of the body and the mind, yet the dynamics of how they first form is poorly understood. Both structures arise from a common precursor, the neural tube, which forms very early in embryonic development. To generate the forces that sculpt and shape the neural tube, changes in cellular architecture must be tightly coordinated in space and time. These morphological rearrangements occur concurrently with biochemical signalling pathways that specify early neural cell fates.

Our research aims to understand how cellular properties and transcriptional regulators interact with mechanical forces in real time to direct vertebrate neural tube formation and neural cell fate specification. We study the dynamics of neural tube formation by applying advanced imaging technologies in transgenic avian models and human stem cell models.

I completed a BSc (Hons) and a PhD at the University of Melbourne before undertaking post-doctoral research at the University of California, Berkeley, and the University of Texas MD Anderson Cancer Center, Houston. My research focused on marsupial and eutherian developmental biology. After 6 years in the US I returned to Australia to study Veterinary Science (BVSc) at the University of Queensland (UQ), going on to work in equine and small animal practice. A longing to get back into research lead to my current position as a Teaching & Research academic in the School of Veterinary Science, UQ. My lab has generated induced pluripotent stem cells (iPSCs) from dogs and horses that are being used to model diseases in vitro and as the basis for research into stem cell-based treatments for a variety of diseases. We have also produced iPSCs from the Tasmanian devil and the platypus, the first stem cells ever described from a marsupial and a monotreme, respectively, allowing us to pursue research directed at treating devil facial tumour disease, understanding marsupial and monotreme embryonic development, and the conservation of endangered species.

Education

• BSc (Hons), University of Melbourne (1990)
• PhD, University of Melbourne (1996)
• BVSc (Hons), University of Queensland (2006)

Employment

• Post-doctoral researcher, University of California, Berkeley, USA (1996-1997)
• Post-doctoral researcher, MD Anderson Cancer Centre, Houston, Texas, USA (1997-2002)
• Veterinary Surgeon (2006-present)
• Lecturer, School of Veterinary Science, University of Queensland (2010-2017)
• Affiliate Senior Research Fellow, Australian Institute for Bioengineering and Nanotechnology, University of Queensland (2016-present)
• Senior Lecturer, School of Veterinary Science, University of Queensland (2017-2022)
• Associate Professor, School of Veterinary Science, University of Queensland (2023-present)

My research group studies animal performance in the laboratory and in the field. We focus on discovering the underlying mechanistic basis of physical performance and it's implications for an individual's survival and reproductive success. We’re particularly interested in how organisms respond to environmental variation, such as seasonal or long-term temperature change, and the costs of these responses to other traits. We examine interactions between behavioural, physiological and morphological traits to better understand how animal performance is optimised. Furthermore, we want to understand how an organism’s performance relates to population-level processes, enabling better conservation practices in urban and wild habitats. Our research is question-driven, and we use a variety of model systems in our studies, including freshwater fish, crayfish, reptiles, marsupials, and humans.

Current projects

• Importance of performance, life history and behaviour to male mating success in the semelparous marsupial the northern quoll
• Relative importance of athleticism, skill and balance to success in complex human activities - focus on soccer players
• When and why do animals lie? Testing hypotheses of deceit and discovering its role in determining animal performance

Having started in animation in the 80s Bradd made the move to science with his studies at The University of Queensland. After completing his PhD Bradd worked as a Post-Doctoral Research Fellow. He has been employed at The University of Queensland since 2000.

His research interests are in agriculture and sustainability with a focus on how industry engages with changing societal expectations.

Professor Wolvetang is an international leader in the area of pluripotent stem cell biology and human functional genomics. he initiated and leads Cell Reprogramming Australia, a collaborative framework that facilitates induced pluripotent stem cell research in Australa and is co-director of the UQ Centre in Stem Cell Ageing and Regenerative Engineering (StemCARE). He has extensive expertise in reprogramming somatic cells, differentiation and tissue engineering with adult, embryonic and induced pluripotent stem cells, genome manipulation with CRISPR, molecular biology, transcriptome analysis, high content image analysis, development and use of microfluidic devices for cell analysis, nanoparticle and scaffold design and delivery, and stem cell and cell-free regenerative medicine approaches.Professor Wolvetang has been instrumental in establishing and enabling the technology for derivation of induced pluripotent stem cells across Australia. Professor Wolvetang made the strategic decision to focus on the generation of induced pluripotent stem from patients with neurological and cardiac disorders because live human cells from such patients can usually not be obtained whereas induced pluripotent stem cells have the ability to generate every cell type of the human brain in unlimited amounts and can recapitulate the disease in the dish. Induced pluripotent stem cells combined with emerging technologies such as CRISPR-based genome editing offers a unique opportunity to study the role of individual genes and combinatorial gene regulatory pathways in the eatiology of monogenic and complex brain disorders. Indeed, combined with RNA-seq and organoid generation we are now for the first time able to gain insight into gene regulatory pathways operational in individual brain cell types of healthy and diseased individuals, investigate the connectivity and function of cells, as well as pinpoint where and when during early development such deregulated pathways lead to pathological changes. Induced pluripotent stem cells further not only provide insight into the underlying pathogenesis of neurological disorders but also constitute a valuable drugscreening platform and, following CRISPR-based gene correction, can form the basis of patient specific cellular therapies for currently incurable diseases.

Professor Wolvetang received his PhD in 1992 from the Department of Biochemistry, University of Amsterdam for his original work on peroxisomal disease (6 papers). He undertook postdoctoral studies at the Department of Biochemistry and the Institute for Reproduction and Development of Monash University, investigating apoptosis, Down syndrome and Ets transcription factors, respectively, obtaining the first evidence for an intra-chromosomal regulatory loop on chromosome 21 involving Ets2 (3 papers), and revealing the role of p53 in immune-suppression in Down syndrome (Hum Mol. Genetics). He then joined Prof Martin Pera in the Australian Stem Cell Centre in 2003 to pioneer human embryonic stem cell research in Australia, resulting in a first author Nature Biotechnology paper in 2006 identifying CD30 as a marker for genetically abnormal hESC (72 cites). He was appointed group leader of the Basic human stem cell biology laboratory in the ASCC research laboratory and senior lecturer in the Department of Anatomy and Cell biology until he accepted his current position as an independent group leader at the AIBN and Professor in stem cell biology at the University of Queensland in 2008. There he started to generate integration-free induced pluripotent stem cells from human neurological diseases such as ataxia-telangiectasia (Stem cells translational medicine). In recognition of his leadership role in this area of research he was appointed leader of the “Reprogramming and Induction of pluripotency” Collaborative Stream of the Australian Stem Cell Centre until the end of that initiative in 2011, coordinating collaborative research between eight stem cell laboratories across Australia. He subsequently initiated and is now the president of Cell Reprogramming Australia, a collaborative framework aiming to facilitate and accelerate iPS cell research in Australia and the Asia pacific region and inform the general public about reprogramming technology. His research continues to combine cell reprogramming technology, genome editing/analysis tools and microfluidic/nanoparticle based detection/ delivery technologies with the aim of creating human in vitro models of disease, unravel the underlying gene regulatory networks and enable novel cell- and delivery-based therapeutics, respectively. He further co-direct the UQ-Centre for stem cell ageing and regenerative engineering (UQ-StemCARE).

Mechanisms of drug-induced liver damage.

Liver disease has long been associated with the abuse and clinical use of drugs. My research interests focus on ethanol, perhaps the most commonly abused drug, and the widely used non-steroidal anti-inflammatory drugs (NSAIDS). Both NSAIDS and ethanol are widely tolerated but induce liver disease in a small number of individuals.

Research projects listed below investigate immunological and genetic phenomena associated with drug-induced liver disease.

• Does ethanol alter hepatic gene expression to cause liver damage?
• Does ethanol alter hepatocyte sensitivity to cytokines leading to cell death?
• Is protein modification by ethanol metabolites involved in the aetiology of alcoholic liver disease?
• Do keratin 8 or 18 mutants sensitise the liver to toxins?
• Is an aberrant immune response involved in NSAID adverse reactions?
• What is the mechanism of toxicity of the Bracken fern toxin ptaquiloside?

My group studies the role of cadherin cell adhesion molecules in morphogenesis and tumor development. E-cadherin is a key mediator of cell-cell recognition. It participates in tissue patterning and its dysfunction contributes to tumor progression and invasion.

Associate Professor Yap is the group leader for Cadherin cell adhesion molecules, Epithelial morphogenesis & Cell locomotion research at the IMB.

I have a multidisciplinary background in chemical and civil engineering, chemistry and materials science. Currently, I am the UQ leader of the National Centre for Timber Durability and Design Life, based at USC. I apply my expertise to understand the effects of fungal decay and moisture intrusion in timber connections, as well as the improvement of the fire performance of timber. I supervise 6 PhD students.

I have over 10 years of research and work experience in the field of mining land rehabilitation, acquiring a total of>3.5 million in fund support from the Australian government, research council and mining companies. My extensive experience in industrial engagement, field trial design and application also increased my growth as the leader in sustainable mining waste management.

I am an Advanced Queensland research fellow in the leading global research group of Ecological Engineering of Mine Wastes at the Sustainable Mineral Institute (SMI). My research interest is investigating important molecular and cellular processes in eukaryotes that first arose in bacteria and archaea, and microbial metabolic activities control numerous geochemical cycles in soil formation for sustainable mineral waste management. I have intensive work experience on multiple representative mining wastes, including Cu-Au, Pb-Zn, Iron ore, Uranium mine waste rock and bauxite tailings and residues.

My research strength lies in my multidisciplinary work and research program spans the interface between environmental microbiology, geochemistry, and plants. My expertise includes 1) mineral characterization, 2) soil and rhizosphere element cycling, 3) next-generation sequencing and online-controlled bioreactor techniques. Through the integrated application of environmental 'omics approaches, stable isotope analysis and imaging would give new insights into the fundamental element cycling processes of mined land mining wastes, and upon which I could develop novel biotechnology and methodology to prime sustainable mined land management and bioinoculum product with the field validated designated performance.

I have a keen interest in the evolutionary relationships that underpin symbioses, particularly those involved in plant disease. There are countless examples of how diseases have impacted on different crops throughout history, and this is an ongoing issue that deleteriously impacts food security. My research involves developing a better understanding of the epidemiology of plant diseases and pests, and delivering improved diagnostics and field management. Working with collaborators and international experts, my work involves research on a broad range of plants that are affected by bacteria, fungi, oomycetes and viruses. I have a strong interest in the biotic factors that govern soil health and the methods by which we can promote the development of beneficial microbial communities.

The study of insect abundance and distribution.

I am an insect ecologist by "bent" and my students and I work on various applied and basic research areas. We generally take an individuals-process based approach to the study of insect abundance and distribution. We use various "model" systems to ask questions ranging from the effect of host chemistry on oviposition behaviour and early stage caterpillar survival, to the effects of learning on oviposition behaviour at a landscape level and the effects of climate on insect abundance. I prefer to work on Butterfly-plant interactions, particularly Monarchs and milkweeds.

A substantial amount of our applied research has been on the ecology and biology of Helicoverpa spp, the major pest of Australian field crops, and more recently Diamondback moth, a key pest of horticulture.

Dr Jian Zeng is a statistical geneticist and NHMRC Emerging Leadership Fellow at the Institute for Molecular Bioscience (IMB) at the University of Queensland (UQ). He received his PhD in animal breeding and genetics at Iowa State University and joined the Program in Complex Trait Genomics (PCTG) at UQ in 2016. His research focuses on the development and application of innovative statistical methods for estimating the genetic architecture and evolutionary signals in complex traits, identifying genetic variants, genes and other molecular intermediates associated with phenotype variation, and predicting trait phenotypes using genome sequence data. In 2019, he was awarded an NHMRC Investigator Emerging Leadership Grant to develop statistical methods and software tools for best predict an individual’s disease risk using genomic and omics data. He was an invited speaker at the prestigious Gordon Research Conference in 2019.

Biography:

Dr. Xueqin Zhang is currently a Research Fellow, and an ARC DECRA Fellow at Australian Centre of Water and Environmental Biotechnology (ACWEB, formerly AWMC), and School of Chemical Engineering. He obtained his Ph.D. in 2021 at Advanced Water Management Centre (AWMC) and then worked as a Postdoctoral Research Fellow at ACWEB till November 2023. His research focuses on the physiology and ecology of novel microorganisms in biogeochemical cycling, bioelectrochemistry in carbon (methane) cycles and environmental bioremediation, and greenhouse gas (bio)conversion for value-adding applications. He has published over 40 peer-reviewed articles in top-tier journals including Nature Microbiology, Nature Communications, Environmental Science and Technology and Water Research. He acted as a Guest Editor of two journals and has been invited as a reviewer for over 10 journals. He serves on the editorial board of Frontiers of Environmental Science Engineering.

Teaching and Learning:

• Lecturer in Advanced Wastewater and Biosolids Treatment (WATR6103)
• Supervisor in Thesis project (CHEE7382)

I am a Research Fellow in Bioinformatics, holding a joint position with QBI the Bredy group (50%) and IMB the Palpant group (50%). With over 15 years of experience in the bioinformatics/NGS field, my journey began with the greenfield development of three NGS platforms: 454, Illumina, and SOLiD. This experience has equipped me with extensive expertise in bioinformatic analysis, particularly in analyzing a variety of NGS data types. As the leader of the bioinformatics core facility at QBI from 2012 to 2022, my role was primarily focused on providing bioinformatics services. However, I have also been actively engaged in custom programming and analysis for numerous projects, allowing me to make significant intellectual contributions and deepen my involvement in research studies. Despite the typical service-oriented position of bioinformaticians, my publication record is notable, featuring over 40 peer-reviewed publications, with me serving as the first, co-first, or last author on 16 of them. Since 2019, my work has garnered 1,525 citations (as per Google Scholar, as of 12 Jan 2024), with 41.2% of my publications ranking in the top 10% of journals based on the CiteScore Percentile Source from SciVal. My contributions to bioinformatics are showcased in prestigious journals, with notable examples including lncRNA capture sequencing and ATAC-seq data analysis (Nature Communications, 2023) and (Cell Reports, 2022), de novo transcriptome assembly (Development, 2022), noncanonical structure Z-DNA analysis (Nature Neuroscience, 2020), DNA modification m6dA data analysis (Nature Neuroscience, 2019), whole-exome sequencing data analysis (Genome Medicine, 2017), and cross-ethnic meta-analysis (Nature Communications, 2017).